{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:14:29Z","timestamp":1792174469279,"version":"4.4.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T00:00:00Z","timestamp":1205971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T00:00:00Z","timestamp":1205971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2008,4,9]]},"DOI":"10.1038\/emboj.2008.51","type":"journal-article","created":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T07:36:02Z","timestamp":1205998562000},"page":"1017-1028","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":247,"title":["Liver\u2010specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks"],"prefix":"10.1038","volume":"27","author":[{"given":"Sarah K","family":"Knutson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda J","family":"Chyla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M","family":"Amann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srividya","family":"Bhaskara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey S","family":"Huppert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W","family":"Hiebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,20]]},"reference":[{"key":"BFEMBJ200851_CR1","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.88.5.1977","volume":"88","author":"M Alcalay","year":"1991","unstructured":"Alcalay M, Zangrilli D, Pandolfi PP, Longo L, Mencarelli A, Giacomucci A, Rocchi M, Biondi A, Rambaldi A, Lo Coco F, E, F, PG (1991) Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus. Proc Natl Acad Sci USA 88: 1977\u20131981","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ200851_CR2","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1128\/MCB.21.19.6470-6483.2001","volume":"21","author":"JM Amann","year":"2001","unstructured":"Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (2001) ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol 21: 6470\u20136483","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ200851_CR3","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1128\/MCB.21.20.7065-7077.2001","volume":"21","author":"BP Ashburner","year":"2001","unstructured":"Ashburner BP, Westerheide SD, Baldwin Jr AS (2001) The p65 (RelA) subunit of NF\u2010kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 21: 7065\u20137077","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ200851_CR4","doi-asserted-by":"crossref","unstructured":"Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Hiebert SW (2008) Deletion of Histone Deacetylase 3 reveals critical roles in S\u2010phase progression and DNA damage control. Molecular Cell (in press)","DOI":"10.1016\/j.molcel.2008.02.030"},{"key":"BFEMBJ200851_CR5","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.metabol.2007.06.016","volume":"56","author":"NF Brown","year":"2007","unstructured":"Brown NF, Stefanovic\u2010Racic M, Sipula IJ, Perdomo G (2007) The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes. Metabolism 56: 1500\u20131507","journal-title":"Metabolism"},{"key":"BFEMBJ200851_CR6","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1006\/bbrc.1999.1605","volume":"264","author":"SR Chakrabarti","year":"1999","unstructured":"Chakrabarti SR, Nucifora G (1999) The leukemia\u2010associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A. Biochem Biophys Res Commun 264: 871\u2013877","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ200851_CR7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1463-1326.2006.00608.x","volume":"9","author":"JC Clapham","year":"2007","unstructured":"Clapham JC, Arch JR (2007) Thermogenic and metabolic antiobesity drugs: rationale and opportunities. Diabetes Obes Metab 9: 259\u2013275","journal-title":"Diabetes Obes Metab"},{"key":"BFEMBJ200851_CR8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","volume":"370","author":"AJ de Ruijter","year":"2003","unstructured":"de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370: 737\u2013749","journal-title":"Biochem J"},{"key":"BFEMBJ200851_CR9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0003-9861(02)00418-6","volume":"409","author":"N Debeljak","year":"2003","unstructured":"Debeljak N, Fink M, Rozman D (2003) Many facets of mammalian lanosterol 14alpha\u2010demethylase from the evolutionarily conserved cytochrome P450 family CYP51. Arch Biochem Biophys 409: 159\u2013171","journal-title":"Arch Biochem Biophys"},{"key":"BFEMBJ200851_CR10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1534-5807(02)00360-X","volume":"3","author":"L Fajas","year":"2002","unstructured":"Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, Debril MB, Miard S, Auwerx J (2002) The retinoblastoma\u2010histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell 3: 903\u2013910","journal-title":"Dev Cell"},{"key":"BFEMBJ200851_CR11","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.1128\/MCB.19.10.6566","volume":"19","author":"R Fenrick","year":"1999","unstructured":"Fenrick R, Amann JM, Lutterbach B, Wang L, Westendorf JJ, Downing JR, Hiebert SW (1999) Both TEL and AML\u20101 contribute repression domains to the t(12;21) fusion protein. Mol Cell Biol 19: 6566\u20136574","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ200851_CR12","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1128\/MCB.20.16.5828-5839.2000","volume":"20","author":"R Fenrick","year":"2000","unstructured":"Fenrick R, Wang L, Nip J, Amann JM, Rooney RJ, Walker\u2010Daniels J, Crawford HC, Hulboy DL, Kinch MS, Matrisian LM, Hiebert SW (2000) TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras\u2010transformed cells while repressing the transcription of stromelysin\u20101. Mol Cell Biol 20: 5828\u20135839","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ200851_CR13","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","volume":"23","author":"DC Fingar","year":"2004","unstructured":"Fingar DC, Blenis J (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23: 3151\u20133171","journal-title":"Oncogene"},{"key":"BFEMBJ200851_CR14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1097-2765(01)00429-4","volume":"9","author":"W Fischle","year":"2002","unstructured":"Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (2002) Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT\/N\u2010CoR. Mol Cell 9: 45\u201357","journal-title":"Mol Cell"},{"key":"BFEMBJ200851_CR15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/sj.cr.7310149","volume":"17","author":"P Gallinari","year":"2007","unstructured":"Gallinari P, Di Marco S, Jones P, Pallaoro M, Steinkuhler C (2007) HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics. Cell Res 17: 195\u2013211","journal-title":"Cell Res"},{"key":"BFEMBJ200851_CR16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1369-5274(00)00064-3","volume":"3","author":"MR Gartenberg","year":"2000","unstructured":"Gartenberg MR (2000) The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more. Curr Opin Microbiol 3: 132\u2013137","journal-title":"Curr Opin Microbiol"},{"key":"BFEMBJ200851_CR17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.bbrc.2003.09.043","volume":"310","author":"KB Glaser","year":"2003","unstructured":"Glaser KB, Li J, Staver MJ, Wei RQ, Albert DH, Davidsen SK (2003) Role of class I and class II histone deacetylases in carcinoma cells using siRNA. Biochem Biophys Res Commun 310: 529\u2013536","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ200851_CR18","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1128\/MCB.00882-06","volume":"27","author":"S Gregoire","year":"2007","unstructured":"Gregoire S, Xiao L, Nie J, Zhang X, Xu M, Li J, Wong J, Seto E, Yang XJ (2007) Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol 27: 1280\u20131295","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ200851_CR19","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/35901","volume":"391","author":"F Grignani","year":"1998","unstructured":"Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Grignani F, Lazar MA, Minucci S, Pelicci PG (1998) Fusion proteins of the retinoic acid receptor\u2010alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 391: 815\u2013818","journal-title":"Nature"},{"key":"BFEMBJ200851_CR20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1101\/gad.1263305","volume":"19","author":"HP Guan","year":"2005","unstructured":"Guan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev 19: 453\u2013461","journal-title":"Genes Dev"},{"key":"BFEMBJ200851_CR21","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.1128\/MCB.21.18.6091-6101.2001","volume":"21","author":"MG Guenther","year":"2001","unstructured":"Guenther MG, Barak O, Lazar MA (2001) The SMRT and N\u2010CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 21: 6091\u20136101","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ200851_CR22","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1182\/blood.V91.8.2634.2634_2634_2642","volume":"91","author":"F Guidez","year":"1998","unstructured":"Guidez F, Ivins S, Zhu J, Soderstrom M, Waxman S, Zelent A (1998) Reduced retinoic acid\u2010sensitivities of nuclear receptor corepressor binding to PML\u2010 and PLZF\u2010RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. Blood 91: 2634\u20132642","journal-title":"Blood"},{"key":"BFEMBJ200851_CR23","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1182\/blood.V96.7.2557","volume":"96","author":"F Guidez","year":"2000","unstructured":"Guidez F, Petrie K, Ford AM, Lu H, Bennett CA, MacGregor A, Hannemann J, Ito Y, Ghysdael J, Greaves M, Wiedemann LM, Zelent A (2000) Recruitment of the nuclear receptor corepressor N\u2010CoR by the TEL moiety of the childhood leukemia\u2010associated TEL\u2010AML1 oncoprotein. Blood 96: 2557\u20132561","journal-title":"Blood"},{"key":"BFEMBJ200851_CR24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jhep.2005.03.027","volume":"43","author":"S Haga","year":"2005","unstructured":"Haga S, Ogawa W, Inoue H, Terui K, Ogino T, Igarashi R, Takeda K, Akira S, Enosawa S, Furukawa H, Todo S, Ozaki M (2005) Compensatory recovery of liver mass by Akt\u2010mediated hepatocellular hypertrophy in liver\u2010specific STAT3\u2010deficient mice. J Hepatol 43: 799\u2013807","journal-title":"J Hepatol"},{"key":"BFEMBJ200851_CR25","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/sj.embor.7400391","volume":"6","author":"HB Hartman","year":"2005","unstructured":"Hartman HB, Yu J, Alenghat T, Ishizuka T, Lazar MA (2005) The histone\u2010binding code of nuclear receptor co\u2010repressors matches the substrate specificity of histone deacetylase 3. EMBO Rep 6: 445\u2013451","journal-title":"EMBO Rep"},{"key":"BFEMBJ200851_CR26","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","volume":"18","author":"N Hay","year":"2004","unstructured":"Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18: 1926\u20131945","journal-title":"Genes Dev"},{"key":"BFEMBJ200851_CR27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/ng0298-126","volume":"18","author":"LZ He","year":"1998","unstructured":"He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP (1998) Distinct interactions of PML\u2010RARalpha and PLZF\u2010RARalpha with co\u2010repressors determine differential responses to RA in APL. Nat Genet 18: 126\u2013135","journal-title":"Nat Genet"},{"key":"BFEMBJ200851_CR28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-5793(01)02353-5","volume":"494","author":"R Hernandez","year":"2001","unstructured":"Hernandez R, Teruel T, Lorenzo M (2001) Akt mediates insulin induction of glucose uptake and up\u2010regulation of GLUT4 gene expression in brown adipocytes. FEBS Lett 494: 225\u2013231","journal-title":"FEBS Lett"},{"key":"BFEMBJ200851_CR29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/417455a","volume":"417","author":"C Hubbert","year":"2002","unstructured":"Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, Yoshida M, Wang XF, Yao TP (2002) HDAC6 is a microtubule\u2010associated deacetylase. Nature 417: 455\u2013458","journal-title":"Nature"},{"key":"BFEMBJ200851_CR30","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35001622","volume":"403","author":"S Imai","year":"2000","unstructured":"Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD\u2010dependent histone deacetylase. Nature 403: 795\u2013800","journal-title":"Nature"},{"key":"BFEMBJ200851_CR31","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/ncb1183","volume":"6","author":"E Jacinto","year":"2004","unstructured":"Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, Hall MN (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122\u20131128","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ200851_CR32","doi-asserted-by":"crossref","first-page":"20436","DOI":"10.1074\/jbc.M000202200","volume":"275","author":"LJ Juan","year":"2000","unstructured":"Juan LJ, Shia WJ, Chen MH, Yang WM, Seto E, Lin YS, Wu CW (2000) Histone deacetylases specifically down\u2010regulate p53\u2010dependent gene activation. J Biol Chem 275: 20436\u201320443","journal-title":"J Biol Chem"},{"key":"BFEMBJ200851_CR33","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.7660125","volume":"269","author":"R Kuhn","year":"1995","unstructured":"Kuhn R, Schwenk F, Aguet M, Rajewsky K (1995) Inducible gene targeting in mice. Science 269: 1427\u20131429","journal-title":"Science"},{"key":"BFEMBJ200851_CR34","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/emboj\/21.11.2672","volume":"21","author":"G Lagger","year":"2002","unstructured":"Lagger G, O'Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, Schuettengruber B, Hauser C, Brunmeir R, Jenuwein T, Seiser C. (2002) Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J 21: 2672\u20132681","journal-title":"EMBO J"},{"key":"BFEMBJ200851_CR35","doi-asserted-by":"crossref","first-page":"17335","DOI":"10.1073\/pnas.0706487104","volume":"104","author":"A Lahm","year":"2007","unstructured":"Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, Sambucini S, Bottomley MJ, Lo Surdo P, Carfi A, Koch U, De Francesco R, Steinkuhler C, Gallinari P (2007) Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci USA 104: 17335\u201317340","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ200851_CR36","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","volume":"270","author":"JM Lehmann","year":"1995","unstructured":"Lehmann JM, Moore LB, Smith\u2010Oliver TA, Wilkison WO, Willson TM, Kliewer SA (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator\u2010activated receptor gamma (PPAR gamma). J Biol Chem 270: 12953\u201312956","journal-title":"J Biol Chem"},{"key":"BFEMBJ200851_CR37","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1093\/emboj\/19.16.4342","volume":"19","author":"J Li","year":"2000","unstructured":"Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (2000) Both corepressor proteins SMRT and N\u2010CoR exist in large protein complexes containing HDAC3. EMBO J 19: 4342\u20134350","journal-title":"EMBO J"},{"key":"BFEMBJ200851_CR38","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1101\/gad.1455006","volume":"20","author":"Y Li","year":"2006","unstructured":"Li Y, Kao GD, Garcia BA, Shabanowitz J, Hunt DF, Qin J, Phelan C, Lazar MA (2006) A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev 20: 2566\u20132579","journal-title":"Genes Dev"},{"key":"BFEMBJ200851_CR39","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/35895","volume":"391","author":"RJ Lin","year":"1998","unstructured":"Lin RJ, Nagy L, Inoue S, Shao W, Miller Jr WH, Evans RM (1998) Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391: 811\u2013814","journal-title":"Nature"},{"key":"BFEMBJ200851_CR40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","volume":"10","author":"R Loewith","year":"2002","unstructured":"Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10: 457\u2013468","journal-title":"Mol Cell"},{"key":"BFEMBJ200851_CR41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/35042612","volume":"408","author":"J Luo","year":"2000","unstructured":"Luo J, Su F, Chen D, Shiloh A, Gu W (2000) Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408: 377\u2013381","journal-title":"Nature"},{"key":"BFEMBJ200851_CR42","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00001622-200111000-00010","volume":"13","author":"PA Marks","year":"2001","unstructured":"Marks PA, Richon VM, Breslow R, Rifkind RA (2001) Histone deacetylase inhibitors as new cancer drugs. Curr Opin Oncol 13: 477\u2013483","journal-title":"Curr Opin Oncol"},{"key":"BFEMBJ200851_CR43","doi-asserted-by":"crossref","first-page":"D247","DOI":"10.1093\/nar\/gkl869","volume":"35","author":"H Mi","year":"2007","unstructured":"Mi H, Guo N, Kejariwal A, Thomas PD (2007) PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways. Nucleic Acids Res 35: D247\u2013D252","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ200851_CR44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbrc.2007.08.004","volume":"362","author":"S Mordier","year":"2007","unstructured":"Mordier S, Iynedjian PB (2007) Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. Biochem Biophys Res Commun 362: 206\u2013211","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ200851_CR45","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.2337\/diabetes.52.12.2905","volume":"52","author":"H Ono","year":"2003","unstructured":"Ono H, Shimano H, Katagiri H, Yahagi N, Sakoda H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Viana AY, Fukushima Y, Abe M, Shojima N, Kikuchi M, Yamada N, Oka Y, Asano T (2003) Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement. Diabetes 52: 2905\u20132913","journal-title":"Diabetes"},{"key":"BFEMBJ200851_CR46","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0168-8278(03)00288-5","volume":"39","author":"P Papeleu","year":"2003","unstructured":"Papeleu P, Loyer P, Vanhaecke T, Elaut G, Geerts A, Guguen\u2010Guillouzo C, Rogiers V (2003) Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen\u2010stimulated rat hepatocytes. J Hepatol 39: 374\u2013382","journal-title":"J Hepatol"},{"key":"BFEMBJ200851_CR47","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nature02583","volume":"429","author":"F Picard","year":"2004","unstructured":"Picard F, Kurtev M, Chung N, Topark\u2010Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR\u2010gamma. Nature 429: 771\u2013776","journal-title":"Nature"},{"key":"BFEMBJ200851_CR48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V","volume":"26","author":"C Postic","year":"2000","unstructured":"Postic C, Magnuson MA (2000) DNA excision in liver by an albumin\u2010Cre transgene occurs progressively with age. Genesis 26: 149\u2013150","journal-title":"Genesis"},{"key":"BFEMBJ200851_CR49","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1074\/jbc.274.1.305","volume":"274","author":"C Postic","year":"1999","unstructured":"Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell\u2010specific gene knock\u2010outs using Cre recombinase. J Biol Chem 274: 305\u2013315","journal-title":"J Biol Chem"},{"key":"BFEMBJ200851_CR50","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1101\/gad.953802","volume":"16","author":"D Ren","year":"2002","unstructured":"Ren D, Collingwood TN, Rebar EJ, Wolffe AP, Camp HS (2002) PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Genes Dev 16: 27\u201332","journal-title":"Genes Dev"},{"key":"BFEMBJ200851_CR51","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/138920007780655397","volume":"8","author":"V Santini","year":"2007","unstructured":"Santini V, Gozzini A, Ferrari G (2007) Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr Drug Metab 8: 383\u2013393","journal-title":"Curr Drug Metab"},{"key":"BFEMBJ200851_CR52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ncpgasthep0084","volume":"2","author":"AJ Sanyal","year":"2005","unstructured":"Sanyal AJ (2005) Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease. Nat Clin Pract Gastroenterol Hepatol 2: 46\u201353","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"BFEMBJ200851_CR53","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1038\/sj.onc.1209731","volume":"25","author":"T Shimazu","year":"2006","unstructured":"Shimazu T, Komatsu Y, Nakayama KI, Fukazawa H, Horinouchi S, Yoshida M (2006) Regulation of SV40 large T\u2010antigen stability by reversible acetylation. Oncogene 25: 7391\u20137400","journal-title":"Oncogene"},{"key":"BFEMBJ200851_CR54","doi-asserted-by":"crossref","first-page":"16191","DOI":"10.1074\/jbc.M908066199","volume":"275","author":"Y Takami","year":"2000","unstructured":"Takami Y, Nakayama T (2000) N\u2010terminal region, C\u2010terminal region, nuclear export signal, and deacetylation activity of histone deacetylase\u20103 are essential for the viability of the DT40 chicken B cell line. J Biol Chem 275: 16191\u201316201","journal-title":"J Biol Chem"},{"key":"BFEMBJ200851_CR55","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1101\/gr.772403","volume":"13","author":"PD Thomas","year":"2003","unstructured":"Thomas PD, Campbell MJ, Kejariwal A, Mi H, Karlak B, Daverman R, Diemer K, Muruganujan A, Narechania A (2003) PANTHER: a library of protein families and subfamilies indexed by function. Genome Res 13: 2129\u20132141","journal-title":"Genome Res"},{"key":"BFEMBJ200851_CR56","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-X","volume":"79","author":"P Tontonoz","year":"1994","unstructured":"Tontonoz P, Hu E, Spiegelman BM (1994) Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid\u2010activated transcription factor. Cell 79: 1147\u20131156","journal-title":"Cell"},{"key":"BFEMBJ200851_CR57","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nm1552","volume":"13","author":"CM Trivedi","year":"2007","unstructured":"Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA (2007) Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med 13: 324\u2013331","journal-title":"Nat Med"},{"key":"BFEMBJ200851_CR58","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1038\/sj.onc.1204479","volume":"20","author":"L Wang","year":"2001","unstructured":"Wang L, Hiebert SW (2001) TEL contacts multiple co\u2010repressors and specifically associates with histone deacetylase\u20103. Oncogene 20: 3716\u20133725","journal-title":"Oncogene"},{"key":"BFEMBJ200851_CR59","doi-asserted-by":"crossref","first-page":"20230","DOI":"10.1074\/jbc.272.32.20230","volume":"272","author":"A Werman","year":"1997","unstructured":"Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal\u2010Puig AJ, Flier JS (1997) Ligand\u2010independent activation domain in the N terminus of peroxisome proliferator\u2010activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and \u20102 isoforms and influence of insulin. J Biol Chem 272: 20230\u201320235","journal-title":"J Biol Chem"},{"key":"BFEMBJ200851_CR60","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1042\/bj3160915","volume":"316","author":"J Widmer","year":"1996","unstructured":"Widmer J, Fassihi KS, Schlichter SC, Wheeler KS, Crute BE, King N, Nutile\u2010McMenemy N, Noll WW, Daniel S, Ha J, Kim KH, Witters LA (1996) Identification of a second human acetyl\u2010CoA carboxylase gene. Biochem J 316 (Part 3): 915\u2013922","journal-title":"Biochem J"},{"key":"BFEMBJ200851_CR61","doi-asserted-by":"crossref","first-page":"14551","DOI":"10.1073\/pnas.0503590102","volume":"102","author":"F Xu","year":"2005","unstructured":"Xu F, Rychnovsky SD, Belani JD, Hobbs HH, Cohen JC, Rawson RB (2005) Dual roles for cholesterol in mammalian cells. Proc Natl Acad Sci USA 102: 14551\u201314556","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ200851_CR62","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/emboj\/cdg120","volume":"22","author":"HG Yoon","year":"2003","unstructured":"Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (2003) Purification and functional characterization of the human N\u2010CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J 22: 1336\u20131346","journal-title":"EMBO J"},{"key":"BFEMBJ200851_CR63","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1074\/jbc.M210062200","volume":"278","author":"S Yu","year":"2003","unstructured":"Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, Rao MS, Gonzalez FJ, Reddy JK (2003) Adipocyte\u2010specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator\u2010activated receptor gamma1 (PPARgamma1) overexpression. J Biol Chem 278: 498\u2013505","journal-title":"J Biol Chem"},{"key":"BFEMBJ200851_CR64","doi-asserted-by":"crossref","first-page":"37603","DOI":"10.1074\/jbc.M604709200","volume":"281","author":"YL Zhang","year":"2006","unstructured":"Zhang YL, Hernandez\u2010Ono A, Siri P, Weisberg S, Conlon D, Graham MJ, Crooke RM, Huang LS, Ginsberg HN (2006) Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J Biol Chem 281: 37603\u201337615","journal-title":"J Biol Chem"},{"key":"BFEMBJ200851_CR65","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.metabol.2005.04.019","volume":"54","author":"MY Zhu","year":"2005","unstructured":"Zhu MY, Hasty AH, Harris C, Linton MF, Fazio S, Swift LL (2005) Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes. Metabolism 54: 1309\u20131315","journal-title":"Metabolism"},{"key":"BFEMBJ200851_CR66","doi-asserted-by":"crossref","first-page":"26817","DOI":"10.1016\/S0021-9258(19)74184-2","volume":"268","author":"Y Zhu","year":"1993","unstructured":"Zhu Y, Alvares K, Huang Q, Rao MS, Reddy JK (1993) Cloning of a new member of the peroxisome proliferator\u2010activated receptor gene family from mouse liver. J Biol Chem 268: 26817\u201326820","journal-title":"J Biol Chem"},{"key":"BFEMBJ200851_CR67","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.1128\/MCB.01220-06","volume":"26","author":"G Zupkovitz","year":"2006","unstructured":"Zupkovitz G, Tischler J, Posch M, Sadzak I, Ramsauer K, Egger G, Grausenburger R, Schweifer N, Chiocca S, Decker T, Seiser C (2006) Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol 26: 7913\u20137928","journal-title":"Mol Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Femboj.2008.51","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/emboj.2008.51.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/emboj.2008.51","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/emboj.2008.51","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/emboj.2008.51.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:53:09Z","timestamp":1779234789000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/emboj.2008.51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,20]]},"references-count":67,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,4,9]]}},"alternative-id":["BFEMBJ200851"],"URL":"https:\/\/doi.org\/10.1038\/emboj.2008.51","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,20]]},"assertion":[{"value":"5 February 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}