{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:05Z","timestamp":1791276905108,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2010,4,7]]},"DOI":"10.1038\/emboj.2010.19","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T09:09:37Z","timestamp":1267088977000},"page":"1235-1247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy"],"prefix":"10.1038","volume":"29","author":[{"given":"Simona","family":"Pedrotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Bielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Paronetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Ciccosanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Fimia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Stamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L","family":"Manley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"BFEMBJ201019_CR1","first-page":"177","volume":"57","author":"A Aiyar","year":"1996","unstructured":"Aiyar A, Xiang Y, Leis J (1996) Site\u2010directed mutagenesis using overlap extension PCR. Methods Mol Biol 57: 177\u2013191","journal-title":"Methods Mol Biol"},{"key":"BFEMBJ201019_CR2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1101\/sqb.2006.71.001","volume":"71","author":"DJ Battle","year":"2006","unstructured":"Battle DJ, Kasim M, Yong J, Lotti F, Lau CK, Mouaikel J, Zhang Z, Han K, Wan L, Dreyfuss G (2006) The SMN complex: an assembly machine for RNPs. Cold Spring Harb Symp Quant Biol 71: 313\u2013320","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"BFEMBJ201019_CR3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ymthe.2006.01.012","volume":"14","author":"T Baughan","year":"2006","unstructured":"Baughan T, Shababi M, Coady TH, Dickson AM, Tullis GE, Lorson CL (2006) Stimulating full\u2010length SMN2 expression by delivering bifunctional RNAs via a viral vector. Mol Ther 14: 54\u201362","journal-title":"Mol Ther"},{"key":"BFEMBJ201019_CR4","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/hmg\/ddp076","volume":"18","author":"TD Baughan","year":"2009","unstructured":"Baughan TD, Dickson A, Osman EY, Lorson CL (2009) Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy. Hum Mol Genet 18: 1600\u20131611","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ201019_CR5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biochem.72.121801.161720","volume":"72","author":"DL Black","year":"2003","unstructured":"Black DL (2003) Mechanisms of alternative pre\u2010messenger RNA splicing. Annu Rev Biochem 72: 291\u2013336","journal-title":"Annu Rev Biochem"},{"key":"BFEMBJ201019_CR6","doi-asserted-by":"crossref","first-page":"28852","DOI":"10.1074\/jbc.M805376200","volume":"283","author":"JK Bose","year":"2008","unstructured":"Bose JK, Wang IF, Hung L, Tarn WY, Shen CK (2008) TDP\u201043 overexpression enhances exon 7 inclusion during the survival of motor neuron pre\u2010mRNA splicing. J Biol Chem 283: 28852\u201328859","journal-title":"J Biol Chem"},{"key":"BFEMBJ201019_CR7","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrn2670","volume":"10","author":"AH Burghes","year":"2009","unstructured":"Burghes AH, Beattie CE (2009) Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? Nat Rev Neurosci 10: 597\u2013609","journal-title":"Nat Rev Neurosci"},{"key":"BFEMBJ201019_CR8","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1038\/sj.onc.1210224","volume":"26","author":"R Bus\u00e0","year":"2007","unstructured":"Bus\u00e0 R, Paronetto MP, Farini D, Pierantozzi E, Botti F, Angelini DF, Attisani F, Vespasiani G, Sette C (2007) The RNA\u2010binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells. Oncogene 26: 4372\u20134382","journal-title":"Oncogene"},{"key":"BFEMBJ201019_CR9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrg775","volume":"3","author":"L Cartegni","year":"2002","unstructured":"Cartegni L, Chew SL, Krainer AR (2002) Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet 3: 285\u2013298","journal-title":"Nat Rev Genet"},{"key":"BFEMBJ201019_CR10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1086\/498853","volume":"78","author":"L Cartegni","year":"2006","unstructured":"Cartegni L, Hastings ML, Calarco JA, de Stanchina E, Krainer AR (2006) Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. Am J Hum Genet 78: 63\u201377","journal-title":"Am J Hum Genet"},{"key":"BFEMBJ201019_CR11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng854","volume":"30","author":"L Cartegni","year":"2002","unstructured":"Cartegni L, Krainer AR (2002) Disruption of an SF2\/ASF\u2010dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1. Nat Genet 30: 377\u2013384","journal-title":"Nat Genet"},{"key":"BFEMBJ201019_CR12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/MCB.01349-08","volume":"29","author":"G Chawla","year":"2009","unstructured":"Chawla G, Lin CH, Han A, Shiue L, Ares Jr M, Black DL (2009) Sam68 regulates a set of alternatively spliced exons during neurogenesis. Mol Cell Biol 29: 201\u2013213","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ201019_CR13","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1128\/MCB.01332-08","volume":"28","author":"HH Chen","year":"2008","unstructured":"Chen HH, Chang JG, Lu RM, Peng TY, Tarn WY (2008) The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene. Mol Cell Biol 28: 6929\u20136938","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ201019_CR14","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2777","volume":"10","author":"M Chen","year":"2009","unstructured":"Chen M, Manley JL (2009) Diverse mechanisms of alternative splicing regulation: Insights from molecular and genomic analyses. Nat Rev Mol Cell Biol 10: 741\u2013754","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ201019_CR15","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1128\/MCB.17.10.5707","volume":"17","author":"T Chen","year":"1997","unstructured":"Chen T, Damaj BB, Herrera C, Lasko P, Richard S (1997) Self\u2010association of the single\u2010KH\u2010domain family members Sam68, GRP33, GLD\u20101, and Qk1: role of the KH domain. Mol Cell Biol 17: 5707\u20135718","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ201019_CR16","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.molcel.2005.10.026","volume":"20","author":"C Ghigna","year":"2005","unstructured":"Ghigna C, Giordano S, Shen H, Benvenuto F, Castiglioni F, Comoglio PM, Green MR, Riva S, Biamonti G (2005) Cell motility is controlled by SF2\/ASF through alternative splicing of the Ron proto oncogene. Mol Cell 20: 881\u2013890","journal-title":"Mol Cell"},{"key":"BFEMBJ201019_CR17","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.1073\/pnas.160181697","volume":"97","author":"Y Hofmann","year":"2000","unstructured":"Hofmann Y, Lorson CL, Stamm S, Androphy EJ, Wirth B (2000) Htra2\u2010beta 1 stimulates an exonic splicing enhancer and can restore full\u2010length SMN expression to survival motor neuron 2 (SMN2). Proc Natl Acad Sci USA 97: 9618\u20139623","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ201019_CR18","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1371\/journal.pbio.0050073","volume":"5","author":"Y Hua","year":"2007","unstructured":"Hua Y, Vickers TA, Baker BF, Bennett CF, Krainer AR (2007) Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon. PLoS Biol 5: e73","journal-title":"PLoS Biol"},{"key":"BFEMBJ201019_CR19","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ajhg.2008.01.014","volume":"82","author":"Y Hua","year":"2008","unstructured":"Hua Y, Vickers TA, Okunola HL, Bennett CF, Krainer AR (2008) Antisense masking of an hnRNP A1\/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice. Am J Hum Genet 82: 834\u2013848","journal-title":"Am J Hum Genet"},{"key":"BFEMBJ201019_CR20","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1128\/MCB.01707-08","volume":"29","author":"ME Huot","year":"2009","unstructured":"Huot ME, Brown CM, Lamarche\u2010Vane N, Richard S (2009) An adaptor role for cytoplasmic Sam68 in modulating Src activity during cell polarization. Mol Cell Biol 29: 1933\u20131943","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ201019_CR21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0014-5793(97)00455-9","volume":"409","author":"T Ishidate","year":"1997","unstructured":"Ishidate T, Yoshihara S, Kawasaki Y, Roy BC, Toyoshima K, Akiyama T (1997) Identification of a novel nuclear localization signal in Sam68. FEBS Lett 409: 237\u2013241","journal-title":"FEBS Lett"},{"key":"BFEMBJ201019_CR22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ng1207","volume":"34","author":"T Kashima","year":"2003","unstructured":"Kashima T, Manley JL (2003) A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy. Nat Genet 34: 460\u2013463","journal-title":"Nat Genet"},{"key":"BFEMBJ201019_CR23","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1093\/hmg\/ddm276","volume":"16","author":"T Kashima","year":"2007","unstructured":"Kashima T, Rao N, David CJ, Manley JL (2007a) hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing. Hum Mol Genet 16: 3149\u20133159","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ201019_CR24","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1073\/pnas.0700343104","volume":"104","author":"T Kashima","year":"2007","unstructured":"Kashima T, Rao N, Manley JL (2007b) An intronic element contributes to splicing repression in spinal muscular atrophy. Proc Natl Acad Sci USA 104: 3426\u20133431","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ201019_CR25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ng0797-265","volume":"16","author":"S Lefebvre","year":"1997","unstructured":"Lefebvre S, Burlet P, Liu Q, Bertrandy S, Clermont O, Munnich A, Dreyfuss G, Melki J (1997) Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet 16: 265\u2013269","journal-title":"Nat Genet"},{"key":"BFEMBJ201019_CR26","doi-asserted-by":"crossref","first-page":"27274","DOI":"10.1074\/jbc.272.43.27274","volume":"272","author":"Q Lin","year":"1997","unstructured":"Lin Q, Taylor SJ, Shalloway D (1997) Specificity and determinants of Sam68 RNA binding. Implications for the biological function of K homology domains. J Biol Chem 272: 27274\u201327280","journal-title":"J Biol Chem"},{"key":"BFEMBJ201019_CR27","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1189\/jlb.1206746","volume":"82","author":"M Loiarro","year":"2007","unstructured":"Loiarro M, Capolunghi F, Fant\u00f2 N, Gallo G, Campo S, Arseni B, Carsetti R, Carminati P, De Santis R, Ruggiero V, Sette C (2007) Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J Leukoc Biol 82: 801\u2013810","journal-title":"J Leukoc Biol"},{"key":"BFEMBJ201019_CR28","doi-asserted-by":"crossref","first-page":"15809","DOI":"10.1074\/jbc.C400613200","volume":"280","author":"M Loiarro","year":"2005","unstructured":"Loiarro M, Sette C, Gallo G, Ciacci A, Fant\u00f2 N, Mastroianni D, Carminati P, Ruggiero V (2005) Peptide\u2010mediated interference of TIR domain dimerization in MyD88 inhibits interleukin\u20101\u2010dependent activation of NF\u2010{kappa}B. J Biol Chem 280: 15809\u201315814","journal-title":"J Biol Chem"},{"key":"BFEMBJ201019_CR29","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","volume":"96","author":"CL Lorson","year":"1999","unstructured":"Lorson CL, Hahnen E, Androphy EJ, Wirth B (1999) A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. Proc Natl Acad Sci USA 96: 6307\u20136311","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ201019_CR30","first-page":"73","volume":"1653","author":"KE Lukong","year":"2003","unstructured":"Lukong KE, Richard S (2003) Sam68, the KH domain\u2010containing superSTAR. Biochim Biophys Acta 1653: 73\u201386","journal-title":"Biochim Biophys Acta"},{"key":"BFEMBJ201019_CR31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbr.2008.01.010","volume":"189","author":"KE Lukong","year":"2008","unstructured":"Lukong KE, Richard S (2008) Motor coordination defects in mice deficient for the Sam68 RNA\u2010binding protein. Behav Brain Res 189: 357\u2013363","journal-title":"Behav Brain Res"},{"key":"BFEMBJ201019_CR32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nrm1645","volume":"6","author":"AJ Matlin","year":"2005","unstructured":"Matlin AJ, Clark F, Smith CW (2005) Understanding alternative splicing: towards a cellular code. Nat Rev Mol Cell Biol 6: 386\u2013398","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ201019_CR33","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nature01153","volume":"420","author":"N Matter","year":"2002","unstructured":"Matter N, Herrlich P, Konig H (2002) Signal\u2010dependent regulation of splicing via phosphorylation of Sam68. Nature 420: 691\u2013695","journal-title":"Nature"},{"key":"BFEMBJ201019_CR34","doi-asserted-by":"crossref","first-page":"35353","DOI":"10.1074\/jbc.M004692200","volume":"275","author":"N Matter","year":"2000","unstructured":"Matter N, Marx M, Weg\u2010Remers S, Ponta H, Herrlich P, K\u00f6nig H (2000) Heterogeneous ribonucleoprotein A1 is part of an exon\u2010specific splice\u2010silencing complex controlled by oncogenic signaling pathways. J Biol Chem 275: 35353\u201335360","journal-title":"J Biol Chem"},{"key":"BFEMBJ201019_CR35","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuron.2005.12.001","volume":"48","author":"UR Monani","year":"2005","unstructured":"Monani UR (2005) Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron\u2010specific disease. Neuron 48: 885\u2013896","journal-title":"Neuron"},{"key":"BFEMBJ201019_CR36","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","volume":"8","author":"UR Monani","year":"1999","unstructured":"Monani UR, Lorson CL, Parsons DW, Prior TW, Androphy EJ, Burghes AH, McPherson JD (1999) A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2. Hum Mol Genet 8: 1177\u20131183","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ201019_CR37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/hmg\/9.3.333","volume":"9","author":"UR Monani","year":"2000","unstructured":"Monani UR, Sendtner M, Coovert DD, Parsons DW, Andreassi C, Le TT, Jablonka S, Schrank B, Rossoll W, Prior TW, Morris GE, Burghes AH (2000) The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(\u2212\/\u2212) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet 9: 333\u2013339","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ201019_CR38","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1128\/MCB.01678-08","volume":"29","author":"HL Okunola","year":"2009","unstructured":"Okunola HL, Krainer AR (2009) Cooperative\u2010binding and splicing\u2010repressive properties of hnRNP A1. Mol Cell Biol 29: 5620\u20135631","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ201019_CR39","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1083\/jcb.200701005","volume":"176","author":"MP Paronetto","year":"2007","unstructured":"Paronetto MP, Achsel T, Massiello A, Chalfant CE, Sette C (2007) The RNA\u2010binding protein Sam68 modulates the alternative splicing of Bcl\u2010x. J Cell Biol 176: 929\u2013939","journal-title":"J Cell Biol"},{"key":"BFEMBJ201019_CR40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1158\/0008-5472.CAN-09-2788","volume":"70","author":"MP Paronetto","year":"2010","unstructured":"Paronetto MP, Cappellari M, Bus\u00e0 R, Pedrotti S, Vitali R, Comstock C, Hyslop T, Knudsen KE, Sette C (2010) Alternative splicing of the cyclin D1 proto\u2010oncogene is regulated by the RNA\u2010binding protein Sam68. Cancer Res 70: 229\u2013239","journal-title":"Cancer Res"},{"key":"BFEMBJ201019_CR41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1083\/jcb.200811138","volume":"185","author":"MP Paronetto","year":"2009","unstructured":"Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, Palombi F, Stefanini M, Geremia R, Richard S, Sette C (2009) Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis. J Cell Biol 185: 235\u2013249","journal-title":"J Cell Biol"},{"key":"BFEMBJ201019_CR42","doi-asserted-by":"crossref","first-page":"8707","DOI":"10.1038\/sj.onc.1207016","volume":"22","author":"MP Paronetto","year":"2003","unstructured":"Paronetto MP, Venables JP, Elliott DJ, Geremia R, Rossi P, Sette C (2003) Tr\u2010kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68. Oncogene 22: 8707\u20138715","journal-title":"Oncogene"},{"key":"BFEMBJ201019_CR43","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(80)90847-8","volume":"1","author":"J Pearn","year":"1980","unstructured":"Pearn J (1980) Classification of spinal muscular atrophies. Lancet 1: 919\u2013922","journal-title":"Lancet"},{"key":"BFEMBJ201019_CR44","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/sj.embor.7400941","volume":"8","author":"L Pellizzoni","year":"2007","unstructured":"Pellizzoni L (2007) Chaperoning ribonucleoprotein biogenesis in health and disease. EMBO Rep 8: 340\u2013345","journal-title":"EMBO Rep"},{"key":"BFEMBJ201019_CR45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/path.2324","volume":"215","author":"P Rajan","year":"2008","unstructured":"Rajan P, Gaughan L, Dalgliesh C, El\u2010Sherif A, Robson CN, Leung HY, Elliott DJ (2008) The RNA\u2010binding and adaptor protein Sam68 modulates signal\u2010dependent splicing and transcriptional activity of the androgen receptor. J Pathol 215: 67\u201377","journal-title":"J Pathol"},{"key":"BFEMBJ201019_CR46","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4161\/rna.6.3.8723","volume":"6","author":"NN Singh","year":"2009","unstructured":"Singh NN, Shishimorova M, Cao LC, Gangwani L, Singh RN (2009) A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy. RNA Biol 6: 341\u2013350","journal-title":"RNA Biol"},{"key":"BFEMBJ201019_CR47","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nsmb961","volume":"12","author":"R Singh","year":"2005","unstructured":"Singh R, Valc\u00e1rcel J (2005) Building specificity with nonspecific RNA\u2010binding proteins. Nat Struct Mol Biol 12: 645\u2013653","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBJ201019_CR48","first-page":"5:5","volume":"22","author":"SJ Taylor","year":"2004","unstructured":"Taylor SJ, Resnick RJ, Shalloway D (2004) Sam68 exerts separable effects on cell cycle progression and apoptosis. B M C Cell Biol 22: 5:5","journal-title":"B M C Cell Biol"},{"key":"BFEMBJ201019_CR49","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.178.5.2655","volume":"178","author":"VY Toshchakov","year":"2007","unstructured":"Toshchakov VY, Fenton MJ, Vogel SN (2007) Cutting Edge: Differential inhibition of TLR signaling pathways by cell\u2010permeable peptides representing BB loops of TLRs. J Immunol 178: 2655\u20132660","journal-title":"J Immunol"},{"key":"BFEMBJ201019_CR50","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.nbd.2008.05.014","volume":"31","author":"LK Tsai","year":"2008","unstructured":"Tsai LK, Tsai MS, Ting CH, Wang SH, Li H (2008) Restoring Bcl\u2010x(L) levels benefits a mouse model of spinal muscular atrophy. Neurobiol Dis 31: 361\u2013367","journal-title":"Neurobiol Dis"},{"key":"BFEMBJ201019_CR51","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrg2164","volume":"8","author":"GS Wang","year":"2007","unstructured":"Wang GS, Cooper TA (2007) Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev Genet 8: 749\u2013761","journal-title":"Nat Rev Genet"},{"key":"BFEMBJ201019_CR52","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1074\/jbc.270.5.2010","volume":"270","author":"LL Wang","year":"1995","unstructured":"Wang LL, Richard S, Shaw AS (1995) P62 association with RNA is regulated by tyrosine phosphorylation. J Biol Chem 270: 2010\u20132013","journal-title":"J Biol Chem"},{"key":"BFEMBJ201019_CR53","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2008.03.031","volume":"133","author":"Z Zhang","year":"2008","unstructured":"Zhang Z, Lotti F, Dittmar K, Younis I, Wan L, Kasim M, Dreyfuss G (2008) SMN deficiency causes tissue\u2010specific perturbations in the repertoire of snRNAs and widespread defects in splicing. Cell 133: 585\u2013600","journal-title":"Cell"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Femboj.2010.19","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/emboj.2010.19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/emboj.2010.19","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/emboj.2010.19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:07:12Z","timestamp":1779235632000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/emboj.2010.19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,25]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,4,7]]}},"alternative-id":["BFEMBJ201019"],"URL":"https:\/\/doi.org\/10.1038\/emboj.2010.19","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,25]]},"assertion":[{"value":"27 October 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}