{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:22:11Z","timestamp":1791350531222,"version":"4.3.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T00:00:00Z","timestamp":1282867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T00:00:00Z","timestamp":1282867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2010,9,15]]},"DOI":"10.1038\/emboj.2010.205","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T10:04:30Z","timestamp":1282903470000},"page":"3156-3169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery"],"prefix":"10.1038","volume":"29","author":[{"given":"Francesca","family":"Ammazzalorso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Maria","family":"Pirzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Bignami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annapaola","family":"Franchitto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Pichierri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,27]]},"reference":[{"key":"BFEMBJ2010205_CR1","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1038\/sj.onc.1204003","volume":"19","author":"M Ababou","year":"2000","unstructured":"Ababou M, Dutertre S, Lecluse Y, Onclercq R, Chatton B, Amor\u2010Gueret M (2000) ATM\u2010dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation. Oncogene 19: 5955\u20135963","journal-title":"Oncogene"},{"key":"BFEMBJ2010205_CR2","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.dnarep.2006.05.010","volume":"5","author":"MF Arlt","year":"2006","unstructured":"Arlt MF, Durkin SG, Ragland RL, Glover TW (2006) Common fragile sites as targets for chromosome rearrangements. DNA Repair (Amst) 5: 1126\u20131135","journal-title":"DNA Repair (Amst)"},{"key":"BFEMBJ2010205_CR3","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1006\/jmbi.2001.4564","volume":"307","author":"C Arnaudeau","year":"2001","unstructured":"Arnaudeau C, Lundin C, Helleday T (2001) DNA double\u2010strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J Mol Biol 307: 1235\u20131245","journal-title":"J Mol Biol"},{"key":"BFEMBJ2010205_CR4","doi-asserted-by":"crossref","first-page":"30515","DOI":"10.1074\/jbc.M203801200","volume":"277","author":"H Beamish","year":"2002","unstructured":"Beamish H, Kedar P, Kaneko H, Chen P, Fukao T, Peng C, Beresten S, Gueven N, Purdie D, Lees\u2010Miller S, Ellis N, Kondo N, Lavin MF (2002) Functional link between BLM defective in Bloom's syndrome and the ataxia\u2010telangiectasia\u2010mutated protein, ATM. J Biol Chem 277: 30515\u201330523","journal-title":"J Biol Chem"},{"key":"BFEMBJ2010205_CR5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tibs.2008.09.003","volume":"33","author":"VA Bohr","year":"2008","unstructured":"Bohr VA (2008) Rising from the RecQ\u2010age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci 33: 609\u2013620","journal-title":"Trends Biochem Sci"},{"key":"BFEMBJ2010205_CR6","doi-asserted-by":"crossref","first-page":"23236","DOI":"10.1074\/jbc.M111446200","volume":"277","author":"Jr RM Brosh","year":"2002","unstructured":"Brosh Jr RM, Waheed J, Sommers JA (2002) Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase. J Biol Chem 277: 23236\u201323245","journal-title":"J Biol Chem"},{"key":"BFEMBJ2010205_CR7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(02)01113-3","volume":"111","author":"AM Casper","year":"2002","unstructured":"Casper AM, Nghiem P, Arlt MF, Glover TW (2002) ATR regulates fragile site stability. Cell 111: 779\u2013789","journal-title":"Cell"},{"key":"BFEMBJ2010205_CR8","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.1074\/jbc.M806739200","volume":"284","author":"RA Chanoux","year":"2009","unstructured":"Chanoux RA, Yin B, Urtishak KA, Asare A, Bassing CH, Brown EJ (2009) ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem 284: 5994\u20136003","journal-title":"J Biol Chem"},{"key":"BFEMBJ2010205_CR9","doi-asserted-by":"crossref","first-page":"34603","DOI":"10.1074\/jbc.M401901200","volume":"279","author":"S Choudhary","year":"2004","unstructured":"Choudhary S, Sommers JA, Brosh Jr RM (2004) Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of Werner syndrome protein. J Biol Chem 279: 34603\u201334613","journal-title":"J Biol Chem"},{"key":"BFEMBJ2010205_CR10","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","volume":"9","author":"KA Cimprich","year":"2008","unstructured":"Cimprich KA, Cortez D (2008) ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 9: 616\u2013627","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ2010205_CR11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/emboj\/17.1.159","volume":"17","author":"WA Cliby","year":"1998","unstructured":"Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH (1998) Overexpression of a kinase\u2010inactive ATR protein causes sensitivity to DNA\u2010damaging agents and defects in cell cycle checkpoints. EMBO J 17: 159\u2013169","journal-title":"EMBO J"},{"key":"BFEMBJ2010205_CR12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/embo-reports\/kvd004","volume":"1","author":"A Constantinou","year":"2000","unstructured":"Constantinou A, Tarsounas M, Karow JK, Brosh RM, Bohr VA, Hickson ID, West SC (2000) Werner's syndrome protein (WRN) migrates Holliday junctions and co\u2010localizes with RPA upon replication arrest. EMBO Rep 1: 80\u201384","journal-title":"EMBO Rep"},{"key":"BFEMBJ2010205_CR13","doi-asserted-by":"crossref","first-page":"37139","DOI":"10.1074\/jbc.M307088200","volume":"278","author":"D Cortez","year":"2003","unstructured":"Cortez D (2003) Caffeine inhibits checkpoint responses without inhibiting the ataxia\u2010telangiectasia\u2010mutated (ATM) and ATM\u2010 and Rad3\u2010related (ATR) protein kinases. J Biol Chem 278: 37139\u201337145","journal-title":"J Biol Chem"},{"key":"BFEMBJ2010205_CR14","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1128\/MCB.24.3.1279-1291.2004","volume":"24","author":"SL Davies","year":"2004","unstructured":"Davies SL, North PS, Dart A, Lakin ND, Hickson ID (2004) Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S\u2010phase arrest. Mol Cell Biol 24: 1279\u20131291","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2010205_CR15","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.4161\/cc.3.10.1185","volume":"3","author":"A Franchitto","year":"2004","unstructured":"Franchitto A, Pichierri P (2004) Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery. Cell Cycle 3: 1331\u20131339","journal-title":"Cell Cycle"},{"key":"BFEMBJ2010205_CR16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1083\/jcb.200803173","volume":"183","author":"A Franchitto","year":"2008","unstructured":"Franchitto A, Pirzio LM, Prosperi E, Sapora O, Bignami M, Pichierri P (2008) Replication fork stalling in WRN\u2010deficient cells is overcome by prompt activation of a MUS81\u2010dependent pathway. J Cell Biol 183: 241\u2013252","journal-title":"J Cell Biol"},{"key":"BFEMBJ2010205_CR17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ceb.2009.01.017","volume":"21","author":"AM Friedel","year":"2009","unstructured":"Friedel AM, Pike BL, Gasser SM (2009) ATR\/Mec1: coordinating fork stability and repair. Curr Opin Cell Biol 21: 237\u2013244","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBJ2010205_CR18","doi-asserted-by":"crossref","first-page":"R197","DOI":"10.1093\/hmg\/ddi265","volume":"14","author":"TW Glover","year":"2005","unstructured":"Glover TW, Arlt MF, Casper AM, Durkin SG (2005) Mechanisms of common fragile site instability. Hum Mol Genet 14 (Spec No. 2): R197\u2013R205","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ2010205_CR19","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.1140735","volume":"319","author":"TD Halazonetis","year":"2008","unstructured":"Halazonetis TD, Gorgoulis VG, Bartek J (2008) An oncogene\u2010induced DNA damage model for cancer development. Science 319: 1352\u20131355","journal-title":"Science"},{"key":"BFEMBJ2010205_CR20","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nsmb1313","volume":"14","author":"K Hanada","year":"2007","unstructured":"Hanada K, Budzowska M, Davies SL, van Drunen E, Onizawa H, Beverloo HB, Maas A, Essers J, Hickson ID, Kanaar R (2007) The structure\u2010specific endonuclease Mus81 contributes to replication restart by generating double\u2010strand DNA breaks. Nat Struct Mol Biol 14: 1096\u20131104","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBJ2010205_CR21","doi-asserted-by":"crossref","first-page":"37538","DOI":"10.1074\/jbc.274.53.37538","volume":"274","author":"ST Kim","year":"1999","unstructured":"Kim ST, Lim DS, Canman CE, Kastan MB (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 274: 37538\u201337543","journal-title":"J Biol Chem"},{"key":"BFEMBJ2010205_CR22","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1101\/gad.14.12.1448","volume":"14","author":"Q Liu","year":"2000","unstructured":"Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini\u2010Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ (2000) Chk1 is an essential kinase that is regulated by Atr and required for the G(2)\/M DNA damage checkpoint. Genes Dev 14: 1448\u20131459","journal-title":"Genes Dev"},{"key":"BFEMBJ2010205_CR23","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1021\/bi0615487","volume":"45","author":"A Machwe","year":"2006","unstructured":"Machwe A, Xiao L, Groden J, Orren DK (2006) The Werner and Bloom syndrome proteins catalyze regression of a model replication fork. Biochemistry 45: 13939\u201313946","journal-title":"Biochemistry"},{"key":"BFEMBJ2010205_CR24","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","volume":"316","author":"S Matsuoka","year":"2007","unstructured":"Matsuoka S, Ballif BA, Smogorzewska A, McDonald III ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160\u20131166","journal-title":"Science"},{"key":"BFEMBJ2010205_CR25","doi-asserted-by":"crossref","first-page":"20067","DOI":"10.1074\/jbc.M400022200","volume":"279","author":"CJ Merrick","year":"2004","unstructured":"Merrick CJ, Jackson D, Diffley JF (2004) Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem 279: 20067\u201320075","journal-title":"J Biol Chem"},{"key":"BFEMBJ2010205_CR26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/emboj\/19.3.463","volume":"19","author":"C Morrison","year":"2000","unstructured":"Morrison C, Sonoda E, Takao N, Shinohara A, Yamamoto K, Takeda S (2000) The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J 19: 463\u2013471","journal-title":"EMBO J"},{"key":"BFEMBJ2010205_CR27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00439-008-0562-0","volume":"124","author":"M Muftuoglu","year":"2008","unstructured":"Muftuoglu M, Oshima J, von Kobbe C, Cheng WH, Leistritz DF, Bohr VA (2008) The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet 124: 369\u2013377","journal-title":"Hum Genet"},{"key":"BFEMBJ2010205_CR28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0092-8674(01)00227-6","volume":"104","author":"K Myung","year":"2001","unstructured":"Myung K, Datta A, Kolodner RD (2001) Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell 104: 397\u2013408","journal-title":"Cell"},{"key":"BFEMBJ2010205_CR29","first-page":"4671","volume":"51","author":"PL Olive","year":"1991","unstructured":"Olive PL, Wlodek D, Banath JP (1991) DNA double\u2010strand breaks measured in individual cells subjected to gel electrophoresis. Cancer Res 51: 4671\u20134676","journal-title":"Cancer Res"},{"key":"BFEMBJ2010205_CR30","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1242\/jcs.03291","volume":"119","author":"M Otterlei","year":"2006","unstructured":"Otterlei M, Bruheim P, Ahn B, Bussen W, Karmakar P, Baynton K, Bohr VA (2006) Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL\u2010induced replication arrest. J Cell Sci 119: 5137\u20135146","journal-title":"J Cell Sci"},{"key":"BFEMBJ2010205_CR31","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.molcel.2010.01.021","volume":"37","author":"E Petermann","year":"2010","unstructured":"Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T (2010) Hydroxyurea\u2010stalled replication forks become progressively inactivated and require two different RAD51\u2010mediated pathways for restart and repair. Mol Cell 37: 492\u2013502","journal-title":"Mol Cell"},{"key":"BFEMBJ2010205_CR32","first-page":"130","volume":"56","author":"P Pichierri","year":"2007","unstructured":"Pichierri P (2007) Interplay between wrn and the checkpoint in s\u2010phase. Ital J Biochem 56: 130\u2013140","journal-title":"Ital J Biochem"},{"key":"BFEMBJ2010205_CR33","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1091\/mbc.12.8.2412","volume":"12","author":"P Pichierri","year":"2001","unstructured":"Pichierri P, Franchitto A, Mosesso P, Palitti F (2001) Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S\u2010phase of cell cycle. Mol Biol Cell 12: 2412\u20132421","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ2010205_CR34","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/sj.onc.1206169","volume":"22","author":"P Pichierri","year":"2003","unstructured":"Pichierri P, Rosselli F, Franchitto A (2003) Werner's syndrome protein is phosphorylated in an ATR\/ATM\u2010dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene 22: 1491\u20131500","journal-title":"Oncogene"},{"key":"BFEMBJ2010205_CR35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.200705126","volume":"180","author":"LM Pirzio","year":"2008","unstructured":"Pirzio LM, Pichierri P, Bignami M, Franchitto A (2008) Werner syndrome helicase activity is essential in maintaining fragile site stability. J Cell Biol 180: 305\u2013314","journal-title":"J Cell Biol"},{"key":"BFEMBJ2010205_CR36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s004390050903","volume":"104","author":"M Poot","year":"1999","unstructured":"Poot M, Gollahon KA, Rabinovitch PS (1999) Werner syndrome lymphoblastoid cells are sensitive to camptothecin\u2010induced apoptosis in S\u2010phase. Hum Genet 104: 10\u201314","journal-title":"Hum Genet"},{"key":"BFEMBJ2010205_CR37","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1096\/fj.00-0611fje","volume":"15","author":"M Poot","year":"2001","unstructured":"Poot M, Yom JS, Whang SH, Kato JT, Gollahon KA, Rabinovitch PS (2001) Werner syndrome cells are sensitive to DNA cross\u2010linking drugs. FASEB J 15: 1224\u20131226","journal-title":"FASEB J"},{"key":"BFEMBJ2010205_CR38","doi-asserted-by":"crossref","first-page":"8925","DOI":"10.1128\/MCB.25.20.8925-8937.2005","volume":"25","author":"VA Rao","year":"2005","unstructured":"Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y (2005) Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma\u2010H2AX after topoisomerase I\u2010induced replication damage. Mol Cell Biol 25: 8925\u20138937","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2010205_CR39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0047-6374(02)00131-8","volume":"124","author":"AM Rodriguez\u2010Lopez","year":"2003","unstructured":"Rodriguez\u2010Lopez AM, Jackson DA, Nehlin JO, Iborra F, Warren AV, Cox LS (2003) Characterisation of the interaction between WRN, the helicase\/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA. Mech Ageing Dev 124: 167\u2013174","journal-title":"Mech Ageing Dev"},{"key":"BFEMBJ2010205_CR40","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.dnarep.2008.07.017","volume":"7","author":"JM Sidorova","year":"2008","unstructured":"Sidorova JM (2008) Roles of the Werner syndrome RecQ helicase in DNA replication. DNA Repair (Amst) 7: 1776\u20131786","journal-title":"DNA Repair (Amst)"},{"key":"BFEMBJ2010205_CR41","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4161\/cc.7.6.5566","volume":"7","author":"JM Sidorova","year":"2008","unstructured":"Sidorova JM, Li N, Folch A, Monnat Jr RJ (2008) The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Cell Cycle 7: 796\u2013807","journal-title":"Cell Cycle"},{"key":"BFEMBJ2010205_CR42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ncb1212","volume":"7","author":"CS Sorensen","year":"2005","unstructured":"Sorensen CS, Hansen LT, Dziegielewski J, Syljuasen RG, Lundin C, Bartek J, Helleday T (2005) The cell\u2010cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 7: 195\u2013201","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ2010205_CR43","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1038\/sj.emboj.7601045","volume":"25","author":"K Trenz","year":"2006","unstructured":"Trenz K, Smith E, Smith S, Costanzo V (2006) ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J 25: 1764\u20131774","journal-title":"EMBO J"},{"key":"BFEMBJ2010205_CR44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/carcin\/bgm238","volume":"29","author":"V Tripathi","year":"2008","unstructured":"Tripathi V, Kaur S, Sengupta S (2008) Phosphorylation\u2010dependent interactions of BLM and 53BP1 are required for their anti\u2010recombinogenic roles during homologous recombination. Carcinogenesis 29: 52\u201361","journal-title":"Carcinogenesis"},{"key":"BFEMBJ2010205_CR45","doi-asserted-by":"crossref","first-page":"52997","DOI":"10.1074\/jbc.M308338200","volume":"278","author":"C von Kobbe","year":"2003","unstructured":"von Kobbe C, Thoma NH, Czyzewski BK, Pavletich NP, Bohr VA (2003) Werner syndrome protein contains three structure\u2010specific DNA binding domains. J Biol Chem 278: 52997\u201353006","journal-title":"J Biol Chem"},{"key":"BFEMBJ2010205_CR46","first-page":"85","volume":"525","author":"SS Yuan","year":"2003","unstructured":"Yuan SS, Chang HL, Lee EY (2003) Ionizing radiation\u2010induced Rad51 nuclear focus formation is cell cycle\u2010regulated and defective in both ATM(\u2212\/\u2212) and c\u2010Abl(\u2212\/\u2212) cells. Mutat Res 525: 85\u201392","journal-title":"Mutat Res"},{"key":"BFEMBJ2010205_CR47","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/MCB.25.2.563-574.2005","volume":"25","author":"G Zachos","year":"2005","unstructured":"Zachos G, Rainey MD, Gillespie DA (2005) Chk1\u2010dependent S\u2010M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures. Mol Cell Biol 25: 563\u2013574","journal-title":"Mol Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Femboj.2010.205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/emboj.2010.205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/emboj.2010.205","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/emboj.2010.205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/emboj.2010.205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:07:46Z","timestamp":1779235666000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/emboj.2010.205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,27]]},"references-count":47,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2010,9,15]]}},"alternative-id":["BFEMBJ2010205"],"URL":"https:\/\/doi.org\/10.1038\/emboj.2010.205","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.6105962.6152055","asserted-by":"object"}]},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,27]]},"assertion":[{"value":"12 April 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}