{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:32:06Z","timestamp":1790775126129,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"24","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2013,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The histone deacetylases HDAC1 and HDAC2 remove acetyl moieties from lysine residues of histones and other proteins and are important regulators of gene expression. By deleting different combinations of\n                    <jats:italic>Hdac1<\/jats:italic>\n                    and\n                    <jats:italic>Hdac2<\/jats:italic>\n                    alleles in the epidermis, we reveal a dosage\u2010dependent effect of HDAC1\/HDAC2 activity on epidermal proliferation and differentiation. Conditional ablation of either HDAC1 or HDAC2 in the epidermis leads to no obvious phenotype due to compensation by the upregulated paralogue. Strikingly, deletion of a single\n                    <jats:italic>Hdac2<\/jats:italic>\n                    allele in HDAC1 knockout mice results in severe epidermal defects, including alopecia, hyperkeratosis, hyperproliferation and spontaneous tumour formation. These mice display impaired Sin3A co\u2010repressor complex function, increased levels of c\u2010Myc protein, p53 expression and apoptosis in hair follicles (HFs) and misregulation of HF bulge stem cells. Surprisingly, ablation of HDAC1 but not HDAC2 in a skin tumour model leads to accelerated tumour development. Our data reveal a crucial function of HDAC1\/HDAC2 in the control of lineage specificity and a novel role of HDAC1 as a tumour suppressor in the epidermis.\n                  <\/jats:p>","DOI":"10.1038\/emboj.2013.243","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T10:01:53Z","timestamp":1384509713000},"page":"3176-3191","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis"],"prefix":"10.1038","volume":"32","author":[{"given":"Mircea","family":"Winter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam A","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Machat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Mattes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate M","family":"Lichtenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Brunmeir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Weissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Murko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Humer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Meischel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Brosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Matthias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sibilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Seiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"BFEMBJ2013243_CR1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/sj.jid.5701146","volume":"128","author":"L Aarenstrup","year":"2008","unstructured":"Aarenstrup L, Flindt EN, Otkjaer K, Kirkegaard M, Andersen JS, Kristiansen K (2008) HDAC activity is required for p65\/RelA\u2010dependent repression of PPARdelta\u2010mediated transactivation in human keratinocytes. J Invest Dermatol 128: 1095\u20131106","journal-title":"J Invest Dermatol"},{"key":"BFEMBJ2013243_CR2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0960-9822(01)00154-3","volume":"11","author":"I Arnold","year":"2001","unstructured":"Arnold I, Watt FM (2001) c\u2010Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 11: 558\u2013568","journal-title":"Curr Biol"},{"key":"BFEMBJ2013243_CR3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/emmm.200900047","volume":"2","author":"MA Berta","year":"2010","unstructured":"Berta MA, Baker CM, Cottle DL, Watt FM (2010) Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation. EMBO Mol Med 2: 16\u201325","journal-title":"EMBO Mol Med"},{"key":"BFEMBJ2013243_CR4","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.ejmech.2010.02.030","volume":"45","author":"P Bertrand","year":"2010","unstructured":"Bertrand P (2010) Inside HDAC with HDAC inhibitors. Eur J Med Chem 45: 2095\u20132116","journal-title":"Eur J Med Chem"},{"key":"BFEMBJ2013243_CR5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.cellbio.22.010305.104357","volume":"22","author":"C Blanpain","year":"2006","unstructured":"Blanpain C, Fuchs E (2006) Epidermal stem cells of the skin. Annu Rev Cell Dev Biol 22: 339\u2013373","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFEMBJ2013243_CR6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrm2636","volume":"10","author":"C Blanpain","year":"2009","unstructured":"Blanpain C, Fuchs E (2009) Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol 10: 207\u2013217","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ2013243_CR7","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/carcin\/bgs136","volume":"33","author":"K Boehnke","year":"2012","unstructured":"Boehnke K, Falkowska\u2010Hansen B, Stark HJ, Boukamp P (2012) Stem cells of the human epidermis and their niche: composition and function in epidermal regeneration and carcinogenesis. Carcinogenesis 33: 1247\u20131258","journal-title":"Carcinogenesis"},{"key":"BFEMBJ2013243_CR8","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1038\/jid.2012.182","volume":"132","author":"VA Botchkarev","year":"2012","unstructured":"Botchkarev VA, Gdula MR, Mardaryev AN, Sharov AA, Fessing MY (2012) Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol 132: 2505\u20132521","journal-title":"J Invest Dermatol"},{"key":"BFEMBJ2013243_CR9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1387\/ijdb.082649rb","volume":"53","author":"R Brunmeir","year":"2009","unstructured":"Brunmeir R, Lagger S, Seiser C (2009) Histone deacetylase HDAC1\/HDAC2\u2010controlled embryonic development and cell differentiation. Int J Dev Biol 53: 275\u2013289","journal-title":"Int J Dev Biol"},{"key":"BFEMBJ2013243_CR10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nn.2780","volume":"14","author":"Y Chen","year":"2011","unstructured":"Chen Y, Wang H, Yoon SO, Xu X, Hottiger MO, Svaren J, Nave KA, Kim HA, Olson EN, Lu QR (2011) HDAC\u2010mediated deacetylation of NF\u2010kappaB is critical for Schwann cell myelination. Nat Neurosci 14: 437\u2013441","journal-title":"Nat Neurosci"},{"key":"BFEMBJ2013243_CR11","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1182\/blood-2012-07-441949","volume":"121","author":"OM Dovey","year":"2013","unstructured":"Dovey OM, Foster CT, Conte N, Edwards SA, Edwards JM, Singh R, Vassiliou G, Bradley A, Cowley SM (2013) Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice. Blood 121: 1335\u20131344","journal-title":"Blood"},{"key":"BFEMBJ2013243_CR12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1101\/gad.2019811","volume":"25","author":"E Ezhkova","year":"2011","unstructured":"Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E (2011) EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev 25: 485\u2013498","journal-title":"Genes Dev"},{"key":"BFEMBJ2013243_CR13","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.cell.2008.12.043","volume":"136","author":"E Ezhkova","year":"2009","unstructured":"Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue\u2010specific stem cells. Cell 136: 1122\u20131135","journal-title":"Cell"},{"key":"BFEMBJ2013243_CR14","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.stem.2013.06.018","volume":"13","author":"AR Folgueras","year":"2013","unstructured":"Folgueras AR, Guo X, Pasolli HA, Stokes N, Polak L, Zheng D, Fuchs E (2013) Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell 13: 314\u2013327","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2013243_CR15","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1242\/dev.00462","volume":"130","author":"M Frye","year":"2003","unstructured":"Frye M, Gardner C, Li ER, Arnold I, Watt FM (2003) Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development 130: 2793\u20132808","journal-title":"Development"},{"key":"BFEMBJ2013243_CR16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.bbrc.2003.09.043","volume":"310","author":"KB Glaser","year":"2003","unstructured":"Glaser KB, Li J, Staver MJ, Wei RQ, Albert DH, Davidsen SK (2003) Role of class I and class II histone deacetylases in carcinoma cells using siRNA. Biochem Biophys Res Commun 310: 529\u2013536","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ2013243_CR17","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.4049\/jimmunol.0903610","volume":"185","author":"R Grausenburger","year":"2010","unstructured":"Grausenburger R, Bilic I, Boucheron N, Zupkovitz G, El\u2010Housseiny L, Tschismarov R, Zhang Y, Rembold M, Gaisberger M, Hartl A, Epstein MM, Matthias P, Seiser C, Ellmeier W (2010) Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol 185: 3489\u20133497","journal-title":"J Immunol"},{"key":"BFEMBJ2013243_CR18","doi-asserted-by":"crossref","first-page":"14663","DOI":"10.1074\/jbc.M109.081679","volume":"285","author":"M Haberland","year":"2010","unstructured":"Haberland M, Carrer M, Mokalled MH, Montgomery RL, Olson EN (2010) Redundant control of adipogenesis by histone deacetylases 1 and 2. J Biol Chem 285: 14663\u201314670","journal-title":"J Biol Chem"},{"key":"BFEMBJ2013243_CR19","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1128\/MCB.22.22.7820-7830.2002","volume":"22","author":"C Hauser","year":"2002","unstructured":"Hauser C, Schuettengruber B, Bartl S, Lagger G, Seiser C (2002) Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. Mol Cell Biol 22: 7820\u20137830","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2013243_CR20","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1182\/blood-2012-08-450916","volume":"121","author":"MR Heideman","year":"2013","unstructured":"Heideman MR, Wilting RH, Yanover E, Velds A, de Jong J, Kerkhoven RM, Jacobs H, Wessels LF, Dannenberg JH (2013) Dosage\u2010dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c\u2010Myc collaborating genes and p53 function. Blood 121: 2038\u20132050","journal-title":"Blood"},{"key":"BFEMBJ2013243_CR21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/jid.2013.283","volume":"134","author":"MW Hughes","year":"2013","unstructured":"Hughes MW, Jiang TX, Lin SJ, Leung Y, Kobielak K, Widelitz RB, Chuong CM (2013) Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis. J Invest Dermatol 134: 24\u201332","journal-title":"J Invest Dermatol"},{"key":"BFEMBJ2013243_CR22","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/nm1328","volume":"11","author":"M Ito","year":"2005","unstructured":"Ito M, Liu Y, Yang Z, Nguyen J, Liang F, Morris RJ, Cotsarelis G (2005) Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med 11: 1351\u20131354","journal-title":"Nat Med"},{"key":"BFEMBJ2013243_CR23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nn.2762","volume":"14","author":"C Jacob","year":"2011","unstructured":"Jacob C, Christen CN, Pereira JA, Somandin C, Baggiolini A, Lotscher P, Ozcelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P, Suter U (2011) HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Nat Neurosci 14: 429\u2013436","journal-title":"Nat Neurosci"},{"key":"BFEMBJ2013243_CR24","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1101\/gad.1115203","volume":"17","author":"CK Kaufman","year":"2003","unstructured":"Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, Dai X, Alegre ML, Fuchs E (2003) GATA\u20103: an unexpected regulator of cell lineage determination in skin. Genes Dev 17: 2108\u20132122","journal-title":"Genes Dev"},{"key":"BFEMBJ2013243_CR25","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1046\/j.1523-1747.1998.00385.x","volume":"111","author":"K Kizawa","year":"1998","unstructured":"Kizawa K, Tsuchimoto S, Hashimoto K, Uchiwa H (1998) Gene expression of mouse S100A3, a cysteine\u2010rich calcium\u2010binding protein, in developing hair follicle. J Invest Dermatol 111: 879\u2013886","journal-title":"J Invest Dermatol"},{"key":"BFEMBJ2013243_CR26","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2133.2005.06754.x","volume":"153","author":"N Komatsu","year":"2005","unstructured":"Komatsu N, Saijoh K, Toyama T, Ohka R, Otsuki N, Hussack G, Takehara K, Diamandis EP (2005) Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases. Br J Dermatol 153: 274\u2013281","journal-title":"Br J Dermatol"},{"key":"BFEMBJ2013243_CR27","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/emboj\/21.11.2672","volume":"21","author":"G Lagger","year":"2002","unstructured":"Lagger G, O'Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, Schuettengruber B, Hauser C, Brunmeir R, Jenuwein T, Seiser C (2002) Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J 21: 2672\u20132681","journal-title":"EMBO J"},{"key":"BFEMBJ2013243_CR28","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1038\/emboj.2010.264","volume":"29","author":"S Lagger","year":"2010","unstructured":"Lagger S, Meunier D, Mikula M, Brunmeir R, Schlederer M, Artaker M, Pusch O, Egger G, Hagelkruys A, Mikulits W, Weitzer G, Muellner EW, Susani M, Kenner L, Seiser C (2010) Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans. EMBO J 29: 3992\u20134007","journal-title":"EMBO J"},{"key":"BFEMBJ2013243_CR29","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.devcel.2010.10.015","volume":"19","author":"M LeBoeuf","year":"2011","unstructured":"LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE (2011) Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell 19: 807\u2013818","journal-title":"Dev Cell"},{"key":"BFEMBJ2013243_CR30","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1634\/stemcells.2007-0651","volume":"26","author":"C Lo Celso","year":"2008","unstructured":"Lo Celso C, Berta MA, Braun KM, Frye M, Lyle S, Zouboulis CC, Watt FM (2008) Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c\u2010Myc and beta\u2010catenin. Stem Cells 26: 1241\u20131252","journal-title":"Stem Cells"},{"key":"BFEMBJ2013243_CR31","first-page":"E481","volume":"109","author":"P Ma","year":"2012","unstructured":"Ma P, Pan H, Montgomery RL, Olson EN, Schultz RM (2012) Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proc Natl Acad Sci USA 109: E481\u2013E489","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2013243_CR32","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1101\/gr.2709404","volume":"14","author":"N Martin","year":"2004","unstructured":"Martin N, Patel S, Segre JA (2004) Long\u2010range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation. Genome Res 14: 2430\u20132438","journal-title":"Genome Res"},{"key":"BFEMBJ2013243_CR33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/dvdy.10245","volume":"226","author":"S Mazzalupo","year":"2003","unstructured":"Mazzalupo S, Wong P, Martin P, Coulombe PA (2003) Role for keratins 6 and 17 during wound closure in embryonic mouse skin. Dev Dyn 226: 356\u2013365","journal-title":"Dev Dyn"},{"key":"BFEMBJ2013243_CR34","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gad.1563807","volume":"21","author":"RL Montgomery","year":"2007","unstructured":"Montgomery RL, Davis CA, Potthoff MJ, Haberland M, Fielitz J, Qi X, Hill JA, Richardson JA, Olson EN (2007) Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev 21: 1790\u20131802","journal-title":"Genes Dev"},{"key":"BFEMBJ2013243_CR35","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/ncb2385","volume":"13","author":"EM Nascimento","year":"2011","unstructured":"Nascimento EM, Cox CL, MacArthur S, Hussain S, Trotter M, Blanco S, Suraj M, Nichols J, Kubler B, Benitah SA, Hendrich B, Odom DT, Frye M (2011) The opposing transcriptional functions of Sin3a and c\u2010Myc are required to maintain tissue homeostasis. Nat Cell Biol 13: 1395\u20131405","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ2013243_CR36","doi-asserted-by":"crossref","first-page":"10826","DOI":"10.1128\/MCB.24.24.10826-10834.2004","volume":"24","author":"JH Patel","year":"2004","unstructured":"Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ, Rakowski C, Chatterjee C, Lieberman PM, Lane WS, Blobel GA, McMahon SB (2004) The c\u2010MYC oncoprotein is a substrate of the acetyltransferases hGCN5\/PCAF and TIP60. Mol Cell Biol 24: 10826\u201310834","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2013243_CR37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/gene.20025","volume":"39","author":"A Ramirez","year":"2004","unstructured":"Ramirez A, Page A, Gandarillas A, Zanet J, Pibre S, Vidal M, Tusell L, Genesca A, Whitaker DA, Melton DW, Jorcano JL (2004) A keratin K5Cre transgenic line appropriate for tissue\u2010specific or generalized Cre\u2010mediated recombination. Genesis 39: 52\u201357","journal-title":"Genesis"},{"key":"BFEMBJ2013243_CR38","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1158\/0008-5472.CAN-11-0046","volume":"71","author":"MR Ramsey","year":"2011","unstructured":"Ramsey MR, He L, Forster N, Ory B, Ellisen LW (2011) Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. Cancer Res 71: 4373\u20134379","journal-title":"Cancer Res"},{"key":"BFEMBJ2013243_CR39","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s00018-012-0921-9","volume":"69","author":"N Reichert","year":"2012","unstructured":"Reichert N, Choukrallah MA, Matthias P (2012) Multiple roles of class I HDACs in proliferation, differentiation, and development. Cell Mol Life Sci 69: 2173\u20132187","journal-title":"Cell Mol Life Sci"},{"key":"BFEMBJ2013243_CR40","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1242\/jcs.121558","volume":"125","author":"ED Robertson","year":"2012","unstructured":"Robertson ED, Weir L, Romanowska M, Leigh IM, Panteleyev AA (2012) ARNT controls the expression of epidermal differentiation genes through HDAC\u2010 and EGFR\u2010dependent pathways. J Cell Sci 125: 3320\u20133332","journal-title":"J Cell Sci"},{"key":"BFEMBJ2013243_CR41","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/emboj.2012.149","volume":"31","author":"J Schuijers","year":"2012","unstructured":"Schuijers J, Clevers H (2012) Adult mammalian stem cells: the role of Wnt, Lgr5 and R\u2010spondins. EMBO J 31: 2685\u20132696","journal-title":"EMBO J"},{"key":"BFEMBJ2013243_CR42","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1128\/MCB.00494-07","volume":"27","author":"S Senese","year":"2007","unstructured":"Senese S, Zaragoza K, Minardi S, Muradore I, Ronzoni S, Passafaro A, Bernard L, Draetta GF, Alcalay M, Seiser C, Chiocca S (2007) Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol 27: 4784\u20134795","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2013243_CR43","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/embor.2009.102","volume":"10","author":"T Shaw","year":"2009","unstructured":"Shaw T, Martin P (2009) Epigenetic reprogramming during wound healing: loss of polycomb\u2010mediated silencing may enable upregulation of repair genes. EMBO Rep 10: 881\u2013886","journal-title":"EMBO Rep"},{"key":"BFEMBJ2013243_CR44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00026-X","volume":"102","author":"M Sibilia","year":"2000","unstructured":"Sibilia M, Fleischmann A, Behrens A, Stingl L, Carroll J, Watt FM, Schlessinger J, Wagner EF (2000) The EGF receptor provides an essential survival signal for SOS\u2010dependent skin tumor development. Cell 102: 211\u2013220","journal-title":"Cell"},{"key":"BFEMBJ2013243_CR45","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1126\/science.1184733","volume":"327","author":"HJ Snippert","year":"2010","unstructured":"Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H (2010) Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327: 1385\u20131389","journal-title":"Science"},{"key":"BFEMBJ2013243_CR46","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/sj.embor.embor821","volume":"4","author":"J Vervoorts","year":"2003","unstructured":"Vervoorts J, Luscher\u2010Firzlaff JM, Rottmann S, Lilischkis R, Walsemann G, Dohmann K, Austen M, Luscher B (2003) Stimulation of c\u2010MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep 4: 484\u2013490","journal-title":"EMBO Rep"},{"key":"BFEMBJ2013243_CR47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/88889","volume":"28","author":"RL Waikel","year":"2001","unstructured":"Waikel RL, Kawachi Y, Waikel PA, Wang XJ, Roop DR (2001) Deregulated expression of c\u2010Myc depletes epidermal stem cells. Nat Genet 28: 165\u2013168","journal-title":"Nat Genet"},{"key":"BFEMBJ2013243_CR48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2008.08.016","volume":"277","author":"O Witt","year":"2009","unstructured":"Witt O, Deubzer HE, Milde T, Oehme I (2009) HDAC family: What are the cancer relevant targets? Cancer Lett 277: 8\u201321","journal-title":"Cancer Lett"},{"key":"BFEMBJ2013243_CR49","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1101\/gad.552310","volume":"24","author":"T Yamaguchi","year":"2010","unstructured":"Yamaguchi T, Cubizolles F, Zhang Y, Reichert N, Kohler H, Seiser C, Matthias P (2010) Histone deacetylases 1 and 2 act in concert to promote the G1\u2010to\u2010S progression. Genes Dev 24: 455\u2013469","journal-title":"Genes Dev"},{"key":"BFEMBJ2013243_CR50","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1128\/MCB.01500-09","volume":"30","author":"G Zupkovitz","year":"2010","unstructured":"Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C (2010) The cyclin\u2010dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Mol Cell Biol 30: 1171\u20131181","journal-title":"Mol Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Femboj.2013.243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/emboj.2013.243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/emboj.2013.243","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/emboj.2013.243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/emboj.2013.243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:35:08Z","timestamp":1779237308000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/emboj.2013.243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,15]]},"references-count":50,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2013,12,11]]}},"alternative-id":["BFEMBJ2013243"],"URL":"https:\/\/doi.org\/10.1038\/emboj.2013.243","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,15]]},"assertion":[{"value":"8 May 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}