{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:40:36Z","timestamp":1774525236633,"version":"3.50.1"},"reference-count":32,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Emerging Microbes & Infections"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1038\/emi.2017.49","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T07:20:36Z","timestamp":1499844036000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Modelling person-to-person transmission in an Enterovirus A71 orally infected hamster model of hand-foot-and-mouth disease and encephalomyelitis"],"prefix":"10.1080","volume":"6","author":[{"given":"Win Kyaw","family":"Phyu","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of MedicineUniversity of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kien Chai","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of MedicineUniversity of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kum Thong","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of MedicineUniversity of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_3_2_2_1","first-page":"723","author":"Knipe DM","year":"2001","unstructured":"Knipe DM, Howley PM.Fields Virology. In: Griffin DEet al (eds). Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses, and Newer Enteroviruses. 4th ed.USA: Lippincott Williams & Wilkins.2001, 723\u2013775.","journal-title":"Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses, and Newer Enteroviruses."},{"key":"e_1_3_2_3_1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00705-010-0722-0","article-title":"Emergence of enterovirus 71 \u201cdouble-recombinant\u201d strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71","volume":"155","author":"Yip CCY","year":"2010","unstructured":"Yip CCY, Lau SKP, Zhou Bet al.Emergence of enterovirus 71 \u201cdouble-recombinant\u201d strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71. Arch Virol 2010;155: 1413\u20131424.","journal-title":"Arch Virol"},{"key":"e_1_3_2_4_1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan","volume":"341","author":"Ho M","year":"1999","unstructured":"Ho M, Chen ER, Hsu KHet al.An epidemic of enterovirus 71 infection in Taiwan. N Engl J Med 1999;341: 929\u2013935.","journal-title":"N Engl J Med"},{"key":"e_1_3_2_5_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1086\/511073","article-title":"Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study","volume":"44","author":"Ooi MH","year":"2007","unstructured":"Ooi MH, Wong SC, Podin Yet al.Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study. Clin Infect Dis 2007;44: 646\u2013656.","journal-title":"Clin Infect Dis"},{"key":"e_1_3_2_6_1","first-page":"57","article-title":"Enterovirus 71 in the Asia-Pacific region: an emerging cause of acute neurological disease in young children","volume":"8","author":"Mcminn PC","year":"2003","unstructured":"Mcminn PC.Enterovirus 71 in the Asia-Pacific region: an emerging cause of acute neurological disease in young children. Neurol J Southeast Asia 2003;8: 57\u201363.","journal-title":"Neurol J Southeast Asia"},{"key":"e_1_3_2_7_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(13)70342-6","article-title":"Hand, foot, and mouth disease in China, 2008\u201312: an epidemiological study","volume":"14","author":"Xing W","year":"2014","unstructured":"Xing W, Liao Q, Viboud Cet al.Hand, foot, and mouth disease in China, 2008\u201312: an epidemiological study. Lancet Infect Dis 2014;14: 308\u2013318.","journal-title":"Lancet Infect Dis"},{"key":"e_1_3_2_8_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3201\/eid1301.020112","article-title":"Epidemic hand, foot and mouth disease caused by human EV71, Singapore","volume":"9","author":"Chan KP","year":"2003","unstructured":"Chan KP, Goh KT, Chong CYet al.Epidemic hand, foot and mouth disease caused by human EV71, Singapore. Emerg Infect Dis 2003;9: 78\u201385.","journal-title":"Emerg Infect Dis"},{"key":"e_1_3_2_9_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1542\/peds.2006-3331","article-title":"Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005","volume":"120","author":"Chen KT","year":"2007","unstructured":"Chen KT, Chang HL, Wang STet al.Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. Pediatrics 2007;120: 244\u2013252.","journal-title":"Pediatrics"},{"key":"e_1_3_2_10_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/path.4438","article-title":"Tissue tropism, pathology and pathogenesis of enterovirus infection","volume":"235","author":"Muehlenbachs A","year":"2015","unstructured":"Muehlenbachs A, Bhatnagar J, Zaki SR.Tissue tropism, pathology and pathogenesis of enterovirus infection. J Pathol 2015;235: 217\u2013228.","journal-title":"J Pathol"},{"key":"e_1_3_2_11_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1542\/pir.19.6.183","article-title":"Enterovirus Infections","volume":"19","author":"Zaoutis T","year":"1998","unstructured":"Zaoutis T, Klein JD.Enterovirus Infections. Pediatr Rev 1998;19: 183\u2013191.","journal-title":"Pediatr Rev"},{"key":"e_1_3_2_12_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7883\/yoken.63.229","article-title":"Clinical and molecular characterization of hand-foot and mouth disease in Thailand, 2008-2009","volume":"63","author":"Chatproedprai S","year":"2010","unstructured":"Chatproedprai S, Theanboonlers A, Korkong Set al.Clinical and molecular characterization of hand-foot and mouth disease in Thailand, 2008-2009. Jpn J Infect Dis 2010;63: 229\u2013233.","journal-title":"Jpn J Infect Dis"},{"key":"e_1_3_2_13_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1001\/jama.291.2.222","article-title":"Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan","volume":"291","author":"Chang LY","year":"2004","unstructured":"Chang LY, Tsao KC, Hsia SHet al.Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan. JAMA 2004;291: 222\u2013227.","journal-title":"JAMA"},{"key":"e_1_3_2_14_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1651-2227.2003.tb02478.x","article-title":"Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases","volume":"92","author":"Chong CY","year":"2003","unstructured":"Chong CY, Chan KP, Ng WYMet al.Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases. Acta Paediatr 2003;92: 1163\u20131169.","journal-title":"Acta Paediatr"},{"key":"e_1_3_2_15_1","first-page":"6","article-title":"Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years","author":"Podin Y","year":"2006","unstructured":"Podin Y, Gias EL, Ong Fet al.Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years. BMC Public Health 2006, 6.","journal-title":"BMC Public Health"},{"key":"e_1_3_2_16_1","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1128\/JVI.75.16.7732-7738.2001","article-title":"Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia","volume":"75","author":"McMinn P","year":"2001","unstructured":"McMinn P, Lindsay K, Perera Det al.Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia. J Virol 2001;75: 7732\u20137738.","journal-title":"J Virol"},{"key":"e_1_3_2_17_1","first-page":"715","article-title":"Tonsillar crypt epithelium is an important extracentral nervous system site for viral replication in EV71 encephalomyelitis","volume":"184","author":"He Y","year":"2014","unstructured":"He Y, Ong KC, Gao Zet al.Tonsillar crypt epithelium is an important extracentral nervous system site for viral replication in EV71 encephalomyelitis. Am J Pathol 2014;184: 715\u2013720.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_18_1","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1128\/JCM.01394-06","article-title":"Evaluation of different clinical sample types in diagnosis of human enterovirus 71-associated hand-foot-and-mouth disease","volume":"45","author":"Ooi MH","year":"2007","unstructured":"Ooi MH, Solomon T, Podin Yet al.Evaluation of different clinical sample types in diagnosis of human enterovirus 71-associated hand-foot-and-mouth disease. J Clin Microbiol 2007;45: 1858\u20131866.","journal-title":"J Clin Microbiol"},{"key":"e_1_3_2_19_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/1471-2334-10-178","article-title":"Long persistence of EV71 specific nucleotides in respiratory and feces samples of the patients with hand-foot-mouth disease after recovery","volume":"10","author":"Han J","year":"2010","unstructured":"Han J, Ma XJ, Wan JFet al.Long persistence of EV71 specific nucleotides in respiratory and feces samples of the patients with hand-foot-mouth disease after recovery. BMC Infect Dis 2010;10: 178.","journal-title":"BMC Infect Dis"},{"key":"e_1_3_2_20_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1743-422X-10-28","article-title":"Strategies to develop antivirals against enterovirus 71","volume":"10","author":"Kuo RL","year":"2013","unstructured":"Kuo RL, Shih SR.Strategies to develop antivirals against enterovirus 71. Virol J 2013;10: 28.","journal-title":"Virol J"},{"key":"e_1_3_2_21_1","doi-asserted-by":"crossref","first-page":"45069","DOI":"10.1038\/srep45069","article-title":"Squamous epitheliotropism of Enterovirus A71 in human epidermis and oral mucosa","volume":"7","author":"Phyu WK","year":"2017","unstructured":"Phyu WK, Ong KC, Kong CKet al.Squamous epitheliotropism of Enterovirus A71 in human epidermis and oral mucosa. Sci Rep 2017;7: 45069.","journal-title":"Sci Rep"},{"key":"e_1_3_2_22_1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3201\/eid1405.071121","article-title":"Acute encephalitis caused by intrafamilial transmission of EV71 in adult","author":"Hamaguchi T","year":"2008","unstructured":"Hamaguchi T, Fujisawa H, Sakai Ket al.Acute encephalitis caused by intrafamilial transmission of EV71 in adult. Emerg Infect Dis 2008, 828\u2013830.","journal-title":"Emerg Infect Dis"},{"key":"e_1_3_2_23_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1099\/vir.0.19423-0","article-title":"A murine oral enterovirus 71 infection model with central nervous system involvement","volume":"85","author":"Chen YC","year":"2004","unstructured":"Chen YC, Yu CK, Wang YFet al.A murine oral enterovirus 71 infection model with central nervous system involvement. J Gen Virol 2004;85: 69\u201377.","journal-title":"J Gen Virol"},{"key":"e_1_3_2_24_1","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/labinvest.2011.82","article-title":"Pathogenesis study of enterovirus 71 infection in rhesus monkeys","volume":"91","author":"Zhang Y","year":"2011","unstructured":"Zhang Y, Cui W, Liu Let al.Pathogenesis study of enterovirus 71 infection in rhesus monkeys. Lab Invest 2011;91: 1337\u20131350.","journal-title":"Lab Invest"},{"key":"e_1_3_2_25_1","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1128\/JVI.06103-11","article-title":"A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection","volume":"86","author":"Khong WX","year":"2012","unstructured":"Khong WX, Yan B, Yeo Het al.A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection. J Virol 2012;86: 2121\u20132131.","journal-title":"J Virol"},{"key":"e_1_3_2_26_1","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1073\/pnas.1217563110","article-title":"Transgenic mouse model for the study of enterovirus 71 neuropathogenesis","volume":"110","author":"Fujii K","year":"2013","unstructured":"Fujii K, Nagata N, Sato Yet al.Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. Proc Natl Acad Sci USA 2013;110: 14753\u201314758.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_2_27_1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/NEN.0b013e31817713e7","article-title":"Pathologic characterization of a murine model of human enterovirus 71 encephalomyelitis","volume":"67","author":"Ong KC","year":"2008","unstructured":"Ong KC, Badmanathan M, Devi Set al.Pathologic characterization of a murine model of human enterovirus 71 encephalomyelitis. J Neuropatho Exp Neurol 2008;67: 532\u2013542.","journal-title":"J Neuropatho Exp Neurol"},{"key":"e_1_3_2_28_1","doi-asserted-by":"crossref","first-page":"e0147463","DOI":"10.1371\/journal.pone.0147463","article-title":"A consistent orally-infected hamster model for enterovirus A71 encephalomyelitis demonstrates squamous lesions in the paws, skin and oral cavity reminiscent of hand-foot-and-mouth disease","volume":"11","author":"Phyu WK","year":"2016","unstructured":"Phyu WK, Ong KC, Wong KT.A consistent orally-infected hamster model for enterovirus A71 encephalomyelitis demonstrates squamous lesions in the paws, skin and oral cavity reminiscent of hand-foot-and-mouth disease. PLoS One 2016;11: e0147463.","journal-title":"PLoS One"},{"key":"e_1_3_2_29_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.antiviral.2016.04.015","article-title":"A monoclonal antibody to ameliorate central nervous system infection and improve survival in a murine model of human Enterovirus-A71 encephalomyelitis","volume":"132","author":"Tan SH","year":"2016","unstructured":"Tan SH, Ong KC, Perera Det al.A monoclonal antibody to ameliorate central nervous system infection and improve survival in a murine model of human Enterovirus-A71 encephalomyelitis. Antiviral Res 2016;132: 196\u2013203.","journal-title":"Antiviral Res"},{"key":"e_1_3_2_30_1","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1128\/JVI.78.15.7916-7924.2004","article-title":"A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection","volume":"78","author":"Wang YF","year":"2004","unstructured":"Wang YF, Chou CT, Lei HYet al.A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. J Virol 2004;78: 7916\u20137924.","journal-title":"J Virol"},{"key":"e_1_3_2_31_1","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1038\/emi.2014.35","article-title":"A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses","volume":"3","author":"Yang X","year":"2014","unstructured":"Yang X, Li G, Wen Ket al.A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses. Emerg Microbes Infect 2014;3: e35.","journal-title":"Emerg Microbes Infect"},{"key":"e_1_3_2_32_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon T","year":"2010","unstructured":"Solomon T, Lewthwaite P, Perera Det al.Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis 2010;10: 778\u2013790.","journal-title":"Lancet Infect Dis"},{"key":"e_1_3_2_33_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/1874297100801010010","article-title":"Human enterovirus 71 disease clinical features, epidemiology, virology, and management","volume":"1","author":"Chen KT","year":"2008","unstructured":"Chen KT, Lee TC, Chang HLet al.Human enterovirus 71 disease clinical features, epidemiology, virology, and management. Open Epidemiol J 2008;1: 10\u201316.","journal-title":"Open Epidemiol J"}],"container-title":["Emerging Microbes & Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1038\/emi.2017.49","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T12:26:22Z","timestamp":1695385582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1038\/emi.2017.49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1038\/emi.2017.49"],"URL":"https:\/\/doi.org\/10.1038\/emi.2017.49","relation":{},"ISSN":["2222-1751"],"issn-type":[{"value":"2222-1751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=temi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=temi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}