{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:14:34Z","timestamp":1775042074467,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"DOI":"10.1038\/emm.2013.129","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T12:31:22Z","timestamp":1384518682000},"page":"e62-e62","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Negative-pressure wound therapy induces endothelial progenitor cell mobilization in diabetic patients with foot infection or skin defects"],"prefix":"10.1038","volume":"45","author":[{"given":"Sang Gyo","family":"Seo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyun","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JI Hye","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Beom","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Joon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Yeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"BFemm2013129_CR1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2337\/diacare.19.1.48","volume":"19","author":"LA Lavery","year":"1996","unstructured":"Lavery LA, Ashry HR, vanHoutum W, Pugh JA, Harkless LB, Basu S . Variation in the incidence and proportion at diabetes-related amputations in minorities. Diabetes care 1996; 19: 48\u201352.","journal-title":"Diabetes care"},{"key":"BFemm2013129_CR2","first-page":"71","volume":"78","author":"MS Bader","year":"2008","unstructured":"Bader MS . Diabetic foot infection. Am Fam Phys 2008; 78: 71\u201379.","journal-title":"Am Fam Phys"},{"key":"BFemm2013129_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3810\/pgm.2012.03.2541","volume":"124","author":"M Bader","year":"2012","unstructured":"Bader M, Brooks A . Medical management of diabetic foot infections. Postgrad Med 2012; 124: 102.","journal-title":"Postgrad Med"},{"key":"BFemm2013129_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2337\/dc07-2196","volume":"31","author":"PA Blume","year":"2008","unstructured":"Blume PA, Walters J, Payne W, Ayala J, Lantis J . Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers. Diabetes care 2008; 31: 631\u2013636.","journal-title":"Diabetes care"},{"key":"BFemm2013129_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4103\/2006-8808.78466","volume":"3","author":"PS Nain","year":"2011","unstructured":"Nain PS, Uppal SK, Garg R, Bajaj K, Garg S . Role of negative pressure wound therapy in healing of diabetic foot ulcers. J Surg Tech Case Rep 2011; 3: 17\u201322.","journal-title":"J Surg Tech Case Rep"},{"key":"BFemm2013129_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/dmrr.2243","volume":"28","author":"M Schintler","year":"2012","unstructured":"Schintler M . Negative pressure therapy: theory and practice. Diabetes Metab Res Rev 2012; 28: 72\u201377.","journal-title":"Diabetes Metab Res Rev"},{"key":"BFemm2013129_CR7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1177\/14746514070070050601","volume":"7","author":"M Kirby","year":"2007","unstructured":"Kirby M . Negative pressure wound therapy. Br J Diabet Vasc Dis 2007; 7: 230\u2013234.","journal-title":"Br J Diabet Vasc Dis"},{"key":"BFemm2013129_CR8","first-page":"12","volume":"150","author":"A Rejzek","year":"1998","unstructured":"Rejzek A, Weyer F . Der Einsatz des VAC-Systems in der Therapie von Ulcus cruris und diabetischer Gangr\u00e4n. Acta Chir Austriaca 1998; 150: 12\u201313.","journal-title":"Acta Chir Austriaca"},{"key":"BFemm2013129_CR9","doi-asserted-by":"publisher","first-page":"121S","DOI":"10.1097\/01.prs.0000225450.12593.12","volume":"117","author":"MJ Morykwas","year":"2006","unstructured":"Morykwas MJ, Simpson J, Punger K, Argenta A, Kremers L, Argenta J . Vacuum-assisted closure: state of basic research and physiologic foundation. Plast Reconstr Surg 2006; 117: 121S.","journal-title":"Plast Reconstr Surg"},{"key":"BFemm2013129_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1749-8090-5-75","volume":"5","author":"C Torbrand","year":"2010","unstructured":"Torbrand C, Ugander M, Engblom H, Arheden H, Ingemansson R, Malmsj\u00f6 M . Wound contraction and macro-deformation during negative pressure therapy of sternotomy wounds. J Cardiothorac Surg 2010; 5: 75.","journal-title":"J Cardiothorac Surg"},{"key":"BFemm2013129_CR11","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1097\/01.PRS.0000135330.51408.97","volume":"114","author":"V Saxena","year":"2004","unstructured":"Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP . Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg 2004; 114: 1086.","journal-title":"Plast Reconstr Surg"},{"key":"BFemm2013129_CR12","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1126\/science.275.5302.964","volume":"275","author":"T Asahara","year":"1997","unstructured":"Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964\u2013967.","journal-title":"Science"},{"key":"BFemm2013129_CR13","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1161\/STROKEAHA.107.499236","volume":"39","author":"K Chu","year":"2008","unstructured":"Chu K, Jung KH, Lee ST, Park HK, Sinn DI, Kim JM et al. Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke. Stroke 2008; 39: 1441\u20131447.","journal-title":"Stroke"},{"key":"BFemm2013129_CR14","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1161\/hc2301.092122","volume":"103","author":"S Shintani","year":"2001","unstructured":"Shintani S, Murohara T, Ikeda H, Ueno T, Honma T, Katoh A et al. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation 2001; 103: 2776\u20132779.","journal-title":"Circulation"},{"key":"BFemm2013129_CR15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1056\/NEJMoa022287","volume":"348","author":"JM Hill","year":"2003","unstructured":"Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003; 348: 593\u2013600.","journal-title":"N Engl J Med"},{"key":"BFemm2013129_CR16","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.jacc.2004.11.067","volume":"45","author":"GP Fadini","year":"2005","unstructured":"Fadini GP, Miorin M, Facco M, Bonamico S, Baesso I, Grego F et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 2005; 45: 1449\u20131457.","journal-title":"J Am Coll Cardiol"},{"key":"BFemm2013129_CR17","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.bone.2008.05.001","volume":"43","author":"T Matsumoto","year":"2008","unstructured":"Matsumoto T, Kuroda R, Mifune Y, Kawamoto A, Shoji T, Miwa M et al. Circulating endothelial\/skeletal progenitor cells for bone regeneration and healing. Bone 2008; 43: 434\u2013439.","journal-title":"Bone"},{"key":"BFemm2013129_CR18","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.2353\/ajpath.2006.060064","volume":"169","author":"T Matsumoto","year":"2006","unstructured":"Matsumoto T, Kawamoto A, Kuroda R, Ishikawa M, Mifune Y, Iwasaki H et al. Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing. Am J Pathol 2006; 169: 1440\u20131457.","journal-title":"Am J Pathol"},{"key":"BFemm2013129_CR19","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/jcp.21309","volume":"215","author":"T Matsumoto","year":"2008","unstructured":"Matsumoto T, Mifune Y, Kawamoto A, Kuroda R, Shoji T, Iwasaki H et al. Fracture induced mobilization and incorporation of bone marrow-derived endothelial progenitor cells for bone healing. J Cell Physiol 2008; 215: 234\u2013242.","journal-title":"J Cell Physiol"},{"key":"BFemm2013129_CR20","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.bone.2008.01.007","volume":"42","author":"DY Lee","year":"2008","unstructured":"Lee DY, Cho TJ, Kim JA, Lee HR, Yoo WJ, Chung CY et al. Mobilization of endothelial progenitor cells in fracture healing and distraction osteogenesis. Bone 2008; 42: 932\u2013941.","journal-title":"Bone"},{"key":"BFemm2013129_CR21","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.bone.2009.10.018","volume":"46","author":"DY Lee","year":"2010","unstructured":"Lee DY, Cho TJ, Lee HR, Park MS, Yoo WJ, Chung CY et al. Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man. Bone 2010; 46: 673\u2013679.","journal-title":"Bone"},{"key":"BFemm2013129_CR22","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1161\/01.RES.0000137877.89448.78","volume":"95","author":"C Urbich","year":"2004","unstructured":"Urbich C, Dimmeler S . Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 2004; 95: 343\u2013353.","journal-title":"Circ Res"},{"key":"BFemm2013129_CR23","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1161\/hh1301.093953","volume":"89","author":"M Vasa","year":"2001","unstructured":"Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001; 89: E1\u2013E7.","journal-title":"Circ Res"},{"key":"BFemm2013129_CR24","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1161\/CIRCULATIONAHA.104.504340","volume":"111","author":"C Schmidt-Lucke","year":"2005","unstructured":"Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kamper U et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005; 111: 2981\u20132987.","journal-title":"Circulation"},{"key":"BFemm2013129_CR25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1161\/01.RES.85.3.221","volume":"85","author":"T Asahara","year":"1999","unstructured":"Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85: 221\u2013228.","journal-title":"Circ Res"},{"key":"BFemm2013129_CR26","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1634\/stemcells.2007-0820","volume":"26","author":"Y Mifune","year":"2008","unstructured":"Mifune Y, Matsumoto T, Kawamoto A, Kuroda R, Shoji T, Iwasaki H et al. Local delivery of granulocyte colony stimulating factor-mobilized CD34-positive progenitor cells using bioscaffold for modality of unhealing bone fracture. Stem Cells 2008; 26: 1395\u20131405.","journal-title":"Stem Cells"},{"key":"BFemm2013129_CR27","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1097\/TA.0b013e318171971a","volume":"66","author":"L Labler","year":"2009","unstructured":"Labler L, Rancan M, Mica L, Harter L, Mihic-Probst D, Keel M . Vacuum-assisted closure therapy increases local interleukin-8 and vascular endothelial growth factor levels in traumatic wounds. J Trauma 2009; 66: 749\u2013757.","journal-title":"J Trauma"}],"container-title":["Experimental & Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/emm2013129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/emm2013129","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/emm2013129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T20:41:40Z","timestamp":1672951300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/emm2013129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,15]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11]]}},"alternative-id":["BFemm2013129"],"URL":"https:\/\/doi.org\/10.1038\/emm.2013.129","relation":{},"ISSN":["2092-6413"],"issn-type":[{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,15]]},"assertion":[{"value":"26 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}