{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:49:13Z","timestamp":1790189353656,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"DOI":"10.1038\/emm.2013.134","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T02:53:51Z","timestamp":1387508031000},"page":"e69-e69","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury"],"prefix":"10.1038","volume":"45","author":[{"given":"Juhyun","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Joo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yeong","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ah","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Taek","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"BFemm2013134_CR1","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1161\/01.STR.26.8.1478","volume":"26","author":"K Abe","year":"1995","unstructured":"Abe K, Aoki M, Kawagoe J, Yoshida T, Hattori A, Kogure K et al. Ischemic delayed neuronal death. A mitochondrial hypothesis. Stroke 1995; 26: 1478\u20131489.","journal-title":"Stroke"},{"key":"BFemm2013134_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1172\/JCI40543","volume":"120","author":"O Lindvall","year":"2010","unstructured":"Lindvall O, Kokaia Z . Stem cells in human neurodegenerative disorders--time for clinical translation? J Clin Invest 2010; 120: 29\u201340.","journal-title":"J Clin Invest"},{"key":"BFemm2013134_CR3","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1126\/science.1553558","volume":"255","author":"BA Reynolds","year":"1992","unstructured":"Reynolds BA, Weiss S . Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992; 255: 1707\u20131710.","journal-title":"Science"},{"key":"BFemm2013134_CR4","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/0165-6147(92)90041-4","volume":"13","author":"GP Reynolds","year":"1992","unstructured":"Reynolds GP . Developments in the drug treatment of schizophrenia. Trends in pharmacol sci 1992; 13: 116\u2013121.","journal-title":"Trends in pharmacol sci"},{"key":"BFemm2013134_CR5","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.stem.2012.05.012","volume":"10","author":"LC Fuentealba","year":"2012","unstructured":"Fuentealba LC, Obernier K, Alvarez-Buylla A . Adult neural stem cells bridge their niche. Cell Stem Cell 2012; 10: 698\u2013708.","journal-title":"Cell Stem Cell"},{"key":"BFemm2013134_CR6","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nature08533","volume":"462","author":"T Graf","year":"2009","unstructured":"Graf T, Enver T . Forcing cells to change lineages. Nature 2009; 462: 587\u2013594.","journal-title":"Nature"},{"issue":"Suppl 2","key":"BFemm2013134_CR7","first-page":"S101","volume":"64","author":"CW Olanow","year":"2008","unstructured":"Olanow CW, Kieburtz K, Schapira AH . Why have we failed to achieve neuroprotection in Parkinson's disease? Annals of neurology 2008; 64 (Suppl 2): S101\u2013S110.","journal-title":"Annals of neurology"},{"key":"BFemm2013134_CR8","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nature03889","volume":"436","author":"S Pluchino","year":"2005","unstructured":"Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G et al. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 2005; 436: 266\u2013271.","journal-title":"Nature"},{"key":"BFemm2013134_CR9","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.stem.2008.11.001","volume":"3","author":"D Lau","year":"2008","unstructured":"Lau D, Ogbogu U, Taylor B, Stafinski T, Menon D, Caulfield T . Stem cell clinics online: the direct-to-consumer portrayal of stem cell medicine. Cell Stem Cell 2008; 3: 591\u2013594.","journal-title":"Cell Stem Cell"},{"key":"BFemm2013134_CR10","doi-asserted-by":"publisher","first-page":"9805","DOI":"10.1074\/jbc.275.13.9805","volume":"275","author":"K Takeda","year":"2000","unstructured":"Takeda K, Hatai T, Hamazaki TS, Nishitoh H, Saitoh M, Ichijo H . Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells. J Biol Chem 2000; 275: 9805\u20139813.","journal-title":"J Biol Chem"},{"key":"BFemm2013134_CR11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1126\/science.275.5296.90","volume":"275","author":"H Ichijo","year":"1997","unstructured":"Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK\/JNK and p38 signaling pathways. Science 1997; 275: 90\u201394.","journal-title":"Science"},{"key":"BFemm2013134_CR12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1093\/embo-reports\/kve046","volume":"2","author":"K Tobiume","year":"2001","unstructured":"Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K et al. ASK1 is required for sustained activations of JNK\/p38 MAP kinases and apoptosis. EMBO Rep 2001; 2: 222\u2013228.","journal-title":"EMBO Rep"},{"key":"BFemm2013134_CR13","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1074\/jbc.M003425200","volume":"276","author":"K Sayama","year":"2001","unstructured":"Sayama K, Hanakawa Y, Shirakata Y, Yamasaki K, Sawada Y, Sun L et al. Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation. J Biol Chem 2001; 276: 999\u20131004.","journal-title":"J Biol Chem"},{"key":"BFemm2013134_CR14","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1002\/ana.20845","volume":"59","author":"ST Carmichael","year":"2006","unstructured":"Carmichael ST . Cellular and molecular mechanisms of neural repair after stroke: making waves. Ann Neurol 2006; 59: 735\u2013742.","journal-title":"Ann Neurol"},{"key":"BFemm2013134_CR15","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1523\/JNEUROSCI.4480-05.2006","volume":"26","author":"PT Tsai","year":"2006","unstructured":"Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J et al. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci 2006; 26: 1269\u20131274.","journal-title":"J Neurosci"},{"key":"BFemm2013134_CR16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.brainres.2011.07.018","volume":"1412","author":"HW Kim","year":"2011","unstructured":"Kim HW, Cho KJ, Lee SK, Kim GW . Apoptosis signal-regulating kinase 1 (Ask1) targeted small interfering RNA on ischemic neuronal cell death. Brain Res 2011; 1412: 73\u201378.","journal-title":"Brain Res"},{"key":"BFemm2013134_CR17","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1523\/JNEUROSCI.16-03-01091.1996","volume":"16","author":"A Gritti","year":"1996","unstructured":"Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, Wanke E et al. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J Neurosci 1996; 16: 1091\u20131100.","journal-title":"J Neurosci"},{"key":"BFemm2013134_CR18","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.neuron.2008.10.025","volume":"60","author":"E Kokovay","year":"2008","unstructured":"Kokovay E, Shen Q, Temple S . The incredible elastic brain: how neural stem cells expand our minds. Neuron 2008; 60: 420\u2013429.","journal-title":"Neuron"},{"key":"BFemm2013134_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.stem.2008.07.004","volume":"3","author":"Z Mirzadeh","year":"2008","unstructured":"Mirzadeh Z, Merkle FT, Soriano-Navarro M, Garcia-Verdugo JM, Alvarez-Buylla A . Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Cell Stem Cell 2008; 3: 265\u2013278.","journal-title":"Cell Stem Cell"},{"key":"BFemm2013134_CR20","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.stem.2008.07.025","volume":"3","author":"M Tavazoie","year":"2008","unstructured":"Tavazoie M, Van der Veken L, Silva-Vargas V, Louissaint M, Colonna L, Zaidi B et al. A specialized vascular niche for adult neural stem cells. Cell Stem Cell 2008; 3: 279\u2013288.","journal-title":"Cell Stem Cell"},{"key":"BFemm2013134_CR21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.stem.2008.07.026","volume":"3","author":"Q Shen","year":"2008","unstructured":"Shen Q, Wang Y, Kokovay E, Lin G, Chuang SM, Goderie SK et al. Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 2008; 3: 289\u2013300.","journal-title":"Cell Stem Cell"},{"key":"BFemm2013134_CR22","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.lfs.2012.10.010","volume":"91","author":"SK Ahn","year":"2012","unstructured":"Ahn SK, Hong S, Park YM, Choi JY, Lee WT, Park KA et al. Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activity. Life Sci 2012; 91: 1345\u20131350.","journal-title":"Life Sci"},{"key":"BFemm2013134_CR23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/scrt224","volume":"4","author":"T Yuan","year":"2013","unstructured":"Yuan T, Liao W, Feng NH, Lou YL, Niu X, Zhang AJ et al. Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurological function in a rat model of middle cerebral artery occlusion. Stem Cell Res Ther 2013; 4: 73.","journal-title":"Stem Cell Res Ther"},{"key":"BFemm2013134_CR24","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/jcbfm.2010.134","volume":"31","author":"RL Zhang","year":"2011","unstructured":"Zhang RL, Chopp M, Roberts C, Jia L, Wei M, Lu M et al. Ascl1 lineage cells contribute to ischemia-induced neurogenesis and oligodendrogenesis. J Cereb Blood Flow Metab 2011; 31: 614\u2013625.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFemm2013134_CR25","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.stem.2007.09.002","volume":"1","author":"H Suh","year":"2007","unstructured":"Suh H, Consiglio A, Ray J, Sawai T, D'Amour KA, Gage FH . In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell 2007; 1: 515\u2013528.","journal-title":"Cell Stem Cell"},{"key":"BFemm2013134_CR26","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1128\/MCB.24.1.280-293.2004","volume":"24","author":"R Faigle","year":"2004","unstructured":"Faigle R, Brederlau A, Elmi M, Arvidsson Y, Hamazaki TS, Uramoto H et al. ASK1 inhibits astroglial development via p38 mitogen-activated protein kinase and promotes neuronal differentiation in adult hippocampus-derived progenitor cells. Mol Cell Biol 2004; 24: 280\u2013293.","journal-title":"Mol Cell Biol"},{"key":"BFemm2013134_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1247\/csf.28.23","volume":"28","author":"K Takeda","year":"2003","unstructured":"Takeda K, Matsuzawa A, Nishitoh H, Ichijo H . Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct 2003; 28: 23\u201329.","journal-title":"Cell Struct Funct"},{"key":"BFemm2013134_CR28","doi-asserted-by":"publisher","first-page":"e8575","DOI":"10.1371\/journal.pone.0008575","volume":"5","author":"G Santilli","year":"2010","unstructured":"Santilli G, Lamorte G, Carlessi L, Ferrari D, Rota Nodari L, Binda E et al. Mild hypoxia enhances proliferation and multipotency of human neural stem cells. PLoS One 2010; 5: e8575.","journal-title":"PLoS One"}],"container-title":["Experimental & Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/emm2013134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/emm2013134","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/emm2013134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T15:14:16Z","timestamp":1672931656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/emm2013134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,20]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12]]}},"alternative-id":["BFemm2013134"],"URL":"https:\/\/doi.org\/10.1038\/emm.2013.134","relation":{},"ISSN":["2092-6413"],"issn-type":[{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,20]]},"assertion":[{"value":"30 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}