{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:44:15Z","timestamp":1781275455606,"version":"3.54.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"DOI":"10.1038\/emm.2016.161","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T08:01:31Z","timestamp":1488528091000},"page":"e299-e299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Toluene diisocyanate exposure induces airway inflammation of bronchial epithelial cells via the activation of transient receptor potential melastatin 8"],"prefix":"10.1038","volume":"49","author":[{"given":"Joo-Hee","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Sook","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Suck","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-8964","authenticated-orcid":false,"given":"Seung-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Min","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Sim","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"BFemm2016161_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4168\/aair.2011.3.1.21","volume":"3","author":"NS Palikhe","year":"2011","unstructured":"Palikhe NS, Kim JH, Park HS . Biomarkers predicting isocyanate-induced asthma. Allergy Asthma Immunol Res 2011; 3: 21\u201326.","journal-title":"Allergy Asthma Immunol Res"},{"key":"BFemm2016161_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4168\/aair.2015.7.1.51","volume":"7","author":"SC Kwon","year":"2015","unstructured":"Kwon SC, Song J, Kim YK, Calvert GM . Work-related asthma in korea - findings from the Korea Work-Related Asthma Surveillance (KOWAS) program, 2004-2009. Allergy Asthma Immunol Res 2015; 7: 51\u201359.","journal-title":"Allergy Asthma Immunol Res"},{"key":"BFemm2016161_CR3","first-page":"e16","volume":"8","author":"ML Fajt","year":"2016","unstructured":"Fajt ML, Wenzel SE . Development of new therapies for severe asthma. Allergy Asthma Immunol Res 2016; 8: e16.","journal-title":"Allergy Asthma Immunol Res"},{"key":"BFemm2016161_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/ACI.0b013e32835e0322","volume":"13","author":"YS Shin","year":"2013","unstructured":"Shin YS, Kim MA, Pham LD, Park HS . Cells and mediators in diisocyanate-induced occupational asthma. Curr Opin Allergy Clin Immunol 2013; 13: 125\u2013131.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"BFemm2016161_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1745-6673-9-21","volume":"9","author":"M Ruegger","year":"2014","unstructured":"Ruegger M, Droste D, Hofmann M, Jost M, Miedinger D . Diisocyanate-induced asthma in Switzerland: long-term course and patients' self-assessment after a 12-year follow-up. J Occup Med Toxicol 2014; 9: 21.","journal-title":"J Occup Med Toxicol"},{"key":"BFemm2016161_CR6","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1111\/j.1365-2222.2006.02547.x","volume":"36","author":"YM Ye","year":"2006","unstructured":"Ye YM, Kang YM, Kim SH, Kim CW, Kim HR, Hong CS et al. Relationship between neurokinin 2 receptor gene polymorphisms and serum vascular endothelial growth factor levels in patients with toluene diisocyanate-induced asthma. Clin Exp Allergy 2006; 36: 1153\u20131160.","journal-title":"Clin Exp Allergy"},{"key":"BFemm2016161_CR7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1365-2222.2008.03117.x","volume":"39","author":"SH Kim","year":"2009","unstructured":"Kim SH, Cho BY, Park CS, Shin ES, Cho EY, Yang EM et al. Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis. Clin Exp Allergy 2009; 39: 203\u2013212.","journal-title":"Clin Exp Allergy"},{"key":"BFemm2016161_CR8","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1111\/bph.12538","volume":"171","author":"MS Grace","year":"2014","unstructured":"Grace MS, Baxter M, Dubuis E, Birrell MA, Belvisi MG . Transient receptor potential (TRP) channels in the airway: role in airway disease. Br J Pharmacol 2014; 171: 2593\u20132607.","journal-title":"Br J Pharmacol"},{"key":"BFemm2016161_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1177\/1073858414567884","volume":"22","author":"RJ Laing","year":"2016","unstructured":"Laing RJ, Dhaka A . ThermoTRPs and pain. Neuroscientist 2016; 22: 171\u2013187.","journal-title":"Neuroscientist"},{"key":"BFemm2016161_CR10","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1165\/rcmb.2007-0440OC","volume":"39","author":"AS Sabnis","year":"2008","unstructured":"Sabnis AS, Shadid M, Yost GS, Reilly CA . Human lung epithelial cells express a functional cold-sensing TRPM8 variant. Am J Respir Cell Mol Biol 2008; 39: 466\u2013474.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFemm2016161_CR11","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.jaci.2011.04.032","volume":"128","author":"M Li","year":"2011","unstructured":"Li M, Li Q, Yang G, Kolosov VP, Perelman JM, Zhou XD . Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8)-mediated mechanism. J Allergy Clin Immunol 2011; 128: 626\u2013634.","journal-title":"J Allergy Clin Immunol"},{"key":"BFemm2016161_CR12","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nm.2737","volume":"18","author":"BN Lambrecht","year":"2012","unstructured":"Lambrecht BN, Hammad H . The airway epithelium in asthma. Nat Med 2012; 18: 684\u2013692.","journal-title":"Nat Med"},{"key":"BFemm2016161_CR13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.coi.2015.02.001","volume":"34","author":"CM Lloyd","year":"2015","unstructured":"Lloyd CM, Saglani S . Epithelial cytokines and pulmonary allergic inflammation. Curr Opin Immunol 2015; 34: 52\u201358.","journal-title":"Curr Opin Immunol"},{"key":"BFemm2016161_CR14","doi-asserted-by":"publisher","first-page":"246","DOI":"10.4168\/aair.2016.8.3.246","volume":"8","author":"B-G Kim","year":"2016","unstructured":"Kim B-G, Lee P-H, Lee S-H, Kim Y-E, Shin M-Y, Kang Y et al. Long-term effects of diesel exhaust particles on airway inflammation and remodeling in a mouse model. Allergy Asthma Immunol Res 2016; 8: 246\u2013256.","journal-title":"Allergy Asthma Immunol Res"},{"key":"BFemm2016161_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1164\/ajrccm.158.1.9704061","volume":"158","author":"CE Mapp","year":"1998","unstructured":"Mapp CE, Lucchini RE, Miotto D, Chitano P, Jovine L, Saetta M et al. Immunization and challenge with toluene diisocyanate decrease tachykinin and calcitonin gene-related peptide immunoreactivity in guinea pig central airways. Am J Respir Crit Care Med 1998; 158: 263\u2013269.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFemm2016161_CR16","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1165\/rcmb.2008-0292OC","volume":"40","author":"TE Taylor-Clark","year":"2009","unstructured":"Taylor-Clark TE, Kiros F, Carr MJ, McAlexander MA . Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. Am J Respir Cell Mol Biol 2009; 40: 756\u2013762.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFemm2016161_CR17","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1183\/13993003.01778-2015","volume":"48","author":"FC Devos","year":"2016","unstructured":"Devos FC, Boonen B, Alpizar YA, Maes T, Hox V, Seys S et al. Neuro-immune interactions in chemical-induced airway hyperreactivity. Eur Respir J 2016; 48: 380\u2013392.","journal-title":"Eur Respir J"},{"key":"BFemm2016161_CR18","first-page":"L320","volume":"259","author":"S Mattoli","year":"1990","unstructured":"Mattoli S, Miante S, Calabro F, Mezzetti M, Fasoli A, Allegra L . Bronchial epithelial cells exposed to isocyanates potentiate activation and proliferation of T-cells. Am J Physiol 1990; 259: L320\u2013L327.","journal-title":"Am J Physiol"},{"key":"BFemm2016161_CR19","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3346\/jkms.2003.18.6.809","volume":"18","author":"YM Lee","year":"2003","unstructured":"Lee YM, Kim HA, Park HS, Lee SK, Nahm DH . Exposure to toluene diisocyanate (TDI) induces IL-8 production from bronchial epithelial cells: effect of pro-inflammatory cytokines. J Korean Med Sci 2003; 18: 809\u2013812.","journal-title":"J Korean Med Sci"},{"key":"BFemm2016161_CR20","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1183\/09031936.00192109","volume":"37","author":"PL Kuo","year":"2011","unstructured":"Kuo PL, Huang MS, Huang SK, Ni WC, Hung JY, Ko YC et al. Signalling pathway of isophorone diisocyanate-responsive interleukin-8 in airway smooth muscle cells. Eur Respir J 2011; 37: 1226\u20131236.","journal-title":"Eur Respir J"},{"key":"BFemm2016161_CR21","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1021\/tx990045h","volume":"12","author":"RW Lange","year":"1999","unstructured":"Lange RW, Day BW, Lemus R, Tyurin VA, Kagan VE, Karol MH . Intracellular S-glutathionyl adducts in murine lung and human bronchoepithelial cells after exposure to diisocyanatotoluene. Chem Res Toxicol 1999; 12: 931\u2013966.","journal-title":"Chem Res Toxicol"},{"key":"BFemm2016161_CR22","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1007\/s10875-009-9314-8","volume":"29","author":"GY Hur","year":"2009","unstructured":"Hur GY, Kim SH, Park SM, Ye YM, Kim CW, Jang AS et al. Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma. J Clin Immunol 2009; 29: 786\u2013794.","journal-title":"J Clin Immunol"},{"key":"BFemm2016161_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2014.01.001","volume":"725","author":"S Zhu","year":"2014","unstructured":"Zhu S, Wang Y, Pan L, Yang S, Sun Y, Wang X et al. Involvement of transient receptor potential melastatin-8 (TRPM8) in menthol-induced calcium entry, reactive oxygen species production and cell death in rheumatoid arthritis rat synovial fibroblasts. Eur J Pharmacol 2014; 725: 1\u20139.","journal-title":"Eur J Pharmacol"},{"key":"BFemm2016161_CR24","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1164\/rccm.201403-0505OC","volume":"190","author":"D Cheng","year":"2014","unstructured":"Cheng D, Xue Z, Yi L, Shi H, Zhang K, Huo X et al. Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma. Am J Respir Crit Care Med 2014; 190: 639\u2013648.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFemm2016161_CR25","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1136\/thoraxjnl-2012-202003","volume":"68","author":"LG Gregory","year":"2013","unstructured":"Gregory LG, Jones CP, Walker SA, Sawant D, Gowers KH, Campbell GA et al. IL-25 drives remodelling in allergic airways disease induced by house dust mite. Thorax 2013; 68: 82\u201390.","journal-title":"Thorax"},{"key":"BFemm2016161_CR26","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S2213-2600(13)70261-3","volume":"2","author":"H Makrinioti","year":"2014","unstructured":"Makrinioti H, Toussaint M, Jackson DJ, Walton RP, Johnston SL . Role of interleukin 33 in respiratory allergy and asthma. Lancet Respir Med 2014; 2: 226\u2013237.","journal-title":"Lancet Respir Med"}],"container-title":["Experimental & Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/emm2016161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/emm2016161","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/emm2016161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T15:39:36Z","timestamp":1671723576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/emm2016161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,3]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3]]}},"alternative-id":["BFemm2016161"],"URL":"https:\/\/doi.org\/10.1038\/emm.2016.161","relation":{},"ISSN":["2092-6413"],"issn-type":[{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,3]]},"assertion":[{"value":"22 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}