{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:45:53Z","timestamp":1790214353076,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"DOI":"10.1038\/emm.2016.57","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T07:07:03Z","timestamp":1469776023000},"page":"e248-e248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["miR-30c regulates proliferation, apoptosis and differentiation via the Shh signaling pathway in P19 cells"],"prefix":"10.1038","volume":"48","author":[{"given":"Xuehua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangbin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"BFemm201657_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature03049","volume":"432","author":"AM Denli","year":"2004","unstructured":"Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ . Processing of primary microRNAs by the Microprocessor complex. Nature 2004; 432: 231\u2013235.","journal-title":"Nature"},{"key":"BFemm201657_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ceb.2004.04.003","volume":"16","author":"EP Murchison","year":"2004","unstructured":"Murchison EP, Hannon GJ . miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol 2004; 16: 223\u2013229.","journal-title":"Curr Opin Cell Biol"},{"key":"BFemm201657_CR3","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1101\/gad.1158803","volume":"17","author":"R Yi","year":"2003","unstructured":"Yi R, Qin Y, Macara IG, Cullen BR . Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003; 17: 3011\u20133016.","journal-title":"Genes Dev"},{"key":"BFemm201657_CR4","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nsmb729","volume":"11","author":"MA Carmell","year":"2004","unstructured":"Carmell MA, Hannon GJ . RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol 2004; 11: 214\u2013218.","journal-title":"Nat Struct Mol Biol"},{"key":"BFemm201657_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0092-8674(04)00293-4","volume":"117","author":"M Tijsterman","year":"2004","unstructured":"Tijsterman M, Plasterk RH . Dicers at RISC; the mechanism of RNAi. Cell 2004; 117: 1\u20133.","journal-title":"Cell"},{"key":"BFemm201657_CR6","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.2217\/pgs.14.76","volume":"15","author":"C Sardu","year":"2014","unstructured":"Sardu C, Marfella R, Santulli G, Paolisso G . Functional role of miRNA in cardiac resynchronization therapy. Pharmacogenomics 2014; 15: 1159\u20131168.","journal-title":"Pharmacogenomics"},{"key":"BFemm201657_CR7","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/eurjhf\/hft018","volume":"15","author":"BA Dickinson","year":"2013","unstructured":"Dickinson BA, Semus HM, Montgomery RL, Stack C, Latimer PA, Lewton SM et al. Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure. Eur J Heart Fail 2013; 15: 650\u2013659.","journal-title":"Eur J Heart Fail"},{"key":"BFemm201657_CR8","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1161\/CIRCULATIONAHA.110.964684","volume":"122","author":"X Wang","year":"2010","unstructured":"Wang X, Zhang X, Ren XP, Chen J, Liu H, Yang J et al. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia\/reperfusion-induced cardiac injury. Circulation 2010; 122: 1308\u20131318.","journal-title":"Circulation"},{"key":"BFemm201657_CR9","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S0092-8674(01)00404-4","volume":"105","author":"D Wang","year":"2001","unstructured":"Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E et al. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 2001; 105: 851\u2013862.","journal-title":"Cell"},{"key":"BFemm201657_CR10","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1006\/dbio.1996.0212","volume":"178","author":"RP Harvey","year":"1996","unstructured":"Harvey RP . NK-2 homeobox genes and heart development. Dev Biol 1996; 178: 203\u2013216.","journal-title":"Dev Biol"},{"key":"BFemm201657_CR11","doi-asserted-by":"publisher","first-page":"e003905","DOI":"10.1161\/JAHA.112.003905","volume":"1","author":"JA Balderman","year":"2012","unstructured":"Balderman JA, Lee HY, Mahoney CE, Handy DE, White K, Annis S et al. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. J Am Heart Assoc 2012; 1: e003905.","journal-title":"J Am Heart Assoc"},{"key":"BFemm201657_CR12","doi-asserted-by":"publisher","first-page":"e96290","DOI":"10.1371\/journal.pone.0096290","volume":"9","author":"WJ Wijnen","year":"2014","unstructured":"Wijnen WJ, van der Made I, van den Oever S, Hiller M, de Boer BA, Picavet DI et al. Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy. PLoS ONE 2014; 9: e96290.","journal-title":"PLoS ONE"},{"issue":"Pt 2","key":"BFemm201657_CR13","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1042\/bj2760337","volume":"276","author":"K Ohkubo","year":"1991","unstructured":"Ohkubo K, Ogata S, Misumi Y, Takami N, Sinohara H, Ikehara Y . Cloning, structure and expression of cDNA for mouse contrapsin and a related protein. Biochem J 1991; 276 (Pt 2): 337\u2013342.","journal-title":"Biochem J"},{"key":"BFemm201657_CR14","doi-asserted-by":"publisher","first-page":"e38847","DOI":"10.1371\/journal.pone.0038847","volume":"7","author":"M Tanic","year":"2012","unstructured":"Tanic M, Yanowsky K, Rodriguez-Antona C, Andres R, Marquez-Rodas I, Osorio A et al. Deregulated miRNAs in hereditary breast cancer revealed a role for miR-30c in regulating KRAS oncogene. PLoS ONE 2012; 7: e38847.","journal-title":"PLoS ONE"},{"key":"BFemm201657_CR15","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s10549-012-2346-4","volume":"137","author":"J Bockhorn","year":"2013","unstructured":"Bockhorn J, Yee K, Chang YF, Prat A, Huo D, Nwachukwu C et al. MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat 2013; 137: 373\u2013382.","journal-title":"Breast Cancer Res Treat"},{"key":"BFemm201657_CR16","doi-asserted-by":"publisher","first-page":"e48700","DOI":"10.1371\/journal.pone.0048700","volume":"7","author":"XH Li","year":"2012","unstructured":"Li XH, Ha CT, Fu D, Xiao M . Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation. PLoS ONE 2012; 7: e48700.","journal-title":"PLoS ONE"},{"key":"BFemm201657_CR17","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1101\/gad.938601","volume":"15","author":"PW Ingham","year":"2001","unstructured":"Ingham PW, McMahon AP . Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15: 3059\u20133087.","journal-title":"Genes Dev"},{"key":"BFemm201657_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/383407a0","volume":"383","author":"C Chiang","year":"1996","unstructured":"Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 1996; 383: 407\u2013413.","journal-title":"Nature"},{"key":"BFemm201657_CR19","doi-asserted-by":"publisher","first-page":"11376","DOI":"10.1073\/pnas.96.20.11376","volume":"96","author":"T Tsukui","year":"1999","unstructured":"Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S et al. Multiple left-right asymmetry defects in Shh(-\/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci USA 1999; 96: 11376\u201311381.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFemm201657_CR20","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.ydbio.2009.03.028","volume":"330","author":"LA Dyer","year":"2009","unstructured":"Dyer LA, Kirby ML . Sonic hedgehog maintains proliferation in secondary heart field progenitors and is required for normal arterial pole formation. Dev Biol 2009; 330: 305\u2013317.","journal-title":"Dev Biol"},{"key":"BFemm201657_CR21","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/0092-8674(95)90477-8","volume":"82","author":"M Levin","year":"1995","unstructured":"Levin M, Johnson RL, Stern CD, Kuehn M, Tabin C . A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 1995; 82: 803\u2013814.","journal-title":"Cell"},{"key":"BFemm201657_CR22","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1128\/MCB.26.9.3365-3377.2006","volume":"26","author":"Y Pan","year":"2006","unstructured":"Pan Y, Bai CB, Joyner AL, Wang B . Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol 2006; 26: 3365\u20133377.","journal-title":"Mol Cell Biol"},{"key":"BFemm201657_CR23","doi-asserted-by":"publisher","first-page":"21022","DOI":"10.1074\/jbc.M502977200","volume":"280","author":"PJ Gianakopoulos","year":"2005","unstructured":"Gianakopoulos PJ, Skerjanc IS . Hedgehog signaling induces cardiomyogenesis in P19 cells. J Biol Chem 2005; 280: 21022\u201321028.","journal-title":"J Biol Chem"},{"key":"BFemm201657_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S1050-1738(99)00017-1","volume":"9","author":"IS Skerjanc","year":"1999","unstructured":"Skerjanc IS . Cardiac and skeletal muscle development in P19 embryonal carcinoma cells. Trends Cardiovasc Med 1999; 9: 139\u2013143.","journal-title":"Trends Cardiovasc Med"},{"key":"BFemm201657_CR25","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0008-6363(03)00247-5","volume":"58","author":"MA van der Heyden","year":"2003","unstructured":"van der Heyden MA, van Kempen MJ, Tsuji Y, Rook MB, Jongsma HJ, Opthof T . P19 embryonal carcinoma cells: a suitable model system for cardiac electrophysiological differentiation at the molecular and functional level. Cardiovasc Res 2003; 58: 410\u2013422.","journal-title":"Cardiovasc Res"},{"key":"BFemm201657_CR26","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0008-6363(02)00771-X","volume":"58","author":"MA van der Heyden","year":"2003","unstructured":"van der Heyden MA, Defize LH . Twenty one years of P19 cells: what an embryonal carcinoma cell line taught us about cardiomyocyte differentiation. Cardiovasc Res 2003; 58: 292\u2013302.","journal-title":"Cardiovasc Res"},{"key":"BFemm201657_CR27","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1038\/ncomms2393","volume":"4","author":"J Bockhorn","year":"2013","unstructured":"Bockhorn J, Dalton R, Nwachukwu C, Huang S, Prat A, Yee K et al. MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun 2013; 4: 1393.","journal-title":"Nat Commun"},{"key":"BFemm201657_CR28","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.3892\/mmr.2014.3037","volume":"11","author":"X Liu","year":"2015","unstructured":"Liu X, Yang L, Wang H, Xu G, Zhu S, Li M et al. Effects of miR-19b knockdown on the cardiac differentiation of P19 mouse embryonic carcinoma cells. Mol Med Rep 2015; 11: 2504\u20132512.","journal-title":"Mol Med Rep"},{"key":"BFemm201657_CR29","first-page":"341","volume":"16","author":"O Trojnarska","year":"2009","unstructured":"Trojnarska O, Grajek S, Katarzynski S, Kramer L . Predictors of mortality in adult patients with congenital heart disease. Cardiol J 2009; 16: 341\u2013347.","journal-title":"Cardiol J"},{"key":"BFemm201657_CR30","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1136\/heart.83.3.367","volume":"83","author":"L Allan","year":"2000","unstructured":"Allan L . Antenatal diagnosis of heart disease. Heart 2000; 83: 367.","journal-title":"Heart"},{"key":"BFemm201657_CR31","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.3109\/14767058.2012.703716","volume":"25","author":"M Eleftheriades","year":"2012","unstructured":"Eleftheriades M, Tsapakis E, Sotiriadis A, Manolakos E, Hassiakos D, Botsis D . Detection of congenital heart defects throughout pregnancy; impact of first trimester ultrasound screening for cardiac abnormalities. J Matern Fetal Neonatal Med 2012; 25: 2546\u20132550.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"BFemm201657_CR32","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/nature06801","volume":"451","author":"BG Bruneau","year":"2008","unstructured":"Bruneau BG . The developmental genetics of congenital heart disease. Nature 2008; 451: 943\u2013948.","journal-title":"Nature"},{"key":"BFemm201657_CR33","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1126\/science.1132292","volume":"313","author":"EN Olson","year":"2006","unstructured":"Olson EN . Gene regulatory networks in the evolution and development of the heart. Science 2006; 313: 1922\u20131927.","journal-title":"Science"},{"key":"BFemm201657_CR34","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1093\/cvr\/cvn137","volume":"79","author":"T Thum","year":"2008","unstructured":"Thum T, Catalucci D, Bauersachs J . MicroRNAs: novel regulators in cardiac development and disease. Cardiovasc Res 2008; 79: 562\u2013570.","journal-title":"Cardiovasc Res"},{"key":"BFemm201657_CR35","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cca.2013.05.010","volume":"424","author":"S Zhu","year":"2013","unstructured":"Zhu S, Cao L, Zhu J, Kong L, Jin J, Qian L et al. Identification of maternal serum microRNAs as novel non-invasive biomarkers for prenatal detection of fetal congenital heart defects. Clin Chim Acta 2013; 424: 66\u201372.","journal-title":"Clin Chim Acta"},{"key":"BFemm201657_CR36","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.oraloncology.2013.03.430","volume":"49","author":"CC Chang","year":"2013","unstructured":"Chang CC, Yang YJ, Li YJ, Chen ST, Lin BR, Wu TS et al. MicroRNA-17\/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma. Oral Oncol 2013; 49: 923\u2013931.","journal-title":"Oral Oncol"},{"key":"BFemm201657_CR37","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1261\/rna.2414110","volume":"16","author":"MS Ebert","year":"2010","unstructured":"Ebert MS, Sharp PA . MicroRNA sponges: progress and possibilities. RNA 2010; 16: 2043\u20132050.","journal-title":"RNA"},{"key":"BFemm201657_CR38","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nmeth1079","volume":"4","author":"MS Ebert","year":"2007","unstructured":"Ebert MS, Neilson JR, Sharp PA . MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 2007; 4: 721\u2013726.","journal-title":"Nat Methods"},{"key":"BFemm201657_CR39","doi-asserted-by":"publisher","first-page":"e0123519","DOI":"10.1371\/journal.pone.0123519","volume":"10","author":"S Zhu","year":"2015","unstructured":"Zhu S, Hu X, Yu Z, Peng Y, Zhu J, Liu X et al. Effect of miR-20b on apoptosis, differentiation, the BMP signaling pathway and mitochondrial function in the P19 cell model of cardiac differentiation in vitro. PLoS ONE 2015; 10: e0123519.","journal-title":"PLoS ONE"},{"key":"BFemm201657_CR40","doi-asserted-by":"publisher","first-page":"8145","DOI":"10.1073\/pnas.90.17.8145","volume":"90","author":"I Komuro","year":"1993","unstructured":"Komuro I, Izumo S . Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci USA 1993; 90: 8145\u20138149.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFemm201657_CR41","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/BF03402205","volume":"2","author":"D Turbay","year":"1996","unstructured":"Turbay D, Wechsler SB, Blanchard KM, Izumo S . Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx. Mol Med 1996; 2: 86\u201396.","journal-title":"Mol Med"},{"key":"BFemm201657_CR42","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/(SICI)1520-6408(1998)22:3<239::AID-DVG6>3.0.CO;2-7","volume":"22","author":"M Tanaka","year":"1998","unstructured":"Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H et al. Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Dev Genet 1998; 22: 239\u2013249.","journal-title":"Dev Genet"},{"key":"BFemm201657_CR43","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1101\/gad.9.13.1654","volume":"9","author":"I Lyons","year":"1995","unstructured":"Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 1995; 9: 1654\u20131666.","journal-title":"Genes Dev"},{"key":"BFemm201657_CR44","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1136\/jmg.2003.017483","volume":"41","author":"SM Reamon-Buettner","year":"2004","unstructured":"Reamon-Buettner SM, Borlak J . Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease. J Med Genet 2004; 41: 684\u2013690.","journal-title":"J Med Genet"},{"key":"BFemm201657_CR45","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1016\/S0002-9440(10)63770-4","volume":"164","author":"SM Reamon-Buettner","year":"2004","unstructured":"Reamon-Buettner SM, Hecker H, Spanel-Borowski K, Craatz S, Kuenzel E, Borlak J . Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations. Am J Pathol 2004; 164: 2117\u20132125.","journal-title":"Am J Pathol"},{"key":"BFemm201657_CR46","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1136\/jmg.2008.060277","volume":"46","author":"JM Draus Jr","year":"2009","unstructured":"Draus JM Jr, Hauck MA, Goetsch M, Austin EH 3rd, Tomita-Mitchell A, Mitchell ME . Investigation of somatic NKX2-5 mutations in congenital heart disease. J Med Genet 2009; 46: 115\u2013122.","journal-title":"J Med Genet"},{"key":"BFemm201657_CR47","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.ijcard.2003.08.010","volume":"96","author":"P Fiorina","year":"2004","unstructured":"Fiorina P, Corradi D, Pinelli S, Maestri R, Lagrasta C, Buscaglia M et al. Apoptotic\/mytogenic pathways during human heart development. Int J Cardiol 2004; 96: 409\u2013417.","journal-title":"Int J Cardiol"},{"key":"BFemm201657_CR48","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.jacc.2006.09.049","volume":"49","author":"M Levy","year":"2007","unstructured":"Levy M, Maurey C, Celermajer DS, Vouhe PR, Danel C, Bonnet D et al. Impaired apoptosis of pulmonary endothelial cells is associated with intimal proliferation and irreversibility of pulmonary hypertension in congenital heart disease. J Am Coll Cardiol 2007; 49: 803\u2013810.","journal-title":"J Am Coll Cardiol"},{"key":"BFemm201657_CR49","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1203\/01.PDR.0000148710.69159.61","volume":"57","author":"AC Gittenberger-de Groot","year":"2005","unstructured":"Gittenberger-de Groot AC, Bartelings MM, Deruiter MC, Poelmann RE . Basics of cardiac development for the understanding of congenital heart malformations. Pediatr Res 2005; 57: 169\u2013176.","journal-title":"Pediatr Res"},{"key":"BFemm201657_CR50","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/S0002-9297(07)62934-6","volume":"67","author":"EH Villavicencio","year":"2000","unstructured":"Villavicencio EH, Walterhouse DO, Iannaccone PM . The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 2000; 67: 1047\u20131054.","journal-title":"Am J Hum Genet"},{"key":"BFemm201657_CR51","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1034\/j.1399-0004.2001.600515.x","volume":"60","author":"ML Martinez-Frias","year":"2001","unstructured":"Martinez-Frias ML, Bermejo E, Frias JL . The VACTERL association: lessons from the Sonic hedgehog pathway. Clin Genet 2001; 60: 397\u2013398.","journal-title":"Clin Genet"},{"key":"BFemm201657_CR52","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/dev.125.14.2533","volume":"125","author":"Q Ding","year":"1998","unstructured":"Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J et al. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 1998; 125: 2533\u20132543.","journal-title":"Development"},{"key":"BFemm201657_CR53","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1242\/jcs.049676","volume":"122","author":"CA Clement","year":"2009","unstructured":"Clement CA, Kristensen SG, Mollgard K, Pazour GJ, Yoder BK, Larsen LA et al. The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci 2009; 122: 3070\u20133082.","journal-title":"J Cell Sci"}],"container-title":["Experimental &amp; Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/emm201657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/emm201657","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/emm201657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T08:23:11Z","timestamp":1672820591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/emm201657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,29]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7]]}},"alternative-id":["BFemm201657"],"URL":"https:\/\/doi.org\/10.1038\/emm.2016.57","relation":{},"ISSN":["2092-6413"],"issn-type":[{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,29]]},"assertion":[{"value":"18 November 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}