{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:07:33Z","timestamp":1777576053087,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1038\/emm.2017.116","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T10:32:03Z","timestamp":1503052323000},"page":"e368-e368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis"],"prefix":"10.1038","volume":"49","author":[{"given":"Ka Hyon","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duck-Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Hyun","family":"Huh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyuseok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Hyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunkyung","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Hun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Suk","family":"Kook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Tae","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang-Soo","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shee Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je-Hwang","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"BFemm2017116_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis G . Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 2015; 15: 30\u201344.","journal-title":"Nat Rev Immunol"},{"key":"BFemm2017116_CR2","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/IAI.64.7.2371-2380.1996","volume":"64","author":"SP Nair","year":"1996","unstructured":"Nair SP, Meghji S, Wilson M, Reddi K, White P, Henderson B . Bacterially induced bone destruction: mechanisms and misconceptions. Infect Immun 1996; 64: 2371\u20132380.","journal-title":"Infect Immun"},{"key":"BFemm2017116_CR3","doi-asserted-by":"publisher","first-page":"12512","DOI":"10.1074\/jbc.M809789200","volume":"284","author":"J Liu","year":"2009","unstructured":"Liu J, Wang S, Zhang P, Said-Al-Naief N, Michalek SM, Feng X . Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis. J Biol Chem 2009; 284: 12512\u201312523.","journal-title":"J Biol Chem"},{"key":"BFemm2017116_CR4","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.pharmthera.2003.08.003","volume":"100","author":"M Fujihara","year":"2003","unstructured":"Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H, Ikeda H . Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther 2003; 100: 171\u2013194.","journal-title":"Pharmacol Ther"},{"key":"BFemm2017116_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2741\/2692","volume":"13","author":"FO Martinez","year":"2008","unstructured":"Martinez FO, Sica A, Mantovani A, Locati M . Macrophage activation and polarization. Front Biosci J Virtual Libr 2008; 13: 453\u2013461.","journal-title":"Front Biosci J Virtual Libr"},{"key":"BFemm2017116_CR6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1365-2249.2012.04634.x","volume":"171","author":"AJ Naylor","year":"2013","unstructured":"Naylor AJ, Filer A, Buckley CD . The role of stromal cells in the persistence of chronic inflammation. Clin Exp Immunol 2013; 171: 30\u201335.","journal-title":"Clin Exp Immunol"},{"key":"BFemm2017116_CR7","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1017\/erm.2013.8","volume":"15","author":"T Yucel-Lindberg","year":"2013","unstructured":"Yucel-Lindberg T, B\u00e5ge T . Inflammatory mediators in the pathogenesis of periodontitis. Expert Rev Mol Med 2013; 15: e7.","journal-title":"Expert Rev Mol Med"},{"key":"BFemm2017116_CR8","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1902\/jop.2010.100321","volume":"81","author":"BW Chaffee","year":"2010","unstructured":"Chaffee BW, Weston SJ . Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. J Periodontol 2010; 81: 1708\u20131724.","journal-title":"J Periodontol"},{"key":"BFemm2017116_CR9","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1210\/jc.2012-3552","volume":"98","author":"L Nibali","year":"2013","unstructured":"Nibali L, Tatarakis N, Needleman I, Tu Y-K, D\u2019Aiuto F, Rizzo M et al. Clinical review: association between metabolic syndrome and periodontitis: a systematic review and meta-analysis. J Clin Endocrinol Metab 2013; 98: 913\u2013920.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFemm2017116_CR10","first-page":"107","volume":"7","author":"NGM Ch\u00e1varry","year":"2009","unstructured":"Ch\u00e1varry NGM, Vettore MV, Sansone C, Sheiham A . The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis. Oral Health Prev Dent 2009; 7: 107\u2013127.","journal-title":"Oral Health Prev Dent"},{"key":"BFemm2017116_CR11","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1600-0757.2007.00221.x","volume":"45","author":"PM Preshaw","year":"2007","unstructured":"Preshaw PM, Foster N, Taylor JJ . Cross-susceptibility between periodontal disease and type 2 diabetes mellitus: an immunobiological perspective. Periodontol 2000 2007; 45: 138\u2013157.","journal-title":"Periodontol 2000"},{"key":"BFemm2017116_CR12","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/dmrr.1201","volume":"27","author":"Y-H Chang","year":"2011","unstructured":"Chang Y-H, Chang D-M, Lin K-C, Shin S-J, Lee Y-J . Visfatin in overweight\/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review. Diabetes Metab Res Rev 2011; 27: 515\u2013527.","journal-title":"Diabetes Metab Res Rev"},{"key":"BFemm2017116_CR13","doi-asserted-by":"publisher","first-page":"76","DOI":"10.4274\/Jcrpe.547","volume":"4","author":"D Ta\u015fkesen","year":"2012","unstructured":"Ta\u015fkesen D, Kirel B, Us T . Serum visfatin levels, adiposity and glucose metabolism in obese adolescents. J Clin Res Pediatr Endocrinol 2012; 4: 76\u201381.","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"BFemm2017116_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4172\/1948-593X.1000038","volume":"3","author":"LQ Zhang","year":"2011","unstructured":"Zhang LQ, Heruth DP, Ye SQ . Nicotinamide phosphoribosyltransferase in human diseases. J Bioanal Biomed 2011; 3: 13\u201325.","journal-title":"J Bioanal Biomed"},{"key":"BFemm2017116_CR15","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1902\/jop.2011.110230","volume":"83","author":"D Lakkis","year":"2012","unstructured":"Lakkis D, Bissada NF, Saber A, Khaitan L, Palomo L, Narendran S et al. Response to periodontal therapy in patients who had weight loss after bariatric surgery and obese counterparts: a pilot study. J Periodontol 2012; 83: 684\u2013689.","journal-title":"J Periodontol"},{"key":"BFemm2017116_CR16","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1042\/CS20070196","volume":"114","author":"H Tilg","year":"2008","unstructured":"Tilg H, Moschen AR . Role of adiponectin and PBEF\/visfatin as regulators of inflammation: involvement in obesity-associated diseases. Clin Sci (Lond) 2008; 114: 275\u2013288.","journal-title":"Clin Sci (Lond)"},{"key":"BFemm2017116_CR17","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/omi.12070","volume":"29","author":"J Deschner","year":"2014","unstructured":"Deschner J, Eick S, Damanaki A, Nokhbehsaim M . The role of adipokines in periodontal infection and healing. Mol Oral Microbiol 2014; 29: 258\u2013269.","journal-title":"Mol Oral Microbiol"},{"key":"BFemm2017116_CR18","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1902\/jop.2011.100690","volume":"82","author":"AR Pradeep","year":"2011","unstructured":"Pradeep AR, Raghavendra NM, Prasad MVR, Kathariya R, Patel SP, Sharma A . Gingival crevicular fluid and serum visfatin concentration: their relationship in periodontal health and disease. J Periodontol 2011; 82: 1314\u20131319.","journal-title":"J Periodontol"},{"key":"BFemm2017116_CR19","doi-asserted-by":"publisher","first-page":"912821","DOI":"10.1155\/2014\/912821","volume":"2014","author":"A Damanaki","year":"2014","unstructured":"Damanaki A, Nokhbehsaim M, Eick S, G\u00f6tz W, Winter J, Wahl G et al. Regulation of NAMPT in human gingival fibroblasts and biopsies. Mediators Inflamm 2014; 2014: 912821.","journal-title":"Mediators Inflamm"},{"key":"BFemm2017116_CR20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00784-013-0935-1","volume":"18","author":"AVB Nogueira","year":"2014","unstructured":"Nogueira AVB, Nokhbehsaim M, Eick S, Bourauel C, J\u00e4ger A, Jepsen S et al. Regulation of visfatin by microbial and biomechanical signals in PDL cells. Clin Oral Investig 2014; 18: 171\u2013178.","journal-title":"Clin Oral Investig"},{"key":"BFemm2017116_CR21","first-page":"437123","volume":"2013","author":"M Nokhbehsaim","year":"2013","unstructured":"Nokhbehsaim M, Eick S, Nogueira AVB, Hoffmann P, Herms S, Fr\u00f6hlich H et al. Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells. Mediators Inflamm 2013; 2013: 437123.","journal-title":"Mediators Inflamm"},{"key":"BFemm2017116_CR22","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1136\/annrheumdis-2013-204355","volume":"74","author":"S Yang","year":"2015","unstructured":"Yang S, Ryu JH, Oh H, Jeon J, Kwak JS, Kim JH et al. NAMPT (visfatin), a direct target of hypoxia-inducible factor-2\u03b1, is an essential catabolic regulator of osteoarthritis. Ann Rheum Dis 2015; 74: 595\u2013602.","journal-title":"Ann Rheum Dis"},{"key":"BFemm2017116_CR23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.2174\/138161209787185814","volume":"15","author":"S-I Imai","year":"2009","unstructured":"Imai S-I . Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des 2009; 15: 20\u201328.","journal-title":"Curr Pharm Des"},{"key":"BFemm2017116_CR24","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/IAI.67.6.2804-2809.1999","volume":"67","author":"PJ Baker","year":"1999","unstructured":"Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, Roopenian DC . CD4+ T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun 1999; 67: 2804\u20132809.","journal-title":"Infect Immun"},{"key":"BFemm2017116_CR25","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/jre.12063","volume":"48","author":"JS Moon","year":"2013","unstructured":"Moon JS, Cheong NR, Yang SY, Kim IS, Chung HJ, Jeong YW et al. Lipopolysaccharide-induced indoleamine 2,3-dioxygenase expression in the periodontal ligament. J Periodontal Res 2013; 48: 733\u2013739.","journal-title":"J Periodontal Res"},{"key":"BFemm2017116_CR26","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1016\/j.joca.2015.07.009","volume":"23","author":"H Oh","year":"2015","unstructured":"Oh H, Kwak JS, Yang S, Gong MK, Kim JH, Rhee J et al. Reciprocal regulation by hypoxia-inducible factor-2\u03b1 and the NAMPT-NAD(+-SIRT axis in articular chondrocytes is involved in osteoarthritis. Osteoarthritis Cartilage 2015; 23: 2288\u20132296.","journal-title":"Osteoarthritis Cartilage"},{"key":"BFemm2017116_CR27","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.molcel.2005.02.022","volume":"17","author":"JL Avalos","year":"2005","unstructured":"Avalos JL, Bever KM, Wolberger C . Mechanism of sirtuin inhibition by nicotinamide: altering the NAD+ cosubstrate specificity of a Sir2 enzyme. Mol Cell 2005; 17: 855\u2013868.","journal-title":"Mol Cell"},{"key":"BFemm2017116_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1128\/MCB.26.1.28-38.2006","volume":"26","author":"JM Solomon","year":"2006","unstructured":"Solomon JM, Pasupuleti R, Xu L, McDonagh T, Curtis R, DiStefano PS et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 2006; 26: 28\u201338.","journal-title":"Mol Cell Biol"},{"key":"BFemm2017116_CR29","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1146\/annurev-nutr-071811-150746","volume":"32","author":"TB Dahl","year":"2012","unstructured":"Dahl TB, Holm S, Aukrust P, Halvorsen B . Visfatin\/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology. Annu Rev Nutr 2012; 32: 229\u2013243.","journal-title":"Annu Rev Nutr"},{"key":"BFemm2017116_CR30","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1902\/jop.2012.120254","volume":"84","author":"GS Zimmermann","year":"2013","unstructured":"Zimmermann GS, Bastos MF, Dias Gon\u00e7alves TE, Chambrone L, Duarte PM . Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis. J Periodontol 2013; 84: 624\u2013633.","journal-title":"J Periodontol"},{"key":"BFemm2017116_CR31","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1902\/jop.2010.090741","volume":"81","author":"Y Shimada","year":"2010","unstructured":"Shimada Y, Komatsu Y, Ikezawa-Suzuki I, Tai H, Sugita N, Yoshie H . The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. J Periodontol 2010; 81: 1118\u20131123.","journal-title":"J Periodontol"},{"key":"BFemm2017116_CR32","doi-asserted-by":"publisher","first-page":"192","DOI":"10.4103\/0976-237X.114878","volume":"4","author":"SP Patel","year":"2013","unstructured":"Patel SP, Raju PA . Resistin in serum and gingival crevicular fluid as a marker of periodontal inflammation and its correlation with single-nucleotide polymorphism in human resistin gene at -420. Contemp Clin Dent 2013; 4: 192\u2013197.","journal-title":"Contemp Clin Dent"},{"key":"BFemm2017116_CR33","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1600-051X.2007.01078.x","volume":"34","author":"BV Karthikeyan","year":"2007","unstructured":"Karthikeyan BV, Pradeep AR . Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease. J Clin Periodontol 2007; 34: 467\u2013472.","journal-title":"J Clin Periodontol"},{"key":"BFemm2017116_CR34","doi-asserted-by":"publisher","first-page":"e0148024","DOI":"10.1371\/journal.pone.0148024","volume":"11","author":"RC Williams","year":"2016","unstructured":"Williams RC, Skelton AJ, Todryk SM, Rowan AD, Preshaw PM, Taylor JJ . Leptin and pro-inflammatory stimuli synergistically upregulate MMP-1 and MMP-3 secretion in human gingival fibroblasts. PloS ONE 2016; 11: e0148024.","journal-title":"PloS ONE"},{"key":"BFemm2017116_CR35","doi-asserted-by":"publisher","first-page":"615486","DOI":"10.1155\/2015\/615486","volume":"2015","author":"SA Hienz","year":"2015","unstructured":"Hienz SA, Paliwal S, Ivanovski S . Mechanisms of bone resorption in periodontitis. J Immunol Res 2015; 2015: 615486.","journal-title":"J Immunol Res"},{"key":"BFemm2017116_CR36","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/j.1600-0765.2011.01394.x","volume":"46","author":"Y-M Lee","year":"2011","unstructured":"Lee Y-M, Shin S-I, Shin K-S, Lee Y-R, Park B-H, Kim E-C . The role of sirtuin 1 in osteoblastic differentiation in human periodontal ligament cells. J Periodontal Res 2011; 46: 712\u2013721.","journal-title":"J Periodontal Res"},{"key":"BFemm2017116_CR37","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1365-2249.2011.04549.x","volume":"168","author":"S-I Lee","year":"2012","unstructured":"Lee S-I, Park K-H, Kim S-J, Kang Y-G, Lee Y-M, Kim E-C . Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol 2012; 168: 113\u2013124.","journal-title":"Clin Exp Immunol"}],"container-title":["Experimental & Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/emm2017116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/emm2017116","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/emm.2017.116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/emm2017116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:20:54Z","timestamp":1684430454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/emm2017116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["BFemm2017116"],"URL":"https:\/\/doi.org\/10.1038\/emm.2017.116","relation":{},"ISSN":["1226-3613","2092-6413"],"issn-type":[{"value":"1226-3613","type":"print"},{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"16 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}