{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:27:57Z","timestamp":1792250877459,"version":"4.4.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1038\/emm.2017.144","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T14:40:17Z","timestamp":1508856017000},"page":"e381-e381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Upregulation of Fc\u03b3RIIB by resveratrol via NF-\u03baB activation reduces B-cell numbers and ameliorates lupus"],"prefix":"10.1038","volume":"49","author":[{"given":"Jyun-Pei","family":"Jhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Yin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Wan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duen-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiang-Jong","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,29]]},"reference":[{"key":"BFemm2017144_CR1","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1056\/NEJMra1100359","volume":"365","author":"GC Tsokos","year":"2011","unstructured":"Tsokos GC . Systemic lupus erythematosus. N Engl J Med 2011; 365: 2110\u20132121.","journal-title":"N Engl J Med"},{"key":"BFemm2017144_CR2","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s10067-014-2531-4","volume":"33","author":"MF Ugarte-Gil","year":"2014","unstructured":"Ugarte-Gil MF, Alarc\u00f3n GS . Systemic lupus erythematosus: a therapeutic challenge for the XXI century. Clin Rheumatol 2014; 33: 441\u2013450.","journal-title":"Clin Rheumatol"},{"key":"BFemm2017144_CR3","doi-asserted-by":"publisher","first-page":"6838","DOI":"10.1038\/ncomms7838","volume":"6","author":"M Waibel","year":"2015","unstructured":"Waibel M, Christiansen AJ, Hibbs ML, Shortt J, Jones SA, Simpson I et al. Manipulation of B-cell responses with histone deacetylase inhibitors. Nat Commun 2015; 6: 6838\u20136849.","journal-title":"Nat Commun"},{"key":"BFemm2017144_CR4","doi-asserted-by":"publisher","first-page":"4852","DOI":"10.2741\/3044","volume":"13","author":"M Zouali","year":"2008","unstructured":"Zouali M . B lymphocytes\u2014chief players and therapeutic targets in autoimmune diseases. Front Biosci 2008; 13: 4852\u20134861.","journal-title":"Front Biosci"},{"key":"BFemm2017144_CR5","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.bbadis.2015.01.014","volume":"1852","author":"EJ Park","year":"2015","unstructured":"Park EJ, Pezzuto JM . The pharmacology of resveratrol in animals and humans. Biochim Biophys Acta 2015; 1852: 1071\u20131113.","journal-title":"Biochim Biophys Acta"},{"key":"BFemm2017144_CR6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.2174\/1871530315666150316120316","volume":"15","author":"H Inoue","year":"2015","unstructured":"Inoue H, Nakata R . Resveratrol targets in inflammation. Endocr Metab Immune Disord Drug Targets 2015; 15: 186\u2013195.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"BFemm2017144_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5582\/ddt.2015.01007","volume":"9","author":"G Han","year":"2015","unstructured":"Han G, Xia J, Gao J, Inagaki Y, Tang W, Kokudo N . Anti-tumor effects and cellular mechanisms of resveratrol. Drug Discov Ther 2015; 9: 1\u201312.","journal-title":"Drug Discov Ther"},{"key":"BFemm2017144_CR8","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","volume":"23","author":"F Yeung","year":"2004","unstructured":"Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA et al. Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23: 2369\u20132380.","journal-title":"EMBO J"},{"key":"BFemm2017144_CR9","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1016\/j.yexcr.2008.07.011","volume":"314","author":"J Sequeira","year":"2008","unstructured":"Sequeira J, Boily G, Bazinet S, Saliba S, He X, Jardine K et al. Sirt1-null mice develop an autoimmune-like condition. Exp Cell Res 2008; 314: 3069\u20133074.","journal-title":"Exp Cell Res"},{"key":"BFemm2017144_CR10","first-page":"804","volume":"35","author":"N Hu","year":"2008","unstructured":"Hu N, Qiu X, Luo Y, Yuan J, Li Y, Lei W et al. Abnormal histone modification patterns in lupus CD4+ T cells. J Rheumatol 2008; 35: 804\u2013810.","journal-title":"J Rheumatol"},{"key":"BFemm2017144_CR11","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1007\/s11033-014-3294-3","volume":"41","author":"CR Consiglio","year":"2014","unstructured":"Consiglio CR, Juliana da Silveira S, Monticielo OA, Xavier RM, Brenol JC, Chies JA . SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus. Mol Biol Rep 2014; 41: 4233\u20134239.","journal-title":"Mol Biol Rep"},{"key":"BFemm2017144_CR12","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/imr.12368","volume":"269","author":"M Esp\u00e9li","year":"2016","unstructured":"Esp\u00e9li M, Smith KG, Clatworthy MR . Fc\u03b3RIIB and autoimmunity. Immunol Rev 2016; 269: 194\u2013211.","journal-title":"Immunol Rev"},{"key":"BFemm2017144_CR13","first-page":"131","volume":"382","author":"M Daeron","year":"2014","unstructured":"Daeron M . Fc receptors as adaptive immunoreceptors. Curr Top Microbiol Immunol 2014; 382: 131\u2013164.","journal-title":"Curr Top Microbiol Immunol"},{"key":"BFemm2017144_CR14","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.4049\/jimmunol.157.6.2234","volume":"157","author":"GW Chacko","year":"1996","unstructured":"Chacko GW, Tridandapani S, Damen JE, Liu L, Krystal G, Coggeshall K . Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J Immunol 1996; 157: 2234\u20132238.","journal-title":"J Immunol"},{"key":"BFemm2017144_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/383263a0","volume":"383","author":"M Ono","year":"1996","unstructured":"Ono M, Bolland S, Tempst P, Ravetch JV . Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc\u03b3RIIB. Nature 1996; 383: 263\u2013266.","journal-title":"Nature"},{"key":"BFemm2017144_CR16","doi-asserted-by":"publisher","first-page":"35247","DOI":"10.1074\/jbc.M505308200","volume":"280","author":"SJ Tzeng","year":"2005","unstructured":"Tzeng SJ, Bolland S, Inabe K, Kurosaki T, Pierce SK . The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway. J Biol Chem 2005; 280: 35247\u201335254.","journal-title":"J Biol Chem"},{"key":"BFemm2017144_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12929-015-0200-9","volume":"22","author":"SJ Tzeng","year":"2015","unstructured":"Tzeng SJ, Li WY, Wang HY . Fc\u03b3RIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK. J Biomed Sci 2015; 22: 87\u201398.","journal-title":"J Biomed Sci"},{"key":"BFemm2017144_CR18","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S1074-7613(00)00027-3","volume":"13","author":"S Bolland","year":"2000","unstructured":"Bolland S, Ravetch JV . Spontaneous autoimmune disease in Fc\u03b3RIIB-deficient mice results from strain-specific epistasis. Immunity 2000; 13: 277\u2013285.","journal-title":"Immunity"},{"key":"BFemm2017144_CR19","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.4049\/jimmunol.175.3.1440","volume":"175","author":"ZS Rahman","year":"2005","unstructured":"Rahman ZS, Manser T . Failed up-regulation of the inhibitory IgG Fc receptor Fc\u03b3RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc\u03b3RIIB gene. J Immunol 2005; 175: 1440\u20131449.","journal-title":"J Immunol"},{"key":"BFemm2017144_CR20","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.autrev.2010.02.003","volume":"9","author":"JM Kelley","year":"2010","unstructured":"Kelley JM, Edberg JC, Kimberly RP . Pathways: Strategies for susceptibility genes in SLE. Autoimmun Rev 2010; 9: 473\u2013476.","journal-title":"Autoimmun Rev"},{"key":"BFemm2017144_CR21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/intimm\/dxm132","volume":"20","author":"A Isa\u00e1k","year":"2008","unstructured":"Isa\u00e1k A, Gergely P Jr, Szekeres Z, Prechl J, Po\u00f3r G, Erdei A et al. Physiological up-regulation of inhibitory receptors Fc\u03b3RII and CR1 on memory B cells is lacking in SLE patients. Int Immunol 2008; 20: 185\u2013192.","journal-title":"Int Immunol"},{"key":"BFemm2017144_CR22","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1084\/jem.20051503","volume":"203","author":"M Mackay","year":"2006","unstructured":"Mackay M, Stanevsky A, Wang T, Aranow C, Li M, Koenig S et al. Selective dysregulation of the Fc\u03b3IIB receptor on memory B cells in SLE. J Exp Med 2006; 203: 2157\u20132164.","journal-title":"J Exp Med"},{"key":"BFemm2017144_CR23","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.4049\/jimmunol.178.5.3272","volume":"178","author":"K Su","year":"2007","unstructured":"Su K, Yang H, Li X, Li X, Gibson AW, Cafardi JM et al. Expression profile of Fc\u03b3RIIb on leukocytes and its dysregulation in systemic lupus erythematosus. J Immunol 2007; 178: 3272\u20133280.","journal-title":"J Immunol"},{"key":"BFemm2017144_CR24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/ni1151","volume":"6","author":"H Fukuyama","year":"2005","unstructured":"Fukuyama H, Nimmerjahn F, Ravetch JV . The inhibitory Fc\u03b3 receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells. Nat Immunol 2005; 6: 99\u2013106.","journal-title":"Nat Immunol"},{"key":"BFemm2017144_CR25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/ni1440","volume":"8","author":"Z Xiang","year":"2007","unstructured":"Xiang Z, Cutler AJ, Brownlie RJ, Fairfax K, Lawlor KE, Severinson E et al. Fc\u03b3RIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol 2007; 8: 419\u2013429.","journal-title":"Nat Immunol"},{"key":"BFemm2017144_CR26","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1172\/JCI118584","volume":"97","author":"S Takahashi","year":"1996","unstructured":"Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T et al. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 1996; 97: 1597\u20131604.","journal-title":"J Clin Invest"},{"key":"BFemm2017144_CR27","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1096\/fj.14-269043","volume":"9","author":"OL Blanchard","year":"2015","unstructured":"Blanchard OL, Smoliga JM . Translating dosages from animal models to human clinical trials\u2014revisiting body surface area scaling. FASEB J 2015; 9: 1629\u20131634.","journal-title":"FASEB J"},{"key":"BFemm2017144_CR28","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/nri3795","volume":"15","author":"SL Nutt","year":"2015","unstructured":"Nutt SL, Hodgkin PD, Tarlinton DM, Corcoran LM . The generation of antibody-secreting plasma cells. Nat Rev Immunol 2015; 15: 160\u2013171.","journal-title":"Nat Rev Immunol"},{"key":"BFemm2017144_CR29","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/ki.2012.394","volume":"83","author":"H Fan","year":"2013","unstructured":"Fan H, Yang HC, You L, Wang YY, He WJ, Hao CM . The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia\/reperfusion-induced acute kidney injury. Kidney Int 2013; 83: 404\u2013413.","journal-title":"Kidney Int"},{"key":"BFemm2017144_CR30","doi-asserted-by":"publisher","first-page":"e27081","DOI":"10.1371\/journal.pone.0027081","volume":"11","author":"X Zhu","year":"2011","unstructured":"Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X et al. Activation of Sirt1 by resveratrol inhibits TNF-\u03b1 induced inflammation in fibroblasts. PLoS ONE 2011; 11: e27081.","journal-title":"PLoS ONE"},{"key":"BFemm2017144_CR31","doi-asserted-by":"publisher","first-page":"pii: E12","DOI":"10.3390\/cells5010012","volume":"5","author":"F Christian","year":"2016","unstructured":"Christian F, Smith EL, Carmody RJ . The regulation of NF-\u03baB subunits by phosphorylation. Cells 2016; 5: pii: E12.","journal-title":"Cells"},{"key":"BFemm2017144_CR32","doi-asserted-by":"publisher","first-page":"7966","DOI":"10.1128\/MCB.25.18.7966-7975.2005","volume":"25","author":"LF Chen","year":"2005","unstructured":"Chen LF, Williams SA, Mu Y, Nakano H, Duerr JM, Buckbinder L et al. NF-\u03baB RelA phosphorylation regulates RelA acetylation. Mol Cell Biol 2005; 25: 7966\u20137975.","journal-title":"Mol Cell Biol"},{"key":"BFemm2017144_CR33","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1074\/jbc.M209572200","volume":"278","author":"R Kiernan","year":"2003","unstructured":"Kiernan R, Br\u00e8s V, Ng RW, Coudart MP, El Messaoudi S, Sardet C et al. Post-activation turn-off of NF-\u03baB-dependent transcription is regulated by acetylation of p65. J Biol Chem 2003; 278: 2758\u20132766.","journal-title":"J Biol Chem"},{"key":"BFemm2017144_CR34","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.cellsig.2010.03.017","volume":"22","author":"B Huang","year":"2010","unstructured":"Huang B, Yang XD, Lamb A, Chen LF . Posttranslational modifications of NF-\u03baB: another layer of regulation for NF-\u03baB signaling pathway. Cell Signal 2010; 22: 1282\u20131290.","journal-title":"Cell Signal"},{"key":"BFemm2017144_CR35","doi-asserted-by":"publisher","first-page":"49571","DOI":"10.1074\/jbc.C400442200","volume":"279","author":"H Buss","year":"2004","unstructured":"Buss H, D\u00f6rrie A, Schmitz ML, Frank R, Livingstone M, Resch K et al. Phosphorylation of serine 468 by GSK-3\u03b2 negatively regulates basal p65 NF-\u03baB activity. J Biol Chem 2004; 279: 49571\u201349574.","journal-title":"J Biol Chem"},{"key":"BFemm2017144_CR36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/978-1-4939-0928-5_30","volume":"1172","author":"TP Chang","year":"2014","unstructured":"Chang TP, Kim M, Vancurova I . Analysis of TGF\u03b21 and IL-10 transcriptional regulation in CTCL cells by chromatin immunoprecipitation. Methods Mol Biol 2014; 1172: 329\u2013341.","journal-title":"Methods Mol Biol"},{"key":"BFemm2017144_CR37","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1002\/jcb.22308","volume":"108","author":"N Ogasawara","year":"2009","unstructured":"Ogasawara N, Oguro T, Sakabe T, Matsushima M, Takikawa O, Isobe K et al. Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-\u03baB and the generation of reactive oxygen species. J Cell Biochem 2009; 108: 716\u2013725.","journal-title":"J Cell Biochem"},{"key":"BFemm2017144_CR38","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nrneph.2016.20","volume":"12","author":"F Hiepe","year":"2016","unstructured":"Hiepe F, Radbruch A . Plasma cells as an innovative target in autoimmune disease with renal manifestations. Nat Rev Nephrol 2016; 12: 232\u2013240.","journal-title":"Nat Rev Nephrol"},{"key":"BFemm2017144_CR39","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1084\/jem.20040168","volume":"199","author":"BF Hoyer","year":"2004","unstructured":"Hoyer BF, Moser K, Hauser AE, Peddinghaus A, Voigt C, Eilat D et al. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB\/W mice. J Exp Med 2004; 199: 1577\u20131584.","journal-title":"J Exp Med"},{"key":"BFemm2017144_CR40","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jaut.2012.05.010","volume":"39","author":"IM Mumtaz","year":"2012","unstructured":"Mumtaz IM, Hoyer BF, Panne D, Moser K, Winter O, Cheng QY et al. Bone marrow of NZB\/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: implications for the treatment of autoimmunity. J Autoimmun 2012; 39: 180\u2013188.","journal-title":"J Autoimmun"},{"key":"BFemm2017144_CR41","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3389\/fimmu.2013.00494","volume":"4","author":"M Mah\u00e9vas","year":"2013","unstructured":"Mah\u00e9vas M, Michel M, Weill JC, Reynaud CA . Long-lived plasma cells in autoimmunity: lessons from B-cell depleting therapy. Front Immunol 2013; 4: 494\u2013498.","journal-title":"Front Immunol"},{"key":"BFemm2017144_CR42","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/S1074-7613(00)80074-6","volume":"10","author":"RN Pearse","year":"1999","unstructured":"Pearse RN, Kawabe T, Bolland S, Guinamard R, Kurosaki T, Ravetch JV . SHIP recruitment attenuates Fc\u03b3RIIB-induced B cell apoptosis. Immunity 1999; 10: 753\u2013760.","journal-title":"Immunity"},{"key":"BFemm2017144_CR43","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1084\/jem.20100171","volume":"207","author":"T Tiller","year":"2010","unstructured":"Tiller T, Kofer J, Kreschel C, Busse CE, Riebel S, Wickert S et al. Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc\u03b3RIIB-deficient mice. J Exp Med 2010; 207: 2767\u20132778.","journal-title":"J Exp Med"},{"key":"BFemm2017144_CR44","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1084\/jem.20121752","volume":"209","author":"M Esp\u00e9li","year":"2012","unstructured":"Esp\u00e9li M, Clatworthy MR, B\u00f6kers S, Lawlor KE, Cutler AJ, K\u00f6ntgen F et al. Analysis of a wild mouse promoter variant reveals a novel role for Fc\u03b3RIIb in the control of the germinal center and autoimmunity. J Exp Med 2012; 209: 2307\u20132319.","journal-title":"J Exp Med"},{"key":"BFemm2017144_CR45","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.4049\/jimmunol.180.8.5670","volume":"180","author":"TL McGaha","year":"2008","unstructured":"McGaha TL, Karlsson MC, Ravetch JV . Fc\u03b3RIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. J Immunol 2008; 180: 5670\u20135679.","journal-title":"J Immunol"},{"key":"BFemm2017144_CR46","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1084\/jem.20072565","volume":"205","author":"RJ Brownlie","year":"2008","unstructured":"Brownlie RJ, Lawlor KE, Niederer HA, Cutler AJ, Xiang Z, Clatworthy MR et al. Distinct cell-specific control of autoimmunity and infection by Fc\u03b3RIIb. J Exp Med 2008; 205: 883\u2013895.","journal-title":"J Exp Med"},{"key":"BFemm2017144_CR47","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1126\/science.1105160","volume":"307","author":"TL McGaha","year":"2005","unstructured":"McGaha TL, Sorrentino B, Ravetch JV . Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science 2005; 307: 590\u2013593.","journal-title":"Science"},{"key":"BFemm2017144_CR48","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1124\/dmd.104.000885","volume":"32","author":"T Walle","year":"2004","unstructured":"Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK . High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 2004; 32: 1377\u20131382.","journal-title":"Drug Metab Dispos"},{"key":"BFemm2017144_CR49","doi-asserted-by":"publisher","first-page":"e114792","DOI":"10.1371\/journal.pone.0114792","volume":"9","author":"ZL Wang","year":"2014","unstructured":"Wang ZL, Luo XF, Li MT, Xu D, Zhou S, Chen HZ et al. Resveratrol possesses protective effects in a pristane-induced lupus mouse model. PLoS ONE 2014; 9: e114792.","journal-title":"PLoS ONE"},{"key":"BFemm2017144_CR50","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1093\/carcin\/23.8.1327","volume":"23","author":"H Ferry-Dumazet","year":"2002","unstructured":"Ferry-Dumazet H, Garnier O, Mamani-Matsuda M, Vercauteren J, Belloc F, Billiard C et al. Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells. Carcinogenesis 2002; 23: 1327\u20131333.","journal-title":"Carcinogenesis"},{"key":"BFemm2017144_CR51","doi-asserted-by":"publisher","first-page":"e0147034","DOI":"10.1371\/journal.pone.0147034","volume":"11","author":"W Pan","year":"2016","unstructured":"Pan W, Yu H, Huang S, Zhu P . Resveratrol protects against TNF-\u03b1-induced injury in human umbilical endothelial cells through promoting sirtuin-1-induced repression of NF-\u03baB and p38 MAPK. PLoS ONE 2016; 11: e0147034.","journal-title":"PLoS ONE"},{"key":"BFemm2017144_CR52","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1172\/JCI38902","volume":"119","author":"J Zhang","year":"2009","unstructured":"Zhang J, Lee SM, Shannon S, Gao B, Chen W, Chen A et al. The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest 2009; 119: 3048\u20133058.","journal-title":"J Clin Invest"},{"key":"BFemm2017144_CR53","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/nm.3363","volume":"19","author":"K Hasegawa","year":"2013","unstructured":"Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K et al. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing claudin-1 overexpression in podocytes. Nat Med 2013; 19: 1496\u20131504.","journal-title":"Nat Med"},{"key":"BFemm2017144_CR54","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1681\/ASN.V210s190","volume":"2","author":"RJ Johnson","year":"1992","unstructured":"Johnson RJ, Floege J, Yoshimura A, Iida H, Couser WG, Alpers CE . The activated mesangial cell: a glomerular \u2018myofibroblast\u2019? J Am Soc Nephrol 1992; 2: S190\u2013S197.","journal-title":"J Am Soc Nephrol"},{"key":"BFemm2017144_CR55","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.1002\/eji.200737143","volume":"37","author":"AI Tchorbanov","year":"2007","unstructured":"Tchorbanov AI, Voynova EN, Mihaylova NM, Todorov TA, Nikolova M, Yomtova VM et al. Selective silencing of DNA-specific B lymphocytes delays lupus activity in MRL\/lpr mice. Eur J Immunol 2007; 37: 3587\u20133596.","journal-title":"Eur J Immunol"}],"container-title":["Experimental & Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/emm2017144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/emm2017144","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/emm.2017.144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/emm2017144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T13:52:12Z","timestamp":1693144332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/emm2017144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["BFemm2017144"],"URL":"https:\/\/doi.org\/10.1038\/emm.2017.144","relation":{},"ISSN":["1226-3613","2092-6413"],"issn-type":[{"value":"1226-3613","type":"print"},{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"12 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}