{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:08:29Z","timestamp":1773472109188,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/emm.2017.40","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T09:36:13Z","timestamp":1494581773000},"page":"e328-e328","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Bone-forming peptide-2 derived from BMP-7 enhances osteoblast differentiation from multipotent bone marrow stromal cells and bone formation"],"prefix":"10.1038","volume":"49","author":[{"given":"Hyung Keun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Sik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Keun","family":"Seon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Soon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Ho","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taek Rim","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,12]]},"reference":[{"key":"BFemm201740_CR1","doi-asserted-by":"publisher","first-page":"4404","DOI":"10.1016\/j.biomaterials.2013.02.048","volume":"34","author":"H Liu","year":"2013","unstructured":"Liu H, Peng H, Wu Y, Zhang C, Cai Y, Xu G et al. The promotion of bone regeneration by nanofibrous hydroxyapatite\/chitosan scaffolds by effects on integrin-BMP\/Smad signaling pathway in BMSCs. Biomaterials 2013; 34: 4404\u20134417.","journal-title":"Biomaterials"},{"key":"BFemm201740_CR2","doi-asserted-by":"publisher","first-page":"9811","DOI":"10.1016\/j.biomaterials.2014.09.002","volume":"35","author":"HJ Park","year":"2014","unstructured":"Park HJ, Yu SJ, Yang K, Jin Y, Cho AN, Kim J et al. Paper-based bioactive scaffolds for stem cell-mediated bone tissue engineering. Biomaterials 2014; 35: 9811\u20139823.","journal-title":"Biomaterials"},{"key":"BFemm201740_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.maturitas.2013.03.004","volume":"75","author":"F Jakob","year":"2013","unstructured":"Jakob F, Ebert R, Ignatius A, Matsushita T, Watanabe Y, Groll J et al. Bone tissue engineering in osteoporosis. Maturitas 2013; 75: 118\u2013124.","journal-title":"Maturitas"},{"key":"BFemm201740_CR4","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1016\/j.biomaterials.2008.04.031","volume":"29","author":"DH Kempen","year":"2008","unstructured":"Kempen DH, Lu L, Hefferan TE, Creemers LB, Maran A, Classic KL et al. Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering. Biomaterials 2008; 29: 3245\u20133252.","journal-title":"Biomaterials"},{"key":"BFemm201740_CR5","doi-asserted-by":"publisher","first-page":"7057","DOI":"10.1016\/j.biomaterials.2012.06.036","volume":"33","author":"HK Kim","year":"2012","unstructured":"Kim HK, Kim JH, Park DS, Park KS, Kang SS, Lee JS et al. Osteogenesis induced by a bone forming peptide from the prodomain region of BMP-7. Biomaterials 2012; 33: 7057\u20137063.","journal-title":"Biomaterials"},{"key":"BFemm201740_CR6","doi-asserted-by":"publisher","first-page":"e11917","DOI":"10.1371\/journal.pone.0011917","volume":"5","author":"W Zhang","year":"2010","unstructured":"Zhang W, Deng ZL, Chen L, Zuo GW, Luo Q, Shi Q et al. Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. PLoS ONE 2010; 5: e11917.","journal-title":"PLoS ONE"},{"key":"BFemm201740_CR7","doi-asserted-by":"publisher","first-page":"26441","DOI":"10.1074\/jbc.M114.568964","volume":"289","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Xiao M, Sun B, Zhang Z, Shen T, Duan X et al. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem 2014; 289: 26441\u201326450.","journal-title":"J Biol Chem"},{"key":"BFemm201740_CR8","doi-asserted-by":"publisher","first-page":"39039","DOI":"10.1074\/jbc.M110.168351","volume":"285","author":"Y Sun","year":"2010","unstructured":"Sun Y, Fei T, Yang T, Zhang F, Chen YG, Li H et al. The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem 2010; 285: 39039\u201339050.","journal-title":"J Biol Chem"},{"key":"BFemm201740_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.devcel.2010.06.016","volume":"19","author":"Z Zhou","year":"2010","unstructured":"Zhou Z, Xie J, Lee D, Liu Y, Jung J, Zhou L et al. Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev Cell 2010; 19: 90\u2013102.","journal-title":"Dev Cell"},{"key":"BFemm201740_CR10","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1073\/pnas.0237312100","volume":"100","author":"M Paez-Pereda","year":"2003","unstructured":"Paez-Pereda M, Giacomini D, Refojo D, Nagashima AC, Hopfner U, Grubler Y et al. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad\/estrogen receptor crosstalk. Proc Natl Acad Sci USA 2003; 100: 1034\u20131039.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFemm201740_CR11","doi-asserted-by":"publisher","first-page":"S134","DOI":"10.1097\/00003086-200010001-00018","volume":"379","author":"GA Dahir","year":"2000","unstructured":"Dahir GA, Cui Q, Anderson P, Simon C, Joyner C, Triffitt JT et al. Pluripotential mesenchymal cells repopulate bone marrow and retain osteogenic properties. Clin Orthop Relat Res 2000; 379: S134\u2013S145.","journal-title":"Clin Orthop Relat Res"},{"key":"BFemm201740_CR12","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1007\/s00198-005-1995-0","volume":"16","author":"CH Chen","year":"2005","unstructured":"Chen CH, Ho ML, Chang JK, Hung SH, Wang GJ . Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line. Osteoporos Int 2005; 16: 2039\u20132045.","journal-title":"Osteoporos Int"},{"key":"BFemm201740_CR13","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1196\/annals.1402.038","volume":"1117","author":"PD Damoulis","year":"2007","unstructured":"Damoulis PD, Drakos DE, Gagari E, Kaplan DL . Osteogenic differentiation of human mesenchymal bone marrow cells in silk scaffolds is regulated by nitric oxide. Ann NY Acad Sci 2007; 1117: 367\u2013376.","journal-title":"Ann NY Acad Sci"},{"key":"BFemm201740_CR14","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1002\/jbmr.133","volume":"25","author":"L Chen","year":"2010","unstructured":"Chen L, Jiang W, Huang J, He BC, Zuo GW, Zhang W et al. Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. J Bone Miner Res 2010; 25: 2447\u20132459.","journal-title":"J Bone Miner Res"},{"key":"BFemm201740_CR15","doi-asserted-by":"publisher","first-page":"6859","DOI":"10.1016\/j.biomaterials.2014.04.113","volume":"35","author":"X Gao","year":"2014","unstructured":"Gao X, Usas A, Tang Y, Lu A, Tan J, Schneppendahl J et al. A comparison of bone regeneration with human mesenchymal stem cells and muscle-derived stem cells and the critical role of BMP. Biomaterials 2014; 35: 6859\u20136870.","journal-title":"Biomaterials"},{"key":"BFemm201740_CR16","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1177\/0022034513483771","volume":"92","author":"CG Wilson","year":"2013","unstructured":"Wilson CG, Martin-Saavedra FM, Vilaboa N, Franceschi RT . Advanced BMP gene therapies for temporal and spatial control of bone regeneration. J Dent Res 2013; 92: 409\u2013417.","journal-title":"J Dent Res"},{"key":"BFemm201740_CR17","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1016\/j.biomaterials.2009.01.031","volume":"30","author":"DH Kempen","year":"2009","unstructured":"Kempen DH, Lu L, Heijink A, Hefferan TE, Creemers LB, Maran A et al. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials 2009; 30: 2816\u20132825.","journal-title":"Biomaterials"},{"key":"BFemm201740_CR18","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.celrep.2014.01.010","volume":"6","author":"S Stewart","year":"2014","unstructured":"Stewart S, Gomez AW, Armstrong BE, Henner A, Stankunas K . Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration. Cell Rep 2014; 6: 482\u2013498.","journal-title":"Cell Rep"},{"key":"BFemm201740_CR19","first-page":"478","volume":"3","author":"J Masrour Roudsari","year":"2012","unstructured":"Masrour Roudsari J, Mahjoub S . Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and paget's specimens. Caspian J Intern Med 2012; 3: 478\u2013483.","journal-title":"Caspian J Intern Med"}],"container-title":["Experimental &amp; Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/emm201740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/emm201740","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/emm.2017.40","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/emm201740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:21:48Z","timestamp":1684430508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/emm201740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["BFemm201740"],"URL":"https:\/\/doi.org\/10.1038\/emm.2017.40","relation":{},"ISSN":["1226-3613","2092-6413"],"issn-type":[{"value":"1226-3613","type":"print"},{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"28 April 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}