{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:35:53Z","timestamp":1785173753196,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1038\/emm.2017.75","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T07:01:52Z","timestamp":1497596512000},"page":"e345-e345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Coupling killing to neutralization: combined therapy with ceftriaxone\/Pep19-2.5 counteracts sepsis in rabbits"],"prefix":"10.1038","volume":"49","author":[{"given":"Sergio","family":"B\u00e1rcena-Varela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Mart\u00ednez-de-Tejada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-3499","authenticated-orcid":false,"given":"Tobias","family":"Schuerholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Gloria","family":"Gil-Royo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Goldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Droemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmar","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gutsmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Brandenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Heinbockel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"BFemm201775_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016; 315: 801\u2013810.","journal-title":"JAMA"},{"key":"BFemm201775_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ccm.2016.01.002","volume":"37","author":"JA Kempker","year":"2016","unstructured":"Kempker JA, Martin GS . The changing epidemiology and definitions of sepsis. Clin Chest Med 2016; 37: 165\u2013179.","journal-title":"Clin Chest Med"},{"key":"BFemm201775_CR3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1189\/jlb.0806542","volume":"81","author":"D Rittirsch","year":"2007","unstructured":"Rittirsch D, Hoesel LM, Ward PA . The disconnect between animal models of sepsis and human sepsis. J Leukocyte Biol 2007; 81: 137\u2013143.","journal-title":"J Leukocyte Biol"},{"key":"BFemm201775_CR4","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00011-016-0937-y","volume":"65","author":"CL Lakshmikanth","year":"2016","unstructured":"Lakshmikanth CL, Jacob SP, Chaithra VH, de Castro-Faria-Neto HC, Marathe GK . Sepsis: in search of cure. Inflamm Res 2016; 65: 587\u2013602.","journal-title":"Inflamm Res"},{"issue":"Suppl 1","key":"BFemm201775_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/SHK.0b013e318181a343","volume":"30","author":"LF Poli-de-Figueiredo","year":"2008","unstructured":"Poli-de-Figueiredo LF, Garrido AG, Nakagawa N, Sannomiya P . Experimental models of sepsis and their clinical relevance. Shock 2008; 30 (Suppl 1): 53\u201359.","journal-title":"Shock"},{"key":"BFemm201775_CR6","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1093\/infdis\/167.6.1336","volume":"167","author":"ME Evans","year":"1993","unstructured":"Evans ME, Pollack M . Effect of antibiotic class and concentration on the release of lipopolysaccharide from Escherichia coli. J Infect Dis 1993; 167: 1336\u20131343.","journal-title":"J Infect Dis"},{"key":"BFemm201775_CR7","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1128\/IAI.68.4.2301-2308.2000","volume":"68","author":"R Silverstein","year":"2000","unstructured":"Silverstein R, Wood JG, Xue Q, Norimatsu M, Horn DL, Morrison DC . Differential host inflammatory responses to viable versus antibiotic-killed bacteria in experimental microbial sepsis. Infect Immun 2000; 68: 2301\u20132308.","journal-title":"Infect Immun"},{"key":"BFemm201775_CR8","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1086\/420818","volume":"38","author":"RD Arbeit","year":"2004","unstructured":"Arbeit RD, Maki D, Tally FP, Campanaro E, Eisenstein BI, Daptomycin 98-01 and 99-01 Investigators. The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections. Clin Infect Dis 2004; 38: 1673\u20131681.","journal-title":"Clin Infect Dis"},{"key":"BFemm201775_CR9","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.2174\/138945012802002410","volume":"13","author":"G Martinez de Tejada","year":"2012","unstructured":"Martinez de Tejada G, Sanchez-Gomez S, Razquin-Olazaran I, Kowalski I, Kaconis Y, Heinbockel L et al. Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines. Curr Drug Targets 2012; 13: 1121\u20131130.","journal-title":"Curr Drug Targets"},{"key":"BFemm201775_CR10","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1128\/AAC.02066-12","volume":"57","author":"L Heinbockel","year":"2013","unstructured":"Heinbockel L, Sanchez-Gomez S, Martinez de Tejada G, Domming S, Brandenburg J, Kaconis Y et al. Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors. Antimicrob Agents Chemother 2013; 57: 1480\u20131487.","journal-title":"Antimicrob Agents Chemother"},{"key":"BFemm201775_CR11","doi-asserted-by":"publisher","first-page":"R3","DOI":"10.1186\/cc11920","volume":"17","author":"T Schuerholz","year":"2013","unstructured":"Schuerholz T, Doemming S, Hornef M, Martin L, Simon TP, Heinbockel L et al. The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study. Crit Care 2013; 17: R3.","journal-title":"Crit Care"},{"key":"BFemm201775_CR12","first-page":"120","volume":"58","author":"JA Nemzek","year":"2008","unstructured":"Nemzek JA, Hugunin KM, Opp MR . Modeling sepsis in the laboratory: merging sound science with animal well-being. Comp Med 2008; 58: 120\u2013128.","journal-title":"Comp Med"},{"key":"BFemm201775_CR13","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.4049\/jimmunol.167.5.2759","volume":"167","author":"D Le Roy","year":"2001","unstructured":"Le Roy D, Di Padova F, Adachi Y, Glauser MP, Calandra T, Heumann D . Critical role of lipopolysaccharide-binding protein and CD14 in immune responses against gram-negative bacteria. J Immunol 2001; 167: 2759\u20132765.","journal-title":"J Immunol"},{"key":"BFemm201775_CR14","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/S0171-2985(11)80349-9","volume":"187","author":"C Galanos","year":"1993","unstructured":"Galanos C, Freudenberg MA . Mechanisms of endotoxin shock and endotoxin hypersensitivity. Immunobiology 1993; 187: 346\u2013356.","journal-title":"Immunobiology"},{"key":"BFemm201775_CR15","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1056\/NEJM199305203282005","volume":"328","author":"AM Taveira da Silva","year":"1993","unstructured":"Taveira da Silva AM, Kaulbach HC, Chuidian FS, Lambert DR, Suffredini AF, Danner RL . Brief report: shock and multiple-organ dysfunction after self-administration of Salmonella endotoxin. N Engl J Med 1993; 328: 1457\u20131460.","journal-title":"N Engl J Med"},{"key":"BFemm201775_CR16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.4161\/viru.26083","volume":"5","author":"MP Fink","year":"2014","unstructured":"Fink MP . Animal models of sepsis. Virulence 2014; 5: 143\u2013153.","journal-title":"Virulence"},{"key":"BFemm201775_CR17","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1128\/AAC.00534-10","volume":"54","author":"T Gutsmann","year":"2010","unstructured":"Gutsmann T, Razquin-Olazaran I, Kowalski I, Kaconis Y, Howe J, Bartels R et al. New antiseptic peptides to protect against endotoxin-mediated shock. Antimicrob Agents Chemother 2010; 54: 3817\u20133824.","journal-title":"Antimicrob Agents Chemother"},{"key":"BFemm201775_CR18","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","volume":"41","author":"RP Dellinger","year":"2013","unstructured":"Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41: 580\u2013637.","journal-title":"Crit Care Med"},{"key":"BFemm201775_CR19","first-page":"3","volume":"101","author":"DC Morrison","year":"1996","unstructured":"Morrison DC, Bucklin SE . Evidence for antibiotic-mediated endotoxin release as a contributing factor to lethality in experimental gram-negative sepsis. Scand J Infect Dis Suppl 1996; 101: 3\u20138.","journal-title":"Scand J Infect Dis Suppl"},{"key":"BFemm201775_CR20","doi-asserted-by":"publisher","first-page":"14292","DOI":"10.1038\/srep14292","volume":"5","author":"G Martinez de Tejada","year":"2015","unstructured":"Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Barcena-Varela S et al. Lipoproteins\/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides. Sci Rep 2015; 5: 14292.","journal-title":"Sci Rep"},{"key":"BFemm201775_CR21","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1046\/j.1365-2168.2001.01632.x","volume":"88","author":"SJ Parker","year":"2001","unstructured":"Parker SJ, Watkins PE . Experimental models of gram-negative sepsis. Br J Surg 2001; 88: 22\u201330.","journal-title":"Br J Surg"},{"key":"BFemm201775_CR22","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1042\/CS20150591","volume":"130","author":"C Schoergenhofer","year":"2016","unstructured":"Schoergenhofer C, Schwameis M, Hobl EL, Ay C, Key NS, Derhaschnig U et al. Potent irreversible P2Y12 inhibition does not reduce LPS-induced coagulation activation in a randomized, double-blind, placebo-controlled trial. Clin Sci 2016; 130: 433\u2013440.","journal-title":"Clin Sci"},{"key":"BFemm201775_CR23","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1097\/SHK.0000000000000435","volume":"44","author":"J Doorduin","year":"2015","unstructured":"Doorduin J, Leentjens J, Kox M, van Hees HW, van der Hoeven JG, Pickkers P et al. Effects of experimental human endotoxemia on diaphragm function. Shock 2015; 44: 316\u2013322.","journal-title":"Shock"},{"key":"BFemm201775_CR24","doi-asserted-by":"publisher","first-page":"17441","DOI":"10.1038\/srep17441","volume":"5","author":"D Kiers","year":"2015","unstructured":"Kiers D, Gerretsen J, Janssen E, John A, Groeneveld R, van der Hoeven JG et al. Short-term hyperoxia does not exert immunologic effects during experimental murine and human endotoxemia. Sci Rep 2015; 5: 17441.","journal-title":"Sci Rep"},{"key":"BFemm201775_CR25","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1097\/00003246-199711000-00028","volume":"25","author":"C Krishnamurti","year":"1997","unstructured":"Krishnamurti C, Carter AJ, Maglasang P, Hess JR, Cutting MA, Alving BM . Cardiovascular toxicity of human cross-linked hemoglobin in a rabbit endotoxemia model. Crit Care Med 1997; 25: 1874\u20131880.","journal-title":"Crit Care Med"},{"key":"BFemm201775_CR26","first-page":"41","volume":"26","author":"MP Fink","year":"1988","unstructured":"Fink MP, Morrissey PE, Stein KL, Clement RE, Fiallo V, Gardiner WM . Systemic and regional hemodynamic effects of cyclo-oxygenase and thromboxane synthetase inhibition in normal and hyperdynamic endotoxemic rabbits. Circ Shock 1988; 26: 41\u201357.","journal-title":"Circ Shock"},{"key":"BFemm201775_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-4804(80)90037-2","volume":"29","author":"KA Wichtermann","year":"1980","unstructured":"Wichtermann KA, Bane AE, Chandry IA . Sepsis and septic shock - a review of laboratory models and a proposal. J Surg Res 1980; 29: 189\u2013201.","journal-title":"J Surg Res"},{"key":"BFemm201775_CR28","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1056\/NEJMoa1202290","volume":"366","author":"VM Ranieri","year":"2012","unstructured":"Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S et al. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012; 366: 2055\u20132064.","journal-title":"N Engl J Med"},{"key":"BFemm201775_CR29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.annepidem.2015.10.008","volume":"26","author":"SR Jafarzadeh","year":"2016","unstructured":"Jafarzadeh SR, Thomas BS, Marschall J, Fraser VJ, Gill J, Warren DK . Quantifying the improvement in sepsis diagnosis, documentation, and coding: the marginal causal effect of year of hospitalization on sepsis diagnosis. Ann Epidemiol 2016; 26: 66\u201370.","journal-title":"Ann Epidemiol"},{"key":"BFemm201775_CR30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1128\/AAC.40.1.65","volume":"40","author":"Y Lin","year":"1996","unstructured":"Lin Y, Leach WJ, Ammons WS . Synergistic effect of a recombinant N-terminal fragment of bactericidal\/permeability-increasing protein and cefamandole in treatment of rabbit gram-negative sepsis. Antimicrob Agents Chemother 1996; 40: 65\u201369.","journal-title":"Antimicrob Agents Chemother"},{"key":"BFemm201775_CR31","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1086\/514246","volume":"177","author":"AJ Camerota","year":"1998","unstructured":"Camerota AJ, Creasey AA, Patla V, Larkin VA, Fink MP . Delayed treatment with recombinant human tissue factor pathway inhibitor improves survival in rabbits with gram-negative peritonitis. J Infect Dis 1998; 177: 668\u2013676.","journal-title":"J Infect Dis"},{"key":"BFemm201775_CR32","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1097\/00003246-199408000-00003","volume":"22","author":"C Garcia","year":"1994","unstructured":"Garcia C, Saladino R, Thompson C, Hammer B, Parsonnet J, Wainwright N et al. Effect of a recombinant endotoxin-neutralizing protein on endotoxin shock in rabbits. Crit Care Med 1994; 22: 1211\u20131218.","journal-title":"Crit Care Med"},{"key":"BFemm201775_CR33","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1128\/CMR.15.1.95-110.2002","volume":"15","author":"R Nau","year":"2002","unstructured":"Nau R, Eiffert H . Modulation of release of proinflammatory bacterial compounds by antibacterials: potential impact on course of inflammation and outcome in sepsis and meningitis. Clin Microbiol Rev 2002; 15: 95\u2013110.","journal-title":"Clin Microbiol Rev"},{"key":"BFemm201775_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/BF02013454","volume":"5","author":"J Cohen","year":"1986","unstructured":"Cohen J, McConnell JS . Release of endotoxin from bacteria exposed to ciprofloxacin and its prevention with polymyxin B. Eur J Clin Microbiol 1986; 5: 13\u201317.","journal-title":"Eur J Clin Microbiol"},{"key":"BFemm201775_CR35","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1128\/AAC.42.12.3269","volume":"42","author":"T Sawa","year":"1998","unstructured":"Sawa T, Kurahashi K, Ohara M, Gropper MA, Doshi V, Larrick JW et al. Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model. Antimicrob Agents Chemother 1998; 42: 3269\u20133275.","journal-title":"Antimicrob Agents Chemother"},{"key":"BFemm201775_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1093\/jac\/49.1.193","volume":"49","author":"A Giacometti","year":"2002","unstructured":"Giacometti A, Cirioni O, Ghiselli R, Mocchegiani F, Paggi AM, Orlando F et al. Therapeutic efficacy of intraperitoneal polymyxin B and polymyxin-like peptides alone or combined with levofloxacin in rat models of septic shock. J Antimicrob Chemother 2002; 49: 193\u2013196.","journal-title":"J Antimicrob Chemother"},{"key":"BFemm201775_CR37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1006\/jsre.2002.6518","volume":"108","author":"R Ghiselli","year":"2002","unstructured":"Ghiselli R, Giacometti A, Cirioni O, Mocchegiani F, Viticchi C, Scalise G et al. Cationic peptides combined with betalactams reduce mortality from peritonitis in experimental rat model. J Surg Res 2002; 108: 107\u2013111.","journal-title":"J Surg Res"},{"key":"BFemm201775_CR38","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/j.peptides.2003.07.027","volume":"24","author":"A Giacometti","year":"2003","unstructured":"Giacometti A, Cirioni O, Ghiselli R, Mocchegiani F, Viticchi C, Orlando F et al. Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock. Peptides 2003; 24: 1747\u20131752.","journal-title":"Peptides"},{"key":"BFemm201775_CR39","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00383-004-1256-x","volume":"21","author":"K Fukumoto","year":"2005","unstructured":"Fukumoto K, Nagaoka I, Yamataka A, Kobayashi H, Yanai T, Kato Y et al. Effect of antibacterial cathelicidin peptide CAP18\/LL-37 on sepsis in neonatal rats. Pediatr Surg Int 2005; 21: 20\u201324.","journal-title":"Pediatr Surg Int"},{"key":"BFemm201775_CR40","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1093\/intimm\/dxp057","volume":"21","author":"T Murakami","year":"2009","unstructured":"Murakami T, Obata T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I . Antimicrobial cathelicidin polypeptide CAP11 suppresses the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice. Int Immunol 2009; 21: 905\u2013912.","journal-title":"Int Immunol"},{"key":"BFemm201775_CR41","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/IAI.4.5.563-566.1971","volume":"4","author":"JJ Corrigan Jr","year":"1971","unstructured":"Corrigan JJ Jr, Bell BM . Comparison between the polymyxins and gentamicin in preventing endotoxin-induced intravascular coagulation and leukopenia. Infect Immun 1971; 4: 563\u2013566.","journal-title":"Infect Immun"},{"key":"BFemm201775_CR42","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1203\/00006450-197901000-00011","volume":"13","author":"JJ Corrigan Jr.","year":"1979","unstructured":"Corrigan JJ Jr., Kiernat JF . Effect of polymyxin B sulfate on endotoxin activity in a gram-negative septicemia model. Pediatr Res 1979; 13: 48\u201351.","journal-title":"Pediatr Res"},{"key":"BFemm201775_CR43","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/infdis\/156.5.706","volume":"156","author":"PM Flynn","year":"1987","unstructured":"Flynn PM, Shenep JL, Stokes DC, Fairclough D, Hildner WK . Polymyxin B moderates acidosis and hypotension in established, experimental gram-negative septicemia. J Infect Dis 1987; 156: 706\u2013712.","journal-title":"J Infect Dis"},{"key":"BFemm201775_CR44","first-page":"104","volume":"42","author":"R Saladino","year":"1994","unstructured":"Saladino R, Garcia C, Thompson C, Hammer B, Parsonnet J, Novitsky T et al. Efficacy of a recombinant endotoxin neutralizing protein in rabbits with Escherichia coli sepsis. Circ Shock 1994; 42: 104\u2013110.","journal-title":"Circ Shock"},{"key":"BFemm201775_CR45","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1097\/00003246-199607000-00023","volume":"24","author":"RA Saladino","year":"1996","unstructured":"Saladino RA, Stack AM, Thompson C, Sattler F, Novitsky TJ, Siber GR et al. High-dose recombinant endotoxin neutralizing protein improves survival in rabbits, with Escherichia coli sepsis. Crit Care Med 1996; 24: 1203\u20131207.","journal-title":"Crit Care Med"}],"container-title":["Experimental &amp; Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/emm201775.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/emm201775","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/emm.2017.75","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/emm201775.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:21:57Z","timestamp":1684430517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/emm201775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["BFemm201775"],"URL":"https:\/\/doi.org\/10.1038\/emm.2017.75","relation":{},"ISSN":["1226-3613","2092-6413"],"issn-type":[{"value":"1226-3613","type":"print"},{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"29 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}