{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:33:42Z","timestamp":1778708022537,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[1996,1]]},"DOI":"10.1038\/eye.1996.13","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T10:18:52Z","timestamp":1309774732000},"page":"86-91","source":"Crossref","is-referenced-by-count":49,"title":["Iris mammillations: Significance and associations"],"prefix":"10.1038","volume":"10","author":[{"given":"Nicola K","family":"Ragge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Acheson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Linn","family":"Murphree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFeye199613_CR1","first-page":"164","volume":"32","author":"G Coats","year":"1912","unstructured":"Coats G . Unilateral diffuse melanosis of the uvea, with small elevations on the surface of the iris. Trans Ophthalmol Soc UK 1912; 32: 164\u201371.","journal-title":"Trans Ophthalmol Soc UK"},{"key":"BFeye199613_CR2","first-page":"170","volume":"51","author":"B Fleischer","year":"1913","unstructured":"Fleischer B . Zwei F\u00e4lle von einseitiger Melanosis der Skiera, der Iris und des Augenhintergrundes mit warzenf\u00f6rmigen, kleinen Erhebungen an der Iris vorderfl\u00e4che. Klin Monatsbl Augenheilkd 1913; 51: 170\u20134.","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"BFeye199613_CR3","first-page":"1453","volume":"62","author":"PJ Waardenburg","year":"1918","unstructured":"Waardenburg PJ . Heterochromie en melanosis. Ned T Geneesk 1918; 62: 1453\u20135.","journal-title":"Ned T Geneesk"},{"key":"BFeye199613_CR4","first-page":"51","volume":"54","author":"H Friedenwald","year":"1925","unstructured":"Friedenwald H, Friedenwald JS . Melanosis of the lids, conjunctiva, and sciera, with wart-like growths on the iris. Arch Ophthalmol 1925; 54: 51\u20134.","journal-title":"Arch Ophthalmol"},{"key":"BFeye199613_CR5","first-page":"689","volume":"51","author":"J Fran\u00e7ois","year":"1934","unstructured":"Fran\u00e7ois J . La m\u00e9lanose cong\u00e9nitale et b\u00e9nigne de l'oeil Arch d'Ophtalmol 1934; 51: 689\u2013718, 776-92.","journal-title":"Arch d'Ophtalmol"},{"key":"BFeye199613_CR6","unstructured":"Fran\u00e7ois J . Heredity in ophthalmology. St Louis: CV Mosby, 1961: 532\u20134."},{"key":"BFeye199613_CR7","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/bjo.73.4.289","volume":"73","author":"BC Joondeph","year":"1989","unstructured":"Joondeph BC, Goldberg MF . Familial iris melanosis: a misnomer? Br J Ophthalmol 1989; 73: 289\u201393.","journal-title":"Br J Ophthalmol"},{"key":"BFeye199613_CR8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0002-9394(14)74189-3","volume":"103","author":"El Traboulsi","year":"1987","unstructured":"Traboulsi El, Maumenee IH . Bilateral melanosis of the iris. Am J Ophthalmol 1987; 103: 115\u20136.","journal-title":"Am J Ophthalmol"},{"key":"BFeye199613_CR9","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1001\/archderm.1993.01680240080011","volume":"129","author":"AC Gilliam","year":"1993","unstructured":"Gilliam AC, Ragge NK, Perez MI, Bolognia JL . Phakomatosis pigmentovascularis type IIb with iris mammillations. Arch Dermatol 1993; 129: 340\u20132.","journal-title":"Arch Dermatol"},{"key":"BFeye199613_CR10","first-page":"279","volume":"3","author":"JW Hulke","year":"1861","unstructured":"Hulke JW . A series of cases of carcinoma of the eyeball. R Lond Ophthal Hosp Rep 1861; 3: 279\u201386.","journal-title":"R Lond Ophthal Hosp Rep"},{"key":"BFeye199613_CR11","unstructured":"Leibreich R . Ophthalmosk. Atlas. In: Pigmentierter Optikus bei sogenannter Cyanosis bulbi. 1863: plate 12, figure 3."},{"key":"BFeye199613_CR12","unstructured":"Manz. Melanosis oculi. In: Graefe A, Saemisch T. Handbuch der gesammten Augenheilkunde II. Leipzig, 1876: 117\u20139."},{"key":"BFeye199613_CR13","first-page":"197","volume":"14","author":"ET Collins","year":"1894","unstructured":"Collins ET . Case of a patient with congenital excess of pigment in the uveal tract and pigmentation of the sclerotic in one eye, which late in life became the seat of a melanotic sarcoma. Trans Ophthalmol Soc UK 1894; 14: 197\u20139.","journal-title":"Trans Ophthalmol Soc UK"},{"key":"BFeye199613_CR14","first-page":"127","volume":"131","author":"MA Terson","year":"1904","unstructured":"Terson MA . M\u00e9lanochromie cong\u00e9nitale de la scl\u00e9rotique. Ann d'oculist 1904; 131: 127\u20138.","journal-title":"Ann d'oculist"},{"key":"BFeye199613_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01946243","volume":"29","author":"J Hirschberg","year":"1883","unstructured":"Hirschberg J . Ueber die angeborene Pigmentirung der Sciera und ihre pathogenetische Bedeutung. Graefes Arch Ophthalmol 1883; 29: 1\u201312.","journal-title":"Graefes Arch Ophthalmol"},{"key":"BFeye199613_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/eye.1993.20","volume":"7","author":"NK Ragge","year":"1993","unstructured":"Ragge NK, Falk RE, Cohen WE, Murphree AL . Images of Lisch nodules across the spectrum. Eye 1993; 7: 95\u2013101.","journal-title":"Eye"},{"key":"BFeye199613_CR17","first-page":"129","volume":"37","author":"J Bourquin","year":"1917","unstructured":"Bourquin J . Die angeborene Melanose des Auges. Z Augenheilkd 1917; 37: 129\u201374, 294-311.","journal-title":"Z Augenheilkd"},{"key":"BFeye199613_CR18","unstructured":"Mann I . Developmental abnormalities of the eye, 2nd ed. London: William Clowes and Sons, 1957: 290\u20131."},{"key":"BFeye199613_CR19","first-page":"171","volume":"32","author":"ET Collins","year":"1912","unstructured":"Collins ET . Unilateral melanosis of the uvea and sciera, with numerous small elevations on the surface of the iris. Trans Ophthalmol Soc UK 1912; 32: 171\u20133.","journal-title":"Trans Ophthalmol Soc UK"},{"key":"BFeye199613_CR20","first-page":"137","volume":"93","author":"K Lisch","year":"1937","unstructured":"Lisch K . Ueber Beteiligung der Augen, insbesondere das Vorkommen von Iriskn\u00f6tchen bei der Neurofibromatose (Recklinghausen). Z Augenheilkd 1937; 93: 137\u201343.","journal-title":"Z Augenheilkd"},{"key":"BFeye199613_CR21","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0002-9394(75)90523-1","volume":"80","author":"FC Blodi","year":"1975","unstructured":"Blodi FC . Ocular melanocytosis and melanoma. Am J Ophthalmol 1975; 80: 389\u201395.","journal-title":"Am J Ophthalmol"},{"key":"BFeye199613_CR22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/bjo.49.7.359","volume":"49","author":"B Jay","year":"1965","unstructured":"Jay B . Malignant melanoma of the orbit in a case of oculodermal melanosis. Br J Ophthalmol 1965; 49: 359\u201363.","journal-title":"Br J Ophthalmol"},{"key":"BFeye199613_CR23","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1001\/archopht.1967.00980020515014","volume":"77","author":"RL Font","year":"1967","unstructured":"Font RL, Reynolds AM, Zimmerman LE . Diffuse malignant melanoma of the iris in the nevus of Ota. Arch Ophthalmol 1967; 77: 513\u20138.","journal-title":"Arch Ophthalmol"},{"key":"BFeye199613_CR24","first-page":"723","volume":"172","author":"P Kiewe","year":"1935","unstructured":"Kiewe P, Maneff I . M\u00e9lanose bilat\u00e9rale cong\u00e9nitale et familiale de l'oeil et de la face. Contribution au probleme de la consanguinit\u00e9. Ann Oculistique 1935; 172: 723\u20138.","journal-title":"Ann Oculistique"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye199613.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye199613","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye199613.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:35:20Z","timestamp":1684431320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye199613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["BFeye199613"],"URL":"https:\/\/doi.org\/10.1038\/eye.1996.13","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}