{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:40:44Z","timestamp":1759333244163},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[1998,7]]},"DOI":"10.1038\/eye.1998.154","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T09:11:11Z","timestamp":1309770671000},"page":"615-618","source":"Crossref","is-referenced-by-count":18,"title":["The use of combined intravenous pulse methylprednisolone and oral cyclosporin A in the treatment of corneal graft rejection: A preliminary study"],"prefix":"10.1038","volume":"12","author":[{"given":"Dennis S C","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus K K","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clement C Y","family":"Tham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred T S","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFeye1998154_CR1","first-page":"234","volume":"9","author":"GN Kervic","year":"1990","unstructured":"Kervic GN, Shepherd WF . The pattern of corneal graft rejection. Cornea 1990;9:234\u20137.","journal-title":"Cornea"},{"key":"BFeye1998154_CR2","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0039-6257(90)90110-H","volume":"34","author":"SE Wilson","year":"1990","unstructured":"Wilson SE, Kaufman HE . Graft failure after penetrating keratoplasty. Surv Ophthalmol 1990;34:325\u201356.","journal-title":"Surv Ophthalmol"},{"key":"BFeye1998154_CR3","first-page":"180","volume":"8","author":"AA Khodadoust","year":"1969","unstructured":"Khodadoust AA, Silverstein AM . Transplantation and rejection of individual cell layers of the cornea. Invest Ophthalmol 1969;8:180\u201395.","journal-title":"Invest Ophthalmol"},{"key":"BFeye1998154_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/00004397-198802810-00005","volume":"28","author":"G Smolin","year":"1988","unstructured":"Smolin G, Goodman D . Corneal graft reaction. Int Ophthalmol Clin 1988;28:30\u20136.","journal-title":"Int Ophthalmol Clin"},{"key":"BFeye1998154_CR5","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/0002-9394(89)90262-6","volume":"107","author":"HM Boisjoly","year":"1989","unstructured":"Boisjoly HM, Bernard PM, Dube I, Laughrea PA, Bazin R, Bernier J . Effect of factors unrelated to tissue matching on corneal transplant endothelial rejection. Am J Ophthalmol 1989;107:647\u201354.","journal-title":"Am J Ophthalmol"},{"key":"BFeye1998154_CR6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S0161-6420(91)32291-7","volume":"98","author":"JC Hill","year":"1991","unstructured":"Hill JC, Maske R, Watson P . Corticosteroids in corneal graft rejection: oral versus single pulse therapy. Ophthalmology 1991;98:329\u201333.","journal-title":"Ophthalmology"},{"key":"BFeye1998154_CR7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/eye.1991.67","volume":"5","author":"JC Hill","year":"1991","unstructured":"Hill JC, Maske R, Watson PG . The use of a single pulse of intravenous methylprednisolone in the treatment of corneal graft rejection: a preliminary report. Eye 1991;5:420\u20134.","journal-title":"Eye"},{"key":"BFeye1998154_CR8","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/00003226-199409000-00002","volume":"13","author":"JC Hill","year":"1994","unstructured":"Hill JC . Corticosteroid in corneal graft rejection: double versus single pulse therapy. Cornea 1994;13:383\u20138.","journal-title":"Cornea"},{"key":"BFeye1998154_CR9","first-page":"287","volume":"11","author":"ED Silverman","year":"1984","unstructured":"Silverman ED, Myones BL, Miller JJ . Lymphocyte subpopulation alterations induced by intravenous megadose pulse methylprednisolone. J Rheumatol 1984;11:287\u201390.","journal-title":"J Rheumatol"},{"key":"BFeye1998154_CR10","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1007\/BF01973261","volume":"6","author":"JF Borel","year":"1976","unstructured":"Borel JF, Feurer C, Gubler HU . Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions 1976;6:468\u201375.","journal-title":"Agents Actions"},{"key":"BFeye1998154_CR11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/00003226-199007000-00002","volume":"9","author":"MW Belin","year":"1990","unstructured":"Belin MW, Bouchard CS, Phillips TM . Update on topical cyclosporin A: background, immunology, and pharmacology. Cornea 1990;9:184\u201395.","journal-title":"Cornea"},{"key":"BFeye1998154_CR12","first-page":"349","volume":"13","author":"RY Calne","year":"1981","unstructured":"Calne RY, Rolles K, White DJ, et al. Cyclosporin-A in clinical organ grafting. Transplant Proc 1981;13:349\u201358.","journal-title":"Transplant Proc"},{"key":"BFeye1998154_CR13","first-page":"281","volume":"13","author":"TE Starzl","year":"1981","unstructured":"Starzl TE, Iwatsuki S, Klintmalm G, et al. Liver transplantation, 1980, with particular reference to cyclosporin-A. Transplant Proc 1981;13:281\u20135.","journal-title":"Transplant Proc"},{"key":"BFeye1998154_CR14","first-page":"432","volume":"1","author":"R Sundmacher","year":"1992","unstructured":"Sundmacher R, Reinhard T, Heering P . Six years' experience with systemic cyclosporin A prophylaxis in high-risk perforating keratoplasty patients: a retrospective study. Ger J Ophthalmol 1992;1:432\u20136.","journal-title":"Ger J Ophthalmol"},{"key":"BFeye1998154_CR15","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0161-6420(13)31253-6","volume":"101","author":"JC Hill","year":"1994","unstructured":"Hill JC . Systemic cyclosporin in high-risk keratoplasties: short- versus long-term therapy. Ophthalmology 1994;101:128\u201333.","journal-title":"Ophthalmology"},{"key":"BFeye1998154_CR16","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/0002-9394(89)90494-7","volume":"107","author":"JC Hill","year":"1989","unstructured":"Hill JC . The use of cyclosporin in high-risk keratoplasties. Am J Ophthalmol 1989;107:506\u201310.","journal-title":"Am J Ophthalmol"},{"key":"BFeye1998154_CR17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1097\/00007890-198011000-00009","volume":"30","author":"WP Homan","year":"1980","unstructured":"Homan WP, Fabre JW, Millard PR, Morris PJ . Effect of cyclosporin A upon second-set rejection of rat renal allografts. Transplantation 1980;30:354\u20137.","journal-title":"Transplantation"},{"key":"BFeye1998154_CR18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/00007890-198102000-00011","volume":"31","author":"A Gratwohl","year":"1981","unstructured":"Gratwohl A, Forster I, Speck B . Skin grafts in rabbits with cyclosporin A: absence of induction of tolerance and untoward side effects. Transplantation 1981;31:136\u20138.","journal-title":"Transplantation"},{"key":"BFeye1998154_CR19","first-page":"29","volume":"20","author":"AD Hess","year":"1988","unstructured":"Hess AD, Esa AH, Colombani PM . Mechanisms of action of cyclosporin: effect of cells of the immune system on subcellular events in T cell activation. Transplant Proc 1988;20:29\u201340.","journal-title":"Transplant Proc"},{"key":"BFeye1998154_CR20","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/00007890-198308000-00020","volume":"36","author":"R Margreiter","year":"1983","unstructured":"Margreiter R, Huber C, Spielberger M, Konig P . Cyclosporine in the treatment of acute cadaveric kidney graft rejection refractory to high-dose methylprednisolone. Transplantation 1983;36:203\u20134.","journal-title":"Transplantation"},{"key":"BFeye1998154_CR21","first-page":"1202","volume":"16","author":"R Margreiter","year":"1984","unstructured":"Margreiter R, Lang A, Koenig P, et al. Cyclosporine in the treatment of acute allograft rejection refractory to high-dose methylprednisolone: results of a prospectively randomised trial. Transplant Proc 1984;16:1202\u20134.","journal-title":"Transplant Proc"},{"key":"BFeye1998154_CR22","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1164\/ajrccm\/147.4.1010","volume":"147","author":"MW Rolfe","year":"1993","unstructured":"Rolfe MW, Kunkel SL, Demeester SR, et al. Expression of interleukin-6 in association with rat lung reimplantation and allograft rejection. Am Rev Respir Dis 1993;147:1010\u20136.","journal-title":"Am Rev Respir Dis"},{"key":"BFeye1998154_CR23","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/00007890-199103000-00022","volume":"51","author":"HR Ford","year":"1991","unstructured":"Ford HR, Hoffman RA, Tweardy DJ, et al. Evidence that production of interleukin-6 within rejecting allograft coincides with cytotoxic T lymphocyte development. Transplantation 1991;51:656\u201361.","journal-title":"Transplantation"},{"key":"BFeye1998154_CR24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0039-6060(05)80349-6","volume":"118","author":"RJ Keenan","year":"1995","unstructured":"Keenan RJ, Zeevi A, Iacono AT, et al. Efficacy of inhaled cyclosporine in lung transplant recipients with refractory rejection: correlation of intragraft cytokine gene expression with pulmonary function and histologic characteristics. Surgery 1995;118:385\u201391.","journal-title":"Surgery"},{"key":"BFeye1998154_CR25","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/S0161-6420(89)32756-4","volume":"96","author":"MW Belin","year":"1989","unstructured":"Belin MW, Bouchard CS, Frantz S, Chmielinska J . Topical cyclosporine in high-risk corneal transplants [see comments]. Ophthalmology 1989;96:1144\u201350.","journal-title":"Ophthalmology"},{"key":"BFeye1998154_CR26","unstructured":"Goichot-Bonnat EL, Pouliquen YJM . Topical cyclosporin A in high-risk keratoplasty. In: Cavanagh HD, editor. Third international congress on the cornea. New York: Raven Press, 1988:399\u2013101."},{"key":"BFeye1998154_CR27","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/00007691-199702000-00003","volume":"19","author":"SB Charnick","year":"1997","unstructured":"Charnick SB, Nedelman JR, Chang CT, et al. Description of blood pressure changes in patients beginning cyclosporin A therapy. Ther Drug Monit 1997;19:17\u201324.","journal-title":"Ther Drug Monit"},{"key":"BFeye1998154_CR28","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/00003226-199503000-00008","volume":"14","author":"RA Mills","year":"1995","unstructured":"Mills RA, Jones DB, Winkler CR, Wallace GW, Wilhelmus KR . Topical FK-506 prevents experimental corneal allograft rejection. Cornea 1995;14:157\u201360.","journal-title":"Cornea"},{"key":"BFeye1998154_CR29","first-page":"901","volume":"38","author":"N Hikita","year":"1997","unstructured":"Hikita N, Lopez JS, Chan CC, et al. Use of topical FK506 in a corneal graft rejection model in Lewis rats. Invest Ophthalmol Vis Sci 1997;38:901\u20139.","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye1998154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye1998154","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye1998154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:39:42Z","timestamp":1684431582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye1998154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["BFeye1998154"],"URL":"https:\/\/doi.org\/10.1038\/eye.1998.154","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}