{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:48:30Z","timestamp":1775000910536,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1038\/eye.1998.58","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T09:59:24Z","timestamp":1309773564000},"page":"245-251","source":"Crossref","is-referenced-by-count":37,"title":["Abnormalities in haemorheological factors and lipoprotein (a) in retinal vascular occlusion: Implications for increased vascular risk"],"prefix":"10.1038","volume":"12","author":[{"given":"Peck Lin","family":"Lip","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D","family":"Blann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan F","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFeye199858_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0039-6257(93)90011-U","volume":"37","author":"AK Vine","year":"1993","unstructured":"Vine AK, Samama MM . The role of abnormalities in the anticoagulant and fibrinolytic systems in retinal vascular occlusions. Surv Ophthalmol 1993;37:283\u201392.","journal-title":"Surv Ophthalmol"},{"key":"BFeye199858_CR2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1042\/cs0710137","volume":"71","author":"GDO Lowe","year":"1986","unstructured":"Lowe GDO . Blood rheology in arterial disease. Clin Sci 1986;71:137\u201346.","journal-title":"Clin Sci"},{"key":"BFeye199858_CR3","first-page":"693","volume":"8","author":"GYH Lip","year":"1994","unstructured":"Lip GYH, Beevers DG . Abnormalities of rheology and coagulation in hypertension. J Hum Hypertens 1994;8:693\u2013702.","journal-title":"J Hum Hypertens"},{"key":"BFeye199858_CR4","doi-asserted-by":"publisher","first-page":"956","DOI":"10.7326\/0003-4819-118-12-199306150-00008","volume":"118","author":"E Ernst","year":"1993","unstructured":"Ernst E, Resch KL . Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature. Ann Intern Med 1993;118:956\u201363.","journal-title":"Ann Intern Med"},{"key":"BFeye199858_CR5","first-page":"155","volume":"88","author":"GYH Lip","year":"1995","unstructured":"Lip GYH . Fibrinogen and cardiovascular disease. Q J Med 1995;88:155\u201365.","journal-title":"Q J Med"},{"key":"BFeye199858_CR6","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1136\/hrt.74.6.580","volume":"74","author":"GYH Lip","year":"1995","unstructured":"Lip GYH, Blann AD . von Willebrand factor and its relevance to cardiovascular disorders. Br Heart J 1995;74:580\u20133.","journal-title":"Br Heart J"},{"key":"BFeye199858_CR7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1042\/cs0890205","volume":"89","author":"GYH Lip","year":"1995","unstructured":"Lip GYH, Lowe GDO . Fibrin D-dimer: a useful clinical marker of thrombogenesis? Clin Sci 1995;89:205\u201314.","journal-title":"Clin Sci"},{"key":"BFeye199858_CR8","first-page":"529","volume":"88","author":"GYH Lip","year":"1995","unstructured":"Lip GYH, Jones AF . Lipoprotein (a) and vascular disease: thrombogenesis and atherogenesis. Q J Med 1995;88:529\u201339.","journal-title":"Q J Med"},{"key":"BFeye199858_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1046\/j.1365-2796.1996.331661000.x","volume":"239","author":"KK Wu","year":"1996","unstructured":"Wu KK . Platelet activation mechanisms and markers in arterial thrombosis. J Intern Med 1996;239:17.","journal-title":"J Intern Med"},{"key":"BFeye199858_CR10","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1055\/s-0038-1649788","volume":"74","author":"AD Blann","year":"1995","unstructured":"Blann AD, Dobrotova M, Kubisz P, McCollum CN . von Willebrand factor, soluble P-selectin, tissue plasminogen activator inhibitor in atherosclerosis. Thromb Haemostat 1995;74:626\u201330.","journal-title":"Thromb Haemostat"},{"key":"BFeye199858_CR11","first-page":"355","volume":"12","author":"M Seigneur","year":"1993","unstructured":"Seigneur M, Dufourcq P, Conri C, Constans J, Mercie P, Pruvost A, Boisseau M . Plasma thrombomodulin: a new approach of endothelial damage. Int Angio 1993;12:355\u20139.","journal-title":"Int Angio"},{"key":"BFeye199858_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1136\/bjo.71.1.18","volume":"71","author":"MJ Lavin","year":"1987","unstructured":"Lavin MJ, Dhillon BJ . Cyclic variation in onset of CRVO. Br J Ophthalmol 1987;71:18\u201320.","journal-title":"Br J Ophthalmol"},{"key":"BFeye199858_CR13","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0140-6736(94)92689-1","volume":"343","author":"P Woodhouse","year":"1994","unstructured":"Woodhouse P, Khaw KT, Meade TW, Stirling Y, Plummer M . Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet 1994;343:435\u20139.","journal-title":"Lancet"},{"key":"BFeye199858_CR14","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/0002-9394(53)91373-7","volume":"36","author":"BA Klein","year":"1953","unstructured":"Klein BA . Occlusion of the central retinal vein: clinical importance of certain histo-pathologic observations. Am J Ophthalmol 1953;36:316\u201324.","journal-title":"Am J Ophthalmol"},{"key":"BFeye199858_CR15","first-page":"191","volume":"88","author":"IM Rabinowicz","year":"1968","unstructured":"Rabinowicz IM, Litman S, Michaelson IC . Branch venous thrombosis: a pathological report. Trans Ophthalmol Soc UK 1968;88:191\u2013210.","journal-title":"Trans Ophthalmol Soc UK"},{"key":"BFeye199858_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/BF00919244","volume":"18","author":"RL Smit","year":"1994","unstructured":"Smit RL, Baarsma GS, Koudstaal PJ . The source of embolism in amaurosis fugax and retinal artery occlusion. Int Ophthalmol 1994;18:83\u20136.","journal-title":"Int Ophthalmol"},{"key":"BFeye199858_CR17","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0161-6420(92)31940-2","volume":"99","author":"EZ Rath","year":"1992","unstructured":"Rath EZ, Frank RN, Shin DH, Kim C . Risk factors for retina] vein occlusions: a case-control study. Ophthalmology 1992;99:509\u201314.","journal-title":"Ophthalmology"},{"key":"BFeye199858_CR18","first-page":"114","volume":"104","author":"PM Dodson","year":"1985","unstructured":"Dodson PM, Kritzinger EE . Underlying medical conditions in young patients and ethnic differences in retinal vein occlusion. Trans Ophthalmol Soc UK 1985;104:114\u20139.","journal-title":"Trans Ophthalmol Soc UK"},{"key":"BFeye199858_CR19","first-page":"153","volume":"21","author":"AP Appiah","year":"1989","unstructured":"Appiah AP, Trempe CL . Risk factors associated with branch vs central retinal vein occlusion. Ann Ophthalmol 1989;21:153\u20137.","journal-title":"Ann Ophthalmol"},{"key":"BFeye199858_CR20","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/S0002-9394(14)72731-X","volume":"120","author":"CM Greven","year":"1995","unstructured":"Greven CM, Slusher MM, Weaver RG . Retinal arterial occlusions in young adults. Am J Ophthalmol 1995;120:776\u201383.","journal-title":"Am J Ophthalmol"},{"key":"BFeye199858_CR21","first-page":"51","volume":"250","author":"B Snyers","year":"1993","unstructured":"Snyers B, Serckx JP . [Occlusion of the central retinal vein in young adults: risk factors and visual prognosis]. Bull Soc Beige Ophthalmol 1993;250:51\u20138 (in French).","journal-title":"Bull Soc Beige Ophthalmol"},{"key":"BFeye199858_CR22","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S0161-6420(96)30729-X","volume":"103","author":"O Arend","year":"1996","unstructured":"Arend O, Remky A, Jung F, Kiesewetter H, Reim M, Wolf S . Role of rheologic factors in patients with acute central retinal vein occlusion. Ophthalmology 1996;103:80\u20136.","journal-title":"Ophthalmology"},{"key":"BFeye199858_CR23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1159\/000310294","volume":"204","author":"AM Mansour","year":"1992","unstructured":"Mansour AM, Walsh JB, Henkind P . Mortality and morbidity in patients with central retinal vein occlusion. Ophthalmologica 1992;204:199\u2013204.","journal-title":"Ophthalmologica"},{"key":"BFeye199858_CR24","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1136\/bmj.302.6775.499","volume":"302","author":"GJ Hankey","year":"1991","unstructured":"Hankey GJ, Slattery JM, Warlow CP . Prognosis and prognostic factors of retinal infarction: a prospective cohort study. BMJ 1991;302:499\u2013504.","journal-title":"BMJ"},{"key":"BFeye199858_CR25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-0038-1648808","volume":"72","author":"F Bandello","year":"1994","unstructured":"Bandello F, Vigano D'Angelo S, Parlavecchia M, et al. Hypercoagulability and high lipoprotein (a) levels in patients with central retinal vein occlusion. Thromb Haemost 1994;72:39\u201343.","journal-title":"Thromb Haemost"},{"key":"BFeye199858_CR26","first-page":"27","volume":"108","author":"IV Pimenov","year":"1992","unstructured":"Pimenov IV, Zaitseva NS, Volkolakova RL [Hemostasis in patients with diseases of the retina and uveal tract]. Vestnik Oftalmologii 1992;108:27\u201330 (in Russian).","journal-title":"Vestnik Oftalmologii"},{"key":"BFeye199858_CR27","first-page":"303","volume":"22","author":"S Piermarocchi","year":"1990","unstructured":"Piermarocchi S, Segato T, Bertoja H, et al. Branch retinal vein occlusion: the pathogenic role of blood viscosity. Ann Ophthalmol 1990;22:303\u201311.","journal-title":"Ann Ophthalmol"},{"key":"BFeye199858_CR28","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/S0161-6420(13)31146-4","volume":"101","author":"A Glacet-Bernard","year":"1994","unstructured":"Glacet-Bernard A, Chabanel A, Lelong F, Samama MM, Coscas G . Elevated erythrocyte aggregation in patients with central retinal vein occlusion and without conventional risk factors. Ophthalmology 1994;101:1483\u20137.","journal-title":"Ophthalmology"},{"key":"BFeye199858_CR29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1136\/bjo.80.3.203","volume":"80","author":"TH Williamson","year":"1996","unstructured":"Williamson TH, Rumley A, Lowe GDO . Blood viscosity, coagulation and activated protein C resistance in central retinal vein occlusion: a population controlled study. Br J Ophthalmol 1996;80:203\u20138.","journal-title":"Br J Ophthalmol"},{"key":"BFeye199858_CR30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1136\/bjo.76.3.142","volume":"76","author":"J Wiek","year":"1992","unstructured":"Wiek J, Krause M, Schade M, Wiederholt M, Hansen LL . Haemorheological parameters in patients with retinal artery occlusion and anterior ischaemic optic neuropathy. Br J Ophthalmol 1992;76:142\u20135.","journal-title":"Br J Ophthalmol"},{"key":"BFeye199858_CR31","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1136\/bjo.74.11.665","volume":"74","author":"J Wiek","year":"1990","unstructured":"Wiek J, Schade M, Wiederholt M, Arntz HR, Hansen LL . Haemorheological changes in patients with retinal vein occlusion after isovolaemic haemodilution. Br J Ophthalmol 1990;74:665\u20139.","journal-title":"Br J Ophthalmol"},{"key":"BFeye199858_CR32","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/0140-6736(93)91288-W","volume":"342","author":"FGR Fowkes","year":"1993","unstructured":"Fowkes FGR, Lowe GDO, Housley E, Rattray A, Rumley A, Elton RA, MacGregor IR, Dawes J . Cross-linked fibrin degradation products, progression of peripheral arterial disease, and risk of coronary heart disease. Lancet 1993;342:84\u20136.","journal-title":"Lancet"},{"key":"BFeye199858_CR33","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1161\/01.CIR.90.5.2236","volume":"90","author":"PM Ridker","year":"1994","unstructured":"Ridker PM, Hennekens CH, Cerskus A, Stampfer MJ . Plasma concentrations of cross-linked fibrin degradation product (D-dimer) and the risk of future myocardial infarction among apparently healthy men. Circulation 1994;90:2236\u201340.","journal-title":"Circulation"},{"key":"BFeye199858_CR34","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/00001721-199504000-00030","volume":"6","author":"GDO Lowe","year":"1995","unstructured":"Lowe GDO, Rumley A, Yarnell JWG, Sweetnam PM, Thomas HF . Fibrin D-dimer, von Willebrand factor and tissue plasminogen activator antigens are predictors of major ischaemic heart disease: the Caerphilly study. Blood Coag Fibrinolys 1995;6:156\u20137.","journal-title":"Blood Coag Fibrinolys"},{"key":"BFeye199858_CR35","first-page":"338","volume":"1","author":"HM Muller","year":"1992","unstructured":"Muller HM, Diekstall FF, Schmidt E, Marz W, Canzler H, Demeler U . Lipoprotein (a): a risk factor for retinal vascular occlusion. Ger J Ophthalmol 1992;1:338\u201341.","journal-title":"Ger J Ophthalmol"},{"key":"BFeye199858_CR36","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0049-3848(95)00183-R","volume":"80","author":"A Tavola","year":"1995","unstructured":"Tavola A, D'Angelo SV, Bandello F, et al. Central retinal vein and branch artery occlusion associated with inherited plasminogen deficiency and high lipoprotein (a) levels: a case report. Thromb Res 1995;80:327\u201331.","journal-title":"Thromb Res"},{"key":"BFeye199858_CR37","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1001\/archopht.1994.01090180088041","volume":"112","author":"A Glacet-Bernard","year":"1994","unstructured":"Glacet-Bernard A, Bayani N, Chretien P, Cochard C, Lelong F, Coscas G . Antiphospholipid antibodies in retinal vascular occlusion: a prospective study of 75 patients. Arch Ophthalmol 1994;112:790\u20135.","journal-title":"Arch Ophthalmol"},{"key":"BFeye199858_CR38","doi-asserted-by":"crossref","unstructured":"Wenzler EM, Rademakers AJ, Boers GH, Cruysberg JR, Webers CA, Deutman AF . Hyperhomocysteinemia in retinal artery and retinal vein occlusion. Am J Ophthalmol 1993:162\u20137.","DOI":"10.1016\/S0002-9394(14)73919-4"},{"key":"BFeye199858_CR39","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3109\/09273949309057058","volume":"1","author":"PI Murray","year":"1993","unstructured":"Murray PI, Young DW, Aggarwal RK, Blann AD . Von Willebrand factor, endothelial damage and ocular disease. Ocular Immunol Inflamm 1993;1:315\u201322.","journal-title":"Ocular Immunol Inflamm"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye199858.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye199858","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye199858.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:41:22Z","timestamp":1684431682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye199858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["BFeye199858"],"URL":"https:\/\/doi.org\/10.1038\/eye.1998.58","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}