{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:22:54Z","timestamp":1767925374475,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1038\/eye.2000.192","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T09:02:51Z","timestamp":1310029371000},"page":"724-729","source":"Crossref","is-referenced-by-count":30,"title":["High-altitude retinopathy and retinal vascular dysregulation"],"prefix":"10.1038","volume":"14","author":[{"given":"Andrea","family":"M\u00fcllner-Eidenb\u00f6ck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Rainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Strenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Zidek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFeye2000192_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1056\/NEJM196901232800402","volume":"280","author":"I Singh","year":"1969","unstructured":"Singh I, Khanna PK, Shrivastava MC, Lal M, Roy SB, Subramanyam SV . Acute mountain sickness. N Engl J Med 1969;280:175\u201384.","journal-title":"N Engl J Med"},{"key":"BFeye2000192_CR2","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1056\/NEJM197005212822106","volume":"282","author":"R Frayser","year":"1970","unstructured":"Frayser R, Houston C, Bryan AC, Rennie ID . Retinal hemorrhage at high altitude. N Engl J Med 1970;282:1183\u20134.","journal-title":"N Engl J Med"},{"key":"BFeye2000192_CR3","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1001\/archinte.1971.00310160186014","volume":"127","author":"R Frayser","year":"1971","unstructured":"Frayser R, Houston C, Gray GW, Bryan AC, Rennie ID . The response of the retinal circulation to altitude. Arch Intern Med 1971;127:708\u201311.","journal-title":"Arch Intern Med"},{"key":"BFeye2000192_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1152\/jappl.1971.31.3.357","volume":"31","author":"JL Kobrick","year":"1971","unstructured":"Kobrick JL, Appleton B . Effects of extended hypoxia on visual performance and retinal vascular state. J Appl Physiol 1971;31:357\u201362.","journal-title":"J Appl Physiol"},{"key":"BFeye2000192_CR5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1001\/archopht.1975.01010020418003","volume":"93","author":"WT Shults","year":"1975","unstructured":"Shults WT, Swan KC . High altitude retinopathy in mountain climbers. Arch Ophthalmol 1975;93:401\u20133.","journal-title":"Arch Ophthalmol"},{"key":"BFeye2000192_CR6","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1001\/archopht.1975.01010020409001","volume":"93","author":"M Wiedmann","year":"1975","unstructured":"Wiedmann M . High altitude retinal hemorrhage. Arch Ophthalmol 1975;93:395\u2013400.","journal-title":"Arch Ophthalmol"},{"key":"BFeye2000192_CR7","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1001\/archopht.1975.01010020409001","volume":"93","author":"D Rennie","year":"1975","unstructured":"Rennie D, Morrissey J . Retinal changes in Himalayan climbers. Arch Ophthalmol 1975;93:395\u2013400.","journal-title":"Arch Ophthalmol"},{"key":"BFeye2000192_CR8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1080\/00039896.1975.10666684","volume":"30","author":"GA Schuhmacher","year":"1975","unstructured":"Schuhmacher GA, Petajan JH . High altitude stress and retinal hemorrhage. Arch Environ Health 1975;30:217\u201321.","journal-title":"Arch Environ Health"},{"key":"BFeye2000192_CR9","first-page":"496","volume":"II","author":"C Clarke","year":"1976","unstructured":"Clarke C, Duff J . Mountain sickness, retinal hemorrhages and acclimatisation on Mount Everest in 1975. BMJ 1976;II:496\u20137.","journal-title":"BMJ"},{"key":"BFeye2000192_CR10","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/0002-9343(79)90393-0","volume":"67","author":"PH Hackett","year":"1979","unstructured":"Hackett PH, Rennie D . Rales, peripheral edema, retinal hemorrhage and acute mountain sickness. Am J Med 1979;67:214\u20138.","journal-title":"Am J Med"},{"key":"BFeye2000192_CR11","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1055\/s-2007-1024999","volume":"9","author":"C Clarke","year":"1988","unstructured":"Clarke C . High altitude cerebral edema. Int J Sports Med 1988;9:170\u20134.","journal-title":"Int J Sports Med"},{"key":"BFeye2000192_CR12","first-page":"970","volume":"60","author":"O Brinchmann-Hansen","year":"1989","unstructured":"Brinchmann-Hansen O, Myhre K . Blood pressure, intraocular pressure and retinal vessels after high altitude mountain exposure. Aviat Space Med Environ 1989;60:970\u20136.","journal-title":"Aviat Space Med Environ"},{"key":"BFeye2000192_CR13","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/S0161-6420(92)31891-3","volume":"99","author":"FK Butler","year":"1992","unstructured":"Butler FK, Harris DJ, Reynolds RD . Altitude retinopathy on Mount Everest 1989. Ophthalmology 1992;99:739\u201346.","journal-title":"Ophthalmology"},{"key":"BFeye2000192_CR14","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/S0733-8619(18)30193-2","volume":"4","author":"JR Sutton","year":"1992","unstructured":"Sutton JR . Mountain sickness. Neurol Clin 1992;4:1015\u201330.","journal-title":"Neurol Clin"},{"key":"BFeye2000192_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/jramc-141-01-05","volume":"141","author":"R McLaren","year":"1995","unstructured":"McLaren R . Retinal haemorrhage in Himalayan Mountaineers. JR Army Med Corps 1995;141:25\u201328.","journal-title":"JR Army Med Corps"},{"key":"BFeye2000192_CR16","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1136\/bmj.311.7008.812c","volume":"311","author":"R McLaren","year":"1995","unstructured":"McLaren R . Asymptomatic retinal haemorrhage is common at altitude. BMJ 1995;311:812\u20133.","journal-title":"BMJ"},{"key":"BFeye2000192_CR17","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S0002-9394(14)70149-7","volume":"123","author":"G Lang","year":"1997","unstructured":"Lang G, Kuba G . High altitude retinopathy. Am J Ophthalmol 1997;123:418\u201320.","journal-title":"Am J Ophthalmol"},{"key":"BFeye2000192_CR18","first-page":"125","volume":"7","author":"F Berghold","year":"1994","unstructured":"Berghold F, Schobersberger W . \u00c0tiologie, Klinik und Therapie der Hohenkrankheit. WMW 1994;7:125\u20139.","journal-title":"WMW"},{"key":"BFeye2000192_CR19","first-page":"243","volume":"11","author":"F Berghold","year":"1991","unstructured":"Berghold F, Schaffert W, Pallasmann K . Voraussetzungen und Richtlinien fur die Akklimatisation an grosse und extreme Hohen zur Vorbeugung der Hohenkrankheit. WMW 1991;11:243\u20138.","journal-title":"WMW"},{"key":"BFeye2000192_CR20","first-page":"307","volume":"122","author":"P Bartsch","year":"1992","unstructured":"Bartsch P . Wer wird bergkrank? Schweiz Med Wochenschr 1992;122:307\u201314.","journal-title":"Schweiz Med Wochenschr"},{"key":"BFeye2000192_CR21","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1055\/s-2008-1035365","volume":"207","author":"G Michelson","year":"1995","unstructured":"Michelson G, Groh M, Langhans M, Schmauss B . Zweidimensionale Kartierung der retinalen und papillaren Mikrozirkulation mittels Scanning-Laser-Doppler-Flowmetrie. Klin Monatsbl Augenheilkd 1995;207:180\u201390.","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"BFeye2000192_CR22","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1136\/bjo.81.5.360","volume":"81","author":"K Strenn","year":"1997","unstructured":"Strenn K, Menapace R, Rainer G, Findl O, Woltz M, Schmetterer L . Reproducibility and sensitivity of scanning laser Doppler-flowmetry during graded changes in pO2 . Br J Ophthalmol 1997;81:360\u20134.","journal-title":"Br J Ophthalmol"},{"key":"BFeye2000192_CR23","first-page":"99","volume":"5","author":"G Michelson","year":"1996","unstructured":"Michelson G, Schmauss B, Langhans MJ, Harazny J, Groh MJM . Principle, validity, and reliability of scanning laser Doppler flowmetry. J Glaucoma 1996;5:99\u2013105.","journal-title":"J Glaucoma"},{"key":"BFeye2000192_CR24","unstructured":"Bonner R, Nossal R . Principles of laser-Doppler flowmetry in laser-Doppler blood flowmetry. In: Shepard AP, Oberg AP, editors. Developments in cardiovascular medicine. Boston: Kluwer Academic, 1990:17\u201345."},{"key":"BFeye2000192_CR25","first-page":"342","volume":"4","author":"G Michelson","year":"1995","unstructured":"Michelson G, Langhans MJ, Groh M . Clinical investigation of the combination of a scanning laser ophthalmoscope and laser Doppler flowmeter. Ger J Ophthalmol 1995;4:342\u20139.","journal-title":"Ger J Ophthalmol"},{"key":"BFeye2000192_CR26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1055\/s-2008-1046010","volume":"198","author":"L Schipper","year":"1991","unstructured":"Schipper L . Valsalvamanover: nicht irnmer gutartig. Klin Monatsbl Augenheilkd 1991;198:457\u20139.","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"BFeye2000192_CR27","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/0002-9394(73)90815-5","volume":"11","author":"TH Duane","year":"1973","unstructured":"Duane TH . Valsalva hemorrhagic retinopathy. Am J Ophthalmol 1973;11:637\u201342.","journal-title":"Am J Ophthalmol"},{"key":"BFeye2000192_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0039-6257(94)90157-0","volume":"39","author":"I Haeflinger","year":"1994","unstructured":"Haeflinger I, Meyer P, Flammer J, Luscher T . The vascular endothelium as a regulator of the ocular circulation: A new concept in ophthalmology? Surv Ophthalmol 1994;39:123\u201332.","journal-title":"Surv Ophthalmol"},{"key":"BFeye2000192_CR29","unstructured":"Kaiser HJ, Flammer J, Hendrickson PH . Ocular blood flow: new insights into the pathogenesis of ocular diseases. Glaucoma meeting. Basel: Karger-Verlag, 1995."},{"key":"BFeye2000192_CR30","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/0014-4835(92)90123-A","volume":"55","author":"CE Riva","year":"1992","unstructured":"Riva CE, Harino S, Petrig BL, Shonat RD . Laser Doppler flowmetry in the optic nerve. Exp Eye Res 1992;55:499\u2013506.","journal-title":"Exp Eye Res"},{"key":"BFeye2000192_CR31","first-page":"265","volume":"37","author":"P Lundmark","year":"1996","unstructured":"Lundmark P, Rawij M, Flanagan J, Trope G . Variability of blood flow measurements using the Heidelberger Doppler Flowmeter. Invest Ophthalmol Vis Sci 1996;37(Suppl):265.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2000192_CR32","first-page":"462","volume":"37","author":"A Lietz","year":"1996","unstructured":"Lietz A, Hendrickson PH, Flammer J, Haeflieger IO . Ocular blood flow modulation and HRF parameters at the papilla. Invest Ophthalmol Vis Sci 1996;37:462.","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye2000192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2000192","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2000192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:58:33Z","timestamp":1684429113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye2000192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["BFeye2000192"],"URL":"https:\/\/doi.org\/10.1038\/eye.2000.192","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}