{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:11:29Z","timestamp":1775675489543,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1038\/eye.2000.81","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T09:19:15Z","timestamp":1309771155000},"page":"324-329","source":"Crossref","is-referenced-by-count":49,"title":["Ocular fundus abnormalities in children born before 29 weeks of gestation: A population-based study"],"prefix":"10.1038","volume":"14","author":[{"given":"Ann","family":"Hellstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Lena","family":"H\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almon","family":"Niklasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFeye200081_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1001\/archneur.1972.00490150037007","volume":"27","author":"J De Reuck","year":"1972","unstructured":"De Reuck J, Chatta A, Richardson E . Pathogenesis and evolution of periventricular leukomalacia in infancy. Arch Neurol 1972;27:229\u201336.","journal-title":"Arch Neurol"},{"key":"BFeye200081_CR2","doi-asserted-by":"crossref","unstructured":"The Committee for the Classification of Retinopathy of Prematurity. An international classification of retinopathy of prematurity. Arch Ophthalmol 1984;102:1130\u20134.","DOI":"10.1001\/archopht.1984.01040030908011"},{"key":"BFeye200081_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1136\/bjo.62.1.7","volume":"62","author":"L Fris\u00e9n","year":"1978","unstructured":"Fris\u00e9n L, Holmegaard L . Spectrum of optic nerve hypoplasia. Br J Ophthalmol 1978;62:7\u201315.","journal-title":"Br J Ophthalmol"},{"key":"BFeye200081_CR4","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/S0002-9394(14)73476-2","volume":"116","author":"S Rimmer","year":"1993","unstructured":"Rimmer S, Keating C, Chou T, et al. Growth of the human optic disk and nerve during gestation, childhood, and early adulthood. Am J Ophthalmol 1993;116:748\u201353.","journal-title":"Am J Ophthalmol"},{"key":"BFeye200081_CR5","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1136\/bjo.75.2.84","volume":"75","author":"P Burgess","year":"1991","unstructured":"Burgess P, Johnson A . Ocular defects in infants of extremely low birth weight and low gestational age. Br J Ophthalmol 1991;75:84\u20137.","journal-title":"Br J Ophthalmol"},{"key":"BFeye200081_CR6","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1001\/archopht.1993.01090010070029","volume":"111","author":"MC Brodsky","year":"1993","unstructured":"Brodsky MC, Glasier CM . Optic nerve hypoplasia: clinical significance of associated central nervous system abnormalities on magnetic resonance imaging. Arch Ophthalmo1 1993;111:66\u201374.","journal-title":"Arch Ophthalmo1"},{"key":"BFeye200081_CR7","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1600-0420.1996.tb00094.x","volume":"74","author":"H Fledelius","year":"1996","unstructured":"Fledelius H . Pre-term delivery and subsequent ocular development: a 7-20 year follow-up of children screened 1982-1984 for ROP. Visual function, slit-lamp findings, and fundus appearance. Acta Ophthalmol Scand 1996;74:288\u2013300.","journal-title":"Acta Ophthalmol Scand"},{"key":"BFeye200081_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1469-8749.1984.tb04447.x","volume":"26","author":"D Margalith","year":"1984","unstructured":"Margalith D, Jan JE, McCormick AQ, Tze WJ, Lapointe J . Clinical spectrum of congenital optic nerve hypoplasia: review of 51 patients. Dev Med Child Neurol 1984;26:311\u201322.","journal-title":"Dev Med Child Neurol"},{"key":"BFeye200081_CR9","first-page":"184","volume":"38","author":"A Hellstrom","year":"1997","unstructured":"Hellstrom A, Hard A-L, Chen Y, Niklasson A, Albertsson-Wikland K. Influence of gestational age, birth size, perinatal morbidity, and postnatal growth. Invest Ophthalmol Vis Sci 1997;38:184\u201392.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200081_CR10","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1001\/archopht.1997.01100160433007","volume":"115","author":"L Jacobson","year":"1997","unstructured":"Jacobson L, Hellstrom A, Flodmark O . Large cups in normal sized optic discs: a variant of optic nerve hypoplasia in children with periventricular leukomalacia. Arch Ophthalmol 1997;115:1263\u20139.","journal-title":"Arch Ophthalmol"},{"key":"BFeye200081_CR11","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/S0022-3476(84)80093-1","volume":"105","author":"S Saigal","year":"1984","unstructured":"Saigal S, Rosenbaum P, Stoskopf B, Sinclair JC . Outcome of infants 501 to 1000 g birth weight delivered to residents of the McMaster Health Region. J Pediatr 1984;105:969\u201376.","journal-title":"J Pediatr"},{"key":"BFeye200081_CR12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1136\/bjo.79.5.447","volume":"79","author":"HJ Dowdeswell","year":"1995","unstructured":"Dowdeswell HJ, Slater AM, Broomhall J, Tripp J . Visual deficits in children born at less than 32 weeks\u2019 gestation with and without major ocular pathology and cerebral damage. Br J Ophthalmol 1995;79:447\u201352.","journal-title":"Br J Ophthalmol"},{"key":"BFeye200081_CR13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1034\/j.1600-0420.1998.760302.x","volume":"76","author":"A Hellstrom","year":"1998","unstructured":"Hellstrom A, Svensson E . Optic disc size and retinal vessel characteristics in healthy children. Acta Ophthalmol 1998;76:260\u20137.","journal-title":"Acta Ophthalmol"},{"key":"BFeye200081_CR14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1017\/S0012162200000207","volume":"42","author":"A-L Hard","year":"2000","unstructured":"Hard A-L, Niklasson A, Svensson E, Hellstrom A . Visual function school-aged children born before 29 gestational weeks: a population-based study. Dev Med Child Neurol 2000;42:100\u20135.","journal-title":"Dev Med Child Neurol"},{"key":"BFeye200081_CR15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/BF00166607","volume":"233","author":"K Stromland","year":"1995","unstructured":"Stromland K, Hellstrom A, Gustavsson T . Morphometry of the optic nerve and retinal vessels by computer-assisted image analysis. Graefes Arch Clin Exp Ophthalmol 1995;233:150\u20133.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFeye200081_CR16","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2214\/ajr.132.4.631","volume":"132","author":"J Burstein","year":"1979","unstructured":"Burstein J, Papile L-A, Burstein R . Intraventricular hemorrhage and hydrocephalus in premature newborns: a prospective study with CT. AJR 1979;132:631\u20135.","journal-title":"AJR"},{"key":"BFeye200081_CR17","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/S0140-6736(05)79889-5","volume":"352","author":"A Hellstrom","year":"1998","unstructured":"Hellstrom A, Hard A-L, Niklasson A, Svensson E, Jacobsson B. Abnormal retinal vascularisation in preterm children as a general vascular phenomenon. Lancet 1998;352:1827.","journal-title":"Lancet"},{"key":"BFeye200081_CR18","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0022-3476(99)70133-2","volume":"135","author":"EF Maalouf","year":"1999","unstructured":"Maalouf EF, et al. Magnetic resonance imaging of the brain in a cohort of extremely preterm infants. J Pediatr 1999;135:351\u20137.","journal-title":"J Pediatr"},{"key":"BFeye200081_CR19","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1001\/archopht.1991.01080100121056","volume":"109","author":"HA Quigley","year":"1991","unstructured":"Quigley HA, Coleman AL, Dorman-Pease ME . Larger optic nerve heads have more nerve fibers in normal monkey eyes. Arch Ophthalmol 1991;109:1441\u20133.","journal-title":"Arch Ophthalmol"},{"key":"BFeye200081_CR20","first-page":"2012","volume":"33","author":"JB Jonas","year":"1992","unstructured":"Jonas JB, Schmidt AM, Miiller-Bergh JA, Schlotzer-Schrehardt UM, Naumann GOH . Human optic nerve fiber count and optic disc size. Invest Ophthalmol Vis Sci 1992;33:2012\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200081_CR21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/cne.902380108","volume":"238","author":"JM Provis","year":"1985","unstructured":"Provis JM, van Driel D, Billson FA, Russell P . Human fetal optic nerve: overproduction and elimination of retinal axons during development. J Comp Neurol 1985;238:92\u2013100.","journal-title":"J Comp Neurol"},{"key":"BFeye200081_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0039-6257(87)90069-5","volume":"32","author":"SR Lambert","year":"1987","unstructured":"Lambert SR, Hoyt CS, Narahara MH . Optic nerve hypoplasia. Surv Ophthalmol 1987;32:1\u20139.","journal-title":"Surv Ophthalmol"},{"key":"BFeye200081_CR23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/eye.1992.39","volume":"6","author":"CS Hoyt","year":"1992","unstructured":"Hoyt CS, Good WV . Do we really understand the difference between optic nerve hypoplasia and atrophy? Eye 1992;6:201\u20134.","journal-title":"Eye"},{"key":"BFeye200081_CR24","first-page":"749","volume":"21","author":"JT Dineen","year":"1981","unstructured":"Dineen JT, Hendrickson AE . Age-correlated differences in the amount of retinal degeneration after striate cortex lesions in monkeys. Invest Ophthalmol Vis Sci 1981;21:749\u201352.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200081_CR25","first-page":"233","volume":"18","author":"C Uggetti","year":"1997","unstructured":"Uggetti C, Egitto MG, Fazzi E, et al. Transsynaptic degeneration of lateral geniculate bodies in blind children: in vivo MR demonstration. Am J Neuroradiol 1997;18:233\u20138.","journal-title":"Am J Neuroradiol"},{"key":"BFeye200081_CR26","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/S0161-6420(86)33523-1","volume":"93","author":"RA Gordon","year":"1986","unstructured":"Gordon RA, Donzis PA . Myopia associated with retinopathy of prematurity. Ophthalmology 1986;93:1593\u20138.","journal-title":"Ophthalmology"},{"key":"BFeye200081_CR27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1755-3768.1992.tb04915.x","volume":"204","author":"HC Fledelius","year":"1992","unstructured":"Fledelius HC . Pre-term delivery and the growth of the eye: an oculometric study of the eye size around term-time. Acta Ophthalmol 1992;Suppl 204:10\u20135.","journal-title":"Acta Ophthalmol"},{"key":"BFeye200081_CR28","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/eye.1994.101","volume":"8","author":"DE Laws","year":"1994","unstructured":"Laws DE, Haslett R, Ashby D, O'Brien C, Clark D. Axial length biometry in infants with retinopathy of prematurity. Eye 1994;8:427\u201330.","journal-title":"Eye"},{"key":"BFeye200081_CR29","first-page":"290","volume":"37","author":"J Stone","year":"1996","unstructured":"Stone J, Chan-Ling T, Pe'er J, Itin A, Gnessin H, Keshet E . Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity. Invest Ophthalmol Vis Sci 1996;37:290\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200081_CR30","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1001\/archopht.1996.01100140419009","volume":"114","author":"EA Pierce","year":"1996","unstructured":"Pierce EA, Foley ED, Smith LE . Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol 1996;114:1219\u201328.","journal-title":"Arch Ophthalmol"},{"key":"BFeye200081_CR31","first-page":"251","volume":"94","author":"AS Mushin","year":"1974","unstructured":"Mushin AS . Retinopathy of prematurity: a disease of increasing incidence. Trans Ophthalmol Soc UK 1974;94:251\u20137.","journal-title":"Trans Ophthalmol Soc UK"},{"key":"BFeye200081_CR32","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/eye.1992.46","volume":"6","author":"AR Fielder","year":"1992","unstructured":"Fielder AR, Shaw DE, Robinson J, Ng YK . Natural history of retinopathy of prematurity: a prospective study. Eye 1992;6:233\u201342.","journal-title":"Eye"},{"key":"BFeye200081_CR33","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF02150097","volume":"218","author":"D Bracher","year":"1982","unstructured":"Bracher D . Changes in peripapillary tortuosity of the central retinal arteries in newborns: a phenomenon whose underlying mechanisms need clarification. Graefes Arch Exp Ophthalmol 1982;218:211\u20137.","journal-title":"Graefes Arch Exp Ophthalmol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye200081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye200081","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye200081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:29:13Z","timestamp":1712575753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye200081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["BFeye200081"],"URL":"https:\/\/doi.org\/10.1038\/eye.2000.81","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}