{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:25:23Z","timestamp":1791159923605,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1038\/eye.2000.92","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T09:19:15Z","timestamp":1309771155000},"page":"375-383","source":"Crossref","is-referenced-by-count":53,"title":["Synthesis pattern of matrix metalloproteinases (MMPs) and inhibitors (TIMPs) in human explant organ cultures after treatment with latanoprost and dexamethasone"],"prefix":"10.1038","volume":"14","author":[{"given":"Yosuf","family":"El-Shabrawi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Eckhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Berghold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Faulborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Auboeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Mangge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Ardjomand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFeye200092_CR1","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1016\/S0039-6257(97)80009-4","volume":"41","author":"CB Camras","year":"1997","unstructured":"Camras CB, Aim A . Initial clinical studies with prostaglandins and their analogues. Surv Ophthalmol 1997;41(Suppl 2); S61\u20138.","journal-title":"Surv Ophthalmol"},{"key":"BFeye200092_CR2","first-page":"2214","volume":"38","author":"JD Lindsey","year":"1997","unstructured":"Lindsey JD, Kashiwagi K, Kashiwagi F, Weinreb RN . Prostaglandins alter extracellular matrix adjacent to human ciliary muscle cells in vitro. Invest Ophthalmol Vis Sci 1997;38:2214\u201323.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR3","first-page":"2772","volume":"38","author":"RN Weinreb","year":"1997","unstructured":"Weinreb RN, Kashiwagi K, Kashiwagi F, Tsukahara S, Lindsey JD . Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells. Invest Ophthalmol Vis Sci 1997;38:2772\u201380.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/exer.1998.0508","volume":"67","author":"A Ocklind","year":"1998","unstructured":"Ocklind A . Effect of latanoprost on the extracellular matrix of the ciliary muscle: a study on cultured cells and tissue sections. Exp Eye Res 1998;67:179\u201391.","journal-title":"Exp Eye Res"},{"key":"BFeye200092_CR5","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1006\/exer.1996.0224","volume":"64","author":"AH Krauss","year":"1997","unstructured":"Krauss AH, Wiederholt M, Sturm A, Woodward DF . Prostaglandin effects on the contractility of bovine trabecular meshwork and ciliary muscle. Exp Eye Res 1997;64:447\u201353.","journal-title":"Exp Eye Res"},{"key":"BFeye200092_CR6","doi-asserted-by":"publisher","first-page":"S93","DOI":"10.1016\/S0039-6257(97)80014-8","volume":"41","author":"PFJ Hoyng","year":"1997","unstructured":"Hoyng PFJ, Rulo A, Greve E, Watson P, Aim A . The additive intraocular pressure-lowering effect of latanoprost in combined therapy with other ocular hypotensive agents. Surv Ophthalmol 1997;41 (Suppl 2):S93\u20138.","journal-title":"Surv Ophthalmol"},{"key":"BFeye200092_CR7","first-page":"315","volume":"39","author":"TL Anthony","year":"1998","unstructured":"Anthony TL, Pierce KL, Stamer WP, Regan JW . Prostaglandin F20 < receptors in the human trabecular meshwork. Invest Ophthalmol Vis Sci 1998;39:315\u201321.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR8","first-page":"3386","volume":"34","author":"JR Samples","year":"1993","unstructured":"Samples JR, Alexander JP, Acott TS . Regulation of levels of human trabecular matrix metalloproteinases and inhibitor by interleukin-1 and dexamethasone. Invest Ophthalmol Vis Sci 1993;34:3386\u201395.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0014-4835(73)90164-4","volume":"17","author":"JW Rohen","year":"1973","unstructured":"Rohen JW, Linner E, Witmer R . Electron microscopic studies on the trabecular meshwork in two cases of corticosteroid glaucoma. Exp Eye Res 1973;17:19\u201331.","journal-title":"Exp Eye Res"},{"key":"BFeye200092_CR10","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1001\/archopht.1997.01100150377011","volume":"115","author":"D Johnson","year":"1997","unstructured":"Johnson D, Gottanka J, Flugel C, Hoffmann F, Futa R, Lutjen Drecoll E . Ultrastructural changes in the trabecular meshwork of human eyes treated with corticosteroids. Arch Ophthalmol 1997;115:375\u201383.","journal-title":"Arch Ophthalmol"},{"key":"BFeye200092_CR11","first-page":"421","volume":"174","author":"P Roll","year":"1979","unstructured":"Roll P, O Benedikt . Elektronenoptische Untersuchung des Trabekelwerkes beim Kortikosteroidglaukom. Klin Monatsbl Augenheilkd 1979;174:421\u20138.","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"BFeye200092_CR12","first-page":"242","volume":"35","author":"JD Lindsey","year":"1994","unstructured":"Lindsey JD, To HD, Weinreb RN . Induction of c-fos by prostaglandin F2 alpha in human ciliary smooth muscle cells. Invest Ophthalmol Vis Sci 1994;35:242\u201350.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR13","first-page":"716","volume":"37","author":"A Ocklind","year":"1996","unstructured":"Ocklind A, Lake S, Wentzel P, Nister M, Stjernschantz J . Localisation of prostaglandin F2o receptor messenger RNA and protein in the cynomolgus monkey eye. Invest Ophthalmol Vis Sci 1996;37:716\u201326.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR14","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1006\/exer.1997.0287","volume":"64","author":"LC Padgett","year":"1997","unstructured":"Padgett LC, Lui GM, Werb Z, Lavail MM . Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in the retinal pigment epithelium and interphotoreceptor matrix: vectorial secretion and regulation. Exp Eye Res 1997;64:927\u201338.","journal-title":"Exp Eye Res"},{"key":"BFeye200092_CR15","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S0002-9394(14)70907-9","volume":"124","author":"JA Rowe","year":"1997","unstructured":"Rowe JA, Hattenhauer MG, Herman DC . Adverse side effects associated with latanoprost. Am J Ophthalmol 1997;124:683\u20135.","journal-title":"Am J Ophthalmol"},{"key":"BFeye200092_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0161-6420(98)92977-3","volume":"105","author":"RE Warwar","year":"1998","unstructured":"Warwar RE, Bullock JD, Ballal D . Cystoid macula edema and anterior uveitis associated with latanoprost use: experience and incidence in a retrospective review of 94 patients. Ophthalmology 1998;105:263\u20138.","journal-title":"Ophthalmology"},{"key":"BFeye200092_CR17","first-page":"2194","volume":"39","author":"B Steen","year":"1998","unstructured":"Steen B, Sejersen S, Berglin L, Seregard S, Kvanta A . Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes. Invest Ophthalmol Vis Sci 1998;39:2194\u2013200.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR18","first-page":"90","volume":"29","author":"TS Acott","year":"1988","unstructured":"Acott TS, Kingsley PD, Samples JR, Van Buskirk EM . Human trabecular meshwork organ culture: morphology and glycosaminglycan synthesis. Invest Ophthalmol Vis Sci 1988;29:90\u2013100.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/BF02169449","volume":"227","author":"J Baumgartner","year":"1989","unstructured":"Baumgartner J, Huber-Spitzy V, Grabner G, Mayr WR . HLA typing from human donor eyes. Graefes Arch Clin Exp Ophthalmol 1989;227:541\u20133.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFeye200092_CR20","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1006\/exer.1996.0058","volume":"62","author":"SH Huang","year":"1996","unstructured":"Huang SH, Adamis AP, Wiederschain DG, Shima DT, Shing Y, Moses MA . Matrix metalloproteinases and their inhibitors in aqueous humor. Exp Eye Res 1996;62:481\u201390.","journal-title":"Exp Eye Res"},{"key":"BFeye200092_CR21","first-page":"3541","volume":"34","author":"H Ando","year":"1993","unstructured":"Ando H, Twining SS, Yue BJYT, Zhou X, Fini ME, Kaiya T, et al. MMPs and proteinase inhibitors in the human aqueous humor. Invest Ophthalmol Vis Sci 1993;34:3541\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR22","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1177\/29.4.6166661","volume":"29","author":"SM Hsu","year":"1981","unstructured":"Hsu SM, Raine L, Fanger H . Use of avidin-biotin-peroxidase complex in immunoperoxidase techniques. J Histochem Cytochem 1981;29:577\u201380.","journal-title":"J Histochem Cytochem"},{"key":"BFeye200092_CR23","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/BF00920940","volume":"231","author":"S Tang","year":"1993","unstructured":"Tang S, Scheiffarth OF, Stefani FH . Clinical and immunohistochemical correlations of herpetic keratitis with the expression of HLA-DR antigen. Graefes Arch Clin Exp Ophthalmol 1993;231:162\u20135.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFeye200092_CR24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0002-9394(14)70819-0","volume":"124","author":"B Patelska","year":"1997","unstructured":"Patelska B, Greenfield DS, Liebmann JM, Wand M, Kushnick H, Ritch R . Latanoprost for uncontrolled glaucoma in a compassionate case protocol. Am J Ophthalmol 1997;124:279\u201386.","journal-title":"Am J Ophthalmol"},{"key":"BFeye200092_CR25","doi-asserted-by":"publisher","first-page":"S105","DOI":"10.1016\/S0039-6257(97)80016-1","volume":"41","author":"A Alm","year":"1997","unstructured":"Alm A, Camras CB, Watson PG . Phase III latanoprost studies in Scandinavia, the United Kingdom and the United States. Surv Ophthalmol 1997;41 (Suppl 2):S105\u201310.","journal-title":"Surv Ophthalmol"},{"key":"BFeye200092_CR26","first-page":"2649","volume":"39","author":"JM Bradley","year":"1998","unstructured":"Bradley JM, Vranka J, Colvis CM, Conger DM, Alexander JP, Fisk AS, et al. Effect of matrix metalloproteinases activity on outflow in perfused human organ culture. Invest Ophthalmol Vis Sci 1998;39:2649\u201358.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0002-9394(14)73759-6","volume":"120","author":"CJ Helm","year":"1995","unstructured":"Helm CJ, Holland GN . The effects of posterior sub-Tenon injection of triamcinolone acetonide in patients with intermediate uveitis. Am J Ophthalmol 1995;120:55\u201364.","journal-title":"Am J Ophthalmol"},{"key":"BFeye200092_CR28","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1016\/0016-5085(92)90319-T","volume":"102","author":"RC Tripathi","year":"1992","unstructured":"Tripathi RC, Kirschner BS, Kipp M, Tripathi BJ, Slotwiner D, Borisuth NS, et al. Corticosteroid treatment for inflammatory bowel disease in pediatric patients increases intraocular pressure. Gastroenterology 1992;102:1957\u201361.","journal-title":"Gastroenterology"},{"key":"BFeye200092_CR29","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1006\/exer.1993.1148","volume":"57","author":"RW Synder","year":"1993","unstructured":"Synder RW, Stamer WD, Kramer TR, Seftor REP . Corticosteroid treatment and trabecular meshwork proteinases in cell and organ culture supernatants. Exp Eye Res 1993;57:461\u20138.","journal-title":"Exp Eye Res"},{"key":"BFeye200092_CR30","first-page":"3221","volume":"32","author":"M Matsubara","year":"1991","unstructured":"Matsubara M, Zieski JD, Fini ME . Mechanism of basement membrane dissolution preceding corneal ulceration. Invest Ophthalmol Vis Sci 1991;32:3221\u201337.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR31","first-page":"363","volume":"40","author":"DD Gaton","year":"1999","unstructured":"Gaton DD, Sagra T, Lindsey JD, Weinberg RN . Matrix metalloproteinase-1 localisation in the normal uveoscleral outflow pathway. Invest Ophthalmol Vis Sci 1999;40:363\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye200092_CR32","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3109\/02713689609017656","volume":"15","author":"N Di-Girolamo","year":"1996","unstructured":"Di-Girolamo N, Verma MJ, McCluskey PJ, Lloyd A, Wakefield D . Increased matrix metalloproteinases in the aqueous humor of patients and experimental animals with uveitis. Curr Eye Res 1996;15:1060\u20138.","journal-title":"Curr Eye Res"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye200092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye200092","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye200092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:00:02Z","timestamp":1684429202000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye200092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["BFeye200092"],"URL":"https:\/\/doi.org\/10.1038\/eye.2000.92","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}