{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:31:09Z","timestamp":1780471869861,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T00:00:00Z","timestamp":1213315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1038\/eye.2008.174","type":"journal-article","created":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T06:05:31Z","timestamp":1213337131000},"page":"1192-1198","source":"Crossref","is-referenced-by-count":69,"title":["Limited value of cyclosporine A for the treatment of patients with uveitis associated with juvenile idiopathic arthritis"],"prefix":"10.1038","volume":"23","author":[{"given":"C","family":"Tappeiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Roesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Michels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Ganser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Heiligenhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,13]]},"reference":[{"key":"BFeye2008174_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00347-005-1175-9","volume":"102","author":"A Mingels","year":"2005","unstructured":"Mingels A, Hudde T, Heinz C, Heiligenhaus A . Vision-threatening complications in childhood uveitis. Ophthalmologe 2005; 102: 477\u2013484.","journal-title":"Ophthalmologe"},{"key":"BFeye2008174_CR2","first-page":"367","volume":"17","author":"B Andersson Gare","year":"1999","unstructured":"Andersson Gare B . Juvenile arthritis\u2014who gets it, where and when? A review of current data on incidence and prevalence. Clin Exp Rheumatol 1999; 17: 367\u2013374.","journal-title":"Clin Exp Rheumatol"},{"key":"BFeye2008174_CR3","first-page":"1520","volume":"29","author":"PJ Manners","year":"2002","unstructured":"Manners PJ, Bower C . World-wide prevalence of juvenile arthritis why does it vary so much? J Rheumatol 2002; 29: 1520\u20131530.","journal-title":"J Rheumatol"},{"key":"BFeye2008174_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00417-005-0087-3","volume":"244","author":"PE Carvounis","year":"2006","unstructured":"Carvounis PE, Herman DC, Cha S, Burke JP . Incidence and outcomes of uveitis in juvenile rheumatoid arthritis, a synthesis of the literature. Graefes Arch Clin Exp Ophthalmol 2006; 244: 281\u2013290.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFeye2008174_CR5","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1055\/s-2005-858753","volume":"222","author":"A Heiligenhaus","year":"2005","unstructured":"Heiligenhaus A, Niewerth M, Mingels A, Ganser G, Thon A, Pleyer U et al. Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database. Klin Monatsbl Augenheilkd 2005; 222: 993\u20131001.","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"BFeye2008174_CR6","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1136\/bjo.86.1.51","volume":"86","author":"C Edelsten","year":"2002","unstructured":"Edelsten C, Lee V, Bentley CR, Kanski JJ, Graham EM . An evaluation of baseline risk factors predicting severity in juvenile idiopathic arthritis associated uveitis and other chronic anterior uveitis in early childhood. Br J Ophthalmol 2002; 86: 51\u201356.","journal-title":"Br J Ophthalmol"},{"key":"BFeye2008174_CR7","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1177\/112067210301300704","volume":"13","author":"MP Paroli","year":"2003","unstructured":"Paroli MP, Speranza S, Marino M, Pirraglia MP, Pivetti-Pezzi P . Prognosis of juvenile rheumatoid arthritis-associated uveitis. Eur J Ophthalmol 2003; 13: 616\u2013621.","journal-title":"Eur J Ophthalmol"},{"key":"BFeye2008174_CR8","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1136\/bjo.82.7.737","volume":"82","author":"DJ Kilmartin","year":"1998","unstructured":"Kilmartin DJ, Forrester JV, Dick AD . Cyclosporin A therapy in refractory non-infectious childhood uveitis. Br J Ophthalmol 1998; 82: 737\u2013742.","journal-title":"Br J Ophthalmol"},{"key":"BFeye2008174_CR9","first-page":"469","volume":"16","author":"K Kotaniemi","year":"1998","unstructured":"Kotaniemi K . Late onset uveitis in juvenile-type chronic polyarthritis controlled with prednisolone, cyclosporin A and methotrexate. Clin Exp Rheumatol 1998; 16: 469\u2013471.","journal-title":"Clin Exp Rheumatol"},{"key":"BFeye2008174_CR10","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1093\/rheumatology\/40.8.907","volume":"40","author":"V Gerloni","year":"2001","unstructured":"Gerloni V, Cimaz R, Gattinara M, Arnoldi C, Pontikaki I, Fantini F . Efficacy and safety profile of cyclosporin A in the treatment of juvenile chronic (idiopathic) arthritis. Results of a 10-year prospective study. Rheumatology (Oxford) 2001; 40: 907\u2013913.","journal-title":"Rheumatology (Oxford)"},{"key":"BFeye2008174_CR11","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1056\/NEJM199206183262502","volume":"326","author":"G Feutren","year":"1992","unstructured":"Feutren G, Mihatsch MJ . Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. International Kidney Biopsy Registry of Cyclosporine in Autoimmune Diseases. N Engl J Med 1992; 326: 1654\u20131660.","journal-title":"N Engl J Med"},{"key":"BFeye2008174_CR12","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1016\/S0161-6420(98)91120-4","volume":"105","author":"RC Walton","year":"1998","unstructured":"Walton RC, Nussenblatt RB, Whitcup SM . Cyclosporine therapy for severe sight threatening uveitis in children and adolescents. Ophthalmology 1998; 105: 2028\u20132034.","journal-title":"Ophthalmology"},{"key":"BFeye2008174_CR13","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","volume":"140","author":"DA Jabs","year":"2005","unstructured":"Jabs DA, Nussenblatt RB, Rosenbaum JT . Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 2005; 140: 509\u2013516.","journal-title":"Am J Ophthalmol"},{"key":"BFeye2008174_CR14","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, edmonton 2001. J Rheumatol 2004; 31: 390\u2013392.","journal-title":"J Rheumatol"},{"key":"BFeye2008174_CR15","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1093\/rheumatology\/40.8.896","volume":"40","author":"P Brooks","year":"2001","unstructured":"Brooks P, Hochberg M . Outcome measures and classification criteria for the rheumatic diseases. A compilation of data from OMERACT (Outcome Measures for Arthritis Clinical Trials), ILAR (International League of Associations for Rheumatology), regional leagues and other groups. Rheumatology (Oxford) 2001; 40: 896\u2013906.","journal-title":"Rheumatology (Oxford)"},{"key":"BFeye2008174_CR16","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1093\/rheumatology\/kel030","volume":"45","author":"RK Saurenmann","year":"2006","unstructured":"Saurenmann RK, Levin AV, Rose JB, Parker S, Rabinovitch T, Tyrrell PN et al. Tumour necrosis factor alpha inhibitors in the treatment of childhood uveitis. Rheumatology (Oxford) 2006; 45: 982\u2013989.","journal-title":"Rheumatology (Oxford)"},{"key":"BFeye2008174_CR17","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/eye.1989.39","volume":"3","author":"HM Towler","year":"1989","unstructured":"Towler HM, Cliffe AM, Whiting PH, Forrester JV . Low-dose cyclosporin A therapy in chronic posterior uveitis. Eye 1989; 3: 282\u2013287.","journal-title":"Eye"},{"key":"BFeye2008174_CR18","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0161-6420(96)30683-0","volume":"103","author":"AT Vitale","year":"1996","unstructured":"Vitale AT, Rodriguez A, Foster CS . Low-dose cyclosporin A therapy in treating chronic, noninfectious uveitis. Ophthalmology 1996; 103: 365\u2013373; discussion 373\u2013374.","journal-title":"Ophthalmology"},{"key":"BFeye2008174_CR19","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s003470050070","volume":"93","author":"T Schlote","year":"1996","unstructured":"Schlote T, Dannecker G, Thiel HJ, Zierhut M . Cyclosporin A in therapy of chronic uveitis in childhood. Ophthalmologe 1996; 93: 745\u2013748.","journal-title":"Ophthalmologe"},{"key":"BFeye2008174_CR20","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/j.1651-2227.1990.tb11526.x","volume":"79","author":"PF Hoyer","year":"1990","unstructured":"Hoyer PF, Offner G, Oemar BS, Brodehl J, Ringe B, Pichlmayr R . Four years' experience with cyclosporin A in pediatric kidney transplantation. Acta Paediatr Scand 1990; 79: 622\u2013629.","journal-title":"Acta Paediatr Scand"},{"key":"BFeye2008174_CR21","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2165\/00003495-199500501-00008","volume":"50","author":"P Tugwell","year":"1995","unstructured":"Tugwell P . International consensus recommendations on cyclosporin use in rheumatoid arthritis. Drugs 1995; 50: 48\u201356.","journal-title":"Drugs"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye2008174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2008174","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2008174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:04:27Z","timestamp":1684415067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye2008174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,13]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["BFeye2008174"],"URL":"https:\/\/doi.org\/10.1038\/eye.2008.174","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718381951.793494989","asserted-by":"object"}]},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,13]]}}}