{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:05:34Z","timestamp":1769915134198,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T00:00:00Z","timestamp":1254441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1038\/eye.2009.244","type":"journal-article","created":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T09:52:09Z","timestamp":1254477129000},"page":"1058-1063","source":"Crossref","is-referenced-by-count":27,"title":["Genetic susceptibility to Graves\u2019 ophthalmopathy: the role of polymorphisms in proinflammatory cytokine genes"],"prefix":"10.1038","volume":"24","author":[{"given":"M","family":"Anvari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Khalilzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Esteghamati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Esfahani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Etemadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A A","family":"Amirzargar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,10,2]]},"reference":[{"key":"BFeye2009244_CR1","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1056\/NEJM200010263431707","volume":"343","author":"AP Weetman","year":"2000","unstructured":"Weetman AP . Graves\u2019 disease. N Engl J Med 2000; 343: 1236\u20131248.","journal-title":"N Engl J Med"},{"key":"BFeye2009244_CR2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3109\/08916939209148462","volume":"12","author":"AP Weetman","year":"1992","unstructured":"Weetman AP . Thyroid-associated ophthalmopathy. Autoimmunity 1992; 12: 215\u2013222.","journal-title":"Autoimmunity"},{"key":"BFeye2009244_CR3","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1097\/MED.0b013e32830eb8ab","volume":"15","author":"AG Gianoukakis","year":"2008","unstructured":"Gianoukakis AG, Smith TJ . Recent insights into the pathogenesis and management of thyroid-associated ophthalmopathy. Curr Opin Endocrinol Diabetes Obes 2008; 15: 446\u2013452.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"BFeye2009244_CR4","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1023\/A:1010020621687","volume":"1","author":"AE Heufelder","year":"2000","unstructured":"Heufelder AE . Pathogenesis of ophthalmopathy in autoimmune thyroid disease. Rev Endocr Metab Disord 2000; 1: 87\u201395.","journal-title":"Rev Endocr Metab Disord"},{"key":"BFeye2009244_CR5","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3109\/08916939209014638","volume":"13","author":"RS Bahn","year":"1992","unstructured":"Bahn RS, Heufelder AE . Role of connective tissue autoimmunity in Graves\u2019 ophthalmopathy. Autoimmunity 1992; 13: 75\u201379.","journal-title":"Autoimmunity"},{"key":"BFeye2009244_CR6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1006\/clin.1994.1169","volume":"73","author":"G Kahaly","year":"1994","unstructured":"Kahaly G, Hansen C, Felke B, Dienes HP . Immunohistochemical staining of retrobulbar adipose tissue in Graves\u2019 ophthalmopathy. Clin Immunol Immunopathol 1994; 73: 53\u201362.","journal-title":"Clin Immunol Immunopathol"},{"key":"BFeye2009244_CR7","first-page":"120","volume":"35","author":"AE Heufelder","year":"1994","unstructured":"Heufelder AE, Bahn RS . Modulation of Graves\u2019 orbital fibroblast proliferation by cytokines and glucocorticoid receptor agonists. Invest Ophthalmol Vis Sci 1994; 35: 120\u2013127.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2009244_CR8","first-page":"2037","volume":"33","author":"JM Korducki","year":"1992","unstructured":"Korducki JM, Loftus SJ, Bahn RS . Stimulation of glycosaminoglycan production in cultured human retroocular fibroblasts. Invest Ophthalmol Vis Sci 1992; 33: 2037\u20132042.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2009244_CR9","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1089\/105072502753600160","volume":"12","author":"Y Hiromatsu","year":"2002","unstructured":"Hiromatsu Y, Kaku H, Miyake I, Murayama S, Soejima E . Role of cytokines in the pathogenesis of thyroid-associated ophthalmopathy. Thyroid 2002; 12: 217\u2013221.","journal-title":"Thyroid"},{"issue":"1","key":"BFeye2009244_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.cytogfr.2008.11.006","volume":"20","author":"AJ Smith","year":"2009","unstructured":"Smith AJ, Humphries SE . Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev 2009; 20 (1): 43\u201359.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFeye2009244_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0140-6736(91)90013-F","volume":"338","author":"AP Weetman","year":"1991","unstructured":"Weetman AP . Thyroid-associated eye disease: pathophysiology. Lancet 1991; 338: 25\u201328.","journal-title":"Lancet"},{"key":"BFeye2009244_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3109\/08916939709003857","volume":"26","author":"N Natt","year":"1997","unstructured":"Natt N, Bahn RS . Cytokines in the evolution of Graves\u2019 ophthalmopathy. Autoimmunity 1997; 26: 129\u2013136.","journal-title":"Autoimmunity"},{"key":"BFeye2009244_CR13","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1507\/endocrj.K06-040","volume":"53","author":"Y Hiromatsu","year":"2006","unstructured":"Hiromatsu Y, Fukutani T, Ichimura M, Mukai T, Kaku H, Miyake I et al. Interleukin-12B gene polymorphism does not confer susceptibility to Graves\u2019 ophthalmopathy in Japanese population. Endocr J 2006; 53: 753\u2013759.","journal-title":"Endocr J"},{"key":"BFeye2009244_CR14","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.humimm.2004.02.033","volume":"65","author":"T Bednarczuk","year":"2004","unstructured":"Bednarczuk T, Hiromatsu Y, Seki N, Ploski R, Fukutani T, Kurylowicz A et al. Association of tumor necrosis factor and human leukocyte antigen DRB1 alleles with Graves\u2019 ophthalmopathy. Hum Immunol 2004; 65: 632\u2013639.","journal-title":"Hum Immunol"},{"key":"BFeye2009244_CR15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jaut.2004.03.011","volume":"23","author":"N Bougacha-Elleuch","year":"2004","unstructured":"Bougacha-Elleuch N, Rebai A, Mnif M, Makni H, Bellassouad M, Jouida J et al. Analysis of MHC genes in a Tunisian isolate with autoimmune thyroid diseases: implication of TNF-308 gene polymorphism. J Autoimmun 2004; 23: 75\u201380.","journal-title":"J Autoimmun"},{"key":"BFeye2009244_CR16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/0891693042000193320","volume":"37","author":"T Bednarczuk","year":"2004","unstructured":"Bednarczuk T, Kurylowicz A, Hiromatsu Y, Kiljanskic J, Telichowska A, Nauman J . Association of G-174C polymorphism of the interleukin-6 gene promoter with Graves\u2019 ophthalmopathy. Autoimmunity 2004; 37: 223\u2013226.","journal-title":"Autoimmunity"},{"key":"BFeye2009244_CR17","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1167\/iovs.07-1433","volume":"49","author":"KK Chong","year":"2008","unstructured":"Chong KK, Chiang SW, Wong GW, Tam PO, Ng TK, Hu YJ et al. Association of CTLA-4 and IL-13 gene polymorphisms with Graves\u2019 disease and ophthalmopathy in Chinese children. Invest Ophthalmol Vis Sci 2008; 49: 2409\u20132415.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2009244_CR18","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1046\/j.1365-2265.2000.01011.x","volume":"52","author":"S Kamizono","year":"2000","unstructured":"Kamizono S, Hiromatsu Y, Seki N, Bednarczuk T, Matsumoto H, Kimura A et al. A polymorphism of the 5\u2019 flanking region of tumour necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese. Clin Endocrinol (Oxf) 2000; 52: 759\u2013764.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BFeye2009244_CR19","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1210\/jc.2007-2190","volume":"93","author":"AK Huber","year":"2008","unstructured":"Huber AK, Jacobson EM, Jazdzewski K, Concepcion ES, Tomer Y . Interleukin (IL)-23 receptor is a major susceptibility gene for Graves\u2019 ophthalmopathy: the IL-23\/T-helper 17 axis extends to thyroid autoimmunity. J Clin Endocrinol Metab 2008; 93: 1077\u20131081.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2009244_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1365-2265.2007.02854.x","volume":"67","author":"T Bednarczuk","year":"2007","unstructured":"Bednarczuk T, Gopinath B, Ploski R, Wall JR . Susceptibility genes in Graves\u2019 ophthalmopathy: searching for a needle in a haystack? Clin Endocrinol (Oxf) 2007; 67: 3\u201319.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BFeye2009244_CR21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1210\/jcem-44-1-203","volume":"44","author":"SC Werner","year":"1977","unstructured":"Werner SC . Modification of the classification of the eye changes of Graves\u2019 disease: recommendations of the Ad Hoc Committee of the American Thyroid Association. J Clin Endocrinol Metab 1977; 44: 203\u2013204.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2009244_CR22","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0140-6736(99)01465-8","volume":"354","author":"B Vaidya","year":"1999","unstructured":"Vaidya B, Imrie H, Perros P, Dickinson J, McCarthy MI, Kendall-Taylor P et al. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy. Lancet 1999; 354: 743\u2013744.","journal-title":"Lancet"},{"key":"BFeye2009244_CR23","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.ejim.2008.12.005","volume":"20","author":"A Esteghamati","year":"2009","unstructured":"Esteghamati A, Khalilzadeh O, Mobarra Z, Anvari M, Tahvildari M, Mojazi Amiri H et al. Association of CTLA-4 gene polymorphism with Graves\u2019 disease and ophthalmopathy in Iranian patients. Eur J Intern Med 2009; 20: 424\u2013428.","journal-title":"Eur J Intern Med"},{"issue":"6","key":"BFeye2009244_CR24","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/j.1442-9071.2009.02093.x","volume":"37","author":"O Khalilzadeh","year":"2009","unstructured":"Khalilzadeh O, Anvari M, Esteghamati A, Mahmoudi M, Tahvildari M, Rashidi A et al. Graves\u2019 ophthalmopathy and gene polymorphisms in interleukin-1\u03b1, interleukin-1\u00df, interleukin-1 receptor, and interleukin-1 receptor antagonist. Clin Exp Ophthalm 2009; 37 (6): 614\u2013619.","journal-title":"Clin Exp Ophthalm"},{"key":"BFeye2009244_CR25","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1365-2362.1992.tb01501.x","volume":"22","author":"AE Heufelder","year":"1992","unstructured":"Heufelder AE, Bahn RS . Graves\u2019 immunoglobulins and cytokines stimulate the expression of intercellular adhesion molecule-1 (ICAM-1) in cultured Graves\u2019 orbital fibroblasts. Eur J Clin Invest 1992; 22: 529\u2013537.","journal-title":"Eur J Clin Invest"},{"key":"BFeye2009244_CR26","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1210\/jcem-73-4-739","volume":"73","author":"AE Heufelder","year":"1991","unstructured":"Heufelder AE, Wenzel BE, Gorman CA, Bahn RS . Detection, cellular localization, and modulation of heat shock proteins in cultured fibroblasts from patients with extrathyroidal manifestations of Graves\u2019 disease. J Clin Endocrinol Metab 1991; 73: 739\u2013745.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2009244_CR27","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1210\/jcem-72-5-1169","volume":"72","author":"TJ Smith","year":"1991","unstructured":"Smith TJ, Bahn RS, Gorman CA, Cheavens M . Stimulation of glycosaminoglycan accumulation by interferon gamma in cultured human retroocular fibroblasts. J Clin Endocrinol Metab 1991; 72: 1169\u20131171.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2009244_CR28","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1080\/08916930802422265","volume":"42","author":"Y Ban","year":"2009","unstructured":"Ban Y, Tozaki T, Taniyama M, Nakano Y, Yoneyama K, Ban Y et al. Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population. Autoimmunity 2009; 42: 126\u2013130.","journal-title":"Autoimmunity"},{"key":"BFeye2009244_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1365-2265.1992.tb02284.x","volume":"37","author":"AE Heufelder","year":"1992","unstructured":"Heufelder AE, Bahn RS, Smith TJ . Regulation by glucocorticoids of interferon gamma-induced HLA-DR antigen expression in cultured human orbital fibroblasts. Clin Endocrinol (Oxf) 1992; 37: 59\u201363.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BFeye2009244_CR30","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1210\/jcem-73-2-307","volume":"73","author":"AE Heufelder","year":"1991","unstructured":"Heufelder AE, Smith TJ, Gorman CA, Bahn RS . Increased induction of HLA-DR by interferon-gamma in cultured fibroblasts derived from patients with Graves\u2019 ophthalmopathy and pretibial dermopathy. J Clin Endocrinol Metab 1991; 73: 307\u2013313.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2009244_CR31","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.clinbiochem.2006.11.009","volume":"40","author":"MY Shiau","year":"2007","unstructured":"Shiau MY, Huang CN, Yang TP, Hwang YC, Tsai KJ, Chi CJ et al. Cytokine promoter polymorphisms in Taiwanese patients with Graves\u2019 disease. Clin Biochem 2007; 40: 213\u2013217.","journal-title":"Clin Biochem"},{"key":"BFeye2009244_CR32","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/sj.gene.6364066","volume":"5","author":"MJ Simmonds","year":"2004","unstructured":"Simmonds MJ, Heward JM, Howson JM, Foxall H, Nithiyananthan R, Franklyn JA et al. A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves\u2019 disease. Genes Immun 2004; 5: 267\u2013273.","journal-title":"Genes Immun"},{"key":"BFeye2009244_CR33","first-page":"207","volume":"24","author":"J Nakkuntod","year":"2006","unstructured":"Nakkuntod J, Wongsurawat T, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N . Association of TNF-alpha, TNF-beta, IFN-gamma and IL-1Ra gene polymorphisms with Graves\u2019 disease in the Thai population. Asian Pac J Allergy Immunol 2006; 24: 207\u2013211.","journal-title":"Asian Pac J Allergy Immunol"},{"key":"BFeye2009244_CR34","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s002510050320","volume":"47","author":"T Weissensteiner","year":"1997","unstructured":"Weissensteiner T, Lanchbury JS . TNFB polymorphisms characterize three lineages of TNF region microsatellite haplotypes. Immunogenetics 1997; 47: 6\u201316.","journal-title":"Immunogenetics"},{"key":"BFeye2009244_CR35","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1378\/chest.118.2.503","volume":"118","author":"CA Dinarello","year":"2000","unstructured":"Dinarello CA . Proinflammatory cytokines. Chest 2000; 118: 503\u2013508.","journal-title":"Chest"},{"key":"BFeye2009244_CR36","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s10067-006-0503-z","volume":"26","author":"G Alayli","year":"2007","unstructured":"Alayli G, Aydin F, Coban AY, Sullu Y, Canturk F, Bek Y et al. T helper 1 type cytokines polymorphisms: association with susceptibility to Behcet's disease. Clin Rheumatol 2007; 26: 1299\u20131305.","journal-title":"Clin Rheumatol"},{"key":"BFeye2009244_CR37","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1046\/j.0022-202X.2003.22108.x","volume":"122","author":"M Carrozzo","year":"2004","unstructured":"Carrozzo M, Uboldi de Capei M, Dametto E, Fasano ME, Arduino P, Broccoletti R et al. Tumor necrosis factor-alpha and interferon-gamma polymorphisms contribute to susceptibility to oral lichen planus. J Invest Dermatol 2004; 122: 87\u201394.","journal-title":"J Invest Dermatol"},{"key":"BFeye2009244_CR38","first-page":"666","volume":"82","author":"RA Ajjan","year":"1997","unstructured":"Ajjan RA, Watson PF, Weetman AP . Detection of IL-12, IL-13, and IL-15 messenger ribonucleic acid in the thyroid of patients with autoimmune thyroid disease. J Clin Endocrinol Metab 1997; 82: 666\u2013669.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2009244_CR39","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1046\/j.1365-2265.2003.01708.x","volume":"58","author":"IM Wakelkamp","year":"2003","unstructured":"Wakelkamp IM, Bakker O, Baldeschi L, Wiersinga WM, Prummel MF . TSH-R expression and cytokine profile in orbital tissue of active vs inactive Graves\u2019 ophthalmopathy patients. Clin Endocrinol (Oxf) 2003; 58: 280\u2013287.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BFeye2009244_CR40","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/sj.gene.6363661","volume":"1","author":"MA Hall","year":"2000","unstructured":"Hall MA, McGlinn E, Coakley G, Fisher SA, Boki K, Middleton D et al. Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun 2000; 1: 219\u2013224.","journal-title":"Genes Immun"},{"key":"BFeye2009244_CR41","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1465-9921-4-6","volume":"4","author":"P Latsi","year":"2003","unstructured":"Latsi P, Pantelidis P, Vassilakis D, Sato H, Welsh KI, du Bois RM . Analysis of IL-12 p40 subunit gene and IFN-gamma G5644A polymorphisms in Idiopathic Pulmonary Fibrosis. Respir Res 2003; 4: 6.","journal-title":"Respir Res"},{"key":"BFeye2009244_CR42","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/ana.1107","volume":"50","author":"T van Veen","year":"2001","unstructured":"van Veen T, Crusius JB, Schrijver HM, Bouma G, Killestein J, van Winsen L et al. Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis. Ann Neurol 2001; 50: 275.","journal-title":"Ann Neurol"},{"key":"BFeye2009244_CR43","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/84872","volume":"27","author":"G Morahan","year":"2001","unstructured":"Morahan G, Huang D, Ymer SI, Cancilla MR, Stephen K, Dabadghao P et al. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. Nat Genet 2001; 27: 218\u2013221.","journal-title":"Nat Genet"},{"key":"BFeye2009244_CR44","first-page":"159","volume":"23","author":"A Pawlik","year":"2005","unstructured":"Pawlik A, Kurzawski M, Florczak M, Gawronska Szklarz B, Herczynska M . IL1beta+3953 exon 5 and IL-2 -330 promoter polymorphisms in patients with rheumatoid arthritis. Clin Exp Rheumatol 2005; 23: 159\u2013164.","journal-title":"Clin Exp Rheumatol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye2009244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2009244","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2009244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:09:09Z","timestamp":1684429749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye2009244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,2]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["BFeye2009244"],"URL":"https:\/\/doi.org\/10.1038\/eye.2009.244","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,2]]}}}