{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:36:12Z","timestamp":1790742972806,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T00:00:00Z","timestamp":1268956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1038\/eye.2010.24","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T10:48:11Z","timestamp":1268995691000},"page":"1331-1337","source":"Crossref","is-referenced-by-count":60,"title":["The effect of preservative-free HP-Guar on dry eye after phacoemulsification: a flow cytometric study"],"prefix":"10.1038","volume":"24","author":[{"given":"M A","family":"S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Arriola-Villalobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Torralbo-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"de la Heras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Herrero Vanrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"\u00c1lvarez-Barrientos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Ben\u00edtez-del-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,19]]},"reference":[{"key":"BFeye201024_CR1","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0002-9394(14)71688-5","volume":"124","author":"OD Schein","year":"1997","unstructured":"Schein OD, Munoz B, Tielsch JM, Bandeen-Roche K, West S . Prevalence of dry eye among elderly. Am J Ophthalmol 1997; 124: 723\u2013728.","journal-title":"Am J Ophthalmol"},{"key":"BFeye201024_CR2","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1136\/bjo.76.9.545","volume":"76","author":"C Baudouin","year":"1992","unstructured":"Baudouin C, Haouat N, Brignole F, Bayle J, Gastaud P . Immunopathological findings in conjunctival cells using immunofluorescence staining of impression cytology specimens. Br J Ophthalmol 1992; 76: 545\u2013549.","journal-title":"Br J Ophthalmol"},{"key":"BFeye201024_CR3","first-page":"3943","volume":"35","author":"AK Mircheff","year":"1994","unstructured":"Mircheff AK, Wood RL, Gierow JP . Traffic of major histocompatibility complex class II molecules in rabbit lacrimal gland acinar cells. Invest Ophthalmol Vis Sci 1994; 35: 3943\u20133953.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye201024_CR4","first-page":"28","volume":"40","author":"K Tsubota","year":"1999","unstructured":"Tsubota K, Fukagawa K, Fujihara T, Shimmura S, Saito I, Saito K et al. Regulation of human leukocyte antigen expression in human conjunctival epithelium. Invest Ophthalmol Vis Sci 1999; 40: 28\u201334.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye201024_CR5","first-page":"1458","volume":"8","author":"C Baudouin","year":"1997","unstructured":"Baudouin C, Brignole F, Becquet F, Pisella PJ, Goguel A . Flow cytometry in impression cytology specimens: a new method for evaluation of conjunctival inflammation. Invest Ophthalmol Vis Sci 1997; 8: 1458\u20131464.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye201024_CR6","doi-asserted-by":"crossref","unstructured":"The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007; 5: 75\u201392.","DOI":"10.1016\/S1542-0124(12)70081-2"},{"key":"BFeye201024_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0002-9394(01)01365-4","volume":"133","author":"E Goto","year":"2002","unstructured":"Goto E, Yagi Y, Matsumoto Y, Tsubota K . Impaired functional visual acuity of dry eye patients. Am J Ophthalmol 2002; 133: 181\u2013186.","journal-title":"Am J Ophthalmol"},{"key":"BFeye201024_CR8","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S0161-6420(99)00513-8","volume":"106","author":"Z Liu","year":"1999","unstructured":"Liu Z, Pflugfelder S . Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency. Ophthalmology 1999; 106: 939\u2013943.","journal-title":"Ophthalmology"},{"key":"BFeye201024_CR9","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/S0161-6420(03)00462-7","volume":"110","author":"RM Schiffman","year":"2003","unstructured":"Schiffman RM, Walt JG, Jacobsen G, Doyle JJ, Lebovics G, Sumner W . Utility assessment among patients with dry eye disease. Ophthalmology 2003; 110: 1412\u20131419.","journal-title":"Ophthalmology"},{"key":"BFeye201024_CR10","first-page":"2747","volume":"38","author":"Z Liu","year":"2002","unstructured":"Liu Z, Luo L, Zhang Z, Cheng B, Zheng D, Chen W et al. Tear film changes after phacoemulsification. Zhonghua Yan Ke Za Zhi 2002; 38: 2747.","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"BFeye201024_CR11","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1631\/jzus.B0710359","volume":"9","author":"X Liu","year":"2008","unstructured":"Liu X, Yang-Shun GU, Ye-Sheng XU . Changes of tear film and tear secretion after phacoemulsification in diabetic patients. J Zhejiang Univ Sci B 2008; 9: 324\u2013328.","journal-title":"J Zhejiang Univ Sci B"},{"key":"BFeye201024_CR12","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1097\/ICO.0b013e31812f67ca","volume":"26","author":"XM Li","year":"2007","unstructured":"Li XM, Hu L, Hu J, Wang W . Investigation of dry eye disease and analysis of the phatogenic factors in patients after cataract surgery. Cornea 2007; 26: S16\u2013S20.","journal-title":"Cornea"},{"key":"BFeye201024_CR13","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1097\/ICO.0b013e3180de1c38","volume":"26","author":"GW Ousler","year":"2007","unstructured":"Ousler GW, Michaelson C, Christensen MT . An evaluation of tear film breakup time extension and ocular protection index scores among three marketed lubricant eye drops. Cornea 2007; 26: 949\u2013952.","journal-title":"Cornea"},{"key":"BFeye201024_CR14","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1007\/s12325-008-0112-0","volume":"25","author":"MT Christensen","year":"2008","unstructured":"Christensen MT . Corneal staining reductions observed after treatment with Systane lubricant eye drops. Adv Ther 2008; 25: 1191\u20131199.","journal-title":"Adv Ther"},{"key":"BFeye201024_CR15","doi-asserted-by":"publisher","first-page":"327","DOI":"10.4321\/S0365-66912006000600006","volume":"81","author":"I Cervan-Lopez","year":"2006","unstructured":"Cervan-Lopez I, Saenz-Frances-San-Baldomero F, Benitez-del-Castillo JM, Garcia-Sanchez J . Reduction of corneal permeability in patients treated with HP-Guar: A fluorophotometric study. Arch Soc Esp Oftalmol 2006; 81: 327\u2013332.","journal-title":"Arch Soc Esp Oftalmol"},{"key":"BFeye201024_CR16","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.exer.2003.08.005","volume":"78","author":"F Brignole-Baudouin","year":"2004","unstructured":"Brignole-Baudouin F, Ott AC, Warnet JM, Baudouin C . Flow cytometry in conjunctival impression cytology: a new tool for exploring ocular surface pathologies. Exp Eye Res 2004; 78: 473\u2013481.","journal-title":"Exp Eye Res"},{"key":"BFeye201024_CR17","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1006\/exer.1998.0566","volume":"67","author":"F Brignole","year":"1998","unstructured":"Brignole F, de Saint-Jean M, Goldschild M, Becqet F, Goguel A, Baudouin C . Expression of Fas-Fas ligand antigens and apoptotic marker APO2-7 by the human conjunctival epithelium. Positive correlation with class II HLA DR expression in inflammatory ocular surface disorders. Exp Eye Res 1998; 67: 687\u2013697.","journal-title":"Exp Eye Res"},{"key":"BFeye201024_CR18","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/S0161-6420(00)00347-X","volume":"107","author":"PJ Pisella","year":"2000","unstructured":"Pisella PJ, Brignole F, Debbasch C, Lozat P, Garcher C, Bara J et al. Flow cytometric analysis of conjunctival epithelium in occular rosacea and keratoconjunctivitis sicca. Ophthalmology 2000; 107: 1841\u20131849.","journal-title":"Ophthalmology"},{"key":"BFeye201024_CR19","first-page":"1446","volume":"112","author":"F Brignole","year":"2001","unstructured":"Brignole F, Pisella PJ, De Saint Jean M, Goldschild M, Goguel A, Baudouin C . Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A. Invest Ophthalmol Vis Sci 2001; 112: 1446\u20131454.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye201024_CR20","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1097\/00003226-200310000-00008","volume":"22","author":"AJ Bron","year":"2003","unstructured":"Bron AJ, Evans VE, Smith JA . Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea 2003; 22: 640\u2013650.","journal-title":"Cornea"},{"key":"BFeye201024_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.4321\/S0365-66912004000600004","volume":"79","author":"E Vico","year":"2004","unstructured":"Vico E, Ben\u00edtez del Castillo JM, Jim\u00e9nez RA, Fern\u00e1ndez C, Garc\u00eda S\u00e1nchez J . Tear function index validation for dry eye diagnosis. Arch Soc Esp Oftalmol 2004; 79: 265\u2013271.","journal-title":"Arch Soc Esp Oftalmol"},{"key":"BFeye201024_CR22","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1001\/archopht.119.6.841","volume":"119","author":"RM Schiffman","year":"2001","unstructured":"Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL . Reliability and validity of ocular surface disease index. Arch Ophthalmol 2001; 119: 456.","journal-title":"Arch Ophthalmol"},{"key":"BFeye201024_CR23","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/00003226-199811000-00002","volume":"17","author":"ME Stern","year":"1998","unstructured":"Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC . The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 1998; 17: 584\u2013589.","journal-title":"Cornea"},{"key":"BFeye201024_CR24","first-page":"1356","volume":"41","author":"F Brignole","year":"2000","unstructured":"Brignole F, Pisella PJ, Goldschild M, De Saint Jean M, Goguel A, Baudouin C . Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest Ophthalmol Vis Sci 2000; 41: 1356\u20131363.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye201024_CR25","first-page":"2609","volume":"43","author":"ME Stern","year":"2002","unstructured":"Stern ME, Gao J, Schwalb TA, Ngo M, Tieu DD, Chan CC et al. Conjunctival T-cell subpopulations in Sj\u00f6gren's and non-Sj\u00f6gren's patients with dry eye. Invest Ophthalmol Vis Sci 2002; 43: 2609\u20132614.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye201024_CR26","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1001\/archopht.118.11.1489","volume":"118","author":"KS Kunert","year":"2000","unstructured":"Kunert KS, Tisdale AS, Stern ME, Smith JA, Gipson IK . Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes. Arch Ophthalmol 2000; 118: 1489\u20131496.","journal-title":"Arch Ophthalmol"},{"key":"BFeye201024_CR27","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.jcrs.2007.06.019","volume":"33","author":"R Mont\u00e9s-Mic\u00f3","year":"2007","unstructured":"Mont\u00e9s-Mic\u00f3 R . Role of the tear film in the optical quality of the human eye. J Cataract Refract Surg 2007; 33: 1631\u20131635.","journal-title":"J Cataract Refract Surg"},{"key":"BFeye201024_CR28","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S0161-6420(99)00513-8","volume":"106","author":"Z Liu","year":"1999","unstructured":"Liu Z, Pflugfelder S . Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency. Ophthalmology 1999; 106: 939\u2013943.","journal-title":"Ophthalmology"},{"key":"BFeye201024_CR29","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.ajo.2005.05.001","volume":"140","author":"MR Nilforoushan","year":"2005","unstructured":"Nilforoushan MR, Latkany RA, Speaker MG . Effect of artificial tears on visual acuity. Am J Ophthalmol 2005; 140: 830\u2013835.","journal-title":"Am J Ophthalmol"},{"key":"BFeye201024_CR30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1475-1313.2008.00539.x","volume":"28","author":"S Khanal","year":"2008","unstructured":"Khanal S, Tomlison A, Esakowitz L, Bhatt P, Jones D, Nabili S et al. Changes in corneal sensitivity and tear physiology after phacoemulsification. Ophthal Physiol Opt 2008; 28: 127\u2013134.","journal-title":"Ophthal Physiol Opt"},{"key":"BFeye201024_CR31","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/S0886-3350(98)80237-X","volume":"24","author":"M Kohlhaas","year":"1998","unstructured":"Kohlhaas M . Corneal sensation after cataract and refractive surgery. J Cataract Refract Surg 1998; 24: 1399\u20131409.","journal-title":"J Cataract Refract Surg"},{"key":"BFeye201024_CR32","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1080\/02713680490503787","volume":"28","author":"JL Ubels","year":"2004","unstructured":"Ubels JL, Clousing DP, Van Haitsma TA, Hong BS, Stauffer P, Asgharian B et al. Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent. Curr Eye Res 2004; 28: 437\u2013444.","journal-title":"Curr Eye Res"},{"key":"BFeye201024_CR33","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1001\/archophthalmol.2007.61","volume":"126","author":"S Rashid","year":"2008","unstructured":"Rashid S, Jin Y, Ecoiffier T, Barabino S, Schaumberg DA, Dana MR . Topical omega-3 and omega-6 fatty acids for treatment of dry eye. Arch Ophthalmol 2008; 126: 219\u2013225.","journal-title":"Arch Ophthalmol"},{"key":"BFeye201024_CR34","first-page":"14","volume":"32","author":"CW Roberts","year":"2007","unstructured":"Roberts CW, Elie ER . Dry eye symptoms following cataract surgery. Insight 2007; 32: 14\u201321.","journal-title":"Insight"},{"key":"BFeye201024_CR35","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1111\/j.1442-9071.2009.02134.x","volume":"37","author":"G Fakhraie","year":"2009","unstructured":"Fakhraie G, Lopes JF, Spaeth GL, Almodin J, Ichhpujani P, Moster MR . Effects of postoperative cyclosporine ophthalmic emulsion 0.05% (Restasis) following glaucoma surgery. Clin Experiment Ophthalmol 2009; 37: 842\u2013848.","journal-title":"Clin Experiment Ophthalmol"},{"key":"BFeye201024_CR36","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/S0886-3350(02)01387-1","volume":"28","author":"J Ram","year":"2002","unstructured":"Ram J, Gupta A, Brar GS, Kaushik S, Gupta A . Outcomes of phacoemulsification in patients with dry eye. J Cataract Refract Surg 2002; 28: 1386\u20131389.","journal-title":"J Cataract Refract Surg"},{"key":"BFeye201024_CR37","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1097\/ICO.0b013e31816f6854","volume":"27","author":"DR Hardten","year":"2008","unstructured":"Hardten DR . Dry eye disease in patients after cataract surgery. Cornea 2008; 27: 855.","journal-title":"Cornea"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye201024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye201024","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye201024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:12:05Z","timestamp":1684429925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye201024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,19]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["BFeye201024"],"URL":"https:\/\/doi.org\/10.1038\/eye.2010.24","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,19]]}}}