{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:37:58Z","timestamp":1785213478184,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T00:00:00Z","timestamp":1366329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1038\/eye.2013.73","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T11:52:09Z","timestamp":1366372329000},"page":"823-827","source":"Crossref","is-referenced-by-count":3,"title":["The role of apoptosis in blepharoptosis"],"prefix":"10.1038","volume":"27","author":[{"given":"E","family":"\u015eahl\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B M","family":"Ho\u015fal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Zilelio\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Din\u00e7er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G G","family":"Tezel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,19]]},"reference":[{"key":"BFeye201373_CR1","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/00001665-200603000-00008","volume":"17","author":"L Clauser","year":"2006","unstructured":"Clauser L, Tieghi R, Galie M . Palpebral ptosis: clinical classification, differential diagnosis, and surgical guidelines: an overview. J Craniofac Surg 2006; 17: 246\u2013254.","journal-title":"J Craniofac Surg"},{"key":"BFeye201373_CR2","unstructured":"American Academy of Ophthalmology. Periocular malpositions and involutional changes. In: Basic and Clinical Science Course (BCSC) Section 7: Orbit, Eyelids, and Lacrimal System. American Academy of Ophthalmology: San Francisco, CA, 2007; 201\u2013255."},{"key":"BFeye201373_CR3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/00002341-200207000-00013","volume":"18","author":"HC Baldwin","year":"2002","unstructured":"Baldwin HC, Manners RM . Congenital blepharoptosis: a literature review of the histology of levator palpebrae superioris muscle. Ophtal Plast Reconstr Surg 2002; 18: 301\u2013307.","journal-title":"Ophtal Plast Reconstr Surg"},{"key":"BFeye201373_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/eye.1988.32","volume":"2","author":"FC Sutula","year":"1988","unstructured":"Sutula FC . Histological changes in congenital and acquired blepharoptosis. Eye 1988; 2: 179\u2013184.","journal-title":"Eye"},{"key":"BFeye201373_CR5","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1001\/archopht.1995.01100110074028","volume":"113","author":"BJ Clark","year":"1995","unstructured":"Clark BJ, Kemp EG, Behan WMH, Lee WR . Abnormal extracellular material in the levator palpebrae superioris complex in congenital ptosis. Arch Ophthalmol 1995; 113: 1414\u20131419.","journal-title":"Arch Ophthalmol"},{"key":"BFeye201373_CR6","first-page":"1150","volume":"60","author":"EC Engle","year":"1997","unstructured":"Engle EC, Castro AE, Macy ME, Knoll JH, Beggs AH . A gene for isolated congenital ptosis maps to a 3-cM region within 1p32-p34.1. Am J Hum Genet 1997; 60: 1150\u20131157.","journal-title":"Am J Hum Genet"},{"key":"BFeye201373_CR7","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1086\/302860","volume":"66","author":"TF McMullan","year":"2000","unstructured":"McMullan TF, Collins AR, Tyers AG, Robinson DO . A novel X-linked dominant condition: X-linked congenital isolated ptosis. Am J Hum Genet 2000; 66: 1455\u20131460.","journal-title":"Am J Hum Genet"},{"key":"BFeye201373_CR8","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s00439-002-0679-5","volume":"110","author":"TW McMullan","year":"2002","unstructured":"McMullan TW, Crolla JA, Gregory SG, Carter NP, Cooper RA, Howell GR et al. A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. Hum Genet 2002; 110: 244\u2013250.","journal-title":"Hum Genet"},{"key":"BFeye201373_CR9","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1001\/archopht.1980.01020040897022","volume":"98","author":"RK Dortzbach","year":"1980","unstructured":"Dortzbach RK, Sutula FC . Involutional blepharoptosis: A histopathological study. Arch Ophthalmol 1980; 98: 2045\u20132049.","journal-title":"Arch Ophthalmol"},{"key":"BFeye201373_CR10","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/S0002-9394(14)78107-3","volume":"85","author":"JRO Collin","year":"1978","unstructured":"Collin JRO, Beard C, Wood I . Experimental and clinical data on the insertion of the levator palpebrae superioris muscle. Am J Ophthalmol 1978; 85: 792\u2013801.","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"BFeye201373_CR11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3109\/01676839409107920","volume":"13","author":"BM Hosal","year":"1994","unstructured":"Hosal BM, Pavlin CJ, Hurwitz JJ . Clinical use of ultrasound biomicroscopy in involutional blepharoptosis. Orbit 1994; 13 (4): 167\u2013171.","journal-title":"Orbit"},{"issue":"4","key":"BFeye201373_CR12","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/01.IOP.0000129532.33913.E7","volume":"20","author":"BM Hosal","year":"2004","unstructured":"Hosal BM, Ayer NG, Zilelio\u011flu G, Elhan AH . Ultrasound biomicroscopy of the levator aponeurosis in congenital and aponeurotic blepharoptosis. Ophthal Plast Reconstr Surg 2004; 20 (4): 308\u2013311.","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"BFeye201373_CR13","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/S0344-0338(96)80089-6","volume":"192","author":"FT Bosman","year":"1996","unstructured":"Bosman FT, Visser BC, van Oeveren J . Apoptosis: pathophysiology of programmed cell death. Path Res Pract 1996; 192: 676\u2013683.","journal-title":"Path Res Pract"},{"key":"BFeye201373_CR14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF01007836","volume":"235","author":"TH Tezel","year":"1997","unstructured":"Tezel TH, Del Priore LV . Reattachment to a substrate prevents apoptosis of human retinal pigment epithelium. Graefes. Arch Clin Exp Ophthalmol 1997; 235: 41\u201347.","journal-title":"Graefes. Arch Clin Exp Ophthalmol"},{"key":"BFeye201373_CR15","first-page":"2660","volume":"40","author":"G Tezel","year":"1999","unstructured":"Tezel G, Wax MB . Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci 1999; 40: 2660\u20132667.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye201373_CR16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3109\/13816819609057889","volume":"17","author":"RW Nickells","year":"1996","unstructured":"Nickells RW, Zack DJ . Apoptosis in ocular disease: a molecular overview. Ophthalmic Genetics 1996; 17: 145\u2013165.","journal-title":"Ophthalmic Genetics"},{"key":"BFeye201373_CR17","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1177\/002215549904700901","volume":"47","author":"MC Willingham","year":"1999","unstructured":"Willingham MC . Cytochemical methods for the detection of apoptosis. J Histochem Cytochem 1999; 47: 1101\u20131109.","journal-title":"J Histochem Cytochem"},{"key":"BFeye201373_CR18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0531-5565(98)00031-X","volume":"33","author":"R Sgonc","year":"1998","unstructured":"Sgonc R, Gruber J . Apoptosis detection: an overview. Exp Gerontol 1998; 33: 525\u2013530.","journal-title":"Exp Gerontol"},{"key":"BFeye201373_CR19","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1385\/IJGC:32:2-3:73","volume":"32","author":"M Jinfeng","year":"2002","unstructured":"Jinfeng M, Kimura W, Sakurai F, Moriya T, Takeshita A, Hirai I . Histopathological study of intraductal papillary mucinous tumor of the pancreas: special reference to the roles of Survivin and p53 in tumorigenesis of IPMT. Int J Gastrointest Cancer 2002; 32: 73\u201381.","journal-title":"Int J Gastrointest Cancer"},{"key":"BFeye201373_CR20","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1002\/1097-0142(20010601)91:11<2026::AID-CNCR1228>3.0.CO;2-E","volume":"91","author":"H Kawasaki","year":"2001","unstructured":"Kawasaki H, Toyoda M, Shinohara H, Okuda J, Watanabe I, Yamamoto T et al. Expression of surviving correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. Cancer 2001; 91: 2026\u20132032.","journal-title":"Cancer"},{"key":"BFeye201373_CR21","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1053\/hupa.2000.20372","volume":"31","author":"Y Yoshida","year":"2000","unstructured":"Yoshida Y, Kurokawa T, Fukuno N, Nishikawa Y, Kamitani N, Kotsuji F . Markers of apoptosis and angiogenesis indicate that carcinomatous components play an important role in the malignant behavior of uterine carcinosarcoma. Hum Pathol 2000; 31: 1448\u20131454.","journal-title":"Hum Pathol"},{"key":"BFeye201373_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000030429","volume":"63","author":"B Szende","year":"1999","unstructured":"Szende B, Romics I, Torda I, Bely M, Szegedi Z, Lovasz S . Apoptosis, mitosis, p53, bcl(2), Ki-67 and clinical outcome in prostate carcinoma treated by androgen ablation. Urol Int 1999; 63: 115\u2013119.","journal-title":"Urol Int"},{"key":"BFeye201373_CR23","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1711::AID-CNCR10>3.0.CO;2-L","volume":"85","author":"M Ohtani","year":"1999","unstructured":"Ohtani M, Isozaki H, Fujii K, Nomura E, Niki M, Mabuchi H et al. Impact of the expression of cyclin-dependent kinase inhibitor p27Kip1 and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma. Cancer 1999; 85: 1711\u20131718.","journal-title":"Cancer"},{"key":"BFeye201373_CR24","first-page":"69","volume":"7","author":"A Hornblass","year":"1976","unstructured":"Hornblass A, Adachi M, Wolintz A, Smith B . Clinical and ultrastructural correlation in congenital and acquired ptosis. Ophthal Surg 1976; 7: 69\u201376.","journal-title":"Ophthal Surg"},{"key":"BFeye201373_CR25","first-page":"23","volume":"243","author":"JM Lemagne","year":"1992","unstructured":"Lemagne JM, Colonval S, Moens B, Brucher JM . Anatomical modification of the levator muscle of the eyelid in congenital ptosis. Bull Soc Belge Ophthalmol 1992; 243: 23\u201327.","journal-title":"Bull Soc Belge Ophthalmol"},{"key":"BFeye201373_CR26","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/01.icu.0000186647.00413.21","volume":"16","author":"M Baroody","year":"2005","unstructured":"Baroody M, Holds JB, Vick VL . Advances in the diagnosis and treatment of ptosis. Curr Opin Ophthalmol 2005; 16: 351\u2013355.","journal-title":"Curr Opin Ophthalmol"},{"key":"BFeye201373_CR27","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/00055735-199910000-00010","volume":"10","author":"PJ Sakol","year":"1999","unstructured":"Sakol PJ, Mannor G, Massaro BM . Congenital and acquired blepharoptosis. Curr Opin Ophthalmol 1999; 10: 335\u2013339.","journal-title":"Curr Opin Ophthalmol"},{"key":"BFeye201373_CR28","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0891-5849(97)00388-2","volume":"24","author":"N Maulik","year":"1998","unstructured":"Maulik N, Yoshida T, Das DK . Oxidative stres developed during the reperfusion of ischemic myocardium induces apoptosis. Free Radic Biol Med 1998; 24: 869\u2013875.","journal-title":"Free Radic Biol Med"},{"key":"BFeye201373_CR29","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1196\/annals.1299.135","volume":"1010","author":"J Reszec","year":"2003","unstructured":"Reszec J, Sulkowska M, Kanczuga-Koda L, Janica J, Skawronska M, Pepinski W et al. Evaluation of apoptosis markers in conjunctival and eyelid benign and malignant tumors. Ann NY Acad Sci 2003; 1010: 748\u2013751.","journal-title":"Ann NY Acad Sci"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye201373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye201373","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye201373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:21:21Z","timestamp":1684430481000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye201373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,19]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["BFeye201373"],"URL":"https:\/\/doi.org\/10.1038\/eye.2013.73","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,19]]}}}