{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:00:32Z","timestamp":1791910832666,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T00:00:00Z","timestamp":1406246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1038\/eye.2014.163","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T09:39:44Z","timestamp":1406281184000},"page":"1179-1183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Pulsed vs continuous light accelerated corneal collagen crosslinking: in vivo qualitative investigation by confocal microscopy and corneal OCT"],"prefix":"10.1038","volume":"28","author":[{"given":"C","family":"Mazzotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Traversi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Caragiuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rechichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,25]]},"reference":[{"issue":"5","key":"BFeye2014163_CR1","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler Th . Riboflavin\/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophtalmol 2003; 135 (5): 620\u2013627.","journal-title":"Am J Ophtalmol"},{"issue":"5","key":"BFeye2014163_CR2","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jcrs.2006.01.091","volume":"32","author":"A Caporossi","year":"2006","unstructured":"Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T . Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A-induced crosslinking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg 2006; 32 (5): 837\u2013845.","journal-title":"J Cataract Refract Surg"},{"issue":"12","key":"BFeye2014163_CR3","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1016\/j.jcrs.2007.07.028","volume":"33","author":"F Hafezi","year":"2007","unstructured":"Hafezi F, Kanellopoulos J, Wiltfang R, Seiler T . Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis. J Cataract Refract Surg 2007; 33 (12): 2035\u20132040.","journal-title":"J Cataract Refract Surg"},{"issue":"9","key":"BFeye2014163_CR4","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/S0886-3350(03)00407-3","volume":"29","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T . Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced crosslinking. J Cataract Refract Surg 2003; 29 (9): 1780\u20131785.","journal-title":"J Cataract Refract Surg"},{"issue":"5","key":"BFeye2014163_CR5","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/01.ico.0000105827.85025.7f","volume":"23","author":"G Wollensak","year":"2004","unstructured":"Wollensak G, Wilsch M, Spoerl E, Seiler T . Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin\/UVA. Cornea 2004; 23 (5): 503\u2013507.","journal-title":"Cornea"},{"issue":"1","key":"BFeye2014163_CR6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/02713680490513182","volume":"29","author":"E Spoerl","year":"2004","unstructured":"Spoerl E, Wollensak G, Seiler T . Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 2004; 29 (1): 35\u201340.","journal-title":"Curr Eye Res"},{"issue":"4","key":"BFeye2014163_CR7","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1167\/iovs.11-9385","volume":"53","author":"P Kamaev","year":"2012","unstructured":"Kamaev P, Friedman MD, Sherr E, Muller D . Photochemical kinetics of corneal crosslinking with riboflavin. Invest Ophthalmol Vis Sci. 2012; 53 (4): 2360\u20132367.","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"BFeye2014163_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/exer.1997.0410","volume":"66","author":"E Spoerl","year":"1998","unstructured":"Spoerl E, Huhle M, Seiler T . The Induction of cross links in corneal tissue. Exp Eye Res 1998; 66: 97\u2013103.","journal-title":"Exp Eye Res"},{"issue":"6","key":"BFeye2014163_CR9","first-page":"711","volume":"15","author":"E Spoerl","year":"1999","unstructured":"Spoerl E, Seiler T . Techniques for stiffening the cornea. J Refract Surg 1999; 15 (6): 711\u2013713.","journal-title":"J Refract Surg"},{"issue":"5","key":"BFeye2014163_CR10","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","volume":"34","author":"F Raiskup-Wolf","year":"2008","unstructured":"Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE . Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: Long-term results. J Cataract Refract Surg 2008; 34 (5): 796\u2013801.","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"BFeye2014163_CR11","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ajo.2009.10.021","volume":"149","author":"A Caporossi","year":"2010","unstructured":"Caporossi A, Mazzotta C, Baiocchi S, Caporossi T . Long-term results of riboflavin ultraviolet A corneal collagen crosslinking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 2010; 149 (4): 585\u2013593.","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"BFeye2014163_CR12","doi-asserted-by":"publisher","first-page":"S720","DOI":"10.3928\/1081597X-20080901-15","volume":"24","author":"C Wittig-Silva","year":"2008","unstructured":"Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR . A randomized controlled trial of corneal collagen crosslinking in progressive keratoconus: preliminary results. J Refract Surg 2008; 24 (7): S720\u2013S725.","journal-title":"J Refract Surg"},{"key":"BFeye2014163_CR13","doi-asserted-by":"publisher","first-page":"608041","DOI":"10.1155\/2011\/608041","volume":"2011","author":"A Caporossi","year":"2011","unstructured":"Caporossi A, Mazzotta C, Baiocchi S, Caporossi T, Denaro R . Age-related long-term functional results after riboflavin UV A corneal crosslinking. J Ophthalmol 2011; 2011: 608041.","journal-title":"J Ophthalmol"},{"issue":"3","key":"BFeye2014163_CR14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/ICO.0b013e31822159f6","volume":"31","author":"A Caporossi","year":"2012","unstructured":"Caporossi A, Mazzotta C, Baiocchi S, Caporossi T, Denaro R, Balestrazzi A . Riboflavin-UVA-induced corneal collagen crosslinking in pediatric patients. Cornea 2012; 31 (3): 227\u2013231.","journal-title":"Cornea"},{"issue":"4","key":"BFeye2014163_CR15","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/ICO.0b013e3180334f78","volume":"26","author":"E Spoerl","year":"2007","unstructured":"Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T . Safety of UVA-riboflavin crosslinking of the cornea. Cornea 2007; 26 (4): 385\u2013389.","journal-title":"Cornea"},{"issue":"1","key":"BFeye2014163_CR16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1113\/jphysiol.1952.sp004779","volume":"118","author":"Gs Brindley","year":"1952","unstructured":"Brindley Gs . The Bunsen-Roscoe law for the human eye at very short durations. J Physiol 1952; 118 (1): 135\u2013139.","journal-title":"J Physiol"},{"issue":"12","key":"BFeye2014163_CR17","doi-asserted-by":"publisher","first-page":"9048","DOI":"10.1167\/iovs.11-7818","volume":"52","author":"S Schumacher","year":"2011","unstructured":"Schumacher S, Oeftiger L, Mrochen M . Equivalence of biomechanical changes induced by rapid and standard corneal crosslinking, using riboflavin and ultraviolet radiation. Invest Ophthalmol Vis Sci 2011; 52 (12): 9048\u20139052.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"BFeye2014163_CR18","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1167\/iovs.12-11409","volume":"54","author":"J Wernli","year":"2013","unstructured":"Wernli J, Schumacher S, Spoerl E, Mrochen M . The efficacy of corneal crosslinking shows a sudden decrease with very high intensity UV light and short treatment time. Invest Ophthalmol Vis Sci 2013; 54 (2): 1176\u20131180.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"BFeye2014163_CR19","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/j.jcrs.2012.03.034","volume":"38","author":"HU Celik","year":"2012","unstructured":"Celik HU, Alag\u00f6z N, Yildirim Y, Agca A, Marshall J, Demirok A et al. Accelerated corneal crosslinking concurrent with laser in situ keratomileusis. J Cataract Refract Surg 2012; 38 (8): 1424\u20131431.","journal-title":"J Cataract Refract Surg"},{"key":"BFeye2014163_CR20","volume-title":"Proceedings of the Third International Congress of Corneal Collagen Crosslinking","author":"RR Krueger","year":"2007","unstructured":"Krueger RR, Spoerl E, Herekar S . Rapid vs standard collagen CXL with equivalent energy dosing. In: Proceedings of the Third International Congress of Corneal Collagen Crosslinking 2007 Zurich, Switzerland."},{"key":"BFeye2014163_CR21","unstructured":"Herekar SV inventor; Method for equi-dosed time fractionated pulsed UVA irradiation of collagen\/riboflavin mixtures for ocular structural augmentation. US patent US2009\/0149923A1 11 June 2009."},{"issue":"6","key":"BFeye2014163_CR22","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1136\/bjo.2010.190843","volume":"95","author":"G Wollensak","year":"2011","unstructured":"Wollensak G, Sp\u00f6rl E, Mazzotta C, Kalinski T, Sel S . Interlamellar cohesion after corneal crosslinking using riboflavin and ultraviolet A light. Br J Ophthalmol 2011; 95 (6): 876\u2013880.","journal-title":"Br J Ophthalmol"},{"key":"BFeye2014163_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.4172\/2155-9570.1000313","volume":"4","author":"C Mazzotta","year":"2013","unstructured":"Mazzotta C, Paradiso AL, Baiocchi S, Caragiuli S, Caporossi A . Qualitative investigation of corneal changes after accelerated corneal collagen cross-linking (A-CXL) by in vivo confocal microscopy and corneal OCT. J Clin Exp Ophthalmol 2013; 4: 313.","journal-title":"J Clin Exp Ophthalmol"},{"issue":"3","key":"BFeye2014163_CR24","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1517\/21678707.2013.765799","volume":"1","author":"C Mazzotta","year":"2013","unstructured":"Mazzotta C, Baiocchi S, Caporossi T, Caragiuli S, Paradiso AL, Caporossi A . Riboflavin 0.1% (VibeX) for the treatment of keratoconus. Expert Opin Orphan Drugs 2013; 1 (3): 235\u2013240.","journal-title":"Expert Opin Orphan Drugs"},{"issue":"5","key":"BFeye2014163_CR25","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.jcrs.2009.01.009","volume":"35","author":"S Baiocchi","year":"2009","unstructured":"Baiocchi S, Mazzotta C, Cerretani D, Caporossi T, Caporossi A . Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium. J Cataract Refract Surg. 2009; 35 (5): 893\u2013899.","journal-title":"J Cataract Refract Surg."},{"issue":"6","key":"BFeye2014163_CR26","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.ajo.2014.02.042","volume":"157","author":"C Mazzotta","year":"2014","unstructured":"Mazzotta C, Caragiuli S . Intraoperative corneal thickness measurement by optical coherence tomography in keratoconic patients undergoing corneal collagen cross-linking. Am J Ophthalmol 2014; 157 (6): 1156\u20131162.","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"BFeye2014163_CR27","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/ICO.0b013e318030df5a","volume":"26","author":"C Mazzotta","year":"2007","unstructured":"Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C et al. Treatment of progressive keratoconus by riboflavin-UVA-induced crosslinking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea 2007; 26 (4): 390\u2013397.","journal-title":"Cornea"},{"issue":"4","key":"BFeye2014163_CR28","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ajo.2008.05.042","volume":"146","author":"C Mazzotta","year":"2008","unstructured":"Mazzotta C, Traversi C, Baiocchi S, Caporossi O, Bovone C, Sparano MC et al. Corneal healing after riboflavin ultraviolet-A collagen crosslinking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 2008; 146 (4): 527\u2013533.","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"BFeye2014163_CR29","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3928\/1081597X-20121016-01","volume":"28","author":"D Touboul","year":"2012","unstructured":"Touboul D, Efron N, Smadja D, Praud D, Malet F, Colin J . Corneal confocal microscopy following conventional, transepithelial, and accelerated corneal collagen crosslinking procedures for keratoconus. J Refract Surg 2012; 28 (11): 769\u2013776.","journal-title":"J Refract Surg"},{"issue":"3","key":"BFeye2014163_CR30","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jphotobiol.2005.01.002","volume":"79","author":"H Merwald","year":"2005","unstructured":"Merwald H, Klosner G, Kokesch C, Der-Petrossian M, H\u00f6nigsmann H, Trautinger F . UVA-induced oxidative damage and cytotoxicity depend on the mode of exposure. J Photochem Photobiol B 2005; 79 (3): 197\u2013207.","journal-title":"J Photochem Photobiol B"},{"issue":"2","key":"BFeye2014163_CR31","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1167\/iovs.11-8059","volume":"53","author":"S Schumacher","year":"2012","unstructured":"Schumacher S, Mrochen M, Wernli J, Bueeler M, Seiler T . Optimization model for UV-riboflavin corneal crosslinking. Invest Ophthalmol Vis Sci 2012; 53 (2): 762\u2013769.","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye2014163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2014163","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2014163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:22:11Z","timestamp":1684430531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye2014163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,25]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["BFeye2014163"],"URL":"https:\/\/doi.org\/10.1038\/eye.2014.163","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,25]]},"assertion":[{"value":"4 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}