{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:28:48Z","timestamp":1769617728221,"version":"3.49.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/eye.2016.312","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:08:01Z","timestamp":1484320081000},"page":"698-707","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Nailfold capillary morphology in exfoliation syndrome"],"prefix":"10.1038","volume":"31","author":[{"given":"C C","family":"Cousins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bovee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S H","family":"Greenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Turalba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Q","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Brauner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Boumenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Blum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Levkovitch-Verbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-7547","authenticated-orcid":false,"given":"R","family":"Ritch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Wiggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Knepper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L R","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"BFeye2016312_CR1","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S0161-6420(86)33664-9","volume":"93","author":"AM Prince","year":"1986","unstructured":"Prince AM, Ritch R . Clinical signs of the pseudoexfoliation syndrome. Ophthalmology 1986; 93: 803\u2013807.","journal-title":"Ophthalmology"},{"key":"BFeye2016312_CR2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S1350-9462(99)00019-1","volume":"19","author":"E Vesti","year":"2000","unstructured":"Vesti E, Kivel\u00e4 T . Exfoliation syndrome and exfoliation glaucoma. Prog Retin Eye Res 2000; 19: 345\u2013368.","journal-title":"Prog Retin Eye Res"},{"key":"BFeye2016312_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0039-6257(00)00196-X","volume":"45","author":"R Ritch","year":"2001","unstructured":"Ritch R, Schl\u00f6tzer-Schrehardt U . Exfoliation syndrome. Surv Ophthalmol 2001; 45: 265\u2013315.","journal-title":"Surv Ophthalmol"},{"key":"BFeye2016312_CR4","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1001\/archopht.1992.01080240092038","volume":"110","author":"UM Schl\u00f6tzer-Schrehardt","year":"1992","unstructured":"Schl\u00f6tzer-Schrehardt UM, Koca MR, Naumann GO, Volkholz H . Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophthalmol 1992; 110: 1752\u20131756.","journal-title":"Arch Ophthalmol"},{"key":"BFeye2016312_CR5","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1001\/archopht.1992.01080240097039","volume":"110","author":"BW Streeten","year":"1992","unstructured":"Streeten BW, Li ZY, Wallace RN, Eagle RC Jr., Keshgegian AA . Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol 1992; 110: 1757\u20131762.","journal-title":"Arch Ophthalmol"},{"key":"BFeye2016312_CR6","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1350-9462(02)00014-9","volume":"22","author":"R Ritch","year":"2003","unstructured":"Ritch R, Schl\u00f6tzer-Schrehardt U, Konstas AG . Why is glaucoma associated with exfoliation syndrome? Prog Retin Eye Res 2003; 22: 253\u2013275.","journal-title":"Prog Retin Eye Res"},{"key":"BFeye2016312_CR7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1034\/j.1600-0420.2000.078004437.x","volume":"78","author":"MB Parodi","year":"2000","unstructured":"Parodi MB, Bondel E, Saviano S, Ravalico G . Iris indocyanine green angiography in pseudoexfoliation syndrome and capsular glaucoma. Acta Ophthalmol Scand 2000; 78: 437\u2013442.","journal-title":"Acta Ophthalmol Scand"},{"key":"BFeye2016312_CR8","first-page":"7","volume":"21","author":"M Battaglia Parodi","year":"1998","unstructured":"Battaglia Parodi M, Bondel E, Saviano S, Ravalico G . Fluorescein angiography and indocyanine green videoangiography in the iris of pseudoexfoliation syndrome. Metab Pediatr Syst Ophthalmol (1985) 1998; 21: 7\u201313.","journal-title":"Metab Pediatr Syst Ophthalmol (1985)"},{"key":"BFeye2016312_CR9","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/S0161-6420(87)33329-9","volume":"94","author":"AM Brooks","year":"1987","unstructured":"Brooks AM, Gillies WE . The development of microneovascular changes in the iris in pseudoexfoliation of the lens capsule. Ophthalmology 1987; 94: 1090\u20131097.","journal-title":"Ophthalmology"},{"key":"BFeye2016312_CR10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1177\/112067219900900405","volume":"9","author":"MB Parodi","year":"1999","unstructured":"Parodi MB, Bondel E, Saviano S, Ravalico G . Iris fluorescein angiography and iris indocyanine green videoangiography in pseudoexfoliation syndrome. Eur J Ophthalmol 1999; 9: 284\u2013290.","journal-title":"Eur J Ophthalmol"},{"key":"BFeye2016312_CR11","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1136\/bjo.67.4.249","volume":"67","author":"AM Brooks","year":"1983","unstructured":"Brooks AM, Gillies WE . Fluorescein angiography and fluorophotometry of the iris in pseudoexfoliation of the lens capsule. Br J Ophthalmol 1983; 67: 249\u2013254.","journal-title":"Br J Ophthalmol"},{"key":"BFeye2016312_CR12","first-page":"3","volume":"111","author":"L Laatikainen","year":"1971","unstructured":"Laatikainen L . Fluorescein angiographic studies of the peripapillary and perilimbal regions in simple, capsular and low-tension glaucoma. Acta Ophthalmol Suppl 1971; 111: 3\u201383.","journal-title":"Acta Ophthalmol Suppl"},{"key":"BFeye2016312_CR13","first-page":"879","volume":"10","author":"D Karagiannis","year":"2015","unstructured":"Karagiannis D, Kontadakis GA, Klados NE, Tsoumpris I, Kandarakis AS, Parikakis EA et al. Central retinal vein occlusion and pseudoexfoliation syndrome. Clin Interv Aging 2015; 10: 879\u2013883.","journal-title":"Clin Interv Aging"},{"key":"BFeye2016312_CR14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1755-3768.2009.01578.x","volume":"88","author":"R Ritch","year":"2010","unstructured":"Ritch R, Prata TS, de Moraes CG, Vessani RM, Costa VP, Konstas AG et al. Association of exfoliation syndrome and central retinal vein occlusion: an ultrastructural analysis. Acta Ophthalmol 2010; 88: 91\u201395.","journal-title":"Acta Ophthalmol"},{"key":"BFeye2016312_CR15","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/eye.2010.175","volume":"25","author":"MR Praveen","year":"2011","unstructured":"Praveen MR, Shah SK, Vasavada AR, Diwan RP, Shah SM, Zumkhawala BR et al. Pseudoexfoliation as a risk factor for peripheral vascular disease: a case-control study. Eye 2011; 25: 174\u2013179.","journal-title":"Eye"},{"key":"BFeye2016312_CR16","first-page":"105","volume":"7","author":"G Holl\u00f3","year":"1998","unstructured":"Holl\u00f3 G, Lakatos P, Farkas K . Cold pressor test and plasma endothelin-1 concentration in primary open-angle and capsular glaucoma. J Glaucoma 1998; 7: 105\u2013110.","journal-title":"J Glaucoma"},{"key":"BFeye2016312_CR17","doi-asserted-by":"publisher","first-page":"e505","DOI":"10.1111\/aos.12918","volume":"94","author":"LR Pasquale","year":"2016","unstructured":"Pasquale LR, Borras T, Fingert JH, Wiggs JL, Ritch R . Exfoliation syndrome: assembling the puzzle pieces. Acta Ophthalmol 2016; 94: e505\u2013e512.","journal-title":"Acta Ophthalmol"},{"key":"BFeye2016312_CR18","doi-asserted-by":"publisher","first-page":"847","DOI":"10.4330\/wjc.v6.i8.847","volume":"6","author":"GK Andrikopoulos","year":"2014","unstructured":"Andrikopoulos GK, Alexopoulos DK, Gartaganis SP . Pseudoexfoliation syndrome and cardiovascular diseases. World J Cardiol 2014; 6: 847\u2013854.","journal-title":"World J Cardiol"},{"key":"BFeye2016312_CR19","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.rbr.2014.09.003","volume":"55","author":"EJ Souza","year":"2015","unstructured":"Souza EJ, Kayser C . Nailfold capillaroscopy: relevance to the practice of rheumatology. Rev Bras Reumatol 2015; 55: 264\u2013271.","journal-title":"Rev Bras Reumatol"},{"key":"BFeye2016312_CR20","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1001\/archophthalmol.2011.249","volume":"129","author":"HY Park","year":"2011","unstructured":"Park HY, Park SH, Oh YS, Park CK . Nail bed hemorrhage: a clinical marker of optic disc hemorrhage in patients with glaucoma. Arch Ophthalmol 2011; 129: 1299\u20131304.","journal-title":"Arch Ophthalmol"},{"key":"BFeye2016312_CR21","doi-asserted-by":"publisher","first-page":"7021","DOI":"10.1167\/iovs.15-17860","volume":"56","author":"LR Pasquale","year":"2015","unstructured":"Pasquale LR, Hanyuda A, Ren A, Giovingo M, Greenstein SH, Cousins C et al. Nailfold capillary abnormalities in primary open-angle glaucoma: a multisite study. Invest Ophthalmol Vis Sci 2015; 56: 7021\u20137028.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2016312_CR22","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.3109\/02713683.2010.512113","volume":"35","author":"M Bo\u017eic","year":"2010","unstructured":"Bo\u017eic M, Sencanic PH, Spahic G, Kontic D, Markovic V, Marjanovic I et al. Is nail fold capillaroscopy useful in normotensive and primary open angle glaucoma? A pilot study. Curr Eye Res 2010; 35: 1099\u20131104.","journal-title":"Curr Eye Res"},{"key":"BFeye2016312_CR23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3341\/kjo.2009.23.4.296","volume":"23","author":"Y Song","year":"2009","unstructured":"Song Y, Song YJ, Ko MK . A study of the vascular network of the iris using flat preparation. Korean J Ophthalmol 2009; 23: 296\u2013300.","journal-title":"Korean J Ophthalmol"},{"key":"BFeye2016312_CR24","first-page":"34","volume-title":"Atlas of Capillaroscopy in Rheumatic Diseases","author":"V Smith","year":"2011","unstructured":"Smith V. When and how to perform capillaroscopy. In: Cutolo M (ed). Atlas of Capillaroscopy in Rheumatic Diseases. Elsevier: Milan, Italy, 2011, p 34."},{"key":"BFeye2016312_CR25","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1365-2133.1997.tb08753.x","volume":"136","author":"T Ohtsuka","year":"1997","unstructured":"Ohtsuka T . Nailfold capillary abnormalities in patients with Sj\u00f6gren's syndrome and systemic lupus erythematosus. Br J Dermatol 1997; 136: 94\u201396.","journal-title":"Br J Dermatol"},{"key":"BFeye2016312_CR26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s10067-014-2795-8","volume":"34","author":"A Manfredi","year":"2015","unstructured":"Manfredi A, Sebastiani M, Cassone G, Pipitone N, Giuggioli D, Colaci M et al. Nailfold capillaroscopic changes in dermatomyositis and polymyositis. Clin Rheumatol 2015; 34: 279\u2013284.","journal-title":"Clin Rheumatol"},{"key":"BFeye2016312_CR27","first-page":"83","volume":"13","author":"L Altomonte","year":"1995","unstructured":"Altomonte L, Zoli A, Galossi A, Mirone L, Tulli A, Martone FR et al. Microvascular capillaroscopic abnormalities in rheumatoid arthritis patients. Clin Exp Rheumatol 1995; 13: 83\u201386.","journal-title":"Clin Exp Rheumatol"},{"key":"BFeye2016312_CR28","first-page":"29","volume":"32","author":"S Cortes","year":"2007","unstructured":"Cortes S, Cutolo M . Capillarosecopic patterns in rheumatic diseases. Acta Reumatol Port 2007; 32: 29\u201336.","journal-title":"Acta Reumatol Port"},{"key":"BFeye2016312_CR29","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/j.1464-5491.2011.03325.x","volume":"28","author":"I Barchetta","year":"2011","unstructured":"Barchetta I, Riccieri V, Vasile M, Stefanantoni K, Comberiati P, Taverniti L et al. High prevalence of capillary abnormalities in patients with diabetes and association with retinopathy. Diabet Med 2011; 28: 1039\u20131044.","journal-title":"Diabet Med"},{"key":"BFeye2016312_CR30","first-page":"289","volume":"9","author":"M Ghosh","year":"1974","unstructured":"Ghosh M, Speakman JS . The iris in senile exfoliation of the lens. Can J Ophthalmol 1974; 9: 289\u2013297.","journal-title":"Can J Ophthalmol"},{"issue":"Suppl 1","key":"BFeye2016312_CR31","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1097\/IJG.0000000000000123","volume":"23","author":"M Zenkel","year":"2014","unstructured":"Zenkel M, Schl\u00f6tzer-Schrehardt U . The composition of exfoliation material and the cells involved in its production. J Glaucoma 2014; 23 (Suppl 1): S12\u2013S14.","journal-title":"J Glaucoma"},{"key":"BFeye2016312_CR32","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/ng1297","volume":"36","author":"X Liu","year":"2004","unstructured":"Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA et al. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet 2004; 36: 178\u2013182.","journal-title":"Nat Genet"},{"key":"BFeye2016312_CR33","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1126\/science.1146554","volume":"317","author":"G Thorleifsson","year":"2007","unstructured":"Thorleifsson G, Magnusson KP, Sulem P, Walters GB, Gudbjartsson DF, Stefansson H et al. Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science 2007; 317: 1397\u20131400.","journal-title":"Science"},{"key":"BFeye2016312_CR34","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/IJG.0000000000000128","volume":"25","author":"L Wang","year":"2016","unstructured":"Wang L, Yu Y, Fu S, Zhao W, Liu P . LOXL1 gene polymorphism with exfoliation syndrome\/exfoliation glaucoma: a meta-analysis. J Glaucoma 2016; 25: 62\u201394.","journal-title":"J Glaucoma"},{"key":"BFeye2016312_CR35","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1167\/iovs.13-13033","volume":"55","author":"JL Wiggs","year":"2014","unstructured":"Wiggs JL, Pawlyk B, Connolly E, Adamian M, Miller JW, Pasquale LR et al. Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1). Invest Ophthalmol Vis Sci 2014; 55: 856\u2013864.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2016312_CR36","first-page":"568","volume":"104","author":"PB Dobrin","year":"1988","unstructured":"Dobrin PB, Schwarcz TH, Baker WH . Mechanisms of arterial and aneurysmal tortuosity. Surgery 1988; 104: 568\u2013571.","journal-title":"Surgery"},{"key":"BFeye2016312_CR37","doi-asserted-by":"publisher","first-page":"8488","DOI":"10.1167\/iovs.11-8361","volume":"52","author":"M Zenkel","year":"2011","unstructured":"Zenkel M, Krysta A, Pasutto F, Juenemann A, Kruse FE, Schl\u00f6tzer-Schrehardt U . Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci 2011; 52: 8488\u20138495.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2016312_CR38","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1001\/jamaophthalmol.2014.3326","volume":"132","author":"LR Pasquale","year":"2014","unstructured":"Pasquale LR, Jiwani AZ, Zehavi-Dorin T, Majd A, Rhee DJ, Chen T et al. Solar exposure and residential geographic history in relation to exfoliation syndrome in the United States and Israel. JAMA Ophthalmol 2014; 132: 1439\u20131445.","journal-title":"JAMA Ophthalmol"},{"key":"BFeye2016312_CR39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/IIO.0000000000000040","volume":"54","author":"LR Pasquale","year":"2014","unstructured":"Pasquale LR, Kang JH, Wiggs JL . Consideration for gene-environment interactions as novel determinants of exfoliation syndrome. Int Ophthalmol Clin 2014; 54: 29\u201341.","journal-title":"Int Ophthalmol Clin"},{"key":"BFeye2016312_CR40","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s00417-011-1877-4","volume":"250","author":"F Xu","year":"2012","unstructured":"Xu F, Zhang L, Li M . Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis. Graefes Arch Clin Exp Ophthalmol 2012; 250: 1067\u20131074.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFeye2016312_CR41","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00417-004-1097-2","volume":"243","author":"O Altintas","year":"2005","unstructured":"Altintas O, Maral H, Yuksel N, Karabas VL, Dillioglugil MO, Caglar Y . Homocysteine and nitric oxide levels in plasma of patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 2005; 243: 677\u2013683.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFeye2016312_CR42","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2415-6-6","volume":"6","author":"T Cumurcu","year":"2006","unstructured":"Cumurcu T, Sahin S, Aydin E . Serum homocysteine, vitamin B12 and folic acid levels in different types of glaucoma. BMC Ophthalmol 2006; 6: 6.","journal-title":"BMC Ophthalmol"},{"key":"BFeye2016312_CR43","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ajo.2003.09.041","volume":"137","author":"G Wang","year":"2004","unstructured":"Wang G, Medeiros FA, Barshop BA, Weinreb RN . Total plasma homocysteine and primary open-angle glaucoma. Am J Ophthalmol 2004; 137: 401\u2013406.","journal-title":"Am J Ophthalmol"},{"key":"BFeye2016312_CR44","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/IJG.0b013e31816f7631","volume":"18","author":"CI Clement","year":"2009","unstructured":"Clement CI, Goldberg I, Healey PR, Graham SL . Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma. J Glaucoma 2009; 18: 73\u201378.","journal-title":"J Glaucoma"},{"key":"BFeye2016312_CR45","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0002-9394(03)00077-1","volume":"136","author":"RM Vessani","year":"2003","unstructured":"Vessani RM, Ritch R, Liebmann JM, Jofe M . Plasma homocysteine is elevated in patients with exfoliation syndrome. Am J Ophthalmol 2003; 136: 41\u201346.","journal-title":"Am J Ophthalmol"},{"key":"BFeye2016312_CR46","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1161\/hh1401.093459","volume":"89","author":"JC Chambers","year":"2001","unstructured":"Chambers JC, Ueland PM, Wright M, Dore CJ, Refsum H, Kooner JS . Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects. Circ Res 2001; 89: 187\u2013192.","journal-title":"Circ Res"},{"key":"BFeye2016312_CR47","doi-asserted-by":"publisher","first-page":"H1206","DOI":"10.1152\/ajpheart.00376.2005","volume":"290","author":"D Lominadze","year":"2006","unstructured":"Lominadze D, Roberts AM, Tyagi N, Moshal KS, Tyagi SC . Homocysteine causes cerebrovascular leakage in mice. Am J Physiol Heart Circ Physiol 2006; 290: H1206\u2013H1213.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFeye2016312_CR48","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1212\/WNL.0000000000000720","volume":"83","author":"SB Jeon","year":"2014","unstructured":"Jeon SB, Kang DW, Kim JS, Kwon SU . Homocysteine, small-vessel disease, and atherosclerosis: an MRI study of 825 stroke patients. Neurology 2014; 83: 695\u2013701.","journal-title":"Neurology"},{"key":"BFeye2016312_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000437098","volume":"67","author":"WK Lai","year":"2015","unstructured":"Lai WK, Kan MY . Homocysteine-induced endothelial dysfunction. Ann Nutr Metab 2015; 67: 1\u201312.","journal-title":"Ann Nutr Metab"},{"key":"BFeye2016312_CR50","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1136\/bjo.2005.087908","volume":"90","author":"Z Visontai","year":"2006","unstructured":"Visontai Z, Merisch B, Kollai M, Holl\u00f3 G . Increase of carotid artery stiffness and decrease of baroreflex sensitivity in exfoliation syndrome and glaucoma. Br J Ophthalmol 2006; 90: 563\u2013567.","journal-title":"Br J Ophthalmol"},{"key":"BFeye2016312_CR51","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3109\/02713683.2012.757325","volume":"38","author":"DG Mikropoulos","year":"2013","unstructured":"Mikropoulos DG, Mallini P, Michipouou A, Giannopoulos T, Arranz-Marquez E, Koliakos GG et al. Asymmetric dimethylo arginin (ADMA) concentration in the aqueous humor of patients with exfoliation syndrome or exfoliation glaucoma. Curr Eye Res 2013; 38: 266\u2013270.","journal-title":"Curr Eye Res"},{"key":"BFeye2016312_CR52","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1136\/bjophthalmol-2012-301901","volume":"96","author":"M Tosu","year":"2012","unstructured":"Tosu M, Erdurmus M, Bugdayei G, Celebi S, Alcelik A . Aqueous humour and serum concentration of asymmetric dimethyl arginine in pseudoexfoliation syndrome. Br J Ophthalmol 2012; 96: 1137\u20131140.","journal-title":"Br J Ophthalmol"},{"key":"BFeye2016312_CR53","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s00417-006-0425-0","volume":"245","author":"H Biomter","year":"2007","unstructured":"Biomter H, Puustij\u00e4rvi T, K\u00e4ntkanen M, Valtonen P, Ter\u00e4svirta M, Uusitalo H . Asymmetric dimethylarginine is not related to exfoliation syndrome but symmetric dimethylarginine is related to exfoliative glaucoma. Graefes Arch Clin Exp Ophthalmol 2007; 245: 204\u2013209.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFeye2016312_CR54","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1097\/IJG.0000000000000461","volume":"25","author":"D Goren Sahin","year":"2016","unstructured":"Goren Sahin D, Sahin A, Akay OM . Comparison of rotational thromboelastography findings in pseudoexfoliation syndrome patients and healthy controls. J Glaucoma 2016; 25: 879\u2013882.","journal-title":"J Glaucoma"},{"key":"BFeye2016312_CR55","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/01.ijg.0000243470.13343.8b","volume":"16","author":"SM Jeng","year":"2007","unstructured":"Jeng SM, Karger RA, Hodge DO, Burke JP, Johnson DH, Good MS . The risk of glaucoma in pseudoexfoliation syndrome. J Glaucoma 2007; 16: 117\u2013121.","journal-title":"J Glaucoma"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye2016312","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2016312.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/eye.2016.312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/eye2016312.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:29:24Z","timestamp":1684430964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye2016312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["BFeye2016312"],"URL":"https:\/\/doi.org\/10.1038\/eye.2016.312","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,13]]},"assertion":[{"value":"2 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}