{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:15:59Z","timestamp":1786688159751,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/eye.2017.155","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T09:40:42Z","timestamp":1501839642000},"page":"99-103","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Ocular syphilis: the re-establishment of an old disease"],"prefix":"10.1038","volume":"32","author":[{"given":"J","family":"Wells","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sukthankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N P","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"BFeye2017155_CR1","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1016\/S0140-6736(05)74666-3","volume":"355","author":"SP Higgins","year":"2000","unstructured":"Higgins SP, Sukthankar A, Mahto M, Jarvis RR, Lacey HB . Syphilis increases in Manchester, UK. Lancet 2000; 355: 1466.","journal-title":"Lancet"},{"key":"BFeye2017155_CR2","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1136\/sti.77.5.311","volume":"77","author":"HB Lacey","year":"2001","unstructured":"Lacey HB, Higgins SP, Graham D . An outbreak of early syphilis: cases from North Manchester General Hospital. Sex Transm Infect 2001; 77: 311\u2013313.","journal-title":"Sex Transm Infect"},{"key":"BFeye2017155_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2807\/esm.09.12.00497-en","volume":"9","author":"AA Righarts","year":"2004","unstructured":"Righarts AA, Simms I, Wallace L, Solomou M, Fenton KA . Syphilis surveillance and epidemiology in the United Kingdom. Euro Surveill 2004; 9: 21\u201325.","journal-title":"Euro Surveill"},{"key":"BFeye2017155_CR4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1177\/095646240401500516","volume":"15","author":"MA Kingston","year":"2004","unstructured":"Kingston MA, Higgins SP . Audit of the management of early syphilis at North Manchester General Hospital. Int J STD AIDS 2004; 15: 352\u2013354.","journal-title":"Int J STD AIDS"},{"key":"BFeye2017155_CR5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1136\/sti.79.4.291","volume":"79","author":"M Ashton","year":"2003","unstructured":"Ashton M, Sopwith W, Clark P, McKelvey D, Lighton L, Mandal. D . An outbreak no longer: factors contributing to the return of syphilis in Greater Manchester. Sex Transm Infect 2003; 79: 291\u2013293.","journal-title":"Sex Transm Infect"},{"key":"BFeye2017155_CR6","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/sj.eye.6701954","volume":"20","author":"J Doris","year":"2006","unstructured":"Doris J, Saha K, Jones NP, Sukthankar A . Ocular Syphilis - the new epidemic. Eye 2006; 20: 703\u2013705.","journal-title":"Eye"},{"key":"BFeye2017155_CR7","unstructured":"Anon 2013. Recent epidemiology of infectious syphilis in England. Infection Reports, vol 7, Public Health England: London, UK. November 2013, pp 44."},{"key":"BFeye2017155_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3109\/09273948.2013.770887","volume":"21","author":"R Troutbeck","year":"2013","unstructured":"Troutbeck R, Chhabra R, Jones NP . Polymerase chain reaction testing of vitreous in atypical ocular syphilis. Ocul Immunol Inflamm 2013; 21: 227\u2013230.","journal-title":"Ocul Immunol Inflamm"},{"key":"BFeye2017155_CR9","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1258\/ijsa.2008.008279","volume":"19","author":"M Kingston","year":"2008","unstructured":"Kingston M, French P, Goh B, Goold P, Higgins S, Sukthankar A, Syphilis Guidelines Revision Group 2008. UK National guidelines on the management of syphilis 2008. Int J STD AIDS 2008; 19: 729\u2013740.","journal-title":"Int J STD AIDS"},{"key":"BFeye2017155_CR10","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1177\/0956462415624059","volume":"27","author":"M Kingston","year":"2016","unstructured":"Kingston M, French P, Higgins S, McQuillan O, Sukthankar A, Stott C et alSyphilis Guidelines Revision Group 2015. UK National guidelines on the management of syphilis 2015. Int J STD AIDS 2016; 27: 421\u2013446.","journal-title":"Int J STD AIDS"},{"key":"BFeye2017155_CR11","unstructured":"Anon 2016. Health protection report, vol 10. Public Health England: London, UK, pp 22.."},{"key":"BFeye2017155_CR12","doi-asserted-by":"publisher","first-page":"5394","DOI":"10.1167\/iovs.14-14559","volume":"55","author":"RG Mathew","year":"2014","unstructured":"Mathew RG, Goh BT, Westcott MC . British Ocular Syphilis Study (BOSS): 2-year national surveillance study of intraocular inflammation secondary to ocular syphilis. Invest Ophthalmol Vis Sci 2014; 55: 5394\u20135400.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2017155_CR13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3109\/09273948.2014.968671","volume":"23","author":"NP Jones","year":"2015","unstructured":"Jones NP . Manchester Uveitis Clinic: the first 3000 patients: 2. complications and management. Ocul Immunol Inflamm 2015; 23: 127\u2013134.","journal-title":"Ocul Immunol Inflamm"},{"key":"BFeye2017155_CR14","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1136\/bjophthalmol-2014-306168","volume":"99","author":"LC Northey","year":"2015","unstructured":"Northey LC, Skalicky SE, Gurbaxani A, McCluskey PJ . Syphilitic uveitis and optic neuritis in Sydney, Australia. Br J Ophthalmol 2015; 99: 1215\u20131219.","journal-title":"Br J Ophthalmol"},{"key":"BFeye2017155_CR15","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1097\/IAE.0b013e3182509796","volume":"32","author":"P Yang","year":"2012","unstructured":"Yang P, Zhang N, Li F, Chen Y, Kijlstra A . Ocular manifestations of syphilitic uveitis in Chinese patients. Retina 2012; 32: 1906\u20131914.","journal-title":"Retina"},{"key":"BFeye2017155_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/j.1442-9071.2010.02203.x","volume":"28","author":"BC Amaratunge","year":"2010","unstructured":"Amaratunge BC, Camuglia JE, Hall AJ . Syphilitic uveitis: A review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus-positive and negative patients. Clin Exp Ophthalmol 2010; 28: 68\u201374.","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"BFeye2017155_CR17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3109\/09273948.2013.829106","volume":"22","author":"SC Yap","year":"2014","unstructured":"Yap SC, Tan YL, Chio MTW, Teoh SC . Syphilitic uveitis in a Singaporean population. Ocul Immunol Inflamm 2014; 22 (1): 9\u201314.","journal-title":"Ocul Immunol Inflamm"},{"key":"BFeye2017155_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/01.iae.0000242759.80833.39","volume":"1","author":"Y Matsumoto","year":"2007","unstructured":"Matsumoto Y, Spaide RF . Autofluorescence imaging of acute syphilitic posterior placoid chorioretinitis. Retin Cases Brief Rep 2007; 1: 123\u2013127.","journal-title":"Retin Cases Brief Rep"},{"key":"BFeye2017155_CR19","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/IAE.0b013e3182993f11","volume":"34","author":"F Pichi","year":"2014","unstructured":"Pichi F, Ciardella AP, Cunningham Jr ET, Morara M, Veronese C, Jumper JM et al. Spectral domain optical coherence tomography findings in patients with acute syphilitic posterior placoid chorioretinopathy. Retina 2014; 34: 373\u2013384.","journal-title":"Retina"},{"key":"BFeye2017155_CR20","doi-asserted-by":"publisher","first-page":"606","DOI":"10.3928\/23258160-20141008-02","volume":"45","author":"BK Armstrong","year":"2014","unstructured":"Armstrong BK, Pitcher J, Shah R, Brady C, Perlmutter D, Garg SJ . The evolution of untreated acute syphilitic posterior placoid chorioretinitis captured by multimodal retinal imaging. Ophthalmic Surg Lasers Imaging Retina 2014; 45: 606\u2013609.","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"2","key":"BFeye2017155_CR21","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.ajo.2014.10.030","volume":"159","author":"A Moradi","year":"2015","unstructured":"Moradi A, Salek S, Daniel E, Gangaputra S, Ostheimer TA, Burkholder BM et al. Clinical features and incidence rates of ocular complications in patients with ocular syphilis. Am J Ophth 2015; 159 (2): 334\u2013343.","journal-title":"Am J Ophth"},{"key":"BFeye2017155_CR22","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1097\/IAE.0b013e31825f3851","volume":"32","author":"CM Eandi","year":"2012","unstructured":"Eandi CM, Neri P, Adelman RA, Yannuzzi LA, Cunningham ET Jr, . International Syphilis Study Group. Acute syphilitic posterior placoid chorioretinitis: report of a case series and comprehensive review of the literature. Retina 2012; 32: 1915\u20131941.","journal-title":"Retina"},{"key":"BFeye2017155_CR23","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1136\/bjo.2010.194498","volume":"95","author":"K Balaskas","year":"2011","unstructured":"Balaskas K, Sergentanis TN, Giulieri S, Guex-Crosier Y . Analysis of significant factors influencing visual acuity in ocular syphilis. Br J Ophthalmol 2011; 95: 1568\u20131572.","journal-title":"Br J Ophthalmol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye2017155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2017155","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/eye.2017.155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/eye2017155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:30:52Z","timestamp":1684431052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye2017155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,4]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["BFeye2017155"],"URL":"https:\/\/doi.org\/10.1038\/eye.2017.155","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,4]]},"assertion":[{"value":"10 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}