{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:01:05Z","timestamp":1768086065776,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1038\/eye.2017.194","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T08:21:22Z","timestamp":1505463682000},"page":"364-369","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Choroidal thickness measurements in children with isolated growth hormone deficiency"],"prefix":"10.1038","volume":"32","author":[{"given":"N G","family":"Yalcin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Aktas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Yuce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G D G","family":"Ikiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hasanreisoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bideci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"issue":"Suppl 2","key":"BFeye2017194_CR1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1515\/jpem-2001-s213","volume":"14","author":"J Argente","year":"2001","unstructured":"Argente J, Abusrewil SA, Bona G, Chiarelli F, Kelnar CJ, Skordis N et al. Isolated growth hormone deficiency in children and adolescents. J Pediatr Endocrinol Metab 2001; 14 (Suppl 2): 1003\u20131008.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"BFeye2017194_CR2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s11102-007-0073-3","volume":"10","author":"LM Hern\u00e1ndez","year":"2007","unstructured":"Hern\u00e1ndez LM, Lee PD, Camacho-H\u00fcbner C . Isolated growth hormone deficiency. Pituitary 2007; 10: 351\u2013357.","journal-title":"Pituitary"},{"key":"BFeye2017194_CR3","first-page":"510","volume":"5","author":"S Harvey","year":"2007","unstructured":"Harvey S, Baudet ML, Sanders EJ . Growth hormone and developmental ocular function: clinical and basic studies. Pediatr Endocrinol Rev 2007; 5: 510\u2013515.","journal-title":"Pediatr Endocrinol Rev"},{"key":"BFeye2017194_CR4","first-page":"795","volume":"84","author":"A Hellstr\u00f6m","year":"1999","unstructured":"Hellstr\u00f6m A, Svensson E, Carlsson B, Niklasson A, Albertsson-Wikland K . Reduced retinal vascularization in children with growth hormone deficiency. J Clin Endocrinol Metab 1999; 84: 795\u2013798.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2017194_CR5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1515\/JPEM.1998.11.2.261","volume":"11","author":"PF Collett-Solberg","year":"1998","unstructured":"Collett-Solberg PF, Liu GT, Satin-Smith M, Katz LL, Moshang T Jr . Pseudopapilledema and congenital disc anomalies in growth hormone deficiency. J Pediatr Endocrinol Metab 1998; 11: 261\u2013265.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"BFeye2017194_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1076\/ceyr.28.1.11.23491","volume":"28","author":"F Parentin","year":"2004","unstructured":"Parentin F, Tonini G, Perissutti P . Refractive evaluation in children with growth defect. Curr Eye Res 2004; 28: 11\u201315.","journal-title":"Curr Eye Res"},{"key":"BFeye2017194_CR7","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1755-3768.2009.01519.x","volume":"88","author":"F Parentin","year":"2010","unstructured":"Parentin F, Pensiero S . Central corneal thickness in children with growth hormone deficiency. Acta Ophthalmol 2010; 88: 692\u2013694.","journal-title":"Acta Ophthalmol"},{"key":"BFeye2017194_CR8","doi-asserted-by":"publisher","first-page":"873","DOI":"10.5301\/ejo.5000481","volume":"24","author":"P Nalcacioglu-Yuksekkaya","year":"2014","unstructured":"Nalcacioglu-Yuksekkaya P, Sen E, Yilmaz S, Elgin U, Gunaydin S, Aycan Z . Decreased retinal nerve fiber layer thickness in patients with congenital isolated growth hormone deficiency. Eur J Ophthalmol 2014; 24: 873\u2013878.","journal-title":"Eur J Ophthalmol"},{"key":"BFeye2017194_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00429-004-0422-1","volume":"209","author":"EJ Sanders","year":"2004","unstructured":"Sanders EJ, Harvey S . Growth hormone as an early embryonic growth and differentiation factor. Anat Embryol (Berl) 2004; 209: 1\u20139.","journal-title":"Anat Embryol (Berl)"},{"key":"BFeye2017194_CR10","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1210\/jcem.87.7.8629","volume":"87","author":"A Hellstr\u00f6m","year":"2002","unstructured":"Hellstr\u00f6m A, Carlsson B, Niklasson A, Segnestam K, Boguszewski M, de Lacerda L et al. IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab 2002; 87: 3413\u20133416.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2017194_CR11","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/B978-0-323-05714-1.00010-8","volume-title":"Adler\u2019s Physiology of the Eye","author":"CE Riva","year":"2011","unstructured":"Riva CE, Alm A, Pournaras CJ Ocular circulation. In: Kaufman PL, Alm A (eds). Adler\u2019s Physiology of the Eye, 11th ed. Saunders\/Elsevier: Edingburg, 2011 pp, 243\u2013332."},{"key":"BFeye2017194_CR12","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","volume":"146","author":"RF Spaide","year":"2008","unstructured":"Spaide RF, Koizumi H, Pozonni MC . Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008; 146: 496\u2013500.","journal-title":"Am J Ophthalmol"},{"key":"BFeye2017194_CR13","doi-asserted-by":"publisher","first-page":"041211","DOI":"10.1117\/1.2773728","volume":"12","author":"B Povazay","year":"2007","unstructured":"Povazay B, Hermann B, Unterhuber A, Hofer B, Sattmann H, Zeiler F et al. Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients. J Biomed Opt 2007; 12: 041211.","journal-title":"J Biomed Opt"},{"key":"BFeye2017194_CR14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1136\/adc.44.235.291","volume":"44","author":"WA Marshall","year":"1969","unstructured":"Marshall WA, Tanner JM . Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291\u2013303.","journal-title":"Arch Dis Child"},{"key":"BFeye2017194_CR15","first-page":"3990","volume":"85","author":"Growth Hormone Research Society","year":"2000","unstructured":"Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab 2000; 85: 3990\u20133993.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFeye2017194_CR16","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ajo.2008.12.008","volume":"147","author":"R Margolis","year":"2009","unstructured":"Margolis R, Spaide RF . A pilot study of enhanced depth imaging opticalcoherence tomography of the choroid in normal eyes. Am J Ophthalmol 2009; 147: 811\u2013815.","journal-title":"Am J Ophthalmol"},{"key":"BFeye2017194_CR17","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s11325-014-1025-6","volume":"19","author":"EE Karaca","year":"2015","unstructured":"Karaca EE, Ekici F, Yal\u00e7\u0131n NG, \u00c7ift\u00e7i TU, \u00d6zdek \u015e . Macular choroidal thickness measurements in patients with obstructive sleep apnea syndrome. Sleep Breath 2015; 19: 335\u2013341.","journal-title":"Sleep Breath"},{"key":"BFeye2017194_CR18","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1167\/iovs.11-8782","volume":"53","author":"CS Tan","year":"2012","unstructured":"Tan CS, Ouyang Y, Ruiz H, Sadda SR . Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 2012; 53: 261\u2013266.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2017194_CR19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/pmic.200700952","volume":"8","author":"ML Baudet","year":"2008","unstructured":"Baudet ML, Hassanali Z, Sawicki G, Lis EO . Growth hormone action in the developing neural retina: a proteomic analysis. Proteomics 2008; 8: 389\u2013401.","journal-title":"Proteomics"},{"key":"BFeye2017194_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/BF03347058","volume":"34","author":"A Ciresi","year":"2011","unstructured":"Ciresi A, Amato MC, Morreale D, Lodato G, Galluzzo A, Giordano C . Cornea in acromegalic patients as a possible target of growth hormone action. Endocrinol Invest 2011; 34: 30\u201335.","journal-title":"Endocrinol Invest"},{"key":"BFeye2017194_CR21","first-page":"317","volume":"7","author":"P Nalcacioglu-Yuksekkaya","year":"2014","unstructured":"Nalcacioglu-Yuksekkaya P, Sen E, Elgin U, Hocaoglu M, Ozturk F, Yilmaz SA et al. Corneal properties in children with congenital isolated growth hormone deficiency. Int J Ophthalmol 2014; 7: 317\u2013320.","journal-title":"Int J Ophthalmol"},{"key":"BFeye2017194_CR22","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1167\/iovs.06-0057","volume":"47","author":"KD Beharry","year":"2006","unstructured":"Beharry KD, Modanlou HD, Hasan J, Gharraee Z, Abad-Santos P, Sills JH et al. Comparative effects of early postnatal ibuprofen and indomethacin onVEGF, IGF-I, and GH during rat ocular development. Invest Ophthalmol Vis Sci 2006; 47: 3036\u20133043.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2017194_CR23","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1167\/iovs.05-1046","volume":"47","author":"HD Modanlou","year":"2006","unstructured":"Modanlou HD, Gharraee Z, Hasan J, Waltzman J, Nageotte S, Beharry KD . Ontogeny of VEGF, IGF-I, and GH in neonatal rat serum, vitreous fluid, and retina from birth to weaning. Invest Ophthalmol Vis Sci 2006; 47: 738\u2013744.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2017194_CR24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ghir.2016.07.001","volume":"30-31","author":"VM Pereira-Gurgel","year":"2016","unstructured":"Pereira-Gurgel VM, Faro AC, Salvatori R, Chagas TA, Carvalho-Junior JF, Oliveira CR et al. Abnormal vascular and neural retinal morphology in congenital lifetime isolated growth hormone deficiency. Growth Horm IGF Res 2016; 30-31: 11\u201315.","journal-title":"Growth Horm IGF Res"},{"key":"BFeye2017194_CR25","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1056\/NEJM199512283332608","volume":"333","author":"J Folkman","year":"1995","unstructured":"Folkman J . Clinical applications of research on angiogenesis. N Engl J Med 1995; 333: 1757\u20131763.","journal-title":"N Engl J Med"},{"key":"BFeye2017194_CR26","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1126\/science.276.5319.1706","volume":"276","author":"LEH Smith","year":"1997","unstructured":"Smith LEH, Kopchick JJ, Chen W . Essential role of growth hormone in ischemia-induced retinal neovascularisation. Science 1997; 276: 1706\u20131709.","journal-title":"Science"},{"key":"BFeye2017194_CR27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1242\/dev.107.1.123","volume":"107","author":"RA Cuthbertson","year":"1989","unstructured":"Cuthbertson RA, Beck F, Senior PV, Haralambidis J, Penschow JD, Coghlan JP . Insulin-like growth factor II may play a local role in the regulation of ocular size. Development 1989; 107: 123\u2013130.","journal-title":"Development"},{"key":"BFeye2017194_CR28","doi-asserted-by":"publisher","first-page":"5158","DOI":"10.1210\/endo.142.12.8552","volume":"142","author":"S Takeuchi","year":"2001","unstructured":"Takeuchi S, Haneda M, Teshigawara K, Takahashi S . Identification of a novel GH isoform: a possible link between GH and melanocortin systems in the developing chicken eye. Endocrinology 2001; 142: 5158\u20135166.","journal-title":"Endocrinology"},{"key":"BFeye2017194_CR29","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1677\/joe.0.1690487","volume":"169","author":"S Harvey","year":"2001","unstructured":"Harvey S, Johnson CDM, Sanders EJ . Growth hormone in neural tissues of the chick embryo. J Endocrinol 2001; 169: 487\u2013498.","journal-title":"J Endocrinol"},{"key":"BFeye2017194_CR30","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1242\/dev.114.4.869","volume":"114","author":"J Garcia-Aragon","year":"1992","unstructured":"Garcia-Aragon J, Lobie PE, Muscat GEO, Gobius KS, Norstedt G, Waters MJ . Prenatal expression of growth hormone (GH) receptor\/binding protein in the rat: a role for GH in embryonic and fetal development? Development 1992; 114: 869\u2013876.","journal-title":"Development"},{"key":"BFeye2017194_CR31","first-page":"53","volume-title":"Ocular Anatomy and Physiology","author":"T Saude","year":"1993","unstructured":"Saude T The retina. In: Saude T (ed). Ocular Anatomy and Physiology. Blackwell Scientific Publications: London, UK, 1993, pp 53\u201365."},{"key":"BFeye2017194_CR32","doi-asserted-by":"publisher","first-page":"202","DOI":"10.5301\/ejo.5000351","volume":"24","author":"EE Karaca","year":"2014","unstructured":"Karaca EE, \u00d6zdek \u015e, Yal\u00e7in NG, Ekici F . Reproducibility of choroidal thickness measurements in healthy Turkish subjects. Eur J Ophthalmol 2014; 24: 202\u2013208.","journal-title":"Eur J Ophthalmol"},{"key":"BFeye2017194_CR33","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1167\/iovs.13-11732","volume":"54","author":"SA Read","year":"2013","unstructured":"Read SA, Collins MJ, Vincent SJ, Alonso-Caneiro D . Choroidal thickness in childhood. Invest Ophthalmol Vis Sci 2013; 54: 3586\u20133593.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2017194_CR34","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1167\/iovs.15-16446","volume":"56","author":"SA Read","year":"2015","unstructured":"Read SA, Alonso-Caneiro D, Vincent SJ, Collins MJ . Longitudinal changes in choroidal thickness and eye growth in childhood. Invest Ophthalmol Vis Sci 2015; 56: 3103\u20133112.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFeye2017194_CR35","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1097\/IAE.0000000000000636","volume":"35","author":"L Herrera","year":"2015","unstructured":"Herrera L, Perez-Navarro I, Sanchez-Cano A, Perez-Garcia D, Remon L, Almenara C et al. Choroidal thickness and volume in a healthy pediatric populat\u0131on and its relationsh\u0131p with age, axial length, ametropia, and sex. Retina 2015; 35: 2574\u20132583.","journal-title":"Retina"},{"key":"BFeye2017194_CR36","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1097\/IAE.0b013e3182923477","volume":"33","author":"KA Park","year":"2013","unstructured":"Park KA, Oh SY . Choroidal thickness in healthy children. Retina 2013; 33: 1971\u20131976.","journal-title":"Retina"},{"key":"BFeye2017194_CR37","doi-asserted-by":"publisher","first-page":"23","DOI":"10.5935\/0004-2749.20150007","volume":"78","author":"A Tenlik","year":"2015","unstructured":"Tenlik A, G\u00fcra\u011fa\u00e7 FB, G\u00fcler E, Dervi\u015fo\u011fullar\u0131 MS, Totan Y . Choroidal thickness measurement in healthy pediatric population using Cirrus HD optical coherence tomography. Arq Bras Oftalmol 2015; 78: 23\u201326.","journal-title":"Arq Bras Oftalmol"},{"key":"BFeye2017194_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3928\/15428877-20110627-07","volume":"42","author":"IY Wong","year":"2011","unstructured":"Wong IY, Koizumi H, Lai WW . Enhanced depth imaging optical coherence tomography. Ophthalmic Surg Lasers Imaging 2011; 42: 75\u201384.","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"BFeye2017194_CR39","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1016\/j.ophtha.2012.06.065","volume":"119","author":"G Barteselli","year":"2012","unstructured":"Barteselli G, Chhablani J, El-Emam S, Wang H, Chuang J, Kozak I et al. Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis. Ophthalmology 2012; 119: 2572\u20132578.","journal-title":"Ophthalmology"},{"key":"BFeye2017194_CR40","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1097\/IAE.0b013e3182a487a4","volume":"34","author":"M Bidaut-Garnier","year":"2014","unstructured":"Bidaut-Garnier M, Schwartz C, Puyraveau M, Montard M, Delbosc B, Saleh M . Choroidal thickness measurement in children using optical coherence tomography. Retina 2014; 34: 768\u2013774.","journal-title":"Retina"},{"key":"BFeye2017194_CR41","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1167\/iovs.13-13476","volume":"55","author":"XQ Li","year":"2014","unstructured":"Li XQ, Jeppesen P, Larsen M, Munch IC . Subfoveal choroidal thickness in 1323 children aged 11 to 12 years and association with puberty: the Copenhagen Child Cohort 2000 Eye Study. Invest Ophthalmol Vis Sci 2014; 55: 550\u2013555.","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/eye2017194.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/eye2017194","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/eye.2017.194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/eye2017194.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:37:30Z","timestamp":1693003050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/eye2017194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,15]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["BFeye2017194"],"URL":"https:\/\/doi.org\/10.1038\/eye.2017.194","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,15]]},"assertion":[{"value":"11 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}