{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:40:48Z","timestamp":1789634448070,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,1,14]],"date-time":"2010-01-14T00:00:00Z","timestamp":1263427200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1038\/gene.2009.105","type":"journal-article","created":{"date-parts":[[2010,1,14]],"date-time":"2010-01-14T05:57:48Z","timestamp":1263448668000},"page":"194-198","source":"Crossref","is-referenced-by-count":50,"title":["Association of the AFF3 gene and IL2\/IL21 gene region with juvenile idiopathic arthritis"],"prefix":"10.1038","volume":"11","author":[{"name":"Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hinks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Eyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Packham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Worthington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,14]]},"reference":[{"issue":"R2","key":"BFgene2009105_CR1","doi-asserted-by":"publisher","first-page":"R116","DOI":"10.1093\/hmg\/ddn246","volume":"17","author":"G Lettre","year":"2008","unstructured":"Lettre G, Rioux JD . Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet 2008; 17 (R2): R116\u2013R121.","journal-title":"Hum Mol Genet"},{"key":"BFgene2009105_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nrg2489","volume":"10","author":"A Zhernakova","year":"2009","unstructured":"Zhernakova A, van Diemen CC, Wijmenga C . Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet 2009; 10: 43\u201355.","journal-title":"Nat Rev Genet"},{"key":"BFgene2009105_CR3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0092-8674(00)81110-1","volume":"85","author":"TJ Vyse","year":"1996","unstructured":"Vyse TJ, Todd JA . Genetic analysis of autoimmune disease. Cell 1996; 85: 311\u2013318.","journal-title":"Cell"},{"key":"BFgene2009105_CR4","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","volume":"369","author":"A Ravelli","year":"2007","unstructured":"Ravelli A, Martini A . Juvenile idiopathic arthritis. Lancet 2007; 369: 767\u2013778.","journal-title":"Lancet"},{"key":"BFgene2009105_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/rheumatology\/kel005","volume":"45","author":"A Hinks","year":"2006","unstructured":"Hinks A, Worthington J, Thomson W . The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis. Rheumatology (Oxford) 2006; 45: 365\u2013368.","journal-title":"Rheumatology (Oxford)"},{"key":"BFgene2009105_CR6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/art.24187","volume":"60","author":"A Hinks","year":"2009","unstructured":"Hinks A, Ke X, Barton A, Eyre S, Bowes J, Worthington J et al. Association of the IL2RA\/CD25 gene with juvenile idiopathic arthritis. Arthritis Rheum 2009; 60: 251\u2013257.","journal-title":"Arthritis Rheum"},{"key":"BFgene2009105_CR7","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","volume":"447","author":"The Wellcome Trust Case Control Consortium","year":"2007","unstructured":"The Wellcome Trust Case Control Consortium. Genome-wide association study of 14\u2009000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447: 661\u2013678.","journal-title":"Nature"},{"key":"BFgene2009105_CR8","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/ng2102","volume":"39","author":"CE Lowe","year":"2007","unstructured":"Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007; 39: 1074\u20131082.","journal-title":"Nat Genet"},{"key":"BFgene2009105_CR9","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1365-2265.2007.02762.x","volume":"66","author":"OJ Brand","year":"2007","unstructured":"Brand OJ, Lowe CE, Heward JM, Franklyn JA, Cooper JD, Todd JA et al. Association of the interleukin-2 receptor alpha (IL-2Ralpha)\/CD25 gene region with Graves\u2019 disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf) 2007; 66: 508\u2013512.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BFgene2009105_CR10","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.2337\/diabetes.53.11.3020","volume":"53","author":"D Smyth","year":"2004","unstructured":"Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM et al. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP\/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 2004; 53: 3020\u20133023.","journal-title":"Diabetes"},{"key":"#cr-split#-BFgene2009105_CR11.1","doi-asserted-by":"crossref","unstructured":"1. Hinks A, Eyre S, Ke X, Barton A, Martin P, Flynn E et al. Overlap of disease susceptibility loci for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). Ann Rheum Dis 2009","DOI":"10.1136\/ard.2009.110650"},{"key":"#cr-split#-BFgene2009105_CR11.2","unstructured":"2. e-pub ahead of print 11 August 2009."},{"key":"BFgene2009105_CR12","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ng2058","volume":"39","author":"DA van Heel","year":"2007","unstructured":"van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 2007; 39: 827\u2013829.","journal-title":"Nat Genet"},{"key":"BFgene2009105_CR13","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1086\/522037","volume":"81","author":"A Zhernakova","year":"2007","unstructured":"Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJ, Franke B et al. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. Am J Hum Genet 2007; 81: 1284\u20131288.","journal-title":"Am J Hum Genet"},{"key":"BFgene2009105_CR14","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ng2068","volume":"39","author":"JA Todd","year":"2007","unstructured":"Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39: 857\u2013864.","journal-title":"Nat Genet"},{"key":"BFgene2009105_CR15","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/ng2103","volume":"39","author":"SG Gregory","year":"2007","unstructured":"Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 2007; 39: 1083\u20131091.","journal-title":"Nat Genet"},{"key":"BFgene2009105_CR16","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1038\/ng2106","volume":"39","author":"F Lundmark","year":"2007","unstructured":"Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallstrom E, Khademi M et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007; 39: 1108\u20131113.","journal-title":"Nat Genet"},{"key":"BFgene2009105_CR17","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature01621","volume":"423","author":"H Ueda","year":"2003","unstructured":"Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003; 423: 506\u2013511.","journal-title":"Nature"},{"key":"BFgene2009105_CR18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/gene.2008.82","volume":"10","author":"JP Hafler","year":"2008","unstructured":"Hafler JP, Maier LM, Cooper JD, Plagnol V, Hinks A, Simmonds MJ et al. CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun 2008; 10: 5\u201310.","journal-title":"Genes Immun"},{"key":"BFgene2009105_CR19","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1182\/blood.V87.2.734.bloodjournal872734","volume":"87","author":"C Ma","year":"1996","unstructured":"Ma C, Staudt LM . LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood 1996; 87: 734\u2013745.","journal-title":"Blood"},{"key":"BFgene2009105_CR20","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1093\/hmg\/ddp177","volume":"18","author":"A Barton","year":"2009","unstructured":"Barton A, Eyre S, Ke X, Hinks A, Bowes J, Flynn E et al. Identification of AF4\/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Hum Mol Genet 2009; 18: 2518\u20132522.","journal-title":"Hum Mol Genet"},{"key":"BFgene2009105_CR21","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1002\/art.24296","volume":"60","author":"HM Albers","year":"2009","unstructured":"Albers HM, Kurreeman FA, Stoeken-Rijsbergen G, Brinkman DM, Kamphuis SS, Van Rossum MA et al. Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis. Arthritis Rheum 2009; 60: 901\u2013904.","journal-title":"Arthritis Rheum"},{"key":"BFgene2009105_CR22","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.yexmp.2005.09.004","volume":"80","author":"V Suppiah","year":"2006","unstructured":"Suppiah V, O\u2019doherty C, Heggarty S, Patterson CC, Rooney M, Vandenbroeck K . The CTLA4+49A\/G and CT60 polymorphisms and chronic inflammatory arthropathies in Northern Ireland. Exp Mol Pathol 2006; 80: 141\u2013146.","journal-title":"Exp Mol Pathol"},{"key":"BFgene2009105_CR23","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1002\/art.23602","volume":"58","author":"S Prahalad","year":"2008","unstructured":"Prahalad S, Bohnsack JF, Whiting A, Clifford B, Jorde LB, Guthery SL et al. Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis. Arthritis Rheum 2008; 58: 2147\u20132152.","journal-title":"Arthritis Rheum"},{"key":"BFgene2009105_CR24","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/ng1673","volume":"37","author":"T Vang","year":"2005","unstructured":"Vang T, Congia M, Macis MD, Musumeci L, Orru V, Zavattari P et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005; 37: 1317\u20131319.","journal-title":"Nat Genet"},{"key":"BFgene2009105_CR25","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/ng.175","volume":"40","author":"JC Barrett","year":"2008","unstructured":"Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40: 955\u2013962.","journal-title":"Nat Genet"},{"key":"BFgene2009105_CR26","doi-asserted-by":"publisher","first-page":"e1000322","DOI":"10.1371\/journal.pgen.1000322","volume":"5","author":"LM Maier","year":"2009","unstructured":"Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 2009; 5: e1000322.","journal-title":"PLoS Genet"},{"key":"BFgene2009105_CR27","doi-asserted-by":"publisher","first-page":"e4137","DOI":"10.1371\/journal.pone.0004137","volume":"4","author":"A Alcina","year":"2009","unstructured":"Alcina A, Fedetz M, Ndagire D, Fernandez O, Leyva L, Guerrero M et al. IL2RA\/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). PLoS ONE 2009; 4: e4137.","journal-title":"PLoS ONE"},{"key":"BFgene2009105_CR28","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J et al. International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004; 31: 390\u2013392.","journal-title":"J Rheumatol"},{"key":"BFgene2009105_CR29","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1093\/rheumatology\/41.12.1428","volume":"41","author":"JC Packham","year":"2002","unstructured":"Packham JC, Hall MA . Long-term follow-up of 246 adults with juvenile idiopathic arthritis: functional outcome. Rheumatology (Oxford) 2002; 41: 1428\u20131435.","journal-title":"Rheumatology (Oxford)"},{"key":"BFgene2009105_CR30","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1093\/rheumatology\/ken085","volume":"47","author":"N Adib","year":"2008","unstructured":"Adib N, Hyrich K, Thornton J, Lunt M, Davidson J, Gardner-Medwin J et al. Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the childhood arthritis prospective study. Rheumatology (Oxford) 2008; 47: 991\u2013995.","journal-title":"Rheumatology (Oxford)"},{"key":"BFgene2009105_CR31","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1038\/ng.2007.32","volume":"39","author":"W Thomson","year":"2007","unstructured":"Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J et al. Rheumatoid arthritis association at 6q23. Nat Genet 2007; 39: 1431\u20131433.","journal-title":"Nat Genet"},{"key":"BFgene2009105_CR32","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559\u2013575.","journal-title":"Am J Hum Genet"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/gene2009105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gene2009105","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gene2009105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T16:03:15Z","timestamp":1711123395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene2009105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,14]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["BFgene2009105"],"URL":"https:\/\/doi.org\/10.1038\/gene.2009.105","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,14]]}}}