{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:30:38Z","timestamp":1787002238522,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1038\/gene.2009.84","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T13:12:22Z","timestamp":1259759542000},"page":"S1-S4","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Overview of the Type I Diabetes Genetics Consortium"],"prefix":"10.1038","volume":"10","author":[{"given":"S S","family":"Rich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Akolkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Concannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Erlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Hilner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Julier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Morahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Nerup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Nierras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pociot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"BFgene200984_CR1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.2337\/diab.39.11.1315","volume":"39","author":"SS Rich","year":"1990","unstructured":"Rich SS . Mapping genes in diabetes: a genetic epidemiological perspective. Diabetes 1990; 39: 1315\u20131319.","journal-title":"Diabetes"},{"key":"BFgene200984_CR2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/sj.gene.6363875","volume":"3","author":"F Pociot","year":"2002","unstructured":"Pociot F, McDermott MF . Genetics of type 1 diabetes mellitus (review). Genes Immun 2002; 3: 235\u2013249.","journal-title":"Genes Immun"},{"key":"BFgene200984_CR3","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.2337\/diabetes.54.10.2995","volume":"54","author":"P Concannon","year":"2005","unstructured":"Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F et al. Type 1 diabetes. Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes 2005; 54: 2995\u20133001.","journal-title":"Diabetes"},{"key":"BFgene200984_CR4","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.2337\/db08-1551","volume":"58","author":"P Concannon","year":"2009","unstructured":"Concannon P, Chen W-M, Julier C, Morahan G, Akolkar B, Erlich HA et al. Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes 2009; 58: 1018\u20131022.","journal-title":"Diabetes"},{"key":"BFgene200984_CR5","unstructured":"Fine mapping of the MHC region for Type 1 Diabetes Genes: proceedings of the Type 1 Diabetes Genetics Consortium MHC Fine Mapping Workshop, Washington, DC, 27\u201328 August 2007. Diab Obes Metab 2009; 11 (Suppl 1): 1\u2013109."},{"issue":"Suppl 1","key":"BFgene200984_CR6","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1038\/gene.2009.85","volume":"10","author":"WM Brown","year":"2009","unstructured":"Brown WM, Pierce JJ, Hilner JE, Perdue LH, Lohman K, Lu L et al. and the Type I Diabetes Genetics Consortium. Overview of the Rapid Response data. Genes Immun 2009; 10 (Suppl 1): S5\u2013S15.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR7","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1038\/gene.2009.99","volume":"10","author":"C Julier","year":"2009","unstructured":"Julier C, Akolkar B, Concannon P, Morahan G, Nierras C, Pugliese A and the Type I Diabetes Genetics Consortium. The Type I Diabetes Genetics Consortium \u2018Rapid Response\u2019 family-based candidate gene study: strategy, genes selection, and main outcome. Genes Immun 2009; 10 (Suppl 1): S121\u2013S127.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR8","doi-asserted-by":"publisher","first-page":"S33","DOI":"10.1038\/gene.2009.89","volume":"10","author":"HA Erlich","year":"2009","unstructured":"Erlich HA, Lohman K, Mack SJ, Valdes AM, Julier C, Mirel D et al. for the Type I Diabetes Genetics Consortium. Association analysis of SNPs in the IL4R locus with type I diabetes. Genes Immun 2009; 10 (Suppl 1): S33\u2013S41.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR9","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1038\/gene.2009.86","volume":"10","author":"R Podolsky","year":"2009","unstructured":"Podolsky R, Prasad Linga-Reddy MV, She J-X and the Type I Diabetes Genetics Consortium. Analyses of multiple single nucleotide polymorphisms in the SUMO4\/IDDM5 region in affected sib-pair families with type I diabetes. Genes Immun 2009; 10 (Suppl 1): S16\u2013S20.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR10","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1038\/gene.2009.88","volume":"10","author":"H-Q Qu","year":"2009","unstructured":"Qu H-Q, Bradfield JP, Grant SFA, Hakonarson H, Polychronakos C and the Type I Diabetes Genetics Consortium. Remapping the type I diabetes association of the CTLA4 locus. Genes Immun 2009; 10 (Suppl 1): S27\u2013S32.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR11","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1038\/gene.2009.90","volume":"10","author":"H-Q Qu","year":"2009","unstructured":"Qu H-Q, Bradfield JP, B\u00e9lisle A, Grant SFA, Hakonarson H, Polychronakos C and the Type I Diabetes Genetics Consortium. The type I diabetes association of the IL2RA locus. Genes Immun 2009; 10 (Suppl 1): S42\u2013S48.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR12","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1038\/gene.2009.87","volume":"10","author":"AK Steck","year":"2009","unstructured":"Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P et al. and the Type I Diabetes Genetics Consortium. rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype. Genes Immun 2009; 10 (Suppl 1): S21\u2013S26.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR13","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1038\/gene.2009.91","volume":"10","author":"R Bergholdt","year":"2009","unstructured":"Bergholdt R, Brorsson C, Boehm B, Morahan G, Pociot F and the Type I Diabetes Genetics Consortium. No association of the IRS1 and PAX4 genes with type I diabetes. Genes Immun 2009; 10 (Suppl 1): S49\u2013S53.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR14","doi-asserted-by":"publisher","first-page":"S54","DOI":"10.1038\/gene.2009.92","volume":"10","author":"HA Erlich","year":"2009","unstructured":"Erlich HA, Valdes AM, Julier C, Mirel D, Noble JA and the Type I Diabetes Genetics Consortium. Evidence for association of the TCF7 locus with type I diabetes. Genes Immun 2009; 10 (Suppl 1): S54\u2013S59.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR15","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1038\/gene.2009.93","volume":"10","author":"H Kahles","year":"2009","unstructured":"Kahles H, Morahan G, Todd JA, Badenhoop K and the Type I Diabetes Genetics Consortium. Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes. Genes Immun 2009; 10 (Suppl 1): S60\u2013S63.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR16","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1038\/gene.2009.94","volume":"10","author":"G Morahan","year":"2009","unstructured":"Morahan G, McKinnon E, Berry J, Browning B, Julier C, Pociot F et al. and the Type I Diabetes Genetics Consortium. Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium. Genes Immun 2009; 10 (Suppl 1): S64\u2013S68.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR17","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1038\/gene.2009.95","volume":"10","author":"H-Q Qu","year":"2009","unstructured":"Qu H-Q, Polychronakos C and the Type I Diabetes Genetics Consortium. Reassessment of the type I diabetes association of the OAS1 locus. Genes Immun 2009; 10 (Suppl 1): S69\u2013S73.","journal-title":"Genes Immun"},{"issue":"Suppl 1","key":"BFgene200984_CR18","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1038\/gene.2009.96","volume":"10","author":"JMM Howson","year":"2009","unstructured":"Howson JMM, Walker NM, Smyth DJ, Todd JA and the Type I Diabetes Genetics Consortium. Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Genes Immun 2009; 10 (Suppl 1): S74\u2013S84.","journal-title":"Genes Immun"},{"key":"BFgene200984_CR19","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","volume":"447","author":"Wellcome Trust Case Control Consortium","year":"2007","unstructured":"Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661\u2013678.","journal-title":"Nature"},{"key":"BFgene200984_CR20","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ng2068","volume":"39","author":"JA Todd","year":"2007","unstructured":"Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39: 857\u2013864.","journal-title":"Nat Genet"},{"issue":"Suppl 1","key":"BFgene200984_CR21","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1038\/gene.2009.97","volume":"10","author":"JD Cooper","year":"2009","unstructured":"Cooper JD, Walker NM, Smyth DJ, Downes K, Healy BC, Todd JA and the Type I Diabetes Genetics Consortium. Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes Immun 2009; 10 (Suppl 1): S85\u2013S94.","journal-title":"Genes Immun"},{"key":"BFgene200984_CR22","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1086\/429096","volume":"76","author":"LA Criswell","year":"2005","unstructured":"Criswell LA, Pfeiffer KA, Lum RF, Gonzales B, Novitzke J, Kern M et al. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet 2005; 76: 561\u2013571.","journal-title":"Am J Hum Genet"},{"key":"BFgene200984_CR23","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/ng.120","volume":"40","author":"E Zeggini","year":"2008","unstructured":"Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008; 40: 638\u2013645.","journal-title":"Nat Genet"},{"issue":"Suppl 1","key":"BFgene200984_CR24","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1038\/gene.2009.98","volume":"10","author":"JD Cooper","year":"2009","unstructured":"Cooper JD, Walker NM, Healy BC, Smyth DJ, Downes K, Todd JA and the Type I Diabetes Genetics Consortium. Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3\u2013q14.1. Genes Immun 2009; 10 (Suppl 1): S95\u2013S120.","journal-title":"Genes Immun"},{"key":"BFgene200984_CR25","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/ng.381","volume":"41","author":"JC Barrett","year":"2009","unstructured":"Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009; 41: 703\u2013707.","journal-title":"Nat Genet"}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene200984.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene200984","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene200984.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T12:23:44Z","timestamp":1647951824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene200984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":25,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["BFgene200984"],"URL":"https:\/\/doi.org\/10.1038\/gene.2009.84","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"2 December 2009","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}