{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:46:32Z","timestamp":1792061192101,"version":"4.4.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1038\/gene.2010.3","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T10:02:41Z","timestamp":1267092161000},"page":"246-253","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Involvement of T-cell receptor-\u03b2 alterations in the development of otosclerosis linked to OTSC2"],"prefix":"10.1038","volume":"11","author":[{"given":"I","family":"Schrauwen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Venken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Vanderstraeten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Thys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-J","family":"Hendrickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Van Laer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Govaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Verstreken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Schatteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Stinissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Hellings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Van Camp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"BFgene20103_CR1","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1097\/00129492-200109000-00006","volume":"22","author":"F Declau","year":"2001","unstructured":"Declau F, Van Spaendonck M, Timmermans JP, Michaels L, Liang J, Qiu JP et al. Prevalence of otosclerosis in an unselected series of temporal bones. Otol Neurotol 2001; 22: 596\u2013602.","journal-title":"Otol Neurotol"},{"key":"BFgene20103_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/hmg\/7.2.285","volume":"7","author":"MS Tomek","year":"1998","unstructured":"Tomek MS, Brown MR, Mani SR, Ramesh A, Srisailapathy CR, Coucke P et al. Localization of a gene for otosclerosis to chromosome 15q25-q26. Hum Mol Genet 1998; 7: 285\u2013290.","journal-title":"Hum Mol Genet"},{"key":"BFgene20103_CR3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1086\/318185","volume":"68","author":"K Van Den Bogaert","year":"2001","unstructured":"Van Den Bogaert K, Govaerts PJ, Schatteman I, Brown MR, Caethoven G, Offeciers FE et al. A second gene for otosclerosis, OTSC2, maps to chromosome 7q34-36. Am J Hum Genet 2001; 68: 495\u2013500.","journal-title":"Am J Hum Genet"},{"key":"BFgene20103_CR4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1136\/jmg.39.7.473","volume":"39","author":"W Chen","year":"2002","unstructured":"Chen W, Campbell CA, Green GE, Van Den Bogaert K, Komodikis C, Manolidis LS et al. Linkage of otosclerosis to a third locus (OTSC3) on human chromosome 6p21.3-22.3. J Med Genet 2002; 39: 473\u2013477.","journal-title":"J Med Genet"},{"key":"BFgene20103_CR5","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1001\/archotol.132.4.416","volume":"132","author":"Z Brownstein","year":"2006","unstructured":"Brownstein Z, Goldfarb A, Levi H, Frydman M, Avraham KB . Chromosomal mapping and phenotypic characterization of hereditary otosclerosis linked to the OTSC4 locus. Arch Otolaryngol Head Neck Surg 2006; 132: 416\u2013424.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"BFgene20103_CR6","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1136\/jmg.2004.018671","volume":"41","author":"K Van Den Bogaert","year":"2004","unstructured":"Van Den Bogaert K, De Leenheer EM, Chen W, Lee Y, Nurnberg P, Pennings RJ et al. A fifth locus for otosclerosis, OTSC5, maps to chromosome 3q22-24. J Med Genet 2004; 41: 450\u2013453.","journal-title":"J Med Genet"},{"key":"BFgene20103_CR7","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/sj.ejhg.5201761","volume":"15","author":"M Thys","year":"2007","unstructured":"Thys M, Van Den Bogaert K, Iliadou V, Vanderstraeten K, Dieltjens N, Schrauwen I et al. A seventh locus for otosclerosis, OTSC7, maps to chromosome 6q13-16.1. Eur J Hum Genet 2007; 15: 362\u2013368.","journal-title":"Eur J Hum Genet"},{"key":"BFgene20103_CR8","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00439-008-0470-3","volume":"123","author":"I Bel Hadj Ali","year":"2008","unstructured":"Bel Hadj Ali I, Thys M, Beltaief N, Schrauwen I, Hilgert N, Vanderstraeten K et al. A new locus for otosclerosis, OTSC8, maps to the pericentromeric region of chromosome 9. Hum Genet 2008; 123: 267\u2013272.","journal-title":"Hum Genet"},{"key":"BFgene20103_CR9","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1093\/hmg\/ddm150","volume":"16","author":"M Thys","year":"2007","unstructured":"Thys M, Schrauwen I, Vanderstraeten K, Janssens K, Dieltjens N, Van Den Bogaert K et al. The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations. Hum Mol Genet 2007; 16: 2021\u20132030.","journal-title":"Hum Mol Genet"},{"key":"BFgene20103_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1359\/jbmr.071112","volume":"23","author":"I Schrauwen","year":"2008","unstructured":"Schrauwen I, Thys M, Vanderstraeten K, Fransen E, Dieltjens N, Huyghe JR et al. Association of bone morphogenetic proteins with otosclerosis. J Bone Miner Res 2008; 23: 507\u2013516.","journal-title":"J Bone Miner Res"},{"key":"BFgene20103_CR11","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.ajhg.2009.01.023","volume":"84","author":"I Schrauwen","year":"2009","unstructured":"Schrauwen I, Ealy M, Huentelman MJ, Thys M, Homer N, Vanderstraeten K et al. A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. Am J Hum Genet 2009; 84: 328\u2013338.","journal-title":"Am J Hum Genet"},{"key":"BFgene20103_CR12","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1097\/MAO.0b013e3181ab3058","volume":"30","author":"I Schrauwen","year":"2009","unstructured":"Schrauwen I, Thys M, Vanderstraeten K, Fransen E, Ealy M, Cremers CW et al. No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. Otol Neurotol 2009; 30: 1079\u20131083.","journal-title":"Otol Neurotol"},{"key":"BFgene20103_CR13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1177\/000348948409300107","volume":"93","author":"TJ Yoo","year":"1984","unstructured":"Yoo TJ . Etiopathogenesis of otosclerosis: a hypothesis. Ann Otol Rhinol Laryngol 1984; 93: 28\u201333.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"BFgene20103_CR14","first-page":"14","volume":"1","author":"NN Reshetnikov","year":"1992","unstructured":"Reshetnikov NN, Popova TI . IgA, IgM and IgG levels and antibodies to native DNA and collagen type II in the perilymph of patients with otosclerosis. Vestn Otorinolaringol 1992; 1: 14\u201316.","journal-title":"Vestn Otorinolaringol"},{"key":"BFgene20103_CR15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1177\/000348948309200201","volume":"92","author":"TJ Yoo","year":"1983","unstructured":"Yoo TJ, Tomoda K, Stuart JM, Kang AH, Townes AS . Type II collagen-induced autoimmune otospongiosis. A preliminary report. Ann Otol Rhinol Laryngol 1983; 92: 103\u2013108.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"BFgene20103_CR16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/00016489850183467","volume":"118","author":"SR Lolov","year":"1998","unstructured":"Lolov SR, Edrev GE, Kyurkchiev SD, Kehayov IR . Elevated autoantibodies in sera from otosclerotic patients are related to the disease duration. Acta Otolaryngol 1998; 118: 375\u2013380.","journal-title":"Acta Otolaryngol"},{"key":"BFgene20103_CR17","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3109\/00016488809097004","volume":"105","author":"M Solvsten Sorensen","year":"1988","unstructured":"Solvsten Sorensen M, Nielsen LP, Bretlau P, Jorgensen MB . The role of type II collagen autoimmunity in otosclerosis revisited. Acta Otolaryngol 1988; 105: 242\u2013247.","journal-title":"Acta Otolaryngol"},{"key":"BFgene20103_CR18","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1177\/000348948609500214","volume":"95","author":"JP Harris","year":"1986","unstructured":"Harris JP, Woolf NK, Ryan AF . A reexamination of experimental type II collagen autoimmunity: middle and inner ear morphology and function. Ann Otol Rhinol Laryngol 1986; 95: 176\u2013180.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"BFgene20103_CR19","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1038\/ng.2007.17","volume":"39","author":"PR Burton","year":"2007","unstructured":"Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A et al. Association scan of 14\u2009500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007; 39: 1329\u20131337.","journal-title":"Nat Genet"},{"key":"BFgene20103_CR20","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1001\/archotol.1982.00790600013004","volume":"108","author":"S Gregoriadis","year":"1982","unstructured":"Gregoriadis S, Zervas J, Varletzidis E, Toubis M, Pantazopoulos P, Fessas P . HLA antigens and otosclerosis. A possible new genetic factor. Arch Otolaryngol 1982; 108: 769\u2013771.","journal-title":"Arch Otolaryngol"},{"key":"BFgene20103_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/S0196-0709(99)90019-4","volume":"20","author":"SK Singhal","year":"1999","unstructured":"Singhal SK, Mann SB, Datta U, Panda NK, Gupta AK . Genetic correlation in otosclerosis. Am J Otolaryngol 1999; 20: 102\u2013105.","journal-title":"Am J Otolaryngol"},{"key":"BFgene20103_CR22","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1017\/S0022215100096043","volume":"97","author":"U Pedersen","year":"1983","unstructured":"Pedersen U, Madsen M, Lamm LU, Elbrond O . HLA-A, -B, -C antigens in otosclerosis. J Laryngol Otol 1983; 97: 1095\u20131097.","journal-title":"J Laryngol Otol"},{"key":"BFgene20103_CR23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/00016488909138366","volume":"470","author":"W Arnold","year":"1990","unstructured":"Arnold W, Friedmann I . Immunohistochemistry of otosclerosis. Acta Otolaryngol Suppl 1990; 470: 124\u2013128; discussion 128\u2013129.","journal-title":"Acta Otolaryngol Suppl"},{"key":"BFgene20103_CR24","first-page":"476","volume":"40","author":"HJ Altermatt","year":"1992","unstructured":"Altermatt HJ, Gerber HA, Gaeng D, Muller C, Arnold W . Immunohistochemical findings in otosclerotic lesions. Hno 1992; 40: 476\u2013479.","journal-title":"Hno"},{"key":"BFgene20103_CR25","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1017\/S0022215100106693","volume":"102","author":"W Arnold","year":"1988","unstructured":"Arnold W, Friedmann I . Otosclerosis\u2014an inflammatory disease of the otic capsule of viral aetiology? J Laryngol Otol 1988; 102: 865\u2013871.","journal-title":"J Laryngol Otol"},{"key":"BFgene20103_CR26","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3109\/03008209709160223","volume":"36","author":"M Bodo","year":"1997","unstructured":"Bodo M, Carinci P, Venti G, Giammarioli M, Donti E, Stabellini G et al. Glycosaminoglycan metabolism and cytokine release in normal and otosclerotic human bone cells interleukin-1 treated. Connect Tissue Res 1997; 36: 231\u2013240.","journal-title":"Connect Tissue Res"},{"key":"BFgene20103_CR27","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1097\/01.mlg.0000225928.35838.e5","volume":"116","author":"T Karosi","year":"2006","unstructured":"Karosi T, Jokay I, Konya J, Szabo LZ, Pytel J, Jori J et al. Detection of osteoprotegerin and TNF-alpha mRNA in ankylotic stapes footplates in connection with measles virus positivity. Laryngoscope 2006; 116: 1427\u20131433.","journal-title":"Laryngoscope"},{"key":"BFgene20103_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000111049","volume":"70","author":"HP Niedermeyer","year":"2008","unstructured":"Niedermeyer HP, Arnold W . Otosclerosis and measles virus\u2014association or causation? ORL J Otorhinolaryngol Relat Spec 2008; 70: 63\u201369; discussion 69\u201370.","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"BFgene20103_CR29","doi-asserted-by":"publisher","first-page":"7446","DOI":"10.4049\/jimmunol.174.11.7446","volume":"174","author":"K Naylor","year":"2005","unstructured":"Naylor K, Li G, Vallejo AN, Lee WW, Koetz K, Bryl E et al. The influence of age on T cell generation and TCR diversity. J Immunol 2005; 174: 7446\u20137452.","journal-title":"J Immunol"},{"key":"BFgene20103_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0167-5699(89)90232-6","volume":"10","author":"BF Haynes","year":"1989","unstructured":"Haynes BF, Denning SM, Singer KH, Kurtzberg J . Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development. Immunol Today 1989; 10: 87\u201391.","journal-title":"Immunol Today"},{"key":"BFgene20103_CR31","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1056\/NEJMra055446","volume":"354","author":"H Jiang","year":"2006","unstructured":"Jiang H, Chess L . Regulation of immune responses by T cells. N Engl J Med 2006; 354: 1166\u20131176.","journal-title":"N Engl J Med"},{"key":"BFgene20103_CR32","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1002\/jnr.20852","volume":"83","author":"K Venken","year":"2006","unstructured":"Venken K, Hellings N, Hensen K, Rummens JL, Medaer R, D\u2019Hooghe MB et al. Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression. J Neurosci Res 2006; 83: 1432\u20131446.","journal-title":"J Neurosci Res"},{"key":"BFgene20103_CR33","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.4049\/jimmunol.162.11.6572","volume":"162","author":"AN Vallejo","year":"1999","unstructured":"Vallejo AN, Brandes JC, Weyand CM, Goronzy JJ . Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol 1999; 162: 6572\u20136579.","journal-title":"J Immunol"},{"key":"BFgene20103_CR34","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.clim.2007.01.005","volume":"123","author":"M Thewissen","year":"2007","unstructured":"Thewissen M, Somers V, Venken K, Linsen L, van Paassen P, Geusens P et al. Analyses of immunosenescent markers in patients with autoimmune disease. Clin Immunol 2007; 123: 209\u2013218.","journal-title":"Clin Immunol"},{"key":"BFgene20103_CR35","doi-asserted-by":"publisher","first-page":"R1412","DOI":"10.1186\/ar1840","volume":"7","author":"B Raffeiner","year":"2005","unstructured":"Raffeiner B, Dejaco C, Duftner C, Kullich W, Goldberger C, Vega SC et al. Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis. Arthritis Res Ther 2005; 7: R1412\u2013R1420.","journal-title":"Arthritis Res Ther"},{"key":"BFgene20103_CR36","doi-asserted-by":"publisher","first-page":"6514","DOI":"10.4049\/jimmunol.179.10.6514","volume":"179","author":"M Thewissen","year":"2007","unstructured":"Thewissen M, Somers V, Hellings N, Fraussen J, Damoiseaux J, Stinissen P . CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation. J Immunol 2007; 179: 6514\u20136523.","journal-title":"J Immunol"},{"key":"BFgene20103_CR37","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1210\/er.2007-0038","volume":"29","author":"J Lorenzo","year":"2008","unstructured":"Lorenzo J, Horowitz M, Choi Y . Osteoimmunology: interactions of the bone and immune system. Endocr Rev 2008; 29: 403\u2013440.","journal-title":"Endocr Rev"},{"key":"BFgene20103_CR38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1017\/S0022215100111946","volume":"104","author":"CM Milroy","year":"1990","unstructured":"Milroy CM, Michaels L . Pathology of the otic capsule. J Laryngol Otol 1990; 104: 83\u201390.","journal-title":"J Laryngol Otol"},{"key":"BFgene20103_CR39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cell.2007.06.033","volume":"130","author":"CC Goodnow","year":"2007","unstructured":"Goodnow CC . Multistep pathogenesis of autoimmune disease. Cell 2007; 130: 25\u201335.","journal-title":"Cell"},{"key":"BFgene20103_CR40","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/360225a0","volume":"360","author":"P Mombaerts","year":"1992","unstructured":"Mombaerts P, Clarke AR, Rudnicki MA, Iacomini J, Itohara S, Lafaille JJ et al. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 1992; 360: 225\u2013231.","journal-title":"Nature"},{"key":"BFgene20103_CR41","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.4049\/jimmunol.176.3.1543","volume":"176","author":"ML Joachims","year":"2006","unstructured":"Joachims ML, Chain JL, Hooker SW, Knott-Craig CJ, Thompson LF . Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential\u2014differences between men and mice. J Immunol 2006; 176: 1543\u20131552.","journal-title":"J Immunol"},{"key":"BFgene20103_CR42","doi-asserted-by":"publisher","first-page":"7877","DOI":"10.1073\/pnas.93.15.7877","volume":"93","author":"G Bouvier","year":"1996","unstructured":"Bouvier G, Watrin F, Naspetti M, Verthuy C, Naquet P, Ferrier P . Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci USA 1996; 93: 7877\u20137881.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgene20103_CR43","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/path.2104","volume":"211","author":"AL Gruver","year":"2007","unstructured":"Gruver AL, Hudson LL, Sempowski GD . Immunosenescence of ageing. J Pathol 2007; 211: 144\u2013156.","journal-title":"J Pathol"},{"key":"BFgene20103_CR44","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1093\/nar\/gkm076","volume":"35","author":"S Colella","year":"2007","unstructured":"Colella S, Yau C, Taylor JM, Mirza G, Butler H, Clouston P et al. QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data. Nucleic Acids Res 2007; 35: 2013\u20132025.","journal-title":"Nucleic Acids Res"},{"key":"BFgene20103_CR45","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1101\/gr.6861907","volume":"17","author":"K Wang","year":"2007","unstructured":"Wang K, Li M, Hadley D, Liu R, Glessner J, Grant SF et al. PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res 2007; 17: 1665\u20131674.","journal-title":"Genome Res"},{"key":"BFgene20103_CR46","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1126\/science.272.5269.1755","volume":"272","author":"L Rowen","year":"1996","unstructured":"Rowen L, Koop BF, Hood L . The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science 1996; 272: 1755\u20131762.","journal-title":"Science"},{"key":"BFgene20103_CR47","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","volume":"17","author":"JJ van Dongen","year":"2003","unstructured":"van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257\u20132317.","journal-title":"Leukemia"},{"key":"BFgene20103_CR48","doi-asserted-by":"publisher","first-page":"R19","DOI":"10.1186\/gb-2007-8-2-r19","volume":"8","author":"J Hellemans","year":"2007","unstructured":"Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J . qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol 2007; 8: R19.","journal-title":"Genome Biol"}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene20103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene20103","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene20103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T16:44:58Z","timestamp":1685465098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene20103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,25]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["BFgene20103"],"URL":"https:\/\/doi.org\/10.1038\/gene.2010.3","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,25]]},"assertion":[{"value":"12 August 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2009","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2009","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}