{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:28:41Z","timestamp":1790375321186,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1038\/gene.2010.59","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T11:04:31Z","timestamp":1293102271000},"page":"191-198","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus"],"prefix":"10.1038","volume":"12","author":[{"given":"I-L","family":"Mero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5 R","family":"Lorentzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Smestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E G","family":"Celius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"S\u00e6ther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Saeedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M K","family":"Viken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Skinningsrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D E","family":"Undlien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Aarseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K-M","family":"Myhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Granum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Spurkland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sawcer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Compston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"Lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H F","family":"Harbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"BFgene201059_CR1","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nature06010","volume":"448","author":"H Hakonarson","year":"2007","unstructured":"Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 2007; 448: 591\u2013594.","journal-title":"Nature"},{"key":"BFgene201059_CR2","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1056\/NEJMoa073493","volume":"357","author":"International Multiple Sclerosis Genetics Consortium (IMSGC)","year":"2007","unstructured":"International Multiple Sclerosis Genetics Consortium (IMSGC). Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007; 357: 851\u2013862.","journal-title":"N Engl J Med"},{"key":"BFgene201059_CR3","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","volume":"447","author":"Wellcome Trust Case Control Consortium","year":"2007","unstructured":"Wellcome Trust Case Control Consortium. Genome-wide association study of 14\u2009000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447: 661\u2013678.","journal-title":"Nature"},{"key":"BFgene201059_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/gene.2008.83","volume":"10","author":"International Multiple Sclerosis Genetics Consortium (IMSGC)","year":"2009","unstructured":"International Multiple Sclerosis Genetics Consortium (IMSGC). The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun 2009; 10: 11\u201314.","journal-title":"Genes Immun"},{"key":"BFgene201059_CR5","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/ejhg.2009.50","volume":"17","author":"A Marquez","year":"2009","unstructured":"Marquez A, Varade J, Robledo G, Martinez A, Mendoza JL, Taxonera C et al. Specific association of a CLEC16A\/KIAA0350 polymorphism with NOD2\/CARD15(-) Crohn's disease patients. Eur J Hum Genet 2009; 17: 1304\u20131308.","journal-title":"Eur J Hum Genet"},{"key":"BFgene201059_CR6","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/gene.2008.59","volume":"9","author":"JP Rubio","year":"2008","unstructured":"Rubio JP, Stankovich J, Field J, Tubridy N, Marriott M, Chapman C et al. Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. Genes Immun 2008; 9: 624\u2013630.","journal-title":"Genes Immun"},{"key":"BFgene201059_CR7","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1210\/jc.2008-0821","volume":"93","author":"B Skinningsrud","year":"2008","unstructured":"Skinningsrud B, Husebye ES, Pearce SH, McDonald DO, Brandal K, Boe WA et al. Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. J Clin Endocrinol Metab 2008; 93: 3310\u20133317.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFgene201059_CR8","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1136\/ard.2009.114934","volume":"69","author":"B Skinningsrud","year":"2009","unstructured":"Skinningsrud B, Lie BA, Husebye ES, Kvien TK, Forre O, Flato B et al. A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-CCP negative rheumatoid arthritis. Ann Rheum Dis 2009; 69: 1471\u20131474.","journal-title":"Ann Rheum Dis"},{"key":"BFgene201059_CR9","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ng2068","volume":"39","author":"JA Todd","year":"2007","unstructured":"Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39: 857\u2013864.","journal-title":"Nat Genet"},{"key":"BFgene201059_CR10","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nri2569","volume":"9","author":"TB Geijtenbeek","year":"2009","unstructured":"Geijtenbeek TB, Gringhuis SI . Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol 2009; 9: 465\u2013479.","journal-title":"Nat Rev Immunol"},{"key":"BFgene201059_CR11","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/jhg.2009.96","volume":"54","author":"IA Hoppenbrouwers","year":"2009","unstructured":"Hoppenbrouwers IA, Aulchenko YS, Janssens AC, Ramagopalan SV, Broer L, Kayser M et al. Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis. J Hum Genet 2009; 54: 676\u2013680.","journal-title":"J Hum Genet"},{"key":"BFgene201059_CR12","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ . Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263\u2013265.","journal-title":"Bioinformatics"},{"key":"BFgene201059_CR13","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/nature06258","volume":"449","author":"International HapMap Consortium 2007","year":"2007","unstructured":"International HapMap Consortium 2007. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449: 851\u2013861.","journal-title":"Nature"},{"key":"BFgene201059_CR14","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1136\/ard.2008.098376","volume":"69","author":"A Martinez","year":"2010","unstructured":"Martinez A, Perdigones N, Cenit M, Espino L, Varade J, Lamas JR et al. Chromosomal region 16p13: further evidence of increased predisposition to immune diseases. Ann Rheum Dis 2010; 69: 309\u2013311.","journal-title":"Ann Rheum Dis"},{"key":"BFgene201059_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/gene.2008.84","volume":"10","author":"M Zoledziewska","year":"2009","unstructured":"Zoledziewska M, Costa G, Pitzalis M, Cocco E, Melis C, Moi L et al. Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia. Genes Immun 2009; 10: 15\u201322.","journal-title":"Genes Immun"},{"key":"BFgene201059_CR16","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/gene.2010.7","volume":"11","author":"PG Bronson","year":"2010","unstructured":"Bronson PG, Ramsay PP, Seldin MF, Gregersen PK, Criswell LA, Barcellos LF . A candidate gene study of CLEC16A does not provide evidence of association with risk for anti-CCP-positive rheumatoid arthritis. Genes Immun 2010; 11: 504\u2013508.","journal-title":"Genes Immun"},{"key":"BFgene201059_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jneuroim.2009.03.010","volume":"211","author":"D Perera","year":"2009","unstructured":"Perera D, Stankovich J, Butzkueven H, Taylor BV, Foote SJ, Kilpatrick TJ et al. Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus. J Neuroimmunol 2009; 211: 105\u2013109.","journal-title":"J Neuroimmunol"},{"key":"BFgene201059_CR18","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1126\/science.1167728","volume":"324","author":"S Nejentsev","year":"2009","unstructured":"Nejentsev S, Walker N, Riches D, Egholm M, Todd JA . Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009; 324: 387\u2013389.","journal-title":"Science"},{"key":"BFgene201059_CR19","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00439-010-0789-4","volume":"127","author":"RL Zuvich","year":"2010","unstructured":"Zuvich RL, McCauley JL, Oksenberg JR, Sawcer SJ, De Jager PL, Aubin C et al. Genetic variation in the IL7RA\/IL7 pathway increases multiple sclerosis susceptibility. Hum Genet 2010; 127: 525\u2013535.","journal-title":"Hum Genet"},{"key":"BFgene201059_CR20","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1093\/hmg\/ddq101","volume":"19","author":"PG Bronson","year":"2010","unstructured":"Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL et al. CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet 2010; 19: 2331\u20132340.","journal-title":"Hum Mol Genet"},{"key":"BFgene201059_CR21","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/ana.1032","volume":"50","author":"WI McDonald","year":"2001","unstructured":"McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50: 121\u2013127.","journal-title":"Ann Neurol"},{"key":"BFgene201059_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/ana.410130302","volume":"13","author":"CM Poser","year":"1983","unstructured":"Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13: 227\u2013231.","journal-title":"Ann Neurol"},{"key":"BFgene201059_CR23","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/ng1669","volume":"37","author":"PI de Bakker","year":"2005","unstructured":"de Bakker PI, Yelensky R, Pe\u2019er I, Gabriel SB, Daly MJ, Altshuler D . Efficiency and power in genetic association studies. Nat Genet 2005; 37: 1217\u20131223.","journal-title":"Nat Genet"},{"key":"BFgene201059_CR24","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559\u2013575.","journal-title":"Am J Hum Genet"},{"key":"BFgene201059_CR25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000119108","volume":"66","author":"F Dudbridge","year":"2008","unstructured":"Dudbridge F . Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 2008; 66: 87\u201398.","journal-title":"Hum Hered"}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene201059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201059","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T16:36:42Z","timestamp":1647967002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,23]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["BFgene201059"],"URL":"https:\/\/doi.org\/10.1038\/gene.2010.59","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,23]]},"assertion":[{"value":"3 May 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}