{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:38:58Z","timestamp":1778859538860,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T00:00:00Z","timestamp":1299110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T00:00:00Z","timestamp":1299110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1038\/gene.2011.15","type":"journal-article","created":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T12:52:00Z","timestamp":1299243120000},"page":"457-465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The role of HLA\u2013DR\u2013DQ haplotypes in variable antibody responses to Anthrax Vaccine Adsorbed"],"prefix":"10.1038","volume":"12","author":[{"given":"N M","family":"Pajewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G A","family":"Poland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I G","family":"Ovsyannikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B A","family":"McKinney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V S","family":"Pankratz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Edberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R P","family":"Kimberly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Kaslow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,3,3]]},"reference":[{"key":"BFgene201115_CR1","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3201\/eid0810.020389","volume":"8","author":"J Maillard","year":"2002","unstructured":"Maillard J, Fischer M, McKee KJ, Turner L, Cline J . First case of bioterrorism-related inhalational anthrax, Florida, 2001: North Carolina investigation. Emerg Infect Dis 2002; 8: 1035\u20131038.","journal-title":"Emerg Infect Dis"},{"key":"BFgene201115_CR2","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3201\/eid0810.020353","volume":"8","author":"D Jernigan","year":"2002","unstructured":"Jernigan D, Raghunathan P, Bell B, Brechner R, Bresnitz E, Butler J et al. Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings. Emerg Infect Dis 2002; 8: 1019\u20131028.","journal-title":"Emerg Infect Dis"},{"key":"BFgene201115_CR3","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.3201\/eid0810.020354","volume":"8","author":"M Traeger","year":"2002","unstructured":"Traeger M, Wiersma S, Rosenstein N, Malecki J, Shepard C, Raghunathan P et al. First case of bioterrorism-related inhalational anthrax in the United States, Palm Beach County, Florida, 2001. Emerg Infect Dis 2002; 8: 1029\u20131034.","journal-title":"Emerg Infect Dis"},{"key":"BFgene201115_CR4","unstructured":"McNeil Jr D . Anthrax: In Scotland, six heroin users die of anthrax poisoning. New York Times, 12 January 2010."},{"key":"BFgene201115_CR5","unstructured":"National Institutes of Health. NIAID Biodefense Research Agenda for CDC Category A Agents In: (ed) National Institute of Allergy and Infectious Diseases (NIAID): Bethesda, MD, 2002."},{"key":"BFgene201115_CR6","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1126\/science.7973702","volume":"266","author":"M Meselson","year":"1994","unstructured":"Meselson M, Guillemin J, Hugh-Jones M, Langmuir A, Popova I, Shelokov A et al. The Sverdlovsk anthrax outbreak of 1979. Science 1994; 266: 1202\u20131208.","journal-title":"Science"},{"key":"BFgene201115_CR7","doi-asserted-by":"publisher","first-page":"632","DOI":"10.2105\/AJPH.52.4.632","volume":"52","author":"P Brachman","year":"1962","unstructured":"Brachman P, Gold H, Plotkin S, Fekety F, Werrin M, Ingraham N . Field evaluation of a human anthrax vaccine. Am J Public Health Nations Health 1962; 52: 632\u2013645.","journal-title":"Am J Public Health Nations Health"},{"key":"BFgene201115_CR8","first-page":"1024","volume":"51","author":"Centers for Disease Control, Prevention","year":"2002","unstructured":"Centers for Disease Control, Prevention. Use of anthrax vaccine in response to terrorism: supplemental recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep 2002; 51: 1024\u20131026.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"BFgene201115_CR9","doi-asserted-by":"publisher","first-page":"184","DOI":"10.4161\/hv.5.3.7308","volume":"5","author":"D Bienek","year":"2009","unstructured":"Bienek D, Loomis L, Biagini R . The anthrax vaccine: no new tricks for an old dog. Hum Vaccin 2009; 5: 184\u2013189.","journal-title":"Hum Vaccin"},{"key":"BFgene201115_CR10","unstructured":"Lee C . Mandatory anthrax shots to return. Washington Post, 17 October 2006."},{"key":"BFgene201115_CR11","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1046\/j.1365-2672.1999.00897.x","volume":"87","author":"M Pitt","year":"1999","unstructured":"Pitt M, Little S, Ivins B, Fellows P, Boles J, Barth J et al. In vitro correlate of immunity in an animal model of inhalational anthrax. J Appl Microbiol 1999; 87: 304.","journal-title":"J Appl Microbiol"},{"key":"BFgene201115_CR12","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1016\/S0264-410X(01)00021-4","volume":"19","author":"P Fellows","year":"2001","unstructured":"Fellows P, Linscott M, Ivins B, Pitt M, Rossi C, Gibbs P et al. Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical origin. Vaccine 2001; 19: 3241\u20133247.","journal-title":"Vaccine"},{"key":"BFgene201115_CR13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1086\/653495","volume":"202","author":"S Crowe","year":"2010","unstructured":"Crowe S, Ash L, Engler R, Ballard J, Harley J, Farris A et al. Select human anthrax protective antigen epitope-specific antibodies provide protection from lethal toxin challenge. J Infect Dis 2010; 202: 251\u2013260.","journal-title":"J Infect Dis"},{"key":"BFgene201115_CR14","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.1016\/j.vaccine.2009.05.045","volume":"27","author":"P Parreiras","year":"2009","unstructured":"Parreiras P, Sirota L, Wagner L, Menzies S, Arciniega J . Comparability of ELISA and toxin neutralization to measure immunogenicity of protective antigen in mice, as part of a potency test for anthrax vaccines. Vaccine 2009; 27: 4537\u20134542.","journal-title":"Vaccine"},{"key":"BFgene201115_CR15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0264-410X(00)00174-2","volume":"19","author":"P Pittman","year":"2000","unstructured":"Pittman P, Mangiafico J, Rossi C, Cannon T, Gibbs P, Parker G et al. Anthrax vaccine: increasing intervals between the first two doses enhances antibody response in humans. Vaccine 2000; 19: 213\u2013216.","journal-title":"Vaccine"},{"key":"BFgene201115_CR16","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/S0264-410X(01)00462-5","volume":"20","author":"P Pittman","year":"2002","unstructured":"Pittman P, Kim-Ahn G, Pifat D, Coonan K, Gibbs P, Little S et al. Anthrax vaccine: immunogenicity and safety of a dose-reduction, route-change comparison study in humans. Vaccine 2002; 20: 1412\u20131420.","journal-title":"Vaccine"},{"key":"BFgene201115_CR17","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1016\/S0264-410X(02)00058-0","volume":"20","author":"P Pittman","year":"2002","unstructured":"Pittman P, Hack D, Mangiafico J, Gibbs P, McKee KJ, Friedlander A et al. Antibody response to a delayed booster dose of anthrax vaccine and botulinum toxoid. Vaccine 2002; 20: 2107\u20132115.","journal-title":"Vaccine"},{"key":"BFgene201115_CR18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.vaccine.2007.11.085","volume":"26","author":"D Singer","year":"2008","unstructured":"Singer D, Schneerson R, Bautista C, Rubertone M, Robbins J, Taylor D . Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among US military personnel. Vaccine 2008; 26: 869\u2013873.","journal-title":"Vaccine"},{"key":"BFgene201115_CR19","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1001\/jama.300.13.1532","volume":"300","author":"N Marano","year":"2008","unstructured":"Marano N, Plikaytis B, Martin S, Rose C, Semenova V, Martin S et al. Effects of a reduced dose schedule and intramuscular administration of anthrax vaccine adsorbed on immunogenicity and safety at 7 months: a randomized trial. JAMA 2008; 300: 1532\u20131543.","journal-title":"JAMA"},{"key":"BFgene201115_CR20","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nri2629","volume":"9","author":"B Pulendran","year":"2009","unstructured":"Pulendran B . Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology. Nat Rev Immunol 2009; 9: 741\u2013747.","journal-title":"Nat Rev Immunol"},{"key":"BFgene201115_CR21","doi-asserted-by":"publisher","first-page":"e1000612","DOI":"10.1371\/journal.pgen.1000612","volume":"5","author":"K Seib","year":"2009","unstructured":"Seib K, Dougan G, Rappuoli R . The key role of genomics in modern vaccine and drug design for emerging infectious diseases. PLoS Genet 2009; 5: e1000612.","journal-title":"PLoS Genet"},{"key":"BFgene201115_CR22","doi-asserted-by":"publisher","first-page":"6183","DOI":"10.1016\/j.vaccine.2008.06.057","volume":"26","author":"G Poland","year":"2008","unstructured":"Poland G, Ovsyannikova I, Jacobson R . Vaccine immunogenetics: bedside to bench to population. Vaccine 2008; 26: 6183\u20136188.","journal-title":"Vaccine"},{"key":"BFgene201115_CR23","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00439-009-0763-1","volume":"127","author":"I Ovsyannikova","year":"2010","unstructured":"Ovsyannikova I, Dhiman N, Haralambieva I, Vierkant R, O\u2032Byrne M, Jacobson R et al. Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. Hum Genet 2010; 127: 207\u2013221.","journal-title":"Hum Genet"},{"key":"BFgene201115_CR24","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1086\/649588","volume":"201","author":"I Ovsyannikova","year":"2010","unstructured":"Ovsyannikova I, Haralambieva I, Dhiman N, O\u2032Byrne M, Pankratz V, Jacobson R et al. Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination. J Infect Dis 2010; 201: 207\u2013213.","journal-title":"J Infect Dis"},{"key":"BFgene201115_CR25","unstructured":"BioThrax-Package Insert, http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/BloodBloodProducts\/ApprovedProducts\/LicensedProductsBLAs\/UCM074923.pdf (accessed 15 March 2010)."},{"key":"BFgene201115_CR26","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1093\/aje\/kwk118","volume":"165","author":"H Schmidt","year":"2007","unstructured":"Schmidt H, Williamson D, Ashley-Koch A . HLA-DR15 haplotype and multiple sclerosis: a HuGE review. Am J Epidemiol 2007; 165: 1097\u20131109.","journal-title":"Am J Epidemiol"},{"key":"BFgene201115_CR27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1086\/342290","volume":"71","author":"R Graham","year":"2002","unstructured":"Graham R, Ortmann W, Langefeld C, Jawaheer D, Selby S, Rodine P et al. Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet 2002; 71: 543\u2013553.","journal-title":"Am J Hum Genet"},{"key":"BFgene201115_CR28","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.2337\/db07-1331","volume":"57","author":"H Erlich","year":"2008","unstructured":"Erlich H, Valdes A, Noble J, Carlson J, Varney M, Concannon P et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008; 57: 1084\u20131092.","journal-title":"Diabetes"},{"key":"BFgene201115_CR29","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1002\/hep.20142","volume":"39","author":"C Wang","year":"2004","unstructured":"Wang C, Tang J, Song W, Lobashevsky E, Wilson C, Kaslow R . HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination. Hepatology 2004; 39: 978\u2013988.","journal-title":"Hepatology"},{"key":"BFgene201115_CR30","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00439-009-0720-z","volume":"126","author":"Y Li","year":"2009","unstructured":"Li Y, Ni R, Song W, Shao W, Shrestha S, Ahmad S et al. Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth. Hum Genet 2009; 126: 685\u2013696.","journal-title":"Hum Genet"},{"key":"BFgene201115_CR31","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1086\/500144","volume":"193","author":"I Ovsyannikova","year":"2006","unstructured":"Ovsyannikova I, Pankratz V, Vierkant R, Jacobson R, Poland G . Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. J Infect Dis 2006; 193: 655\u2013663.","journal-title":"J Infect Dis"},{"key":"BFgene201115_CR32","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1002\/art.23433","volume":"58","author":"SJ Bridges","year":"2008","unstructured":"Bridges SJ, Kelley J, Hughes L . The HLA-DRB1 shared epitope in Caucasians with rheumatoid arthritis: a lesson learned from tic-tac-toe. Arthritis Rheum 2008; 58: 1211\u20131215.","journal-title":"Arthritis Rheum"},{"key":"BFgene201115_CR33","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1002\/hep.23515","volume":"51","author":"M Kuniholm","year":"2010","unstructured":"Kuniholm M, Kovacs A, Gao X, Xue X, Marti D, Thio C et al. Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia. Hepatology 2010; 51: 1514\u20131522.","journal-title":"Hepatology"},{"key":"BFgene201115_CR34","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/sj.gene.6363955","volume":"4","author":"A Mart\u00ednez","year":"2003","unstructured":"Mart\u00ednez A, Gual L, Fern\u00e1ndez-Arquero M, Nogales A, Ferreira A, Garcia-Rodriguez M et al. Epistatic effects occurring among susceptibility and protective MHC genes in IgA deficiency. Genes Immun 2003; 4: 316\u2013320.","journal-title":"Genes Immun"},{"key":"BFgene201115_CR35","doi-asserted-by":"publisher","first-page":"e1091","DOI":"10.1542\/peds.2007-1575","volume":"121","author":"I Ovsyannikova","year":"2008","unstructured":"Ovsyannikova I, Jacobson R, Dhiman N, Vierkant R, Pankratz V, Poland G . Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine. Pediatrics 2008; 121: e1091\u2013e1099.","journal-title":"Pediatrics"},{"key":"BFgene201115_CR36","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1128\/IAI.01814-06","volume":"75","author":"E Laughlin","year":"2007","unstructured":"Laughlin E, Miller J, James E, Fillos D, Ibegbu C, Mittler R et al. Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine. Infect Immun 2007; 75: 1852\u20131860.","journal-title":"Infect Immun"},{"issue":"RR-6","key":"BFgene201115_CR37","first-page":"1","volume":"59","author":"JG Wright","year":"2010","unstructured":"Wright JG, Quinn CP, Shadomy S, Messonnier N . Use of anthrax vaccine in the United States: recommendations of the Advisory Committee on immunization ractices (ACIP), 2009. MMWR Recomm Rep 2010; 59 (RR-6): 1\u201330.","journal-title":"MMWR Recomm Rep"},{"key":"BFgene201115_CR38","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJM198909143211103","volume":"321","author":"C Alper","year":"1989","unstructured":"Alper C, Kruskall M, Marcus-Bagley D, Craven D, Katz A, Brink S et al. Genetic prediction of nonresponse to hepatitis B vaccine. N Engl J Med 1989; 321: 708\u2013712.","journal-title":"N Engl J Med"},{"key":"BFgene201115_CR39","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1001\/jama.1997.03540380070034","volume":"277","author":"G Poland","year":"1997","unstructured":"Poland G, Jacobson R, Thampy A, Colbourne S, Wollan P, Lipsky J et al. Measles reimmunization in children seronegative after initial immunization. JAMA 1997; 277: 1156\u20131158.","journal-title":"JAMA"},{"key":"BFgene201115_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2172-9-1","volume":"9","author":"J Sidney","year":"2008","unstructured":"Sidney J, Peters B, Frahm N, Brander C, Sette A . HLA class I supertypes: a revised and updated classification. BMC Immunol 2008; 9: 1.","journal-title":"BMC Immunol"},{"key":"BFgene201115_CR41","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/sj.clpt.6100415","volume":"82","author":"G Poland","year":"2007","unstructured":"Poland G, Ovsyannikova I, Jacobson R, Smith D . Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics. Clin Pharmacol Ther 2007; 82: 653\u2013664.","journal-title":"Clin Pharmacol Ther"},{"key":"BFgene201115_CR42","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"A Price","year":"2006","unstructured":"Price A, Patterson N, Plenge R, Weinblatt M, Shadick N, Reich D . Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38: 904\u2013909.","journal-title":"Nat Genet"},{"key":"BFgene201115_CR43","unstructured":"Anthrax vaccine efficacy: a cross-species analysis. ASM Biodefense and Emerging Diseases Research Meeting. American Society of Microbiology: Baltimore, MD, 2010."},{"key":"BFgene201115_CR44","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.0001-2815.2004.00295.x","volume":"64","author":"W Shao","year":"2004","unstructured":"Shao W, Tang J, Dorak M, Song W, Lobashevsky E, Cobbs C et al. Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplification. Tissue Antigens 2004; 64: 286\u2013292.","journal-title":"Tissue Antigens"},{"key":"BFgene201115_CR45","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.4049\/jimmunol.181.4.2626","volume":"181","author":"J Tang","year":"2008","unstructured":"Tang J, Shao W, Yoo Y, Brill I, Mulenga J, Allen S et al. Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couples. J Immunol 2008; 181: 2626\u20132635.","journal-title":"J Immunol"},{"key":"BFgene201115_CR46","doi-asserted-by":"crossref","DOI":"10.1007\/b97377","volume-title":"Survival Analysis: Techniques for Censored and Truncated Data","author":"J Klein","year":"2003","unstructured":"Klein J, Moeschberger M . Survival Analysis: Techniques for Censored and Truncated Data. Second edn Springer-Verlag: New York, 2003."},{"key":"BFgene201115_CR47","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/bimj.200810425","volume":"50","author":"T Hothorn","year":"2008","unstructured":"Hothorn T, Bretz F, Westfall P . Simultaneous inference in general parametric models. Biom J 2008; 50: 346\u2013363.","journal-title":"Biom J"},{"issue":"Part 2","key":"BFgene201115_CR48","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1542\/peds.96.3.600","volume":"96","author":"G Reed","year":"1995","unstructured":"Reed G, Meade B, Steinhoff M . The reverse cumulative distribution plot: a graphic method for exploratory analysis of antibody data. Pediatrics 1995; 96 (Part 2): 600\u2013603.","journal-title":"Pediatrics"},{"key":"BFgene201115_CR49","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2307\/2344317","volume":"135","author":"R Peto","year":"1972","unstructured":"Peto R, Peto J . Asymptotically efficient rank invariant testing procedures. J R Stat Soc A 1972; 135: 185\u2013207.","journal-title":"J R Stat Soc A"},{"key":"BFgene201115_CR50","unstructured":"R Development Core Team. R: A language and environment for statistical computing. In. R Foundation for Statistical Computing: Vienna, Austria, 2009."}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene201115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201115","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T09:17:02Z","timestamp":1661246222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,3]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["BFgene201115"],"URL":"https:\/\/doi.org\/10.1038\/gene.2011.15","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,3]]},"assertion":[{"value":"8 September 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr Poland has served as a consultant to Emergent Biosolutions Inc. (Rockville, MD, USA). All other authors declare no conflicts of interest or competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}