{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:33:04Z","timestamp":1772130784063,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T00:00:00Z","timestamp":1306368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T00:00:00Z","timestamp":1306368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1038\/gene.2011.38","type":"journal-article","created":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T08:56:09Z","timestamp":1306400169000},"page":"531-543","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of Usp18 and IFN signaling in Salmonella-induced typhlitis"],"prefix":"10.1038","volume":"12","author":[{"given":"E","family":"Richer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K E","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Dauphinee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Larivi\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Malo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,5,26]]},"reference":[{"key":"BFgene201138_CR1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/sj.gene.6363924","volume":"3","author":"MF Roy","year":"2002","unstructured":"Roy MF, Malo D . Genetic regulation of host responses to Salmonella infection in mice. Genes Immun 2002; 3: 381\u2013393.","journal-title":"Genes Immun"},{"key":"BFgene201138_CR2","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/297506a0","volume":"297","author":"E Skamene","year":"1982","unstructured":"Skamene E, Gros P, Forget A, Kongshavn PA, St Charles C, Taylor BA . Genetic regulation of resistance to intracellular pathogens. Nature 1982; 297: 506\u2013509.","journal-title":"Nature"},{"key":"BFgene201138_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev.immunol.26.021607.090304","volume":"26","author":"SM Vidal","year":"2008","unstructured":"Vidal SM, Malo D, Marquis JF, Gros P . Forward genetic dissection of immunity to infection in the mouse. Annu Rev Immunol 2008; 26: 81\u2013132.","journal-title":"Annu Rev Immunol"},{"key":"BFgene201138_CR4","volume-title":"Salmonella Infections","author":"D Maskell","year":"2007","unstructured":"Maskell D . Salmonella Infections, 1st edn. Cambridge University Press: Cambridge, 2007."},{"key":"BFgene201138_CR5","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/S1286-4579(01)01495-2","volume":"3","author":"RL Santos","year":"2001","unstructured":"Santos RL, Zhang S, Tsolis RM, Kingsley RA, Adams LG, Baumler AJ . Animal models of Salmonella infections: enteritis versus typhoid fever. Microbes Infect 2001; 3: 1335\u20131344.","journal-title":"Microbes Infect"},{"key":"BFgene201138_CR6","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","volume":"71","author":"M Barthel","year":"2003","unstructured":"Barthel M, Hapfelmeier S, Quintanilla-Martinez L, Kremer M, Rohde M, Hogardt M et al. Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Infect Immun 2003; 71: 2839\u20132858.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR7","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.tim.2005.08.008","volume":"13","author":"S Hapfelmeier","year":"2005","unstructured":"Hapfelmeier S, Hardt WD . A mouse model for S. typhimurium-induced enterocolitis. Trends Microbiol 2005; 13: 497\u2013503.","journal-title":"Trends Microbiol"},{"key":"BFgene201138_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/j.1462-5822.2008.01258.x","volume":"11","author":"Y Valdez","year":"2009","unstructured":"Valdez Y, Grassl GA, Guttman JA, Coburn B, Gros P, Vallance BA et al. Nramp1 drives an accelerated inflammatory response during Salmonella-induced colitis in mice. Cell Microbiol 2009; 11: 351\u2013362.","journal-title":"Cell Microbiol"},{"key":"BFgene201138_CR9","doi-asserted-by":"publisher","first-page":"5047","DOI":"10.1128\/IAI.00072-06","volume":"74","author":"B Stecher","year":"2006","unstructured":"Stecher B, Paesold G, Barthel M, Kremer M, Jantsch J, Stallmach T et al. Chronic Salmonella enterica serovar Typhimurium-induced colitis and cholangitis in streptomycin-pretreated Nramp1+\/+ mice. Infect Immun 2006; 74: 5047\u20135057.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR10","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1128\/IAI.01491-07","volume":"76","author":"M Vijay-Kumar","year":"2008","unstructured":"Vijay-Kumar M, Aitken JD, Kumar A, Neish AS, Uematsu S, Akira S et al. Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease. Infect Immun 2008; 76: 1276\u20131281.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR11","doi-asserted-by":"publisher","first-page":"e1603","DOI":"10.1371\/journal.pone.0001603","volume":"3","author":"H Woo","year":"2008","unstructured":"Woo H, Okamoto S, Guiney D, Gunn JS, Fierer J . A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice. PLoS One 2008; 3: e1603.","journal-title":"PLoS One"},{"key":"BFgene201138_CR12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/j.1365-2958.2007.05823.x","volume":"65","author":"MC Schlumberger","year":"2007","unstructured":"Schlumberger MC, Kappeli R, Wetter M, Muller AJ, Misselwitz B, Dilling S et al. Two newly identified SipA domains (F1, F2) steer effector protein localization and contribute to Salmonella host cell manipulation. Mol Microbiol 2007; 65: 741\u2013760.","journal-title":"Mol Microbiol"},{"key":"BFgene201138_CR13","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1128\/IAI.73.6.3219-3227.2005","volume":"73","author":"B Coburn","year":"2005","unstructured":"Coburn B, Li Y, Owen D, Vallance BA, Finlay BB . Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis. Infect Immun 2005; 73: 3219\u20133227.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR14","doi-asserted-by":"publisher","first-page":"e32","DOI":"10.1371\/journal.ppat.0010032","volume":"1","author":"NF Brown","year":"2005","unstructured":"Brown NF, Vallance BA, Coombes BK, Valdez Y, Coburn BA, Finlay BB . Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine. PLoS Pathog 2005; 1: e32.","journal-title":"PLoS Pathog"},{"key":"BFgene201138_CR15","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.4049\/jimmunol.174.3.1675","volume":"174","author":"S Hapfelmeier","year":"2005","unstructured":"Hapfelmeier S, Stecher B, Barthel M, Kremer M, Muller AJ, Heikenwalder M et al. The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms. J Immunol 2005; 174: 1675\u20131685.","journal-title":"J Immunol"},{"key":"BFgene201138_CR16","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.4049\/jimmunol.1000890","volume":"185","author":"E Richer","year":"2010","unstructured":"Richer E, Prendergast C, Zhang DE, Qureshi ST, Vidal SM, Malo D . N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-alphabeta signaling and suppresses STAT4-induced IFN-gamma production, resulting in increased susceptibility to Salmonella Typhimurium. J Immunol 2010; 185: 3593\u20133601.","journal-title":"J Immunol"},{"key":"BFgene201138_CR17","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1084\/jem.20070401","volume":"204","author":"T Miyagi","year":"2007","unstructured":"Miyagi T, Gil MP, Wang X, Louten J, Chu WM, Biron CA . High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med 2007; 204: 2383\u20132396.","journal-title":"J Exp Med"},{"key":"BFgene201138_CR18","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1371\/journal.pbio.0050244","volume":"5","author":"B Stecher","year":"2007","unstructured":"Stecher B, Robbiani R, Walker AW, Westendorf AM, Barthel M, Kremer M et al. Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol 2007; 5: 2177\u20132189.","journal-title":"PLoS Biol"},{"key":"BFgene201138_CR19","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/sj.gene.6364309","volume":"7","author":"MF Roy","year":"2006","unstructured":"Roy MF, Lariviere L, Wilkinson R, Tam M, Stevenson MM, Malo D . Incremental expression of Tlr4 correlates with mouse resistance to Salmonella infection and fine regulation of relevant immune genes. Genes Immun 2006; 7: 372\u2013383.","journal-title":"Genes Immun"},{"key":"BFgene201138_CR20","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1128\/IAI.74.5.2787-2802.2006","volume":"74","author":"J Caron","year":"2006","unstructured":"Caron J, Lariviere L, Nacache M, Tam M, Stevenson MM, McKerly C et al. Influence of Slc11a1 on the outcome of Salmonella enterica serovar Enteritidis infection in mice is associated with Th polarization. Infect Immun 2006; 74: 2787\u20132802.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR21","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1084\/jem.182.3.655","volume":"182","author":"S Vidal","year":"1995","unstructured":"Vidal S, Tremblay ML, Govoni G, Gauthier S, Sebastiani G, Malo D et al. The Ity\/Lsh\/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med 1995; 182: 655\u2013666.","journal-title":"J Exp Med"},{"key":"BFgene201138_CR22","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1177\/002215540205000609","volume":"50","author":"I Leverkoehne","year":"2002","unstructured":"Leverkoehne I, Gruber AD . The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells. J Histochem Cytochem 2002; 50: 829\u2013838.","journal-title":"J Histochem Cytochem"},{"key":"BFgene201138_CR23","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/sj.gene.6363850","volume":"3","author":"J Caron","year":"2002","unstructured":"Caron J, Loredo-Osti JC, Laroche L, Skamene E, Morgan K, Malo D . Identification of genetic loci controlling bacterial clearance in experimental Salmonella enteritidis infection: an unexpected role of Nramp1 (Slc11a1) in the persistence of infection in mice. Genes Immun 2002; 3: 196\u2013204.","journal-title":"Genes Immun"},{"key":"BFgene201138_CR24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1084\/jem.20040712","volume":"200","author":"RM O\u2019Connell","year":"2004","unstructured":"O\u2019Connell RM, Saha SK, Vaidya SA, Bruhn KW, Miranda GA, Zarnegar B et al. Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med 2004; 200: 437\u2013445.","journal-title":"J Exp Med"},{"key":"BFgene201138_CR25","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/ni1010","volume":"4","author":"K Hoebe","year":"2003","unstructured":"Hoebe K, Janssen EM, Kim SO, Alexopoulou L, Flavell RA, Han J et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol 2003; 4: 1223\u20131229.","journal-title":"Nat Immunol"},{"key":"BFgene201138_CR26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/ni910","volume":"4","author":"M Karaghiosoff","year":"2003","unstructured":"Karaghiosoff M, Steinborn R, Kovarik P, Kriegshauser G, Baccarini M, Donabauer B et al. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol 2003; 4: 471\u2013477.","journal-title":"Nat Immunol"},{"key":"BFgene201138_CR27","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1128\/IAI.00193-08","volume":"76","author":"L Harrington","year":"2008","unstructured":"Harrington L, Srikanth CV, Antony R, Rhee SJ, Mellor AL, Shi HN et al. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis. Infect Immun 2008; 76: 3045\u20133053.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR28","doi-asserted-by":"publisher","first-page":"7390","DOI":"10.4049\/jimmunol.181.10.7390","volume":"181","author":"R Ahrens","year":"2008","unstructured":"Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E et al. Intestinal macrophage\/epithelial cell-derived CCL11\/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol 2008; 181: 7390\u20137399.","journal-title":"J Immunol"},{"key":"BFgene201138_CR29","doi-asserted-by":"publisher","first-page":"4922","DOI":"10.1128\/IAI.00417-06","volume":"74","author":"B Raupach","year":"2006","unstructured":"Raupach B, Peuschel SK, Monack DM, Zychlinsky A . Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection. Infect Immun 2006; 74: 4922\u20134926.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR30","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1073\/pnas.041618998","volume":"98","author":"A Vazquez-Torres","year":"2001","unstructured":"Vazquez-Torres A, Fantuzzi G, Edwards III CK, Dinarello CA, Fang FC . Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc Natl Acad Sci USA 2001; 98: 2561\u20132565.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgene201138_CR31","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.4049\/jimmunol.156.9.3321","volume":"156","author":"J Hess","year":"1996","unstructured":"Hess J, Ladel C, Miko D, Kaufmann SH . Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location. J Immunol 1996; 156: 3321\u20133326.","journal-title":"J Immunol"},{"key":"BFgene201138_CR32","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1128\/IAI.70.4.1997-2009.2002","volume":"70","author":"G Sebastiani","year":"2002","unstructured":"Sebastiani G, Blais V, Sancho V, Vogel SN, Stevenson MM, Gros P et al. Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Infect Immun 2002; 70: 1997\u20132009.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR33","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1084\/jem.20052069","volume":"203","author":"CD Ellson","year":"2006","unstructured":"Ellson CD, Davidson K, Ferguson GJ, O\u2019Connor R, Stephens LR, Hawkins PT . Neutrophils from p40phox\u2212\/\u2212 mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med 2006; 203: 1927\u20131937.","journal-title":"J Exp Med"},{"key":"BFgene201138_CR34","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature03104","volume":"432","author":"TH Flo","year":"2004","unstructured":"Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004; 432: 917\u2013921.","journal-title":"Nature"},{"key":"BFgene201138_CR35","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1182\/blood-2009-05-223354","volume":"114","author":"M Nairz","year":"2009","unstructured":"Nairz M, Theurl I, Schroll A, Theurl M, Fritsche G, Lindner E et al. Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2. Blood 2009; 114: 3642\u20133651.","journal-title":"Blood"},{"key":"BFgene201138_CR36","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.4049\/jimmunol.0803104","volume":"182","author":"ID Jung","year":"2009","unstructured":"Jung ID, Lee MG, Chang JH, Lee JS, Jeong YI, Lee CM et al. Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock. J Immunol 2009; 182: 3146\u20133154.","journal-title":"J Immunol"},{"key":"BFgene201138_CR37","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1128\/IAI.01810-06","volume":"75","author":"D Borenshtein","year":"2007","unstructured":"Borenshtein D, Nambiar PR, Groff EB, Fox JG, Schauer DB . Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Infect Immun 2007; 75: 3271\u20133281.","journal-title":"Infect Immun"},{"key":"BFgene201138_CR38","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1136\/gut.2009.178665","volume":"58","author":"I Arijs","year":"2009","unstructured":"Arijs I, Li K, Toedter G, Quintens R, Van Lommel L, Van Steen K et al. Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis. Gut 2009; 58: 1612\u20131619.","journal-title":"Gut"},{"key":"BFgene201138_CR39","doi-asserted-by":"publisher","first-page":"6032","DOI":"10.1128\/IAI.70.11.6032-6042.2002","volume":"70","author":"E Boyer","year":"2002","unstructured":"Boyer E, Bergevin I, Malo D, Gros P, Cellier MF . Acquisition of Mn(II) in addition to Fe(II) is required for full virulence of Salmonella enterica serovar Typhimurium. Infect Immun 2002; 70: 6032\u20136042.","journal-title":"Infect Immun"}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene201138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201138","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T02:29:50Z","timestamp":1686104990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,26]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["BFgene201138"],"URL":"https:\/\/doi.org\/10.1038\/gene.2011.38","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,26]]},"assertion":[{"value":"1 February 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}