{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:11:39Z","timestamp":1768684299517,"version":"3.49.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T00:00:00Z","timestamp":1311811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T00:00:00Z","timestamp":1311811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1038\/gene.2011.51","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T09:04:33Z","timestamp":1311843873000},"page":"94-97","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze"],"prefix":"10.1038","volume":"13","author":[{"given":"E V","family":"Br\u00e4uner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Loft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Raaschou-Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P S","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,7,28]]},"reference":[{"key":"BFgene201151_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1056\/NEJM199501193320301","volume":"332","author":"FD Martinez","year":"1995","unstructured":"Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ . Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332: 133\u2013138.","journal-title":"N Engl J Med"},{"key":"BFgene201151_CR2","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nature06014","volume":"448","author":"MF Moffatt","year":"2007","unstructured":"Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470\u2013473.","journal-title":"Nature"},{"key":"BFgene201151_CR3","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1056\/NEJMoa0806604","volume":"359","author":"E Bouzigon","year":"2008","unstructured":"Bouzigon E, Corda E, Aschard H, Dizier MH, Boland A, Bousquet J et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 2008; 359: 1985\u20131994.","journal-title":"N Engl J Med"},{"key":"BFgene201151_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1164\/rccm.200809-1436OC","volume":"179","author":"H Bisgaard","year":"2009","unstructured":"Bisgaard H, Bonnelykke K, Sleiman PM, Brasholt M, Chawes B, Kreiner-Moller E et al. Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. Am J Respir Crit Care Med 2009; 179: 179\u2013185.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFgene201151_CR5","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","volume":"363","author":"MF Moffatt","year":"2010","unstructured":"Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211\u20131221.","journal-title":"N Engl J Med"},{"key":"BFgene201151_CR6","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/nature08787","volume":"463","author":"DK Breslow","year":"2010","unstructured":"Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A et al. Orm family proteins mediate sphingolipid homeostasis. Nature 2010; 463: 1048\u20131053.","journal-title":"Nature"},{"key":"BFgene201151_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/hmg\/ddp471","volume":"19","author":"G Cantero-Recasens","year":"2010","unstructured":"Cantero-Recasens G, Fandos C, Rubio-Moscardo F, Valverde MA, Vicente R . The asthma-associated ORMDL3 gene product regulates -mediated calcium signaling and cellular stress. Hum Mol Genet 2010; 19: 111\u2013121.","journal-title":"Hum Mol Genet"},{"key":"BFgene201151_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijheh.2009.12.003","volume":"213","author":"CM Chen","year":"2010","unstructured":"Chen CM, Tischer C, Schnappinger M, Heinrich J . The role of cats and dogs in asthma and allergy--a systematic review. Int J Hyg Environ Health 2010; 213: 1\u201331.","journal-title":"Int J Hyg Environ Health"},{"key":"BFgene201151_CR9","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/j.1399-3038.2009.00855.x","volume":"20","author":"M S\u00f8rensen","year":"2009","unstructured":"S\u00f8rensen M, Allermann L, Vogel U, Andersen PS, Jespersgaard C, Loft S et al. Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children. Pediatr Allergy Immunol 2009; 20: 614\u2013623.","journal-title":"Pediatr Allergy Immunol"},{"key":"BFgene201151_CR10","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jaci.2005.09.042","volume":"117","author":"A Linneberg","year":"2006","unstructured":"Linneberg A, Simonsen JB, Petersen J, Stensballe LG, Benn CS . Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology. J Allergy Clin Immunol 2006; 117: 184\u2013189.","journal-title":"J Allergy Clin Immunol"},{"key":"BFgene201151_CR11","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1056\/NEJMoa054692","volume":"354","author":"H Bisgaard","year":"2006","unstructured":"Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F . Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 2006; 354: 1998\u20132005.","journal-title":"N Engl J Med"},{"key":"BFgene201151_CR12","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jaci.2009.05.047","volume":"124","author":"JH Flory","year":"2009","unstructured":"Flory JH, Sleiman PM, Christie JD, Annaiah K, Bradfield J, Kim CE et al. 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry. J Allergy Clin Immunol 2009; 124: 605\u2013607.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene201151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201151","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T16:05:45Z","timestamp":1647965145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,28]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["BFgene201151"],"URL":"https:\/\/doi.org\/10.1038\/gene.2011.51","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,28]]},"assertion":[{"value":"5 April 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}