{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:27:24Z","timestamp":1791214044249,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1038\/gene.2011.61","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T05:03:53Z","timestamp":1314853433000},"page":"207-213","source":"Crossref","is-referenced-by-count":141,"title":["Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis"],"prefix":"10.1038","volume":"13","author":[{"given":"S A","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B W","family":"Higgs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Morehouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Won Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Brohawn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Salajegheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Kiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Jallal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"BFgene201161_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/mus.10313","volume":"27","author":"FL Mastaglia","year":"2003","unstructured":"Mastaglia FL, Garlepp MJ, Phillips BA, Zilko PJ . Inflammatory myopathies: clinical, diagnostic and therapeutic aspects. Muscle Nerve 2003; 27: 407\u2013425.","journal-title":"Muscle Nerve"},{"key":"BFgene201161_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.berh.2004.02.009","volume":"18","author":"L Christopher-Stine","year":"2004","unstructured":"Christopher-Stine L, Plotz PH . Adult inflammatory myopathies. Best Pract Res Clin Rheumatol 2004; 18: 331\u2013344.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"BFgene201161_CR3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.nmd.2004.02.006","volume":"14","author":"JE Hoogendijk","year":"2004","unstructured":"Hoogendijk JE, Amato AA, Lecky BR, Choy EH, Lundberg IE, Rose MR et al. 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10\u201312 October 2003, Naarden, The Netherlands. Neuromuscul Disord 2004; 14: 337\u2013345.","journal-title":"Neuromuscul Disord"},{"key":"BFgene201161_CR4","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/00019052-200310000-00002","volume":"16","author":"AA Amato","year":"2003","unstructured":"Amato AA, Griggs RC . Treatment of idiopathic inflammatory myopathies. Curr Opin Neurol 2003; 16: 569\u2013575.","journal-title":"Curr Opin Neurol"},{"key":"BFgene201161_CR5","doi-asserted-by":"crossref","unstructured":"Choy EH, Hoogendijk JE, Lecky B, Winer JB, Gordon P . Withdrawn: immunosuppressant and immunomodulatory treatment for dermatomyositis and polymyositis. Cochrane Database Syst Rev 2009; 4: CD003643.","DOI":"10.1002\/14651858.CD003643.pub3"},{"key":"BFgene201161_CR6","first-page":"450","volume":"63","author":"DA Isenberg","year":"1986","unstructured":"Isenberg DA, Rowe D, Shearer M, Novick D, Beverley PC . Localization of interferons and interleukin 2 in polymyositis and muscular dystrophy. Clin Exp Immunol 1986; 63: 450\u2013458.","journal-title":"Clin Exp Immunol"},{"key":"BFgene201161_CR7","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/0046-8177(89)90128-7","volume":"20","author":"AM Emslie-Smith","year":"1989","unstructured":"Emslie-Smith AM, Arahata K, Engel AG . Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies. Hum Pathol 1989; 20: 224\u2013231.","journal-title":"Hum Pathol"},{"key":"BFgene201161_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0165-5728(95)00122-0","volume":"63","author":"I Lundberg","year":"1995","unstructured":"Lundberg I, Brengman JM, Engel AG . Analysis of cytokine expression in muscle in inflammatory myopathies, Duchenne dystrophy, and non-weak controls. J Neuroimmunol 1995; 63: 9\u201316.","journal-title":"J Neuroimmunol"},{"key":"BFgene201161_CR9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1002\/mus.10462","volume":"28","author":"D Figarella-Branger","year":"2003","unstructured":"Figarella-Branger D, Civatte M, Bartoli C, Pellissier JF . Cytokines, chemokines, and cell adhesion molecules in inflammatory myopathies. Muscle Nerve 2003; 28: 659\u2013682.","journal-title":"Muscle Nerve"},{"key":"BFgene201161_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/08916930600622256","volume":"39","author":"S Salomonsson","year":"2006","unstructured":"Salomonsson S, Lundberg IE . Cytokines in idiopathic inflammatory myopathies. Autoimmunity 2006; 39: 177\u2013190.","journal-title":"Autoimmunity"},{"key":"BFgene201161_CR11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/00005072-197501000-00005","volume":"34","author":"BQ Banker","year":"1975","unstructured":"Banker BQ . Dermatomyostis of childhood, ultrastructural alteratious of muscle and intramuscular blood vessels. J Neuropathol Exp Neurol 1975; 34: 46\u201375.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFgene201161_CR12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1136\/ard.29.1.67","volume":"29","author":"WL Norton","year":"1970","unstructured":"Norton WL, Velayos E, Robison L . Endothelial inclusions in dermatomyositis. Ann Rheum Dis 1970; 29: 67\u201372.","journal-title":"Ann Rheum Dis"},{"key":"BFgene201161_CR13","first-page":"638","volume":"52","author":"PM Grimley","year":"1985","unstructured":"Grimley PM, Davis GL, Kang YH, Dooley JS, Strohmaier J, Hoofnagle JH . Tubuloreticular inclusions in peripheral blood mononuclear cells related to systemic therapy with alpha-interferon. Lab Invest 1985; 52: 638\u2013649.","journal-title":"Lab Invest"},{"key":"BFgene201161_CR14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0140-6736(83)91771-3","volume":"1","author":"SA Rich","year":"1983","unstructured":"Rich SA, Owens TR, Bartholomew LE, Gutterman JU . Immune interferon does not stimulate formation of alpha and beta interferon induced human lupus-type inclusions. Lancet 1983; 1: 127\u2013128.","journal-title":"Lancet"},{"key":"BFgene201161_CR15","first-page":"3480","volume":"44","author":"PM Grimley","year":"1984","unstructured":"Grimley PM, Rutherford MN, Kang YH, Williams T, Woody JN, Silverman RH . Formation of tubuloreticular inclusions in human lymphoma cells compared to the induction of 2\u2032-5\u2032-oligoadenylate synthetase by leucocyte interferon in dose-effect and kinetic studies. Cancer Res 1984; 44: 3480\u20133488.","journal-title":"Cancer Res"},{"key":"BFgene201161_CR16","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3109\/01913128609015565","volume":"10","author":"J Kuyama","year":"1986","unstructured":"Kuyama J, Kanayama Y, Mizutani H, Katagiri S, Tamaki T, Yonezawa T et al. Formation of tubuloreticular inclusions in mitogen-stimulated human lymphocyte cultures by endogenous or exogenous alpha-interferon. Ultrastruct Pathol 1986; 10: 77\u201385.","journal-title":"Ultrastruct Pathol"},{"key":"BFgene201161_CR17","first-page":"584","volume":"58","author":"D Feldman","year":"1988","unstructured":"Feldman D, Goldstein AL, Cox DC, Grimley PM . Cultured human endothelial cells treated with recombinant leukocyte A interferon. Tubuloreticular inclusion formation, antiproliferative effect, and 2\u2032,5\u2032 oligoadenylate synthetase induction. Lab Invest 1988; 58: 584\u2013589.","journal-title":"Lab Invest"},{"key":"BFgene201161_CR18","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1212\/WNL.59.8.1170","volume":"59","author":"SA Greenberg","year":"2002","unstructured":"Greenberg SA, Sanoudou D, Haslett JN, Kohane IS, Kunkel LM, Beggs AH et al. Molecular profiles of inflammatory myopathies. Neurology 2002; 59: 1170\u20131182.","journal-title":"Neurology"},{"issue":"Part 8","key":"BFgene201161_CR19","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1093\/brain\/awh518","volume":"128","author":"R Raju","year":"2005","unstructured":"Raju R, Dalakas MC . Gene expression profile in the muscles of patients with inflammatory myopathies: effect of therapy with IVIg and biological validation of clinically relevant genes. Brain 2005; 128 (Part 8): 1887\u20131896.","journal-title":"Brain"},{"key":"BFgene201161_CR20","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.4049\/jimmunol.168.8.4154","volume":"168","author":"Z Tezak","year":"2002","unstructured":"Tezak Z, Hoffman EP, Lutz JL, Fedczyna TO, Stephan D, Bremer EG et al. Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis. J Immunol 2002; 168: 4154\u20134163.","journal-title":"J Immunol"},{"key":"BFgene201161_CR21","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/BOR.0b013e3282efe261","volume":"19","author":"SA Greenberg","year":"2007","unstructured":"Greenberg SA . A gene expression approach to study perturbed pathways in myositis. Curr Opin Rheumatol 2007; 19: 536\u2013541.","journal-title":"Curr Opin Rheumatol"},{"key":"BFgene201161_CR22","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/ana.20464","volume":"57","author":"SA Greenberg","year":"2005","unstructured":"Greenberg SA, Pinkus JL, Pinkus GS, Burleson T, Sanoudou D, Tawil R et al. Interferon-alpha\/beta-mediated innate immune mechanisms in dermatomyositis. Ann Neurol 2005; 57: 664\u2013678.","journal-title":"Ann Neurol"},{"key":"BFgene201161_CR23","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1002\/art.22928","volume":"56","author":"RJ Walsh","year":"2007","unstructured":"Walsh RJ, Kong SW, Yao Y, Jallal B, Kiener PA, Pinkus JL et al. Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis. Arthritis Rheum 2007; 56: 3784\u20133792.","journal-title":"Arthritis Rheum"},{"key":"BFgene201161_CR24","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1073\/pnas.0337679100","volume":"100","author":"EC Baechler","year":"2003","unstructured":"Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003; 100: 2610\u20132615.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgene201161_CR25","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1084\/jem.20021553","volume":"197","author":"L Bennett","year":"2003","unstructured":"Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003; 197: 711\u2013723.","journal-title":"J Exp Med"},{"key":"BFgene201161_CR26","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1001\/jama.295.19.2275","volume":"295","author":"T Bongartz","year":"2006","unstructured":"Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V . Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. Jama 2006; 295: 2275\u20132285.","journal-title":"Jama"},{"key":"BFgene201161_CR27","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1365-2133.2008.08673.x","volume":"159","author":"AK Brimhall","year":"2008","unstructured":"Brimhall AK, King LN, Licciardone JC, Jacobe H, Menter A . Safety and efficacy of alefacept, efalizumab, etanercept and infliximab in treating moderate to severe plaque psoriasis: a meta-analysis of randomized controlled trials. Br J Dermatol 2008; 159: 274\u2013285.","journal-title":"Br J Dermatol"},{"key":"BFgene201161_CR28","first-page":"515","volume":"9","author":"C Ding","year":"2008","unstructured":"Ding C, Xu J, Li J . ABT-874, a fully human monoclonal anti-IL-12\/IL-23 antibody for the potential treatment of autoimmune diseases. Curr Opin Investig Drugs 2008; 9: 515\u2013522.","journal-title":"Curr Opin Investig Drugs"},{"issue":"Suppl 1","key":"BFgene201161_CR29","first-page":"S16","volume":"65","author":"A Kavanaugh","year":"2007","unstructured":"Kavanaugh A . Interleukin-6 inhibition and clinical efficacy in rheumatoid arthritis treatment\u2014data from randomized clinical trials. Bull NYU Hosp Jt Dis 2007; 65 (Suppl 1): S16\u2013S20.","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"BFgene201161_CR30","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1002\/art.24557","volume":"60","author":"Y Yao","year":"2009","unstructured":"Yao Y, Richman L, Higgs BW, Morehouse C, De los Reyes M, Brohawn P et al. Neutralization of IFN-alpha\/beta-inducible genes and downstream effect in a phase I trial of an anti-IFN-alpa monoclonal antibody in SLE. Arthritis Rheum 2009; 60: 1785\u20131796.","journal-title":"Arthritis Rheum"},{"key":"BFgene201161_CR31","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.4049\/jimmunol.180.3.1913","volume":"180","author":"AS Haider","year":"2008","unstructured":"Haider AS, Lowes MA, Suarez-Farinas M, Zaba LC, Cardinale I, Khatcherian A et al. Identification of cellular pathways of \u2018type 1,\u2019 Th17T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis. J Immunol 2008; 180: 1913\u20131920.","journal-title":"J Immunol"},{"key":"BFgene201161_CR32","doi-asserted-by":"publisher","first-page":"15858","DOI":"10.1073\/pnas.0707413104","volume":"104","author":"PG Woodruff","year":"2007","unstructured":"Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007; 104: 15858\u201315863.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl 1","key":"BFgene201161_CR33","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1186\/ar2885","volume":"12","author":"SA Greenberg","year":"2010","unstructured":"Greenberg SA . Type 1 interferons and myositis. Arthritis Res Ther 2010; 12 (Suppl 1): S4.","journal-title":"Arthritis Res Ther"},{"key":"BFgene201161_CR34","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ana.21805","volume":"67","author":"M Salajegheh","year":"2010","unstructured":"Salajegheh M, Kong SW, Pinkus JL, Walsh RJ, Liao A, Nazareno R et al. Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy. Ann Neurol 2010; 67: 53\u201363.","journal-title":"Ann Neurol"},{"key":"BFgene201161_CR35","doi-asserted-by":"crossref","unstructured":"Yao Y, Higgs BW, Morehouse C, de Los Reyes M, Trigona W, Brohawn P et al. Development of potential pharmacodynamic and diagnostic markers for anti-IFN-\u03b1 monoclonal antibody trials in systemic lupus erythematosus. Hum Genomics Proteomics 2009; 2009: pii: 374312.","DOI":"10.4061\/2009\/374312"},{"key":"BFgene201161_CR36","unstructured":"A phase 1b, randomized, double-blind, placebo-controlled, multicenter study to evaluate safety of multiple-dose, intravenously administered MEDI-545, a fully human anti Interferon-alpha monoclonal antibody, in adult patients with dermatomyositis or polymyositis. http:\/\/clinicaltrialsgov\/ct2\/show\/NCT0053309 ."},{"key":"BFgene201161_CR37","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1056\/NEJM197502132920706","volume":"292","author":"A Bohan","year":"1975","unstructured":"Bohan A, Peter JB . Polymyositis and dermatomyositis (first of two parts). N Engl J Med 1975; 292: 344\u2013347.","journal-title":"N Engl J Med"},{"key":"BFgene201161_CR38","doi-asserted-by":"publisher","first-page":"e2737","DOI":"10.1371\/journal.pone.0002737","volume":"3","author":"Y Yao","year":"2008","unstructured":"Yao Y, Richman L, Morehouse C, de los Reyes M, Higgs BW, Boutrin A et al. Type I interferon: potential therapeutic target for psoriasis? PLoS One 2008; 3: e2737.","journal-title":"PLoS One"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/gene201161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gene201161","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gene201161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:33:13Z","timestamp":1684416793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,1]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["BFgene201161"],"URL":"https:\/\/doi.org\/10.1038\/gene.2011.61","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.714597857.790102911","asserted-by":"object"}]},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,1]]}}}