{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:41:33Z","timestamp":1791175293360,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1038\/gene.2012.56","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T10:04:42Z","timestamp":1355997882000},"page":"83-89","source":"Crossref","is-referenced-by-count":24,"title":["Genetic variation in the serotonin receptor gene affects immune responses in rheumatoid arthritis"],"prefix":"10.1038","volume":"14","author":[{"given":"O","family":"Snir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hesselberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Amoudruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Klareskog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Zarea-Ganji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A I","family":"Catrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Padyukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Malmstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Seddighzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"BFgene201256_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/gm286","volume":"3","author":"AF Wright","year":"2011","unstructured":"Wright AF . Genomics of common diseases: approaching the tipping point. Genome Med 2011; 3: 70.","journal-title":"Genome Med"},{"key":"BFgene201256_CR2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0031-6997(25)06783-3","volume":"46","author":"D Hoyer","year":"1994","unstructured":"Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 1994; 46: 157\u2013203.","journal-title":"Pharmacol Rev"},{"key":"BFgene201256_CR3","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1074\/jbc.M004559200","volume":"276","author":"M Abdouh","year":"2001","unstructured":"Abdouh M, Storring JM, Riad M, Paquette Y, Albert PR, Drobetsky E et al. Transcriptional mechanisms for induction of 5-HT1A receptor mRNA and protein in activated B and T lymphocytes. J Biol Chem 2001; 276: 4382\u20134388.","journal-title":"J Biol Chem"},{"key":"BFgene201256_CR4","doi-asserted-by":"publisher","first-page":"6011","DOI":"10.4049\/jimmunol.172.10.6011","volume":"172","author":"M Idzko","year":"2004","unstructured":"Idzko M, Panther E, Stratz C, Muller T, Bayer H, Zissel G et al. The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release. J Immunol 2004; 172: 6011\u20136019.","journal-title":"J Immunol"},{"key":"BFgene201256_CR5","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1182\/blood-2006-10-052787","volume":"109","author":"M Leon-Ponte","year":"2007","unstructured":"Leon-Ponte M, Ahern GP, O'Connell PJ . Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood 2007; 109: 3139\u20133146.","journal-title":"Blood"},{"key":"BFgene201256_CR6","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.4049\/jimmunol.158.6.2891","volume":"158","author":"H Matsuda","year":"1997","unstructured":"Matsuda H, Ushio H, Geba GP, Askenase PW . Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies. J Immunol 1997; 158: 2891\u20132897.","journal-title":"J Immunol"},{"key":"BFgene201256_CR7","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1182\/blood-2005-07-2903","volume":"107","author":"PJ O'Connell","year":"2006","unstructured":"O'Connell PJ, Wang X, Leon-Ponte M, Griffiths C, Pingle SC, Ahern GP . A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood 2006; 107: 1010\u20131017.","journal-title":"Blood"},{"key":"BFgene201256_CR8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4049\/jimmunol.137.1.276","volume":"137","author":"EM Sternberg","year":"1986","unstructured":"Sternberg EM, Trial J, Parker CW . Effect of serotonin on murine macrophages: suppression of Ia expression by serotonin and its reversal by 5-HT2 serotonergic receptor antagonists. J Immunol 1986; 137: 276\u2013282.","journal-title":"J Immunol"},{"key":"BFgene201256_CR9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1006\/brbi.1998.0532","volume":"12","author":"R Mossner","year":"1998","unstructured":"Mossner R, Lesch KP . Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immun 1998; 12: 249\u2013271.","journal-title":"Brain Behav Immun"},{"key":"BFgene201256_CR10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","volume":"71","author":"D Hoyer","year":"2002","unstructured":"Hoyer D, Hannon JP, Martin GR . Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 2002; 71: 533\u2013554.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFgene201256_CR11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/intimm\/dxg027","volume":"15","author":"I Clo\u00ebz-Tayarani","year":"2003","unstructured":"Clo\u00ebz-Tayarani I, Petit-Bertron AF, Venters HD, Cavaillon JM . Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors. Int Immunol 2003; 15: 233\u2013240.","journal-title":"Int Immunol"},{"key":"BFgene201256_CR12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0163-7258(98)00019-9","volume":"79","author":"BL Roth","year":"1998","unstructured":"Roth BL, Willins DL, Kristiansen K, Kroeze WK . 5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function. Pharmacol Ther 1998; 79: 231\u2013257.","journal-title":"Pharmacol Ther"},{"key":"BFgene201256_CR13","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/BF01965409","volume":"12","author":"F de Clerck","year":"1982","unstructured":"de Clerck F, David JL, Janssen PA . Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist. Agents Actions 1982; 12: 388\u2013397.","journal-title":"Agents Actions"},{"key":"BFgene201256_CR14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1615\/CritRevNeurobiol.v12.i4.30","volume":"12","author":"BL Roth","year":"1998","unstructured":"Roth BL, Berry SA, Kroeze WK, Willins DL, Kristiansen K . Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation. Crit Rev Neurobiol 1998; 12: 319\u2013338.","journal-title":"Crit Rev Neurobiol"},{"key":"BFgene201256_CR15","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/intimm\/dxh242","volume":"17","author":"T Durk","year":"2005","unstructured":"Durk T, Panther E, Muller T, Sorichter S, Ferrari D, Pizzirani C et al. 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int Immunol 2005; 17: 599\u2013606.","journal-title":"Int Immunol"},{"key":"BFgene201256_CR16","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1006\/brbi.1999.0579","volume":"14","author":"J Stefulj","year":"2000","unstructured":"Stefulj J, Jernej B, Cicin-Sain L, Rinner I, Schauenstein K . mRNA expression of serotonin receptors in cells of the immune tissues of the rat. Brain Behav Immun 2000; 14: 219\u2013224.","journal-title":"Brain Behav Immun"},{"key":"BFgene201256_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.intimp.2010.10.007","volume":"11","author":"M Inoue","year":"2011","unstructured":"Inoue M, Okazaki T, Kitazono T, Mizushima M, Omata M, Ozaki S . Regulation of antigen-specific CTL and Th1 cell activation through 5-Hydroxytryptamine 2A receptor. Int Immunopharmacol 2011; 11: 67\u201373.","journal-title":"Int Immunopharmacol"},{"key":"BFgene201256_CR18","doi-asserted-by":"publisher","first-page":"14825","DOI":"10.1074\/jbc.272.23.14825","volume":"272","author":"I Guillet-Deniau","year":"1997","unstructured":"Guillet-Deniau I, Burnol AF, Girard J . Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak\/STAT pathway. J Biol Chem 1997; 272: 14825\u201314829.","journal-title":"J Biol Chem"},{"key":"BFgene201256_CR19","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1124\/jpet.108.143461","volume":"327","author":"B Yu","year":"2008","unstructured":"Yu B, Becnel J, Zerfaoui M, Rohatgi R, Boulares AH, Nichols CD . Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency. J Pharmacol Exp Ther 2008; 327: 316\u2013323.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFgene201256_CR20","doi-asserted-by":"publisher","first-page":"17420","DOI":"10.1073\/pnas.0603119103","volume":"103","author":"JP Walterscheid","year":"2006","unstructured":"Walterscheid JP, Nghiem DX, Kazimi N, Nutt LK, McConkey DJ, Norval M et al. Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor. Proc Natl Acad Sci USA 2006; 103: 17420\u201317425.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgene201256_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s10517-010-1109-7","volume":"150","author":"SM Davydova","year":"2010","unstructured":"Davydova SM, Cheido MA, Gevorgyan MM, Idova GV . Effects of 5-HT2A receptor stimulation and blocking on immune response. Bull Exp Biol Med 2010; 150: 219\u2013221.","journal-title":"Bull Exp Biol Med"},{"key":"BFgene201256_CR22","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/ng.582","volume":"42","author":"EA Stahl","year":"2010","unstructured":"Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 2010; 42: 508\u2013514.","journal-title":"Nat Genet"},{"key":"BFgene201256_CR23","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1056\/NEJM197804202981602","volume":"298","author":"P Stastny","year":"1978","unstructured":"Stastny P . Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 1978; 298: 869\u2013871.","journal-title":"N Engl J Med"},{"key":"BFgene201256_CR24","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/ejhg.2010.12","volume":"18","author":"M Seddighzadeh","year":"2010","unstructured":"Seddighzadeh M, Korotkova M, Kallberg H, Ding B, Daha N, Kurreeman FA et al. Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis. Eur J Hum Genet 2010; 18: 821\u2013826.","journal-title":"Eur J Hum Genet"},{"key":"BFgene201256_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/PL00005315","volume":"359","author":"DL Nelson","year":"1999","unstructured":"Nelson DL, Lucaites VL, Wainscott DB, Glennon RA . Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol 1999; 359: 1\u20136.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"BFgene201256_CR26","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1021\/cr078224o","volume":"108","author":"DE Nichols","year":"2008","unstructured":"Nichols DE, Nichols CD . Serotonin receptors. Chem Rev 2008; 108: 1614\u20131641.","journal-title":"Chem Rev"},{"key":"BFgene201256_CR27","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1016\/0024-3205(91)90612-F","volume":"48","author":"E Arzt","year":"1991","unstructured":"Arzt E, Costas M, Finkielman S, Nahmod VE . Serotonin inhibition of tumor necrosis factor-alpha synthesis by human monocytes. Life Sci 1991; 48: 2557\u20132562.","journal-title":"Life Sci"},{"key":"BFgene201256_CR28","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315\u2013324.","journal-title":"Arthritis Rheum"},{"key":"BFgene201256_CR29","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1086\/379378","volume":"73","author":"M Stephens","year":"2003","unstructured":"Stephens M, Donnelly P . A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73: 1162\u20131169.","journal-title":"Am J Hum Genet"}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/gene201256.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gene201256","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gene201256.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:17Z","timestamp":1745463677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["BFgene201256"],"URL":"https:\/\/doi.org\/10.1038\/gene.2012.56","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}