{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:59:18Z","timestamp":1766516358188},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:00:00Z","timestamp":1385596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:00:00Z","timestamp":1385596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1038\/gene.2013.61","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T09:55:05Z","timestamp":1385632505000},"page":"57-61","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["microRNA miR-17-92 cluster is highly expressed in epidermal Langerhans cells but not required for its development"],"prefix":"10.1038","volume":"15","author":[{"given":"L","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R-Q","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-P","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Weiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D H","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q-S","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,28]]},"reference":[{"key":"BFgene201361_CR1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/cmi.2011.27","volume":"8","author":"L Zhou","year":"2011","unstructured":"Zhou L, Park JJ, Zheng Q, Dong Z, Mi Q . MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function. Cell Mol Immunol 2011; 8: 380\u2013387.","journal-title":"Cell Mol Immunol"},{"key":"BFgene201361_CR2","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1084\/jem.20081062","volume":"205","author":"A Liston","year":"2008","unstructured":"Liston A, Lu LF, O'Carroll D, Tarakhovsky A, Rudensky AY . Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med 2008; 205: 1993\u20132004.","journal-title":"J Exp Med"},{"key":"BFgene201361_CR3","doi-asserted-by":"publisher","first-page":"10266","DOI":"10.1073\/pnas.0811119106","volume":"106","author":"L Zhou","year":"2009","unstructured":"Zhou L, Seo KH, He HZ, Pacholczyk R, Meng DM, Li CG et al. Tie2cre-induced inactivation of the miRNA-processing enzyme Dicer disrupts invariant NKT cell development. Proc Natl Acad Sci USA 2009; 106: 10266\u201310271.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgene201361_CR4","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.4049\/jimmunol.1103342","volume":"188","author":"Q Zheng","year":"2012","unstructured":"Zheng Q, Zhou L, Mi QS . MicroRNA miR-150 is involved in Valpha14 invariant NKT cell development and function. J Immunol 2012; 188: 2118\u20132126.","journal-title":"J Immunol"},{"key":"BFgene201361_CR5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.0105-2896.2009.00886.x","volume":"234","author":"N Romani","year":"2010","unstructured":"Romani N, Clausen BE, Stoitzner P . Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev 2010; 234: 120\u2013141.","journal-title":"Immunol Rev"},{"key":"BFgene201361_CR6","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.it.2010.08.006","volume":"31","author":"DH Kaplan","year":"2010","unstructured":"Kaplan DH . In vivo function of Langerhans cells and dermal dendritic cells. Trends Immunol 2010; 31: 446\u2013451.","journal-title":"Trends Immunol"},{"key":"BFgene201361_CR7","doi-asserted-by":"publisher","first-page":"400","DOI":"10.4049\/jimmunol.0903912","volume":"185","author":"H Kuipers","year":"2010","unstructured":"Kuipers H, Schnorfeil FM, Fehling HJ, Bartels H, Brocker T . Dicer-dependent microRNAs control maturation, function and maintenance of Langerhans cells in vivo. J Immunol 2010; 185: 400\u2013409.","journal-title":"J Immunol"},{"key":"BFgene201361_CR8","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/exd.12008","volume":"21","author":"QS Mi","year":"2012","unstructured":"Mi QS, Xu YP, Qi RQ, Shi YL, Zhou L . Lack of microRNA miR-150 reduces the capacity of epidermal Langerhans cell cross-presentation. Exp Dermatol 2012; 21: 876\u2013877.","journal-title":"Exp Dermatol"},{"key":"BFgene201361_CR9","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.biocel.2012.11.004","volume":"45","author":"QS Mi","year":"2013","unstructured":"Mi QS, Xu YP, Wang H, Qi RQ, Dong Z, Zhou L . Deletion of microRNA miR-223 increases Langerhans cell cross-presentation. Int J Biochem Cell Biol 2013; 45: 395\u2013400.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFgene201361_CR10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/ni1575","volume":"9","author":"C Xiao","year":"2008","unstructured":"Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 2008; 9: 405\u2013414.","journal-title":"Nat Immunol"},{"key":"BFgene201361_CR11","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.cell.2008.02.019","volume":"132","author":"A Ventura","year":"2008","unstructured":"Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 2008; 132: 875\u2013886.","journal-title":"Cell"},{"key":"BFgene201361_CR12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.immuni.2005.10.008","volume":"23","author":"DH Kaplan","year":"2005","unstructured":"Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ . Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005; 23: 611\u2013620.","journal-title":"Immunity"},{"key":"BFgene201361_CR13","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1084\/jem.20071401","volume":"204","author":"DH Kaplan","year":"2007","unstructured":"Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ . Autocrine\/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med 2007; 204: 2545\u20132552.","journal-title":"J Exp Med"},{"key":"BFgene201361_CR14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1128\/MCB.25.1.88-99.2005","volume":"25","author":"A Kissenpfennig","year":"2005","unstructured":"Kissenpfennig A, it-Yahia S, Clair-Moninot V, Stossel H, Badell E, Bordat Y et al. Disruption of the langerin\/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function. Mol Cell Biol 2005; 25: 88\u201399.","journal-title":"Mol Cell Biol"},{"key":"BFgene201361_CR15","doi-asserted-by":"publisher","first-page":"7783","DOI":"10.1073\/pnas.0509307103","volume":"103","author":"P Stoitzner","year":"2006","unstructured":"Stoitzner P, Tripp CH, Eberhart A, Price KM, Jung JY, Bursch L et al. Langerhans cells cross-present antigen derived from skin. Proc Natl Acad Sci USA 2006; 103: 7783\u20137788.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene201361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201361","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T17:12:09Z","timestamp":1647969129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,28]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["BFgene201361"],"URL":"https:\/\/doi.org\/10.1038\/gene.2013.61","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,28]]},"assertion":[{"value":"15 August 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}