{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:32:54Z","timestamp":1772134374978,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1038\/gene.2015.17","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T09:29:52Z","timestamp":1431595792000},"page":"311-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Suppression of autoimmunity by CD5+ IL-10-producing B cells in lupus-prone mice"],"prefix":"10.1038","volume":"16","author":[{"given":"Y","family":"Baglaenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K P","family":"Manion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N-H","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Loh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lajoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Wither","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"BFgene201517_CR1","doi-asserted-by":"publisher","first-page":"8154","DOI":"10.4049\/jimmunol.175.12.8154","volume":"175","author":"Y Cheung","year":"2005","unstructured":"Cheung Y, Chang N, Cai Y, Macleod R, Wither JE, Bonventi G . Functional Interplay between Intrinsic B and T Cell Defects. J Immunol 2005; 175: 8154\u20138164.","journal-title":"J Immunol"},{"key":"BFgene201517_CR2","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/eji.201040983","volume":"41","author":"C Loh","year":"2011","unstructured":"Loh C, Pau E, Chang N-H, Wither JE . An intrinsic B-cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice. Eur J Immunol 2011; 41: 527\u2013536.","journal-title":"Eur J Immunol"},{"key":"BFgene201517_CR3","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.4049\/jimmunol.1003426","volume":"186","author":"C Loh","year":"2011","unstructured":"Loh C, Pau E, Lajoie G, Li TT, Baglaenko Y, Cheung Y-H et al. Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice. J Immunol 2011; 186: 5845\u20135853.","journal-title":"J Immunol"},{"key":"BFgene201517_CR4","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1172\/JCI200317165","volume":"112","author":"D Zeng","year":"2003","unstructured":"Zeng D, Liu Y, Sidobre S, Kronenberg M, Strober S . Activation of natural killer T cells in NZB\/W mice induces Th1-type immune responses exacerbating lupus. J Clin Invest 2003; 112: 1211\u20131222.","journal-title":"J Clin Invest"},{"key":"BFgene201517_CR5","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1002\/art.22490","volume":"56","author":"J-Q Yang","year":"2007","unstructured":"Yang J-Q, Wen X, Liu H, Folayan G, Dong X, Zhou M et al. Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Arthritis Rheum 2007; 56: 1219\u20131233.","journal-title":"Arthritis Rheum"},{"key":"BFgene201517_CR6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jaut.2014.01.002","volume":"50","author":"X Tang","year":"2014","unstructured":"Tang X, Zhang B, Jarrell JA, Price J V, Dai H, Utz PJ et al. Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB\/W mice. J Autoimmun 2014; 50: 87\u201398.","journal-title":"J Autoimmun"},{"key":"BFgene201517_CR7","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1084\/jem.20091314","volume":"207","author":"F Wermeling","year":"2010","unstructured":"Wermeling F, Lind SM, Jord\u00f6 ED, Cardell SL, Karlsson MCI . Invariant NKT cells limit activation of autoreactive CD1d-positive B cells. J Exp Med 2010; 207: 943\u2013952.","journal-title":"J Exp Med"},{"key":"BFgene201517_CR8","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1093\/rheumatology\/keq457","volume":"50","author":"Y-N Cho","year":"2011","unstructured":"Cho Y-N, Kee S-J, Lee S-J, Seo S-R, Kim T-J, Lee S-S et al. Numerical and functional deficiencies of natural killer T cells in systemic lupus erythematosus: their deficiency related to disease activity. Rheumatology 2011; 50: 1054\u20131063.","journal-title":"Rheumatology"},{"key":"BFgene201517_CR9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1600-065X.2008.00661.x","volume":"224","author":"J-D Bouaziz","year":"2008","unstructured":"Bouaziz J-D, Yanaba K, Tedder TF . Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev 2008; 224: 201\u2013214.","journal-title":"Immunol Rev"},{"key":"BFgene201517_CR10","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1084\/jem.20021293","volume":"197","author":"C Mauri","year":"2003","unstructured":"Mauri C, Gray D, Mushtaq N, Londei M . Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003; 197: 489\u2013501.","journal-title":"J Exp Med"},{"key":"BFgene201517_CR11","doi-asserted-by":"publisher","first-page":"5569","DOI":"10.4049\/jimmunol.1100284","volume":"186","author":"Na Carter","year":"2011","unstructured":"Carter N a, Vasconcellos R, Rosser EC, Tulone C, Mu\u00f1oz-Suano A, Kamanaka M et al. Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1\/Th17 but a decrease in regulatory T cells. J Immunol 2011; 186: 5569\u20135579.","journal-title":"J Immunol"},{"key":"BFgene201517_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.it.2007.10.004","volume":"29","author":"C Mauri","year":"2008","unstructured":"Mauri C, Ehrenstein MR . The \u2018short\u2019 history of regulatory B cells. Trends Immunol 2008; 29: 34\u201340.","journal-title":"Trends Immunol"},{"key":"BFgene201517_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","volume":"29","author":"W Ouyang","year":"2011","unstructured":"Ouyang W, Rutz S, Crellin NK, Valdez P a, Hymowitz SG . Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol 2011; 29: 71\u2013109.","journal-title":"Annu Rev Immunol"},{"key":"BFgene201517_CR14","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.4049\/jimmunol.1300649","volume":"191","author":"D Maseda","year":"2013","unstructured":"Maseda D, Candando K . Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN-\u03b3+ CD4+ T Cell Numbers during Colitis Development in Mice. J Immunol 2013; 191: 2780\u20132795.","journal-title":"J Immunol"},{"key":"BFgene201517_CR15","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1016\/j.ajpath.2012.03.010","volume":"180","author":"M Yang","year":"2012","unstructured":"Yang M, Deng J, Liu Y, Ko K-H, Wang X, Jiao Z et al. IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation. Am J Pathol 2012; 180: 2375\u20132385.","journal-title":"Am J Pathol"},{"key":"BFgene201517_CR16","doi-asserted-by":"publisher","first-page":"R32","DOI":"10.1186\/ar3736","volume":"14","author":"Na Carter","year":"2012","unstructured":"Carter N a, Rosser EC, Mauri C . Interleukin-10 produced by B cells is crucial for the suppression of Th17\/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis. Arthritis Res Ther 2012; 14: R32.","journal-title":"Arthritis Res Ther"},{"key":"BFgene201517_CR17","doi-asserted-by":"publisher","first-page":"678","DOI":"10.4049\/jimmunol.1102456","volume":"188","author":"LL Teichmann","year":"2012","unstructured":"Teichmann LL, Kashgarian M, Weaver CT, Roers A, M\u00fcller W, Shlomchik MJ . B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice. J Immunol 2012; 188: 678\u2013685.","journal-title":"J Immunol"},{"key":"BFgene201517_CR18","doi-asserted-by":"publisher","first-page":"4789","DOI":"10.4049\/jimmunol.0902391","volume":"184","author":"KM Haas","year":"2010","unstructured":"Haas KM, Watanabe R, Matsushita T, Nakashima H, Ishiura N, Okochi H et al. Protective and pathogenic roles for B cells during systemic autoimmunity in NZB\/W F1 mice. J Immunol 2010; 184: 4789\u20134800.","journal-title":"J Immunol"},{"key":"BFgene201517_CR19","doi-asserted-by":"publisher","first-page":"4801","DOI":"10.4049\/jimmunol.0902385","volume":"184","author":"R Watanabe","year":"2010","unstructured":"Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K et al. Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol 2010; 184: 4801\u20134809.","journal-title":"J Immunol"},{"key":"BFgene201517_CR20","doi-asserted-by":"publisher","first-page":"e22464","DOI":"10.1371\/journal.pone.0022464","volume":"6","author":"JC Poe","year":"2011","unstructured":"Poe JC, Smith SH, Haas KM, Yanaba K, Tsubata T, Matsushita T et al. Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS One 2011; 6: e22464.","journal-title":"PLoS One"},{"key":"BFgene201517_CR21","doi-asserted-by":"publisher","first-page":"e62855","DOI":"10.1371\/journal.pone.0062855","volume":"8","author":"X Yang","year":"2013","unstructured":"Yang X, Yang J, Chu Y, Wang J, Guan M, Zhu X et al. T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL\/lpr mice. PLoS One 2013; 8: e62855.","journal-title":"PLoS One"},{"key":"BFgene201517_CR22","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1002\/art.38742","volume":"66","author":"N Gao","year":"2014","unstructured":"Gao N, Dresel J, Eckstein V, Gellert R, St\u00f6rch H, Venigalla RKC et al. Impaired suppressive capacity of activation-induced regulatory B cells in systemic lupus erythematosus. Arthritis Rheumatol 2014; 66: 2849\u20132861.","journal-title":"Arthritis Rheumatol"},{"key":"BFgene201517_CR23","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.3899\/jrheum.131025","volume":"41","author":"L Wang","year":"2014","unstructured":"Wang L, Zhao P, Ma L, Shan Y, Jiang Z, Wang J et al. Increased interleukin 21 and follicular helper T-like cells and reduced interleukin 10+ B cells in patients with new-onset systemic lupus erythematosus. J Rheumatol 2014; 41: 1781\u20131792.","journal-title":"J Rheumatol"},{"key":"BFgene201517_CR24","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1186\/s13075-014-0477-1","volume":"16","author":"J Sieber","year":"2014","unstructured":"Sieber J, Daridon C, Fleischer SJ, Fleischer V, Hiepe F, Alexander T et al. Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation. Arthritis Res Ther 2014; 16: 477.","journal-title":"Arthritis Res Ther"},{"key":"BFgene201517_CR25","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1111\/1756-185X.12229","volume":"16","author":"L Jin","year":"2013","unstructured":"Jin L, Weiqian C, Lihuan Y . Peripheral CD24hi CD27+ CD19+ B cells subset as a potential biomarker in na\u00efve systemic lupus erythematosus. Int J Rheum Dis 2013; 16: 698\u2013708.","journal-title":"Int J Rheum Dis"},{"key":"BFgene201517_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.immuni.2009.11.009","volume":"32","author":"PA Blair","year":"2010","unstructured":"Blair PA, Nore\u00f1a LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 2010; 32: 129\u2013140.","journal-title":"Immunity"},{"key":"BFgene201517_CR27","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.4049\/jimmunol.1001307","volume":"185","author":"T Matsushita","year":"2010","unstructured":"Matsushita T, Horikawa M, Iwata Y, Tedder TF . Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. J Immunol 2010; 185: 2240\u20132252.","journal-title":"J Immunol"},{"key":"BFgene201517_CR28","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1182\/blood-2014-09-599159","volume":"125","author":"A De Masson","year":"2015","unstructured":"De Masson A, Bouaziz J-D, Le Buanec H, Robin M, O\u2019Meara A, Parquet N et al. CD24hiCD27+ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease. Blood 2015; 125: 1830\u20131839.","journal-title":"Blood"},{"key":"BFgene201517_CR29","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.immuni.2014.10.016","volume":"41","author":"M Matsumoto","year":"2014","unstructured":"Matsumoto M, Baba A, Yokota T, Nishikawa H, Ohkawa Y, Kayama H et al. Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation. Immunity 2014; 41: 1040\u20131051.","journal-title":"Immunity"},{"key":"BFgene201517_CR30","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.4049\/jimmunol.1103354","volume":"188","author":"A Ray","year":"2012","unstructured":"Ray A, Basu S, Williams CB, Salzman NH, Dittel BN . A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. J Immunol 2012; 188: 3188\u20133198.","journal-title":"J Immunol"},{"key":"BFgene201517_CR31","doi-asserted-by":"publisher","first-page":"6586","DOI":"10.4049\/jimmunol.176.11.6586","volume":"176","author":"T Nishioka","year":"2006","unstructured":"Nishioka T, Shimizu J, Iida R, Yamazaki S, Sakaguchi S . CD4+CD25+Foxp3+ T Cells and CD4+CD25-Foxp3+ T Cells in Aged Mice. J Immunol 2006; 176: 6586\u20136593.","journal-title":"J Immunol"},{"key":"BFgene201517_CR32","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1073\/pnas.0408679102","volume":"102","author":"S Zelenay","year":"2005","unstructured":"Zelenay S, Lopes-Carvalho T, Caramalho I, Moraes-Fontes MF, Rebelo M, Demengeot J . Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci USA 2005; 102: 4091\u20134096.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgene201517_CR33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-immunol-020711-074934","volume":"30","author":"C Mauri","year":"2012","unstructured":"Mauri C, Bosma A . Immune regulatory function of B cells. Annu Rev Immunol 2012; 30: 221\u2013241.","journal-title":"Annu Rev Immunol"},{"key":"BFgene201517_CR34","doi-asserted-by":"publisher","first-page":"e88441","DOI":"10.1371\/journal.pone.0088441","volume":"9","author":"X Yang","year":"2014","unstructured":"Yang X, Yang J, Chu Y, Xue Y, Xuan D, Zheng S et al. T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus. PLoS One 2014; 9: e88441.","journal-title":"PLoS One"},{"key":"BFgene201517_CR35","doi-asserted-by":"publisher","first-page":"6673","DOI":"10.4049\/jimmunol.1002544","volume":"186","author":"Z Xu","year":"2011","unstructured":"Xu Z, Potula H-HSK, Vallurupalli A, Perry D, Baker H, Croker BP et al. Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1. J Immunol 2011; 186: 6673\u20136682.","journal-title":"J Immunol"},{"key":"BFgene201517_CR36","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/art.30146","volume":"63","author":"Z Xu","year":"2011","unstructured":"Xu Z, Cuda CM, Croker BP, Morel L . The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice. Arthritis Rheum 2011; 63: 764\u2013774.","journal-title":"Arthritis Rheum"},{"key":"BFgene201517_CR37","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.4049\/jimmunol.179.2.1340","volume":"179","author":"Y Liu","year":"2007","unstructured":"Liu Y, Li L, Kumar KR, Xie C, Lightfoot S, Zhou XJ et al. Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells. J Immunol 2007; 179: 1340\u20131352.","journal-title":"J Immunol"},{"key":"BFgene201517_CR38","doi-asserted-by":"publisher","first-page":"980286","DOI":"10.1155\/2011\/980286","volume":"2011","author":"K Miyake","year":"2011","unstructured":"Miyake K, Akahoshi M, Nakashima H . Th subset balance in lupus nephritis. J Biomed Biotechnol 2011; 2011: 980286.","journal-title":"J Biomed Biotechnol"},{"key":"BFgene201517_CR39","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1097\/BOR.0b013e328349a255","volume":"23","author":"MS Shin","year":"2011","unstructured":"Shin MS, Lee N, Kang I . Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells. Curr Opin Rheumatol 2011; 23: 444\u2013448.","journal-title":"Curr Opin Rheumatol"},{"key":"BFgene201517_CR40","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/ni1552","volume":"9","author":"H-C Hsu","year":"2008","unstructured":"Hsu H-C, Yang P, Wang J, Wu Q, Myers R, Chen J et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol 2008; 9: 166\u2013175.","journal-title":"Nat Immunol"},{"key":"BFgene201517_CR41","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1681\/ASN.2009070741","volume":"21","author":"J-E Turner","year":"2010","unstructured":"Turner J-E, Paust H-J, Steinmetz OM, Peters A, Riedel J-H, Erhardt A et al. CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. J Am Soc Nephrol 2010; 21: 974\u2013985.","journal-title":"J Am Soc Nephrol"},{"key":"BFgene201517_CR42","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.4049\/jimmunol.1102500","volume":"188","author":"D Maseda","year":"2012","unstructured":"Maseda D, Smith SH, DiLillo DJ, Bryant JM, Candando KM, Weaver CT et al. Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. J Immunol 2012; 188: 1036\u20131048.","journal-title":"J Immunol"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene201517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201517","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T14:35:01Z","timestamp":1647959701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["BFgene201517"],"URL":"https:\/\/doi.org\/10.1038\/gene.2015.17","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725497609.793512369","asserted-by":"object"}]},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,14]]},"assertion":[{"value":"23 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}