{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:13:34Z","timestamp":1773724414579,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1038\/gene.2015.24","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T13:25:51Z","timestamp":1438262751000},"page":"446-451","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis"],"prefix":"10.1038","volume":"16","author":[{"given":"M I","family":"Danila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A O","family":"Westfall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Raman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L B","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D K","family":"Arnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"McGwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Szalai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"van der Heijde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Conn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L F","family":"Callahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L W","family":"Moreland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"S L","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"BFgene201524_CR1","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G . The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205\u20132219.","journal-title":"N Engl J Med"},{"key":"BFgene201524_CR2","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1136\/ard.48.11.905","volume":"48","author":"MT Walters","year":"1989","unstructured":"Walters MT, Stevenson FK, Goswami R, Smith JL, Cawley MI . Comparison of serum and synovial fluid concentrations of beta 2-microglobulin and C reactive protein in relation to clinical disease activity and synovial inflammation in rheumatoid arthritis. Ann Rheum Dis 1989; 48: 905\u2013911.","journal-title":"Ann Rheum Dis"},{"key":"BFgene201524_CR3","first-page":"51","volume":"67","author":"JM Zeller","year":"1989","unstructured":"Zeller JM, Kubak BM, Gewurz H . Binding sites for C-reactive protein on human monocytes are distinct from IgG Fc receptors. Immunology 1989; 67: 51\u201355.","journal-title":"Immunology"},{"key":"BFgene201524_CR4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/BF00915774","volume":"12","author":"LA Potempa","year":"1988","unstructured":"Potempa LA, Zeller JM, Fiedel BA, Kinoshita CM, Gewurz H . Stimulation of human neutrophils, monocytes, and platelets by modified C-reactive protein (CRP) expressing a neoantigenic specificity. Inflammation 1988; 12: 391\u2013405.","journal-title":"Inflammation"},{"key":"BFgene201524_CR5","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1749-6632.1982.tb22143.x","volume":"389","author":"K James","year":"1982","unstructured":"James K, Baum LL, Vetter ML, Gewurz H . Interactions of C-reactive protein with lymphoid cells. Ann N Y Acad Sci 1982; 389: 274\u2013285.","journal-title":"Ann N Y Acad Sci"},{"key":"BFgene201524_CR6","first-page":"747","volume":"48","author":"RK Mallya","year":"1982","unstructured":"Mallya RK, Vergani D, Tee DE, Bevis L, de Beer FC, Berry H et al. Correlation in rheumatoid arthritis of concentrations of plasma C3d, serum rheumatoid factor, immune complexes and C-reactive protein with each other and with clinical features of disease activity. Clin Exp Immunol 1982; 48: 747\u2013753.","journal-title":"Clin Exp Immunol"},{"key":"BFgene201524_CR7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1136\/ard.2006.054205","volume":"66","author":"E Inoue","year":"2007","unstructured":"Inoue E, Yamanaka H, Hara M, Tomatsu T, Kamatani N . Comparison of Disease Activity Score (DAS)28- erythrocyte sedimentation rate and DAS28- C-reactive protein threshold values. Ann Rheum Dis 2007; 66: 407\u2013409.","journal-title":"Ann Rheum Dis"},{"issue":"6 Suppl 43","key":"BFgene201524_CR8","first-page":"S-14","volume":"24","author":"VK Ranganath","year":"2006","unstructured":"Ranganath VK, Khanna D, Paulus HE . ACR remission criteria and response criteria. Clin Exp Rheumatol 2006; 24 (6 Suppl 43): S-14\u2013S-21.","journal-title":"Clin Exp Rheumatol"},{"key":"BFgene201524_CR9","first-page":"1817","volume":"28","author":"F Wolfe","year":"2001","unstructured":"Wolfe F, Pincus T . The level of inflammation in rheumatoid arthritis is determined early and remains stable over the longterm course of the illness. J Rheumatol 2001; 28: 1817\u20131824.","journal-title":"J Rheumatol"},{"key":"BFgene201524_CR10","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1161\/CIRCULATIONAHA.106.615740","volume":"114","author":"DC Crawford","year":"2006","unstructured":"Crawford DC, Sanders CL, Qin X, Smith JD, Shephard C, Wong M et al. Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Circulation 2006; 114: 2458\u20132465.","journal-title":"Circulation"},{"key":"BFgene201524_CR11","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s00109-005-0658-0","volume":"83","author":"AJ Szalai","year":"2005","unstructured":"Szalai AJ, Wu J, Lange EM, McCrory MA, Langefeld CD, Williams A et al. Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level. J Mol Med 2005; 83: 440\u2013447.","journal-title":"J Mol Med"},{"key":"BFgene201524_CR12","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1001\/jama.296.22.2703","volume":"296","author":"LA Lange","year":"2006","unstructured":"Lange LA, Carlson CS, Hindorff LA, Lange EM, Walston J, Durda JP et al. Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA 2006; 296: 2703\u20132711.","journal-title":"JAMA"},{"key":"BFgene201524_CR13","doi-asserted-by":"publisher","first-page":"e1000341","DOI":"10.1371\/journal.pmed.1000341","volume":"7","author":"B Rhodes","year":"2010","unstructured":"Rhodes B, Merriman ME, Harrison A, Nissen MJ, Smith M, Stamp L et al. A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation. PLoS Med 2010; 7: e1000341.","journal-title":"PLoS Med"},{"key":"BFgene201524_CR14","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2215\/CJN.01900309","volume":"5","author":"AM Hung","year":"2010","unstructured":"Hung AM, Crawford DC, Griffin MR, Brown-Gentry K, Lipkowitz MS, Siew ED et al. CRP polymorphisms and progression of chronic kidney disease in African Americans. Clin J Am Soc Nephrol 2010; 5: 24\u201333.","journal-title":"Clin J Am Soc Nephrol"},{"key":"BFgene201524_CR15","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1159\/000319021","volume":"30","author":"G Kuhlenbaeumer","year":"2010","unstructured":"Kuhlenbaeumer G, Huge A, Berger K, Kessler C, Voelzke H, Funke H et al. Genetic variants in the C-reactive protein gene are associated with microangiopathic ischemic stroke. Cerebrovasc Dis 2010; 30: 476\u2013482.","journal-title":"Cerebrovasc Dis"},{"key":"BFgene201524_CR16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1742-2094-8-96","volume":"8","author":"EH Kok","year":"2011","unstructured":"Kok EH, Alanne-Kinnunen M, Isotalo K, Luoto T, Haikonen S, Goebeler S et al. CRP gene variation affects early development of Alzheimer's disease-related plaques. J Neuroinflammation 2011; 8: 96.","journal-title":"J Neuroinflammation"},{"key":"BFgene201524_CR17","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1245\/s10434-011-1575-9","volume":"18","author":"SH Yang","year":"2011","unstructured":"Yang SH, Huang CJ, Chang SC, Lin JK . Association of C-reactive protein gene polymorphisms and colorectal cancer. Ann Surg Oncol 2011; 18: 1907\u20131915.","journal-title":"Ann Surg Oncol"},{"key":"BFgene201524_CR18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1086\/431366","volume":"77","author":"CS Carlson","year":"2005","unstructured":"Carlson CS, Aldred SF, Lee PK, Tracy RP, Schwartz SM, Rieder M et al. Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet 2005; 77: 64\u201377.","journal-title":"Am J Hum Genet"},{"key":"BFgene201524_CR19","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1093\/rheumatology\/kel237","volume":"46","author":"KP Machold","year":"2007","unstructured":"Machold KP, Stamm TA, Nell VP, Pflugbeil S, Aletaha D, Steiner G et al. Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease. Rheumatology (Oxford) 2007; 46: 342\u2013349.","journal-title":"Rheumatology (Oxford)"},{"key":"BFgene201524_CR20","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1002\/acr.20040","volume":"62","author":"SL Bridges Jr","year":"2010","unstructured":"Bridges SL Jr ., Causey ZL, Burgos PI, Huynh BQ, Hughes LB, Danila MI et al. Radiographic severity of rheumatoid arthritis in African Americans: results from a multicenter observational study. Arthritis Care Res (Hoboken) 2010; 62: 624\u2013631.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"BFgene201524_CR21","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.3899\/jrheum.121225","volume":"40","author":"A Tamhane","year":"2013","unstructured":"Tamhane A, Redden DT, McGwin G Jr ., Brown EE, Westfall AO, RJ Reynolds 4th et al. Comparison of the disease activity score using erythrocyte sedimentation rate and C-reactive protein in African Americans with rheumatoid arthritis. J Rheumatol 2013; 40: 1812\u20131822.","journal-title":"J Rheumatol"},{"key":"BFgene201524_CR22","doi-asserted-by":"publisher","first-page":"R214","DOI":"10.1186\/ar4052","volume":"14","author":"D Plant","year":"2012","unstructured":"Plant D, Ibrahim I, Lunt M, Eyre S, Flynn E, Hyrich KL et al. Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Arthritis Res Ther 2012; 14: R214.","journal-title":"Arthritis Res Ther"},{"key":"BFgene201524_CR23","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1136\/ard.2006.068247","volume":"67","author":"SW Syversen","year":"2008","unstructured":"Syversen SW, Gaarder PI, Goll GL, Odegard S, Haavardsholm EA, Mowinckel P et al. High anti-cyclic citrullinated peptide levels and an algorithm of four variables predict radiographic progression in patients with rheumatoid arthritis: results from a 10-year longitudinal study. Ann Rheum Dis 2008; 67: 212\u2013217.","journal-title":"Ann Rheum Dis"},{"key":"BFgene201524_CR24","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1093\/rheumatology\/kep155","volume":"48","author":"N Vastesaeger","year":"2009","unstructured":"Vastesaeger N, Xu S, Aletaha D St, Clair EW, Smolen JS . A pilot risk model for the prediction of rapid radiographic progression in rheumatoid arthritis. Rheumatology (Oxford) 2009; 48: 1114\u20131121.","journal-title":"Rheumatology (Oxford)"},{"key":"BFgene201524_CR25","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1136\/annrheumdis-2011-200627","volume":"71","author":"R Knevel","year":"2012","unstructured":"Knevel R, Grondal G, Huizinga TW, Visser AW, Jonsson H, Vikingsson A et al. Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study. Ann Rheum Dis 2012; 71: 707\u2013709.","journal-title":"Ann Rheum Dis"},{"key":"BFgene201524_CR26","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1093\/hmg\/8.9.1707","volume":"8","author":"A Cox","year":"1999","unstructured":"Cox A, Camp NJ, Cannings C, di Giovine FS, Dale M, Worthington J et al. Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis. Hum Mol Genet 1999; 8: 1707\u20131713.","journal-title":"Hum Mol Genet"},{"key":"BFgene201524_CR27","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1002\/art.21750","volume":"54","author":"D Khanna","year":"2006","unstructured":"Khanna D, Wu H, Park G, Gersuk V, Gold RH, Nepom GT et al. Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort. Arthritis Rheum 2006; 54: 1105\u20131116.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR28","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3899\/jrheum.081075","volume":"36","author":"S Reneses","year":"2009","unstructured":"Reneses S, Gonzalez-Escribano MF, Fernandez-Suarez A, Pestana L, Davila B, Wichmann I et al. The value of HLA-DRB1 shared epitope, -308 tumor necrosis factor-alpha gene promoter polymorphism, rheumatoid factor, anti-citrullinated peptide antibodies, and early erosions for predicting radiological outcome in recent-onset rheumatoid arthritis. J Rheumatol 2009; 36: 1143\u20131149.","journal-title":"J Rheumatol"},{"key":"BFgene201524_CR29","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1002\/art.21832","volume":"54","author":"I Prots","year":"2006","unstructured":"Prots I, Skapenko A, Wendler J, Mattyasovszky S, Yone CL, Spriewald B et al. Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis. Arthritis Rheum 2006; 54: 1491\u20131500.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR30","doi-asserted-by":"publisher","first-page":"R75","DOI":"10.1186\/ar2994","volume":"12","author":"PI Burgos","year":"2010","unstructured":"Burgos PI, Causey ZL, Tamhane A, Kelley JM, Brown EE, Hughes LB et al. Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis. Arthritis Res Ther 2010; 12: R75.","journal-title":"Arthritis Res Ther"},{"key":"BFgene201524_CR31","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1136\/ard.2008.106161","volume":"69","author":"HU Scherer","year":"2010","unstructured":"Scherer HU, van der Linden MP, Kurreeman FA, Stoeken-Rijsbergen G, Cessie S, Huizinga TW et al. Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis. Ann Rheum Dis 2010; 69: 567\u2013570.","journal-title":"Ann Rheum Dis"},{"key":"BFgene201524_CR32","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1136\/annrheumdis-2012-201289","volume":"71","author":"R Knevel","year":"2012","unstructured":"Knevel R, de Rooy DP, Gregersen PK, Lindqvist E, Wilson AG, Grondal G et al. Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts. Ann Rheum Dis 2012; 71: 1753\u20131755.","journal-title":"Ann Rheum Dis"},{"key":"BFgene201524_CR33","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1002\/art.11160","volume":"48","author":"LR Lard","year":"2003","unstructured":"Lard LR, van Gaalen FA, Schonkeren JJ, Pieterman EJ, Stoeken G, Vos K et al. Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis. Arthritis Rheum 2003; 48: 1841\u20131848.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR34","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1002\/art.24721","volume":"60","author":"MP van der Linden","year":"2009","unstructured":"van der Linden MP, Feitsma AL, le Cessie S, Kern M, Olsson LM, Raychaudhuri S et al. Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis. Arthritis Rheum 2009; 60: 2242\u20132247.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR35","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1002\/art.22814","volume":"56","author":"I Marinou","year":"2007","unstructured":"Marinou I, Healy J, Mewar D, Moore DJ, Dickson MC, Binks MH et al. Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status. Arthritis Rheum 2007; 56: 2549\u20132556.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR36","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1196\/annals.1423.019","volume":"1110","author":"P Nemec","year":"2007","unstructured":"Nemec P, Pavkova-Goldbergova M, Gatterova J, Vasku A, Soucek M . Association of the 5\u2009A\/6\u2009A promoter polymorphism of the MMP-3 gene with the radiographic progression of rheumatoid arthritis. Ann N Y Acad Sci 2007; 1110: 166\u2013176.","journal-title":"Ann N Y Acad Sci"},{"key":"BFgene201524_CR37","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1007\/s10067-007-0745-4","volume":"26","author":"T Furuya","year":"2007","unstructured":"Furuya T, Hakoda M, Ichikawa N, Higami K, Nanke Y, Yago T et al. Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. Clin Rheumatol 2007; 26: 2137\u20132141.","journal-title":"Clin Rheumatol"},{"key":"BFgene201524_CR38","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/art.1780340707","volume":"34","author":"D van Zeben","year":"1991","unstructured":"van Zeben D, Hazes JM, Zwinderman AH, Cats A, Schreuder GM, D'Amaro J et al. Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Results of a followup study. Arthritis Rheum 1991; 34: 822\u2013830.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR39","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1002\/art.1780391105","volume":"39","author":"JD Reveille","year":"1996","unstructured":"Reveille JD, Alarcon GS, Fowler SE, Pillemer SR, Neuner R, Clegg DO et al. HLA-DRB1 genes and disease severity in rheumatoid arthritis. The MIRA Trial Group. Minocycline in Rheumatoid Arthritis. Arthritis Rheum 1996; 39: 1802\u20131807.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR40","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/art.1780400219","volume":"40","author":"U Wagner","year":"1997","unstructured":"Wagner U, Kaltenhauser S, Sauer H, Arnold S, Seidel W, Hantzschel H et al. HLA markers and prediction of clinical course and outcome in rheumatoid arthritis. Arthritis Rheum 1997; 40: 341\u2013351.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR41","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/art.23166","volume":"58","author":"LB Hughes","year":"2008","unstructured":"Hughes LB, Morrison D, Kelley JM, Padilla MA, Vaughan LK, Westfall AO et al. The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. Arthritis Rheum 2008; 58: 349\u2013358.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR42","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315\u2013324.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR43","first-page":"261","volume":"27","author":"D van der Heijde","year":"2000","unstructured":"van der Heijde D . How to read radiographs according to the Sharp\/van der Heijde method. J Rheumatol 2000; 27: 261\u2013263.","journal-title":"J Rheumatol"},{"key":"BFgene201524_CR44","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","volume":"107","author":"TA Pearson","year":"2003","unstructured":"Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003; 107: 499\u2013511.","journal-title":"Circulation"},{"key":"BFgene201524_CR45","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1002\/art.22200","volume":"54","author":"TR Mikuls","year":"2006","unstructured":"Mikuls TR, Holers VM, Parrish L, Kuhn KA, Conn DL, Gilkeson G et al. Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis. Arthritis Rheum 2006; 54: 3057\u20133059.","journal-title":"Arthritis Rheum"},{"key":"BFgene201524_CR46","first-page":"652","volume":"10","author":"N Aziz","year":"2003","unstructured":"Aziz N, Fahey JL, Detels R, Butch AW . Analytical performance of a highly sensitive C-reactive protein-based immunoassay and the effects of laboratory variables on levels of protein in blood. Clin Diagn Lab Immunol 2003; 10: 652\u2013657.","journal-title":"Clin Diagn Lab Immunol"},{"key":"BFgene201524_CR47","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s00439-008-0517-5","volume":"123","author":"B Rhodes","year":"2008","unstructured":"Rhodes B, Morris DL, Subrahmanyan L, Aubin C, de Leon CF, Kelly JF et al. Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach. Hum Genet 2008; 123: 633\u2013642.","journal-title":"Hum Genet"},{"key":"BFgene201524_CR48","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/hmg\/ddn004","volume":"17","author":"JC Edberg","year":"2008","unstructured":"Edberg JC, Wu J, Langefeld CD, Brown EE, Marion MC, McGwin G Jr . et al. Genetic variation in the CRP promoter: association with systemic lupus erythematosus. Hum Mol Genet 2008; 17: 1147\u20131155.","journal-title":"Hum Mol Genet"},{"issue":"5375","key":"BFgene201524_CR49","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1126\/science.281.5375.363","volume":"281","author":"M Ronaghi","year":"1998","unstructured":"Ronaghi M, Uhlen M, Nyren P . A sequencing method based on real-time pyrophosphate. Science 1998; 281 (5375): 363\u2013365.","journal-title":"Science"},{"key":"BFgene201524_CR50","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ . Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263\u2013265.","journal-title":"Bioinformatics"},{"key":"BFgene201524_CR51","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146","volume-title":"Applied Logistic Regression","author":"DW Hosmer","year":"2000","unstructured":"Hosmer DW, Lemeshow S . Applied Logistic Regression. Wiley: New York, NY, USA, 2000."}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene201524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201524","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene201524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T18:36:00Z","timestamp":1647974160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene201524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,30]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["BFgene201524"],"URL":"https:\/\/doi.org\/10.1038\/gene.2015.24","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,30]]},"assertion":[{"value":"24 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"DM van der Heijde is Director of Imaging Rheumatology BV, The Netherlands. The remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}