{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:15:48Z","timestamp":1788916548659,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1038\/gene.2015.7","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T15:12:06Z","timestamp":1427382726000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-Ak NOD mice"],"prefix":"10.1038","volume":"16","author":[{"given":"A-N","family":"Pelletier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A","family":"Aliesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Banuelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Chabot-Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lesage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,26]]},"reference":[{"key":"BFgene20157_CR1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","volume":"87","author":"JG Hollowell","year":"2002","unstructured":"Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA et al. T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87: 489\u2013499.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFgene20157_CR2","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1084\/jem.178.3.793","volume":"178","author":"PL Podolin","year":"1993","unstructured":"Podolin PL, Pressey A, DeLarato NH, Fischer PA, Peterson LB, Wicker LS . I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 1993; 178: 793\u2013803.","journal-title":"J Exp Med"},{"key":"BFgene20157_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1006\/clin.1996.0191","volume":"81","author":"L Rasooly","year":"1996","unstructured":"Rasooly L, Burek CL, Rose NR . Iodine-induced autoimmune thyroiditis in NOD-H2h4 mice. Clin Immunol Immunopathol 1996; 81: 287\u2013292.","journal-title":"Clin Immunol Immunopathol"},{"key":"BFgene20157_CR4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1006\/jaut.1999.0272","volume":"12","author":"H Braley-Mullen","year":"1999","unstructured":"Braley-Mullen H, Sharp GC, Medling B, Tang H . Spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J Autoimmun 1999; 12: 157\u2013165.","journal-title":"J Autoimmun"},{"key":"BFgene20157_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1006\/cimm.1998.1446","volume":"192","author":"PR Hutchings","year":"1999","unstructured":"Hutchings PR, Verma S, Phillips JM, Harach SZ, Howlett S, Cooke A . Both CD4(+) T cells and CD8(+) T cells are required for iodine accelerated thyroiditis in NOD mice. Cell Immunol 1999; 192: 113\u2013121.","journal-title":"Cell Immunol"},{"key":"BFgene20157_CR6","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1210\/en.2010-0321","volume":"151","author":"CR Chen","year":"2010","unstructured":"Chen CR, Hamidi S, Braley-Mullen H, Nagayama Y, Bresee C, Aliesky HA et al. Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies. Endocrinology 2010; 151: 4583\u20134593.","journal-title":"Endocrinology"},{"key":"BFgene20157_CR7","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1365-2265.2011.04008.x","volume":"75","author":"I Pedersen","year":"2011","unstructured":"Pedersen I, Knudsen N, Carle A, Vejbjerg P, Jorgensen T, Perrild H et al. A cautious iodization program bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population. Clin Endocrinol (Oxf) 2011; 75: 120\u2013126.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BFgene20157_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1365-2265.2011.04044.x","volume":"75","author":"M Vanderpump","year":"2011","unstructured":"Vanderpump M . Thyroid autoimmunity following an iodization programme. Clin Endocrinol (Oxf) 2011; 75: 10\u201311.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BFgene20157_CR9","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/328432a0","volume":"328","author":"H Nishimoto","year":"1987","unstructured":"Nishimoto H, Kikutani H, Yamamura K, Kishimoto T . Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature 1987; 328: 432\u2013434.","journal-title":"Nature"},{"key":"BFgene20157_CR10","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/345727a0","volume":"345","author":"T Lund","year":"1990","unstructured":"Lund T, O'Reilly L, Hutchings P, Kanagawa O, Simpson E, Gravely R et al. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain. Nature 1990; 345: 727\u2013729.","journal-title":"Nature"},{"key":"BFgene20157_CR11","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1126\/science.174.4014.1137","volume":"174","author":"AO Vladutiu","year":"1971","unstructured":"Vladutiu AO, Rose NR . Autoimmune murine thyroiditis relation to histocompatibility (H-2) type. Science 1971; 174: 1137\u20131139.","journal-title":"Science"},{"key":"BFgene20157_CR12","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/BF00364266","volume":"15","author":"KW Beisel","year":"1982","unstructured":"Beisel KW, David CS, Giraldo AA, Kong YM, Rose NR . Regulation of experimental autoimmune thyroiditis: mapping of susceptibility to the I-A subregion of the mouse H-2. Immunogenetics 1982; 15: 427\u2013430.","journal-title":"Immunogenetics"},{"key":"BFgene20157_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1006\/jaut.2000.0458","volume":"16","author":"S Yu","year":"2001","unstructured":"Yu S, Medling B, Yagita H, Braley-Mullen H . Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice. J Autoimmun 2001; 16: 37\u201346.","journal-title":"J Autoimmun"},{"issue":"2\u20133","key":"BFgene20157_CR14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jaut.2007.07.008","volume":"29","author":"Y Nagayama","year":"2007","unstructured":"Nagayama Y, Horie I, Saitoh O, Nakahara M, Abiru N . CD4+CD25+ naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune thyroiditis in NOD-H2h4 mice. J Autoimmu 2007; 29((2\u20133): 195\u2013202.","journal-title":"J Autoimmu"},{"key":"BFgene20157_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1365-2249.2008.03590.x","volume":"152","author":"R Sharma","year":"2008","unstructured":"Sharma R, Traore K, Trush MA, Rose NR, Burek CL . Intracellular adhesion molecule-1 up-regulation on thyrocytes by iodine of non-obese diabetic.H2(h4) mice is reactive oxygen species-dependent. Clin Exp Immunol 2008; 152: 13\u201320.","journal-title":"Clin Exp Immunol"},{"key":"BFgene20157_CR16","doi-asserted-by":"publisher","first-page":"4940","DOI":"10.4049\/jimmunol.1301253","volume":"191","author":"JS Ellis","year":"2013","unstructured":"Ellis JS, Hong SH, Zaghouani H, Braley-Mullen H . Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis. J Immunol 2013; 191: 4940\u20134949.","journal-title":"J Immunol"},{"key":"BFgene20157_CR17","doi-asserted-by":"publisher","first-page":"897","DOI":"10.4049\/jimmunol.1301628","volume":"192","author":"SH Hong","year":"2014","unstructured":"Hong SH, Braley-Mullen H . Follicular B cells in thyroids of mice with spontaneous autoimmune thyroiditis contribute to disease pathogenesis and are targets of anti-CD20 antibody therapy. J Immunol 2014; 192: 897\u2013905.","journal-title":"J Immunol"},{"key":"BFgene20157_CR18","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1007\/BF00586273","volume":"35","author":"D Weatherall","year":"1992","unstructured":"Weatherall D, Sarvetnick N, Shizuru JA . Genetic control of diabetes mellitus. Diabetologia 1992; 35: S1\u2013S7.","journal-title":"Diabetologia"},{"key":"BFgene20157_CR19","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1146\/annurev.iy.13.040195.001143","volume":"13","author":"LS Wicker","year":"1995","unstructured":"Wicker LS, Todd JA, Peterson LB . Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol 1995; 13: 179\u2013200.","journal-title":"Annu Rev Immunol"},{"key":"BFgene20157_CR20","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1002\/eji.1830271117","volume":"27","author":"D Damotte","year":"1997","unstructured":"Damotte D, Colomb E, Cailleau C, Brousse N, Charreire J, Carnaud C . Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis. Eur J Immunol 1997; 27: 2854\u20132862.","journal-title":"Eur J Immunol"},{"key":"BFgene20157_CR21","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.2337\/diabetes.51.7.2141","volume":"51","author":"O Boulard","year":"2002","unstructured":"Boulard O, Damotte D, Deruytter N, Fluteau G, Carnaud C, Garchon HJ . An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice. Diabetes 2002; 51: 2141\u20132147.","journal-title":"Diabetes"},{"key":"BFgene20157_CR22","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1084\/jem.20020735","volume":"196","author":"S Lesage","year":"2002","unstructured":"Lesage S, Hartley SB, Akkaraju S, Wilson J, Townsend M, Goodnow CC . Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J Exp Med 2002; 196: 1175\u20131188.","journal-title":"J Exp Med"},{"key":"BFgene20157_CR23","first-page":"817","volume":"21","author":"A Liston","year":"2004","unstructured":"Liston A, Lesage S, Gray DH, O'Reilly LA, Strasser A, Fahrer AM et al. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity 2004; 21: 817\u2013830.","journal-title":"Immunity"},{"key":"BFgene20157_CR24","doi-asserted-by":"publisher","first-page":"5193","DOI":"10.4049\/jimmunol.0803969","volume":"182","author":"F Guimont-Desrochers","year":"2009","unstructured":"Guimont-Desrochers F, Cappello ZJ, Chagnon M, McDuffie M, Lesage S . Cutting edge: genetic characterization of IFN-producing killer dendritic cells. J Immunol 2009; 182: 5193\u20135197.","journal-title":"J Immunol"},{"key":"BFgene20157_CR25","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1210\/jcem.87.1.8291","volume":"87","author":"Y Tomer","year":"2002","unstructured":"Tomer Y, Greenberg DA, Concepcion E, Ban Y, Davies TF . Thyroglobulin is a thyroid specific gene for the familial autoimmune thyroid diseases. J Clin Endocrinol Metab 2002; 87: 404\u2013407.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFgene20157_CR26","doi-asserted-by":"publisher","first-page":"15119","DOI":"10.1073\/pnas.2434175100","volume":"100","author":"Y Ban","year":"2003","unstructured":"Ban Y, Greenberg DA, Concepcion E, Skrabanek L, Villanueva R, Tomer Y . Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Proc Natl Acad Sci USA 2003; 100: 15119\u201315124.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgene20157_CR27","doi-asserted-by":"publisher","first-page":"5724","DOI":"10.1210\/en.2007-1024","volume":"148","author":"SM McLachlan","year":"2007","unstructured":"McLachlan SM, Nagayama Y, Pichurin PN, Mizutori Y, Chen CR, Misharin A et al. The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. Endocrinology 2007; 148: 5724\u20135733.","journal-title":"Endocrinology"},{"key":"BFgene20157_CR28","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1089\/thy.2013.0676","volume":"24","author":"P Kolypetri","year":"2014","unstructured":"Kolypetri P, Carayanniotis G . Apoptosis of NOD.H2h4 thyrocytes by low concentrations of iodide is associated with impaired control of oxidative stress. Thyroid 2014; 24: 1170\u20131178.","journal-title":"Thyroid"},{"key":"BFgene20157_CR29","doi-asserted-by":"publisher","first-page":"620313","DOI":"10.1155\/2013\/620313","volume":"2013","author":"EE Hillhouse","year":"2013","unstructured":"Hillhouse EE, Collin R, Chabot-Roy G, Guyon MJ, Tessier N et al. Nearby construction impedes the progression to overt autoimmune diabetes in NOD mice. J Diabetes Res 2013; 2013: 620313.","journal-title":"J Diabetes Res"},{"key":"BFgene20157_CR30","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1084\/jem.145.5.1250","volume":"145","author":"PS Esquivel","year":"1977","unstructured":"Esquivel PS, Rose NR, Kong YC . Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide. J Exp Med 1977; 145: 1250\u20131263.","journal-title":"J Exp Med"},{"key":"BFgene20157_CR31","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.2337\/diab.42.8.1166","volume":"42","author":"X Li","year":"1993","unstructured":"Li X, Golden J, Faustman DL . Faulty major histocompatibility complex class II I-E expression is associated with autoimmunity in diverse strains of mice. Autoantibodies, insulitis, and sialadenitis. Diabetes 1993; 42: 1166\u20131172.","journal-title":"Diabetes"},{"key":"BFgene20157_CR32","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.molimm.2014.06.024","volume":"62","author":"PP Ni","year":"2014","unstructured":"Ni PP, Wang Y, Allen PM . Both positive and negative effects on immune responses by expression of a second class II MHC molecule. Mol Immunol 2014; 62: 199\u2013208.","journal-title":"Mol Immunol"},{"key":"BFgene20157_CR33","doi-asserted-by":"publisher","first-page":"e43517","DOI":"10.1371\/journal.pone.0043517","volume":"7","author":"SM McLachlan","year":"2012","unstructured":"McLachlan SM, Aliesky HA, Chen CR, Chong G, Rapoport B . Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'. PLoS One 2012; 7: e43517.","journal-title":"PLoS One"},{"key":"BFgene20157_CR34","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1210\/endo-125-3-1211","volume":"125","author":"J Ruf","year":"1989","unstructured":"Ruf J, Toubert M, Czarnocka B, Durand-Gorde J, Ferrand M, Carayon P . Relationship between immunological structure and biochemical properties of human thyroid peroxidase. Endocrinology 1989; 125: 1211\u20131218.","journal-title":"Endocrinology"},{"key":"BFgene20157_CR35","doi-asserted-by":"publisher","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","volume":"4","author":"Jr Dennis G","year":"2003","unstructured":"Dennis Jr G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003; 4: P3.","journal-title":"Genome Biol"},{"key":"BFgene20157_CR36","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.4049\/jimmunol.154.10.5567","volume":"154","author":"R Quartey-Papafio","year":"1995","unstructured":"Quartey-Papafio R, Lund T, Chandler P, Picard J, Ozegbe P, Day S et al. Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. J Immunol 1995; 154: 5567\u20135575.","journal-title":"J Immunol"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gene20157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene20157","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gene20157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:48:28Z","timestamp":1691542108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gene20157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,26]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["BFgene20157"],"URL":"https:\/\/doi.org\/10.1038\/gene.2015.7","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,26]]},"assertion":[{"value":"3 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}