{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:22:23Z","timestamp":1791274943173,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":2575,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1038\/gim.2014.76","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T11:19:15Z","timestamp":1403176755000},"page":"3-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["A systematic review and critical assessment of 11 discordant meta-analyses on reduced-function CYP2C19 genotype and risk of adverse clinical outcomes in clopidogrel users"],"prefix":"10.1016","volume":"17","author":[{"given":"Ruben L.","family":"Osnabrugge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Zijlstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurri\u00ebn M.","family":"ten Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam G.","family":"Hunink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Pieter","family":"Kappetein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Cecile J.W.","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/gim.2014.76_bb0010","unstructured":"IMS Institute for Healthcare Informatics. IMS Top 20 Global Products 2012. http:\/\/www.imshealth.com\/deployedfiles\/ims\/Global\/Content\/Corporate\/Press%20Room\/Top-Line%20Market%20Data%20&%20Trends\/Top_20_Global_Products_2012_2.pdf. Accessed 23 August 2013."},{"key":"10.1038\/gim.2014.76_bb0015","author":"O\u2019Gara"},{"key":"10.1038\/gim.2014.76_bb0020","author":"Hulot"},{"key":"10.1038\/gim.2014.76_bb0025","unstructured":"FDA Drug Safety Communication: Reduced effectiveness of Plavix (clopidogrel) in patients who are poor metabolizers of the drug. http:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm203888.htm#AIHP. Accessed 25 April 2014."},{"key":"10.1038\/gim.2014.76_bb0030","author":"Bauer"},{"key":"10.1038\/gim.2014.76_bb0035","author":"Holmes"},{"key":"10.1038\/gim.2014.76_bb0040","author":"Hulot"},{"key":"10.1038\/gim.2014.76_bb0045","author":"Mega"},{"key":"10.1038\/gim.2014.76_bb0050","author":"Jadad"},{"key":"10.1038\/gim.2014.76_bb0055","author":"Davidoff"},{"key":"10.1038\/gim.2014.76_bb0060","author":"Siontis"},{"key":"10.1038\/gim.2014.76_bb0065","author":"Osnabrugge"},{"key":"10.1038\/gim.2014.76_bb0070","author":"Liberati"},{"key":"10.1038\/gim.2014.76_bb0075","author":"Deeks"},{"key":"10.1038\/gim.2014.76_bb0080","author":"GRADE Working Group"},{"key":"10.1038\/gim.2014.76_bb0085","author":"Guyatt"},{"key":"10.1038\/gim.2014.76_bb0090","author":"Shea"},{"key":"10.1038\/gim.2014.76_bb0095","author":"Higgins"},{"key":"10.1038\/gim.2014.76_bb0100","author":"Dickersin"},{"key":"10.1038\/gim.2014.76_bb0105","author":"Egger"},{"key":"10.1038\/gim.2014.76_bb0110","author":"Harbord"},{"key":"10.1038\/gim.2014.76_bb0115","author":"Sterne"},{"key":"10.1038\/gim.2014.76_bb0120","author":"Academic Research Consortium"},{"key":"10.1038\/gim.2014.76_bb0125","author":"Liu"},{"key":"10.1038\/gim.2014.76_bb0130","author":"Zabalza"},{"key":"10.1038\/gim.2014.76_bb0135","author":"Jang"},{"key":"10.1038\/gim.2014.76_bb0140","author":"Singh"},{"key":"10.1038\/gim.2014.76_bb0145","author":"Jin"},{"key":"10.1038\/gim.2014.76_bb0150","author":"Sofi"},{"key":"10.1038\/gim.2014.76_bb0155","author":"Yamaguchi"},{"key":"10.1038\/gim.2014.76_bb0160","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2000."},{"key":"10.1038\/gim.2014.76_bb0165","author":"Erik von"},{"key":"10.1038\/gim.2014.76_bb0170","author":"Little"},{"key":"10.1038\/gim.2014.76_bb0175","author":"Bouman"},{"key":"10.1038\/gim.2014.76_bb0180","author":"Campo"},{"key":"10.1038\/gim.2014.76_bb0185","author":"Ma\u0142ek"},{"key":"10.1038\/gim.2014.76_bb0190","author":"Ono"},{"key":"10.1038\/gim.2014.76_bb0195","author":"Par\u00e9"},{"key":"10.1038\/gim.2014.76_bb0200","author":"Tiroch"},{"key":"10.1038\/gim.2014.76_bb0205","author":"Yamamoto"},{"key":"10.1038\/gim.2014.76_bb0210","author":"Malek"},{"key":"10.1038\/gim.2014.76_bb0215","author":"Collet"},{"key":"10.1038\/gim.2014.76_bb0220","author":"Jeong"},{"key":"10.1038\/gim.2014.76_bb0225","author":"French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators"},{"key":"10.1038\/gim.2014.76_bb0230","author":"van Werkum"},{"key":"10.1038\/gim.2014.76_bb0235","author":"Bebia"},{"key":"10.1038\/gim.2014.76_bb0240","author":"Gurbel"},{"key":"10.1038\/gim.2014.76_bb0245","author":"Gurbel"},{"key":"10.1038\/gim.2014.76_bb0250","author":"Osnabrugge"},{"key":"10.1038\/gim.2014.76_bb0255","author":"Higgins"},{"key":"10.1038\/gim.2014.76_bb0260","author":"Higgins"},{"key":"10.1038\/gim.2014.76_bb0265","author":"Ioannidis"},{"key":"10.1038\/gim.2014.76_bb0270","author":"Moher"},{"key":"10.1038\/gim.2014.76_bb0275","author":"ARCTIC Investigators"},{"key":"10.1038\/gim.2014.76_bb0280","author":"TRILOGY ACS Platelet Function Substudy Investigators"},{"key":"10.1038\/gim.2014.76_bb0285","author":"GRAVITAS Investigators"},{"key":"10.1038\/gim.2014.76_bb0290","author":"Roberts"},{"key":"10.1038\/gim.2014.76_bb0295","unstructured":"Medscape. ARCTIC-GENE Throws Cold Water on Genotype-Guided Antiplatelet Therapy at PCI. http:\/\/www.medscape.com\/viewarticle\/810441. Accessed 1 November 2013."}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/gim201476.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gim201476","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021049339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021049339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gim201476.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:44:58Z","timestamp":1761097498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360021049339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1098360021049339"],"URL":"https:\/\/doi.org\/10.1038\/gim.2014.76","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A systematic review and critical assessment of 11 discordant meta-analyses on reduced-function CYP2C19 genotype and risk of adverse clinical outcomes in clopidogrel users","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/gim.2014.76","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015, The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics","name":"copyright","label":"Copyright"}]}}