{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:16:47Z","timestamp":1787224607248,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":1206,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1038\/gim.2017.261","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T10:46:13Z","timestamp":1522320373000},"page":"1266-1273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Genotype and phenotype correlation in von Hippel\u2013Lindau disease based on alteration of the HIF-\u03b1 binding site in VHL protein"],"prefix":"10.1016","volume":"20","author":[{"given":"Sheng-Jie","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-He","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Hui","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-An","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Wen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Cheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nie-Nie","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Fang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/gim.2017.261_bb0010","author":"Gossage"},{"key":"10.1038\/gim.2017.261_bb0015","author":"Maher"},{"key":"10.1038\/gim.2017.261_bb0020","author":"Chou"},{"key":"10.1038\/gim.2017.261_bb0025","author":"Lonser"},{"key":"10.1038\/gim.2017.261_bb0030","author":"Nordstrom-O\u2019Brien"},{"key":"10.1038\/gim.2017.261_bb0035","author":"Filling-Katz"},{"key":"10.1038\/gim.2017.261_bb0040","author":"Maher"},{"key":"10.1038\/gim.2017.261_bb0045","author":"Webster"},{"key":"10.1038\/gim.2017.261_bb0050","author":"Ning"},{"key":"10.1038\/gim.2017.261_bb0055","author":"Wang"},{"key":"10.1038\/gim.2017.261_bb0060","author":"Latif"},{"key":"10.1038\/gim.2017.261_bb0065","author":"Kibel"},{"key":"10.1038\/gim.2017.261_bb0070","author":"Lee"},{"key":"10.1038\/gim.2017.261_bb0075","author":"Hon"},{"key":"10.1038\/gim.2017.261_bb0080","doi-asserted-by":"crossref","unstructured":"Min JH, Yang H, Ivan M, Gertler F, Kaelin WG Jr, Pavletich NP. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science 2002;296:1886\u20131889.","DOI":"10.1126\/science.1073440"},{"key":"10.1038\/gim.2017.261_bb0085","author":"Forman"},{"key":"10.1038\/gim.2017.261_bb0090","author":"Stebbins"},{"key":"10.1038\/gim.2017.261_bb0095","author":"Kim"},{"key":"10.1038\/gim.2017.261_bb0100","author":"Cybulski"},{"key":"10.1038\/gim.2017.261_bb0105","author":"Sgambati"},{"key":"10.1038\/gim.2017.261_bb0110","author":"Ong"},{"key":"10.1038\/gim.2017.261_bb0115","author":"Cascon"},{"key":"10.1038\/gim.2017.261_bb0120","author":"McNeill"},{"key":"10.1038\/gim.2017.261_bb0125","author":"Hoffman"},{"key":"10.1038\/gim.2017.261_bb0130","author":"Clifford"},{"key":"10.1038\/gim.2017.261_bb0135","author":"Chittiboina"},{"key":"10.1038\/gim.2017.261_bb0140","author":"Melmon"},{"key":"10.1038\/gim.2017.261_bb0145","author":"Wu"},{"key":"10.1038\/gim.2017.261_bb0150","author":"Peng"},{"key":"10.1038\/gim.2017.261_bb0155","author":"Young"},{"key":"10.1038\/gim.2017.261_bb0160","author":"Zhuang"},{"key":"10.1038\/gim.2017.261_bb0165","author":"Taieb"},{"key":"10.1038\/gim.2017.261_bb0170","author":"Roe"},{"key":"10.1038\/gim.2017.261_bb0175","author":"Gallou"},{"key":"10.1038\/gim.2017.261_bb0180","author":"Hammel"},{"key":"10.1038\/gim.2017.261_bb0185","author":"Binderup"},{"key":"10.1038\/gim.2017.261_bb0190","author":"Lonser"}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/gim2017261","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gim2017261.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021046839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021046839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/gim.2017.261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/gim2017261.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:48:27Z","timestamp":1761097707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360021046839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S1098360021046839"],"URL":"https:\/\/doi.org\/10.1038\/gim.2017.261","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genotype and phenotype correlation in von Hippel\u2013Lindau disease based on alteration of the HIF-\u03b1 binding site in VHL protein","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/gim.2017.261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018, The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics","name":"copyright","label":"Copyright"}]}}