{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:23:18Z","timestamp":1789928598685,"version":"4.0.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":1540,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1038\/gim.2017.30","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T11:00:35Z","timestamp":1498129235000},"page":"1187-1201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Treatment of mucopolysaccharidosis type II (Hunter syndrome): results from a systematic evidence review"],"prefix":"10.1016","volume":"19","author":[{"given":"Linda A","family":"Bradley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamish R M","family":"Haddow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn E","family":"Palomaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/gim.2017.30_bb0010","series-title":"GeneReviews","author":"Scarpa","year":"1993"},{"key":"10.1038\/gim.2017.30_bb0015","doi-asserted-by":"crossref","unstructured":"da Silva EMK SM, Andriolo RB, Silva LA. Enzyme replacement therapy with idursulfase for mucopolysaccharidosis type II (Hunter syndrome) (Review). Cochrane Database Syst Rev 2014; Issue 1; Art. No.: CD008185.","DOI":"10.1002\/14651858.CD008185.pub3"},{"key":"10.1038\/gim.2017.30_bb0020","author":"Baehner"},{"key":"10.1038\/gim.2017.30_bb0025","author":"Nelson"},{"key":"10.1038\/gim.2017.30_bb0030","author":"Poorthuis"},{"key":"10.1038\/gim.2017.30_bb0035","author":"Young"},{"key":"10.1038\/gim.2017.30_bb0040","author":"Lin"},{"key":"10.1038\/gim.2017.30_bb0045","unstructured":"Human Gene Mutations Database. Qiagen HGMD Professional, 2016. https:\/\/www.qiagenbioinformatics.com\/products\/human-gene-mutation-database\/1673-2\/. Accessed (with permission) 2 May 2016."},{"key":"10.1038\/gim.2017.30_bb0050","author":"Prasad"},{"key":"10.1038\/gim.2017.30_bb0055","unstructured":"Shire Human Genetic Therapies. Highlights of prescribing information for ELAPRASE [REG] (idursulfase) injection, for intravenous use. 2006; updated in June, 2013. FDA\/Center for Drug Evaluation and Research, Office of Communications. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2013\/125151s0184lbl.pdf. Accessed 11 February 2014."},{"key":"10.1038\/gim.2017.30_bb0060","author":"Scarpa"},{"key":"10.1038\/gim.2017.30_bb0065","unstructured":"Agency for Healthcare Research and Quality Methods guide for effectiveness and comparative effectiveness reviews. No. 10(14)-EHC063-EF. Rockville, MD, January 2014 http:\/\/www.effectivehealthcare.ahrq.gov."},{"key":"10.1038\/gim.2017.30_bb0070","author":"Campbell"},{"key":"10.1038\/gim.2017.30_bb0075","author":"Daly"},{"key":"10.1038\/gim.2017.30_bb0080","author":"Guyatt"},{"key":"10.1038\/gim.2017.30_bb0085","first-page":"S45","article-title":"Efficacy and safety of therapy with idursulfase in patients with mucopolysaccharidosis type II, with and without comparison to placebo: systematic review and meta-analysis","volume":"29","author":"Alegra","year":"2013","journal-title":"Cad Sa\u00fade P\u00fablica (translation from Portuguese in Public Health, online version ISSN 1678-4464)"},{"key":"10.1038\/gim.2017.30_bb0090","author":"Muenzer"},{"key":"10.1038\/gim.2017.30_bb0095","author":"Barbier"},{"key":"10.1038\/gim.2017.30_bb0100","author":"Muenzer"},{"key":"10.1038\/gim.2017.30_bb0105","author":"Muenzer"},{"key":"10.1038\/gim.2017.30_bb0110","author":"Okuyama"},{"key":"10.1038\/gim.2017.30_bb0115","author":"Sohn"},{"key":"10.1038\/gim.2017.30_bb0120","author":"Wyatt"},{"key":"10.1038\/gim.2017.30_bb0125","author":"Giugliani"},{"key":"10.1038\/gim.2017.30_bb0130","author":"Schulze-Frenking"},{"key":"10.1038\/gim.2017.30_bb0135","author":"Burton"},{"key":"10.1038\/gim.2017.30_bb0140","author":"Cho"},{"key":"10.1038\/gim.2017.30_bb0145","author":"Glamuzina"},{"key":"10.1038\/gim.2017.30_bb0150","author":"Guffon"},{"key":"10.1038\/gim.2017.30_bb0155","author":"Jones"},{"key":"10.1038\/gim.2017.30_bb0160","author":"Kim"},{"key":"10.1038\/gim.2017.30_bb0165","author":"Patel"},{"key":"10.1038\/gim.2017.30_bb0170","author":"Sohn"},{"key":"10.1038\/gim.2017.30_bb0175","author":"Tanjuakio"},{"key":"10.1038\/gim.2017.30_bb0180","author":"Tomanin"},{"key":"10.1038\/gim.2017.30_bb0185","author":"Lampe"},{"key":"10.1038\/gim.2017.30_bb0190","author":"Tajima"},{"key":"10.1038\/gim.2017.30_bb0195","author":"Tylki-Szymanska"},{"key":"10.1038\/gim.2017.30_bb0200","author":"Zuber"},{"key":"10.1038\/gim.2017.30_bb0205","author":"Lampe"},{"key":"10.1038\/gim.2017.30_bb0210","author":"Pano"},{"key":"10.1038\/gim.2017.30_bb0215","author":"McDonald"},{"key":"10.1038\/gim.2017.30_bb0220","unstructured":"US Food and Drug Administration Center for Drug Evaluation and Research FDA Advisory Committee briefing document: Vimizim (elosulfase alfa) for patients with mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome). Meeting of the Endrocrinologic and Metabolic Drugs Advisory Committee, 19 November 2013 http:\/\/www.fda.gov\/downloads\/advisorycommittees\/committeesmeetingmaterial\/drugs\/endocrinologicandmetabolicdrugsadvisorycommittee\/ucm3a75126.pdf. Accessed 10 June 2016."},{"key":"10.1038\/gim.2017.30_bb0225","author":"Jurecka"},{"key":"10.1038\/gim.2017.30_bb0230","author":"Jurecka"},{"key":"10.1038\/gim.2017.30_bb0235","author":"Anbu"},{"key":"10.1038\/gim.2017.30_bb0240","author":"Wegrzyn"},{"key":"10.1038\/gim.2017.30_bb0245","author":"Hundsberger"},{"key":"10.1038\/gim.2017.30_bb0250","author":"Muenzer"},{"key":"10.1038\/gim.2017.30_bb0255","author":"Martin"},{"key":"10.1038\/gim.2017.30_bb0260","author":"Wiesmann"},{"key":"10.1038\/gim.2017.30_bb0265","author":"Burton"},{"key":"10.1038\/gim.2017.30_bb0270","author":"Ceravolo"},{"key":"10.1038\/gim.2017.30_bb0275","author":"Bagewadi"},{"key":"10.1038\/gim.2017.30_bb0280","author":"Burton"},{"key":"10.1038\/gim.2017.30_bb0285","author":"Buraczewska"},{"key":"10.1038\/gim.2017.30_bb0290","author":"Boelens"},{"key":"10.1038\/gim.2017.30_bb0295","author":"Annibali"},{"key":"10.1038\/gim.2017.30_bb0300","author":"Guffon"},{"key":"10.1038\/gim.2017.30_bb0305","author":"Vellodi"},{"key":"10.1038\/gim.2017.30_bb0310","author":"Tanaka"},{"key":"10.1038\/gim.2017.30_bb0315","author":"Muenzer"},{"key":"10.1038\/gim.2017.30_bb0320","author":"Potter"}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/gim201730.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/gim201730","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021045743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021045743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/gim.2017.30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/gim201730.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:46:41Z","timestamp":1761097601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360021045743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1098360021045743"],"URL":"https:\/\/doi.org\/10.1038\/gim.2017.30","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of mucopolysaccharidosis type II (Hunter syndrome): results from a systematic evidence review","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/gim.2017.30","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017, The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics","name":"copyright","label":"Copyright"}]}}