{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:19:20Z","timestamp":1791314360331,"version":"4.3.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T00:00:00Z","timestamp":1204761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T00:00:00Z","timestamp":1204761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1038\/gt.2008.23","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T14:18:04Z","timestamp":1204813084000},"page":"966-977","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["AAV\u2013BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment"],"prefix":"10.1038","volume":"15","author":[{"given":"A P","family":"Kells","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,6]]},"reference":[{"key":"BFgt200823_CR1","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ymthe.2004.02.016","volume":"9","author":"AP Kells","year":"2004","unstructured":"Kells AP, Fong DM, Dragunow M, During MJ, Young D, Connor B . AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease. Mol Ther 2004; 9: 682\u2013688.","journal-title":"Mol Ther"},{"key":"BFgt200823_CR2","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1046\/j.1471-4159.2000.0752190.x","volume":"75","author":"E Perez-Navarro","year":"2000","unstructured":"Perez-Navarro E, Canudas AM, Akerund P, Alberch J, Arenas E . Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4\/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease. J Neurochem 2000; 75: 2190\u20132199.","journal-title":"J Neurochem"},{"key":"BFgt200823_CR3","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1523\/JNEUROSCI.16-15-04604.1996","volume":"16","author":"A Martinez-Serrano","year":"1996","unstructured":"Martinez-Serrano A, Bjorklund A . Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells. J Neurosci 1996; 16: 4604\u20134616.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR4","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1089\/10430349950016393","volume":"10","author":"AP Bemelmans","year":"1999","unstructured":"Bemelmans AP, Horellou P, Pradier L, Brunet I, Colin P, Mallet J . Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer. Hum Gene Ther 1999; 10: 2987\u20132997.","journal-title":"Hum Gene Ther"},{"key":"BFgt200823_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0014-4886(03)00044-X","volume":"181","author":"JL McBride","year":"2003","unstructured":"McBride JL, During MJ, Wuu J, Chen EY, Leurgans SE, Kordower JH . Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF. Exp Neurol 2003; 181: 213\u2013223.","journal-title":"Exp Neurol"},{"key":"BFgt200823_CR6","doi-asserted-by":"publisher","first-page":"9345","DOI":"10.1073\/pnas.0508875103","volume":"103","author":"JL McBride","year":"2006","unstructured":"McBride JL, Ramaswamy S, Gasmi M, Bartus RT, Herzog CD, Brandon EP et al. Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease. Proc Natl Acad Sci USA 2006; 103: 9345\u20139350.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgt200823_CR7","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.expneurol.2004.12.009","volume":"193","author":"N Popovic","year":"2005","unstructured":"Popovic N, Maingay M, Kirik D, Brundin P . Lentiviral gene delivery of GDNF into the striatum of R6\/2 Huntington mice fails to attenuate behavioral and neuropathological changes. Exp Neurol 2005; 193: 65\u201374.","journal-title":"Exp Neurol"},{"key":"BFgt200823_CR8","doi-asserted-by":"publisher","first-page":"5168","DOI":"10.1523\/JNEUROSCI.16-16-05168.1996","volume":"16","author":"DF Emerich","year":"1996","unstructured":"Emerich DF, Lindner MD, Winn SR, Chen EY, Frydel BR, Kordower JH . Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J Neurosci 1996; 16: 5168\u20135181.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/096368979700600308","volume":"6","author":"DF Emerich","year":"1997","unstructured":"Emerich DF, Cain CK, Greco C, Saydoff JA, Hu ZY, Liu H et al. Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease. Cell Transplant 1997; 6: 249\u2013266.","journal-title":"Cell Transplant"},{"key":"BFgt200823_CR10","doi-asserted-by":"publisher","first-page":"4478","DOI":"10.1523\/JNEUROSCI.22-11-04478.2002","volume":"22","author":"V Mittoux","year":"2002","unstructured":"Mittoux V, Ouary S, Monville C, Lisovoski F, Poyot T, Conde F et al. Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration. J Neurosci 2002; 22: 4478\u20134486.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR11","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1089\/10430340050015220","volume":"11","author":"V Mittoux","year":"2000","unstructured":"Mittoux V, Joseph JM, Conde F, Palfi S, Dautry C, Poyot T et al. Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease. Hum Gene Ther 2000; 11: 1177\u20131187.","journal-title":"Hum Gene Ther"},{"key":"BFgt200823_CR12","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1006\/nbdi.2001.0388","volume":"8","author":"LP de Almeida","year":"2001","unstructured":"de Almeida LP, Zala D, Aebischer P, Deglon N . Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease. Neurobiol Dis 2001; 8: 433\u2013446.","journal-title":"Neurobiol Dis"},{"key":"BFgt200823_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0006-8993(00)02237-X","volume":"866","author":"I Ferrer","year":"2000","unstructured":"Ferrer I, Goutan E, Marin C, Rey MJ, Ribalta T . Brain-derived neurotrophic factor in Huntington disease. Brain Res 2000; 866: 257\u2013261.","journal-title":"Brain Res"},{"key":"BFgt200823_CR14","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1126\/science.1059581","volume":"293","author":"C Zuccato","year":"2001","unstructured":"Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L et al. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 2001; 293: 493\u2013498.","journal-title":"Science"},{"key":"BFgt200823_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/ng1219","volume":"35","author":"C Zuccato","year":"2003","unstructured":"Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L et al. Huntingtin interacts with REST\/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet 2003; 35: 76\u201383.","journal-title":"Nat Genet"},{"key":"BFgt200823_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.phrs.2005.01.001","volume":"52","author":"C Zuccato","year":"2005","unstructured":"Zuccato C, Liber D, Ramos C, Tarditi A, Rigamonti D, Tartari M et al. Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery. Pharmacol Res 2005; 52: 133\u2013139.","journal-title":"Pharmacol Res"},{"key":"BFgt200823_CR17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","volume":"118","author":"LR Gauthier","year":"2004","unstructured":"Gauthier LR, Charrin BC, Borrell-Pages M, Dompierre JP, Rangone H, Cordelieres FP et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 2004; 118: 127\u2013138.","journal-title":"Cell"},{"key":"BFgt200823_CR18","doi-asserted-by":"publisher","first-page":"12748","DOI":"10.1523\/JNEUROSCI.3873-06.2006","volume":"26","author":"D del Toro","year":"2006","unstructured":"del Toro D, Canals JM, Gines S, Kojima M, Egea G, Alberch J . Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism. J Neurosci 2006; 26: 12748\u201312757.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR19","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1523\/JNEUROSCI.3920-03.2004","volume":"24","author":"ZC Baquet","year":"2004","unstructured":"Baquet ZC, Gorski JA, Jones KR . Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. J Neurosci 2004; 24: 4250\u20134258.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR20","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0166-2236(96)01026-0","volume":"20","author":"S Marty","year":"1997","unstructured":"Marty S, Berzaghi MdaP, Berninger B . Neurotrophins and activity-dependent plasticity of cortical interneurons. Trends Neurosci 1997; 20: 198\u2013202.","journal-title":"Trends Neurosci"},{"key":"BFgt200823_CR21","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/(SICI)1097-4547(20000201)59:3<454::AID-JNR21>3.0.CO;2-H","volume":"59","author":"C Aoki","year":"2000","unstructured":"Aoki C, Wu K, Elste A, Len G, Lin S, McAuliffe G et al. Localization of brain-derived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex. J Neurosci Res 2000; 59: 454\u2013463.","journal-title":"J Neurosci Res"},{"key":"BFgt200823_CR22","doi-asserted-by":"publisher","first-page":"7727","DOI":"10.1523\/JNEUROSCI.1197-04.2004","volume":"24","author":"JM Canals","year":"2004","unstructured":"Canals JM, Pineda JR, Torres-Peraza JF, Bosch M, Martin-Ibanez R, Munoz MT et al. Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease. J Neurosci 2004; 24: 7727\u20137739.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR23","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1111\/j.1471-4159.2005.03047.x","volume":"93","author":"JR Pineda","year":"2005","unstructured":"Pineda JR, Canals JM, Bosch M, Adell A, Mengod G, Artigas F et al. Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease. J Neurochem 2005; 93: 1057\u20131068.","journal-title":"J Neurochem"},{"key":"BFgt200823_CR24","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","volume":"141","author":"TY Pang","year":"2006","unstructured":"Pang TY, Stam NC, Nithianantharajah J, Howard ML, Hannan AJ . Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice. Neuroscience 2006; 141: 569\u2013584.","journal-title":"Neuroscience"},{"key":"BFgt200823_CR25","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1523\/JNEUROSCI.1658-03.2004","volume":"24","author":"TL Spires","year":"2004","unstructured":"Spires TL, Grote HE, Varshney NK, Cordery PM, van Dellen A, Blakemore C et al. Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. J Neurosci 2004; 24: 2270\u20132276.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR26","doi-asserted-by":"publisher","first-page":"4424","DOI":"10.1523\/JNEUROSCI.5113-06.2007","volume":"27","author":"G Lynch","year":"2007","unstructured":"Lynch G, Kramar EA, Rex CS, Jia Y, Chappas D, Gall CM et al. Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J Neurosci 2007; 27: 4424\u20134434.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR27","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1172\/JCI27607","volume":"116","author":"M Borrell-Pages","year":"2006","unstructured":"Borrell-Pages M, Canals JM, Cordelieres FP, Parker JA, Pineda JR, Grange G et al. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J Clin Invest 2006; 116: 1410\u20131424.","journal-title":"J Clin Invest"},{"key":"BFgt200823_CR28","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1523\/JNEUROSCI.4056-03.2004","volume":"24","author":"C Richichi","year":"2004","unstructured":"Richichi C, Lin EJ, Stefanin D, Colella D, Ravizza T, Grignaschi G et al. Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus. J Neurosci 2004; 24: 3051\u20133059.","journal-title":"J Neurosci"},{"key":"BFgt200823_CR29","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/0169-328X(95)00184-T","volume":"34","author":"GA MacGibbon","year":"1995","unstructured":"MacGibbon GA, Lawlor PA, Hughes P, Young D, Dragunow M . Differential expression of inducible transcription factors in basal ganglia neurons. Brain Res Mol Brain Res 1995; 34: 294\u2013302.","journal-title":"Brain Res Mol Brain Res"},{"key":"BFgt200823_CR30","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/cne.903540105","volume":"354","author":"T Herdegen","year":"1995","unstructured":"Herdegen T, Kovary K, Buhl A, Bravo R, Zimmermann M, Gass P . Basal expression of the inducible transcription factors c-Jun, JunB, JunD, c-Fos, FosB, and Krox-24 in the adult rat brain. J Comp Neurol 1995; 354: 39\u201356.","journal-title":"J Comp Neurol"},{"key":"BFgt200823_CR31","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0028-3908(00)00005-8","volume":"39","author":"T Schallert","year":"2000","unstructured":"Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST . CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 2000; 39: 777\u2013787.","journal-title":"Neuropharmacology"},{"key":"BFgt200823_CR32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.brainresbull.2005.08.009","volume":"68","author":"E Dowd","year":"2005","unstructured":"Dowd E, Monville C, Torres EM, Dunnett SB . The corridor task: a simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum. Brain Res Bull 2005; 68: 24\u201330.","journal-title":"Brain Res Bull"},{"key":"BFgt200823_CR33","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/0006-8993(79)90966-1","volume":"170","author":"R Schwarcz","year":"1979","unstructured":"Schwarcz R, Fuxe K, Agnati LF, Hokfelt T, Coyle JT . Rotational behaviour in rats with unilateral striatal kainic acid lesions: a behavioural model for studies on intact dopamine receptors. Brain Res 1979; 170: 485\u2013495.","journal-title":"Brain Res"},{"key":"BFgt200823_CR34","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S1525-0016(03)00012-1","volume":"7","author":"B Hauck","year":"2003","unstructured":"Hauck B, Chen L, Xiao W . Generation and characterization of chimeric recombinant AAV vectors. Mol Ther 2003; 7: 419\u2013425.","journal-title":"Mol Ther"},{"key":"BFgt200823_CR35","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/S0306-4522(99)00296-1","volume":"93","author":"SD Croll","year":"1999","unstructured":"Croll SD, Suri C, Compton DL, Simmons MV, Yancopoulos GD, Lindsay RM et al. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 1999; 93: 1491\u20131506.","journal-title":"Neuroscience"},{"key":"BFgt200823_CR36","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1152\/jn.1997.78.2.1082","volume":"78","author":"HE Scharfman","year":"1997","unstructured":"Scharfman HE . Hyperexcitability in combined entorhinal\/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor. J Neurophysiol 1997; 78: 1082\u20131095.","journal-title":"J Neurophysiol"},{"key":"BFgt200823_CR37","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0014-4886(95)90045-4","volume":"131","author":"MA Pelleymounter","year":"1995","unstructured":"Pelleymounter MA, Cullen MJ, Wellman CL . Characteristics of BDNF-induced weight loss. Exp Neurol 1995; 131: 229\u2013238.","journal-title":"Exp Neurol"},{"key":"BFgt200823_CR38","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1093\/emboj\/19.6.1290","volume":"19","author":"SG Kernie","year":"2000","unstructured":"Kernie SG, Liebl DJ, Parada LF . BDNF regulates eating behavior and locomotor activity in mice. EMBO J 2000; 19: 1290\u20131300.","journal-title":"EMBO J"},{"key":"BFgt200823_CR39","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1006\/mthe.2001.0520","volume":"5","author":"BK Kaspar","year":"2002","unstructured":"Kaspar BK, Erickson D, Schaffer D, Hinh L, Gage FH, Peterson DA . Targeted retrograde gene delivery for neuronal protection. Mol Ther 2002; 5: 50\u201356.","journal-title":"Mol Ther"},{"key":"BFgt200823_CR40","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0896-6273(00)80798-9","volume":"23","author":"P Greengard","year":"1999","unstructured":"Greengard P, Allen PB, Nairn AC . Beyond the dopamine receptor: the DARPP-32\/protein phosphatase-1 cascade. Neuron 1999; 23: 435\u2013447.","journal-title":"Neuron"},{"key":"BFgt200823_CR41","doi-asserted-by":"publisher","first-page":"6809","DOI":"10.1073\/pnas.120166397","volume":"97","author":"JA Bibb","year":"2000","unstructured":"Bibb JA, Yan Z, Svenningsson P, Snyder GL, Pieribone VA, Horiuchi A et al. Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice. Proc Natl Acad Sci USA 2000; 97: 6809\u20136814.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgt200823_CR42","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/0306-4522(89)90128-0","volume":"29","author":"AJ McGeorge","year":"1989","unstructured":"McGeorge AJ, Faull RL . The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 1989; 29: 503\u2013537.","journal-title":"Neuroscience"},{"key":"BFgt200823_CR43","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/cne.902360404","volume":"236","author":"CR Gerfen","year":"1985","unstructured":"Gerfen CR . The neostriatal mosaic. I. Compartmental organization of projections from the striatum to the substantia nigra in the rat. J Comp Neurol 1985; 236: 454\u2013476.","journal-title":"J Comp Neurol"},{"key":"BFgt200823_CR44","first-page":"221","volume":"76","author":"MJ During","year":"2003","unstructured":"During MJ, Young D, Baer K, Lawlor P, Klugmann M . Development and optimization of adeno-associated virus vector transfer into the central nervous system. Methods Mol Med 2003; 76: 221\u2013236.","journal-title":"Methods Mol Med"},{"key":"BFgt200823_CR45","doi-asserted-by":"publisher","first-page":"273","DOI":"10.2174\/1566523054065011","volume":"5","author":"J Timpe","year":"2005","unstructured":"Timpe J, Bevington J, Casper J, Dignam JD, Trempe JP . Mechanisms of adeno-associated virus genome encapsidation. Curr Gene Ther 2005; 5: 273\u2013284.","journal-title":"Curr Gene Ther"},{"key":"BFgt200823_CR46","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jneumeth.2006.11.006","volume":"161","author":"AP Kells","year":"2007","unstructured":"Kells AP, Henry RA, Hughes SM, Connor B . Verification of functional AAV-mediated neurotrophic and anti-apoptotic factor expression. J Neurosci Methods 2007; 161: 291\u2013300.","journal-title":"J Neurosci Methods"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gt200823.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gt200823","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gt200823.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T08:17:50Z","timestamp":1648541870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gt200823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,6]]},"references-count":46,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["BFgt200823"],"URL":"https:\/\/doi.org\/10.1038\/gt.2008.23","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,6]]},"assertion":[{"value":"9 August 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}