{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:15:28Z","timestamp":1791422128032,"version":"4.3.3"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"20","license":[{"start":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T00:00:00Z","timestamp":1210809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T00:00:00Z","timestamp":1210809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1038\/gt.2008.82","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T11:48:32Z","timestamp":1210852112000},"page":"1361-1371","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus"],"prefix":"10.1038","volume":"15","author":[{"given":"J","family":"Foloppe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Futin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Findeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Cordier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Schlesinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Tosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-M","family":"Balloul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Erbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,15]]},"reference":[{"key":"BFgt200882_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0140-6736(98)07127-X","volume":"353","author":"R Midgley","year":"1999","unstructured":"Midgley R, Kerr D . Colorectal cancer. Lancet 1999; 353: 391\u2013399.","journal-title":"Lancet"},{"key":"BFgt200882_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3322\/canjclin.57.1.43","volume":"57","author":"A Jemal","year":"2007","unstructured":"Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ . Cancer statistics. CA Cancer J Clin 2007; 57: 43\u201366.","journal-title":"CA Cancer J Clin"},{"key":"BFgt200882_CR3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1146\/annurev.med.56.082103.104630","volume":"56","author":"DJ Bentrem","year":"2005","unstructured":"Bentrem DJ, Dematteo RP, Blumgart LH . Surgical therapy for metastatic disease to the liver. Annu Rev Med 2005; 56: 139\u2013156.","journal-title":"Annu Rev Med"},{"key":"BFgt200882_CR4","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1006\/mthe.2002.0596","volume":"5","author":"P Mayer-Kuckuk","year":"2002","unstructured":"Mayer-Kuckuk P, Banerjee D, Kemeny N, Fong Y, Bertino JR . Molecular therapies for colorectal cancer metastatic to the liver. Mol Ther 2002; 5: 492\u2013500.","journal-title":"Mol Ther"},{"key":"BFgt200882_CR5","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/S0140-6736(00)02034-1","volume":"355","author":"JY Douillard","year":"2000","unstructured":"Douillard JY, Cunningham D, Roth AD, Navarro M, James RD, Karasek P et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000; 355: 1041\u20131047.","journal-title":"Lancet"},{"key":"BFgt200882_CR6","doi-asserted-by":"publisher","first-page":"4856","DOI":"10.1200\/JCO.2005.05.546","volume":"23","author":"CH Kohne","year":"2005","unstructured":"Kohne CH, van Cutsem E, Wils J, Bokemeyer C, El-Serafi M, Lutz MP et al. European Organisation for Research and Treatment of Cancer Gastrointestinal Group. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. J Clin Oncol 2005; 23: 4856\u20134865.","journal-title":"J Clin Oncol"},{"key":"BFgt200882_CR7","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1200\/JCO.2000.18.16.2938","volume":"18","author":"A de Gramont","year":"2000","unstructured":"de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18: 2938\u20132947.","journal-title":"J Clin Oncol"},{"key":"BFgt200882_CR8","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1200\/JCO.2004.11.037","volume":"22","author":"A Grothey","year":"2004","unstructured":"Grothey A, Sargent D, Goldberg RM, Schmoll HJ . Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004; 22: 1209\u20131214.","journal-title":"J Clin Oncol"},{"key":"BFgt200882_CR9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nrc1074","volume":"3","author":"DB Longley","year":"2003","unstructured":"Longley DB, Harkin DP, Johnston PG . 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003; 3: 330\u2013338.","journal-title":"Nat Rev Cancer"},{"key":"BFgt200882_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1089\/10430340152712638","volume":"13","author":"BG Harvey","year":"2002","unstructured":"Harvey BG, Maroni J, O'Donoghue KA, Chu KW, Muscat JC, Pippo AL et al. Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions. Hum Gene Ther 2002; 13: 15\u201363.","journal-title":"Hum Gene Ther"},{"key":"BFgt200882_CR11","unstructured":"Gene therapy clinical trials world wide. J Gene Med. Available from: www.wiley.co.uk\/genmed\/clinical."},{"key":"BFgt200882_CR12","first-page":"1417","volume":"59","author":"E Kievit","year":"1999","unstructured":"Kievit E, Bershad E, Ng E, Sethna P, Dev I, Lawrence TS et al. Superiority of yeast over bacterial cytosine deaminase for enzyme\/prodrug gene therapy in colon cancer xenografts. Cancer Res 1999; 59: 1417\u20131421.","journal-title":"Cancer Res"},{"key":"BFgt200882_CR13","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1089\/10430349950017356","volume":"10","author":"DA Hamstra","year":"1999","unstructured":"Hamstra DA, Rice DJ, Fahmy S, Ross BD, Rehemtulla A . Enzyme\/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase. Hum Gene Ther 1999; 10: 1993\u20132003.","journal-title":"Hum Gene Ther"},{"key":"BFgt200882_CR14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1574-6968.1998.tb13205.x","volume":"167","author":"M Tiraby","year":"1998","unstructured":"Tiraby M, Cazaux C, Baron M, Drocourt D, Reynes JP, Tiraby G . Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine. FEMS Microbiol Lett 1998; 167: 41\u201349.","journal-title":"FEMS Microbiol Lett"},{"key":"BFgt200882_CR15","first-page":"3813","volume":"60","author":"P Erbs","year":"2000","unstructured":"Erbs P, Regulier E, Kintz J, Leroy P, Poitevin Y, Exinger F et al. qIn vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase\/uracil phosphoribosyltransferase fusion gene. Cancer Res 2000; 60: 3813\u20133822.","journal-title":"Cancer Res"},{"key":"BFgt200882_CR16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/sj.cgt.7701098","volume":"15","author":"P Erbs","year":"2008","unstructured":"Erbs P, Findeli A, Kintz J, Cordier P, Hoffmann C, Geist M et al. Modified vaccinia virus Ankara as a vector for suicide gene therapy. Cancer Gene Ther 2008; 15: 18\u201328.","journal-title":"Cancer Gene Ther"},{"key":"BFgt200882_CR17","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1099\/0022-1317-83-3-491","volume":"83","author":"CJ Ring","year":"2002","unstructured":"Ring CJ . Cytolytic viruses as potential anti-cancer agents. J Gen Virol 2002; 83: 491\u2013502.","journal-title":"J Gen Virol"},{"key":"BFgt200882_CR18","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S1357-4310(97)81456-6","volume":"2","author":"DH Kirn","year":"1996","unstructured":"Kirn DH, McCormick F . Replicating viruses as selective cancer therapeutics. Mol Med Today 1996; 2: 519\u2013527.","journal-title":"Mol Med Today"},{"key":"BFgt200882_CR19","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1172\/JCI9744","volume":"105","author":"RL Martuza","year":"2000","unstructured":"Martuza RL . Conditionally replicating herpes vectors for cancer therapy. J Clin Invest 2000; 105: 841\u2013846.","journal-title":"J Clin Invest"},{"key":"BFgt200882_CR20","first-page":"457","volume":"53","author":"K Figova","year":"2006","unstructured":"Figova K, Hrabeta J, Eckschlager T . Reovirus\u2014possible therapy of cancer. Neoplasma 2006; 53: 457\u2013462.","journal-title":"Neoplasma"},{"key":"BFgt200882_CR21","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ymthe.2004.10.015","volume":"11","author":"Y Shen","year":"2005","unstructured":"Shen Y, Nemunaitis J . Fighting cancer with vaccinia virus: teaching new tricks to an old dog. Mol Ther 2005; 11: 180\u2013195.","journal-title":"Mol Ther"},{"key":"BFgt200882_CR22","first-page":"6070","volume":"62","author":"T Reid","year":"2002","unstructured":"Reid T, Galanis E, Abbruzzese J, Sze D, Wein LM, Andrews J et al. Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints. Cancer Res 2002; 62: 6070\u20136079.","journal-title":"Cancer Res"},{"key":"BFgt200882_CR23","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1097\/01.RVI.0000058422.01661.1E","volume":"14","author":"DY Sze","year":"2003","unstructured":"Sze DY, Freeman SM, Slonim SM, Samuels SL, Andrews JC, Hicks M et al. Dr Gary J Becker Young Investigator Award: intraarterial adenovirus for metastatic gastrointestinal cancer: activity, radiographic response, and survival. J Vasc Interv Radiol 2003; 14: 279\u2013290.","journal-title":"J Vasc Interv Radiol"},{"key":"BFgt200882_CR24","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/317813a0","volume":"317","author":"RM Buller","year":"1985","unstructured":"Buller RM, Smith GL, Cremer K, Notkins AL, Moss B . Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype. Nature 1985; 317: 813\u2013815.","journal-title":"Nature"},{"key":"BFgt200882_CR25","first-page":"17","volume":"1","author":"B Acres","year":"1994","unstructured":"Acres B, Dott K, Stefani L, Kieny MP . Directed cytokine expression in tumour cells in vivo using recombinant vaccinia virus. Ther Immunol 1994; 1: 17\u201323.","journal-title":"Ther Immunol"},{"key":"BFgt200882_CR26","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1089\/10430349950018724","volume":"10","author":"M Puhlmann","year":"1999","unstructured":"Puhlmann M, Gnant M, Brown CK, Alexander Jr HR, Bartlett DL . Thymidine kinase-deleted vaccinia virus expressing purine nucleoside phosphorylase as a vector for tumor-directed gene therapy. Hum Gene Ther 1999; 10: 649\u2013657.","journal-title":"Hum Gene Ther"},{"key":"BFgt200882_CR27","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/sj.cgt.7700075","volume":"7","author":"M Puhlmann","year":"2000","unstructured":"Puhlmann M, Brown CK, Gnant M, Huang J, Libutti SK, Alexander Jr HR et al. Vaccinia as a vector for tumor-directed gene therapy: biodistribution of a thymidine kinase-deleted mutant. Cancer Gene Ther 2000; 7: 66\u201373.","journal-title":"Cancer Gene Ther"},{"key":"BFgt200882_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1099\/0022-1317-72-1-125","volume":"72","author":"G Taylor","year":"1991","unstructured":"Taylor G, Stott EJ, Wertz G, Ball A . Comparison of the virulence of wild-type thymidine kinase (tk)-deficient and tk+ phenotypes of vaccinia virus recombinants after intranasal inoculation of mice. J Gen Virol 1991; 72: 125\u2013130.","journal-title":"J Gen Virol"},{"key":"BFgt200882_CR29","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/0042-6822(92)91246-Q","volume":"190","author":"M Merchlinsky","year":"1992","unstructured":"Merchlinsky M, Moss B . Introduction of foreign DNA into the vaccinia virus genome by in vitro ligation: recombination-independent selectable cloning vectors. Virology 1992; 190: 522\u2013526.","journal-title":"Virology"},{"key":"BFgt200882_CR30","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/sj.gt.3302840","volume":"14","author":"CF Hung","year":"2007","unstructured":"Hung CF, Tsai YC, He L, Coukos G, Fodor I, Qin L et al. Vaccinia virus preferentially infects and controls human and murine ovarian tumors in mice. Gene Therapy 2007; 14: 20\u201329.","journal-title":"Gene Therapy"},{"key":"BFgt200882_CR31","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1093\/jnci\/91.20.1744","volume":"91","author":"MF Gnant","year":"1999","unstructured":"Gnant MF, Noll LA, Irvine KR, Puhlmann M, Terrill RE, Alexander Jr HR et al. Tumor-specific gene delivery using recombinant vaccinia virus in a rabbit model of liver metastases. J Natl Cancer Inst 1999; 91: 1744\u20131750.","journal-title":"J Natl Cancer Inst"},{"key":"BFgt200882_CR32","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1073\/pnas.93.5.1831","volume":"93","author":"M Mesnil","year":"1996","unstructured":"Mesnil M, Piccoli C, Tiraby G, Willecke K, Yamasaki H . Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc Natl Acad Sci USA 1996; 93: 1831\u20131835.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgt200882_CR33","first-page":"1309","volume":"23","author":"S Matono","year":"2003","unstructured":"Matono S, Tanaka T, Sueyoshi S, Yamana H, Fujita H, Shirouzu K . Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer. Int J Oncol 2003; 23: 1309\u20131315.","journal-title":"Int J Oncol"},{"key":"BFgt200882_CR34","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/sj.gt.3301237","volume":"7","author":"JA McCart","year":"2000","unstructured":"McCart JA, Puhlmann M, Lee J, Hu Y, Libutti SK, Alexander Jr HR et al. Complex interactions between the replicating oncolytic effect and the enzyme\/prodrug effect of vaccinia-mediated tumor regression. Gene Therapy 2000; 7: 1217\u20131223.","journal-title":"Gene Therapy"},{"key":"BFgt200882_CR35","first-page":"5447","volume":"61","author":"H Nakamura","year":"2001","unstructured":"Nakamura H, Mullen JT, Chandrasekhar S, Pawlik TM, Yoon SS, Tanabe KK . Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil. Cancer Res 2001; 61: 5447\u20135452.","journal-title":"Cancer Res"},{"key":"BFgt200882_CR36","first-page":"6089","volume":"62","author":"KM Bernt","year":"2002","unstructured":"Bernt KM, Steinwaerder DS, Ni S, Li ZY, Roffler SR, Lieber A . Enzyme-activated prodrug therapy enhances tumor-specific replication of adenovirus vectors. Cancer Res 2002; 62: 6089\u20136098.","journal-title":"Cancer Res"},{"key":"BFgt200882_CR37","doi-asserted-by":"publisher","first-page":"4949","DOI":"10.1158\/0008-5472.CAN-07-0297","volume":"67","author":"S Schepelmann","year":"2007","unstructured":"Schepelmann S, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res 2007; 67: 4949\u20134955.","journal-title":"Cancer Res"},{"key":"BFgt200882_CR38","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.gassur.2005.06.024","volume":"9","author":"DP Eisenberg","year":"2005","unstructured":"Eisenberg DP, Adusumilli PS, Hendershott KJ, Yu Z, Mullerad M, Chan MK et al. 5-Fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer. J Gastrointest Surg 2005; 9: 1068\u20131077.","journal-title":"J Gastrointest Surg"},{"key":"BFgt200882_CR39","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/icb.1990.44","volume":"68","author":"G Karupiah","year":"1990","unstructured":"Karupiah G, Coupar B, Ramshaw I, Boyle D, Blanden R, Andrew M . Vaccinia virus-mediated damage of murine ovaries and protection by virus-expressed interleukin-2. Immunol Cell Biol 1990; 68: 325\u2013333.","journal-title":"Immunol Cell Biol"},{"key":"BFgt200882_CR40","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/00000658-199909000-00008","volume":"230","author":"MF Gnant","year":"1999","unstructured":"Gnant MF, Puhlmann M, Bartlett DL, Alexander Jr HR . Regional versus systemic delivery of recombinant vaccinia virus as suicide gene therapy for murine liver metastases. Ann Surg 1999; 230: 352\u2013360.","journal-title":"Ann Surg"},{"key":"BFgt200882_CR41","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1089\/hum.2006.17.31","volume":"17","author":"AM Naik","year":"2006","unstructured":"Naik AM, Chalikonda S, McCart JA, Xu H, Guo ZS, Langham G et al. Intravenous and isolated limb perfusion delivery of wild type and a tumor-selective replicating mutant vaccinia virus in nonhuman primates. Hum Gene Ther 2006; 17: 31\u201345.","journal-title":"Hum Gene Ther"},{"key":"BFgt200882_CR42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1046\/j.1365-2613.1997.d01-247.x","volume":"78","author":"M Neeman","year":"1997","unstructured":"Neeman M, Abramovitch R, Schiffenbauer YS, Tempel C . Regulation of angiogenesis by hypoxic stress: from solid tumours to the ovarian follicle. Int J Exp Pathol 1997; 78: 57\u201370.","journal-title":"Int J Exp Pathol"},{"key":"BFgt200882_CR43","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0042-6822(92)90752-B","volume":"188","author":"J Tartaglia","year":"1992","unstructured":"Tartaglia J, Perkus ME, Taylor J, Norton EK, Audonnet JC, Cox WI et al. NYVAC: a highly attenuated strain of vaccinia virus. Virology 1992; 188: 217\u2013232.","journal-title":"Virology"},{"key":"BFgt200882_CR44","first-page":"1341","volume":"3","author":"M Kretzschmar","year":"2006","unstructured":"Kretzschmar M, Wallinga J, Teunis P, Xing S, Mikolajczyk R . Frequency of adverse events after vaccination with different vaccinia strains. PLoS Med 2006; 3: 1341\u20131351.","journal-title":"PLoS Med"},{"key":"BFgt200882_CR45","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/312163a0","volume":"312","author":"MP Kieny","year":"1984","unstructured":"Kieny MP, Lathe R, Drillien R, Spehner D, Skory S, Schmitt D et al. Expression of rabies virus glycoprotein from a recombinant vaccinia virus. Nature 1984; 312: 163\u2013166.","journal-title":"Nature"},{"key":"BFgt200882_CR46","doi-asserted-by":"publisher","first-page":"11349","DOI":"10.1073\/pnas.93.21.11349","volume":"93","author":"E Paoletti","year":"1996","unstructured":"Paoletti E . Applications of pox virus vectors to vaccination: an update. Proc Natl Acad Sci USA 1996; 93: 11349\u201311353.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgt200882_CR47","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0378-1119(88)90005-4","volume":"67","author":"DB Smith","year":"1988","unstructured":"Smith DB, Johnson KS . Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 1988; 67: 31\u201340.","journal-title":"Gene"},{"key":"BFgt200882_CR48","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1073\/pnas.77.1.157","volume":"77","author":"GL Greene","year":"1980","unstructured":"Greene GL, Fitch FW, Jensen EV . Monoclonal antibodies to estrophilin: probes for the study of estrogen receptors. Proc Natl Acad Sci USA 1980; 77: 157\u2013161.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgt200882_CR49","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/00001813-199012000-00008","volume":"1","author":"P McBee","year":"1990","unstructured":"McBee P, Petraiuolo W, Katoh A . Inhibition of liver metastases in nude mice by the combined action of 5-fluorouracil and interferon. Anticancer Drugs 1990; 1: 165\u2013170.","journal-title":"Anticancer Drugs"},{"key":"BFgt200882_CR50","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ymthe.2003.12.008","volume":"9","author":"P Sova","year":"2004","unstructured":"Sova P, Ren XW, Ni S, Bernt KM, Mi J, Kiviat N et al. A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. Mol Ther 2004; 9: 496\u2013509.","journal-title":"Mol Ther"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gt200882.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gt200882","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gt200882.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T09:21:29Z","timestamp":1661246489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gt200882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,15]]},"references-count":50,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["BFgt200882"],"URL":"https:\/\/doi.org\/10.1038\/gt.2008.82","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,15]]},"assertion":[{"value":"21 December 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}