{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:15:41Z","timestamp":1791342941068,"version":"4.3.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T00:00:00Z","timestamp":1242864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T00:00:00Z","timestamp":1242864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1038\/gt.2009.52","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T19:43:17Z","timestamp":1242934997000},"page":"927-932","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promoters"],"prefix":"10.1038","volume":"16","author":[{"given":"T","family":"Husain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Passini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M K","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N W","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,5,21]]},"reference":[{"key":"BFgt200952_CR1","first-page":"43","volume-title":"Neurogenetics: Scientific and Clinical Advances","author":"TM Pierson","year":"2005","unstructured":"Pierson TM, Wolfe JH . Gene therapy for inherited diseases of the central nervous system. In: Lynch D (ed). Neurogenetics: Scientific and Clinical Advances. Marcel Dekker, Inc.: New York, NY, 2005, pp 43\u201385."},{"key":"BFgt200952_CR2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ymthe.2005.11.009","volume":"13","author":"RJ Mandel","year":"2006","unstructured":"Mandel RJ, Manfredsson FP, Foust KD, Rising A, Reimsnider S, Nash K et al. Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. Mol Ther 2006; 13: 463\u2013483.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR3","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nm0797-771","volume":"3","author":"RM Taylor","year":"1997","unstructured":"Taylor RM, Wolfe JH . Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of \u03b2-glucuronidase. Nat Med 1997; 3: 771\u2013774.","journal-title":"Nat Med"},{"key":"BFgt200952_CR4","doi-asserted-by":"publisher","first-page":"6437","DOI":"10.1523\/JNEUROSCI.22-15-06437.2002","volume":"22","author":"MA Passini","year":"2002","unstructured":"Passini MA, Lee EB, Heuer GG, Wolfe JH . Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream. J Neurosci 2002; 22: 6437\u20136446.","journal-title":"J Neurosci"},{"key":"BFgt200952_CR5","doi-asserted-by":"publisher","first-page":"9928","DOI":"10.1523\/JNEUROSCI.2185-07.2007","volume":"27","author":"CN Cearley","year":"2007","unstructured":"Cearley CN, Wolfe JH . A single injection of an adeno-associated virus vector into nuclei with divergent connections results in widespread vector distribution in the brain and global correction of a neurogenetic disease. J Neurosci 2007; 27: 9928\u20139940.","journal-title":"J Neurosci"},{"key":"BFgt200952_CR6","first-page":"70","volume":"2","author":"JH Wolfe","year":"1995","unstructured":"Wolfe JH, Kyle JW, Sands MS, Sly WS, Markowitz DG, Parente MK . High level expression and export of beta-glucuronidase from murine mucopolysaccharidosis VII cells corrected by a double-copy retrovirus vector. Gene Therapy 1995; 2: 70\u201378.","journal-title":"Gene Therapy"},{"key":"BFgt200952_CR7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1006\/mthe.2001.0274","volume":"3","author":"WA Frisella","year":"2001","unstructured":"Frisella WA, O'Connor LH, Vogler CA, Roberts M, Walkley S, Levy B et al. Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII. Mol Ther 2001; 3: 351\u2013358.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/sj.mt.6300018","volume":"15","author":"BK Berges","year":"2007","unstructured":"Berges BK, Wolfe JH, Fraser NW . Transduction of brain by herpes simplex virus vectors. Mol Ther 2007; 15: 20\u201329.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR9","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1128\/jvi.64.10.5019-5028.1990","volume":"64","author":"JC Zwaagstra","year":"1990","unstructured":"Zwaagstra JC, Ghiasi H, Slanina SM, Nesburn AB, Wheatley SC, Lillycrop K et al. Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J Virol 1990; 64: 5019\u20135028.","journal-title":"J Virol"},{"key":"BFgt200952_CR10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1006\/mthe.2001.0514","volume":"5","author":"H Fu","year":"2002","unstructured":"Fu H, Samulski RJ, McCown TJ, Picornell YJ, Fletcher D, Muenzer J . Neurological correction of lysosomal storage in a mucopolysaccharidosis IIIB mouse model by adeno-associated virus-mediated gene delivery. Mol Ther 2002; 5: 42\u201349.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR11","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1038\/sj.gt.3301529","volume":"8","author":"R Xu","year":"2001","unstructured":"Xu R, Janson CG, Mastakov M, Lawlor P, Young D, Mouravlev A et al. Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes. Gene Therapy 2001; 8: 1323\u20131332.","journal-title":"Gene Therapy"},{"key":"BFgt200952_CR12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/sj.gt.3300358","volume":"4","author":"AL Peel","year":"1997","unstructured":"Peel AL, Zolotukhin S, Schrimsher GW, Muzyczka N, Reier PJ . Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters. Gene Therapy 1997; 4: 16\u201324.","journal-title":"Gene Therapy"},{"key":"BFgt200952_CR13","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/0888-7543(91)90192-H","volume":"10","author":"JM Shipley","year":"1991","unstructured":"Shipley JM, Miller RD, Wu BM, Grubb JH, Christensen SG, Kyle JW et al. Analysis of the 5\u2032 flanking region of the human beta-glucuronidase gene. Genomics 1991; 10: 1009\u20131018.","journal-title":"Genomics"},{"key":"BFgt200952_CR14","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1073\/pnas.87.10.3914","volume":"87","author":"JW Kyle","year":"1990","unstructured":"Kyle JW, Birkenmeier EH, Gwynn B, Vogler C, Hoppe PC, Hoffmann JW et al. Correction of murine mucopolysaccharidosis VII by a human beta-glucuronidase transgene. Proc Natl Acad Sci USA 1990; 87: 3914\u20133918.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgt200952_CR15","doi-asserted-by":"publisher","first-page":"12382","DOI":"10.1128\/JVI.75.24.12382-12392.2001","volume":"75","author":"MA Passini","year":"2001","unstructured":"Passini MA, Wolfe JH . Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector. J Virol 2001; 75: 12382\u201312392.","journal-title":"J Virol"},{"key":"BFgt200952_CR16","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1038\/sj.gt.3301777","volume":"9","author":"RK Prasad Alur","year":"2002","unstructured":"Prasad Alur RK, Foley B, Parente MK, Tobin DK, Heuer GG, Avadhani AN et al. Modification of multiple transcriptional regulatory elements in a Moloney murine leukemia virus gene transfer vector circumvents silencing in fibroblast grafts and increases levels of expression of the transferred enzyme. Gene Therapy 2002; 9: 1146\u20131154.","journal-title":"Gene Therapy"},{"key":"BFgt200952_CR17","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1006\/mthe.2002.0584","volume":"5","author":"DJ Watson","year":"2002","unstructured":"Watson DJ, Kobinger GP, Passini MA, Wilson JM, Wolfe JH . Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins. Mol Ther 2002; 5: 528\u2013537.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR18","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1128\/MCB.7.3.1085","volume":"7","author":"G Watson","year":"1987","unstructured":"Watson G, Paigen K . Genetic variations in kinetic constants that describe beta-glucuronidase mRNA induction in androgen-treated mice. Mol Cell Biol 1987; 7: 1085\u20131090.","journal-title":"Mol Cell Biol"},{"key":"BFgt200952_CR19","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1038\/sj.gt.3302087","volume":"10","author":"CH Vite","year":"2003","unstructured":"Vite CH, Passini MA, Haskins ME, Wolfe JH . Adeno-associated virus vector-mediated transduction in the cat brain. Gene Therapy 2003; 10: 1874\u20131881.","journal-title":"Gene Therapy"},{"key":"BFgt200952_CR20","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.ymthe.2005.11.015","volume":"13","author":"CN Cearley","year":"2006","unstructured":"Cearley CN, Wolfe JH . Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain. Mol Ther 2006; 13: 528\u2013537.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR21","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1038\/mt.2008.166","volume":"16","author":"CN Cearley","year":"2008","unstructured":"Cearley CN, Vandenberghe LH, Parente MK, Carnish ER, Wilson JM, Wolfe JH . Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain. Mol Ther 2008; 16: 1710\u20131718.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR22","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.ymthe.2005.06.478","volume":"12","author":"BK Berges","year":"2005","unstructured":"Berges BK, Wolfe JH, Fraser NW . Stable levels of long-term transgene expression driven by the latency-associated transcript promoter in a herpes simplex virus type 1 vector. Mol Ther 2005; 12: 1111\u20131119.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR23","doi-asserted-by":"publisher","first-page":"7034","DOI":"10.1128\/JVI.77.12.7034-7040.2003","volume":"77","author":"MA Passini","year":"2003","unstructured":"Passini MA, Watson DJ, Vite CH, Landsburg DJ, Feigenbaum AL, Wolfe JH . Intraventricular brain injection of adeno-associated virus type 1 (AAV1) in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of beta-glucuronidase-deficient mice. J Virol 2003; 77: 7034\u20137040.","journal-title":"J Virol"},{"key":"BFgt200952_CR24","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1038\/sj.gt.3302011","volume":"10","author":"C Wang","year":"2003","unstructured":"Wang C, Wang CM, Clark KR, Sferra TJ . Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain. Gene Therapy 2003; 10: 1528\u20131534.","journal-title":"Gene Therapy"},{"key":"BFgt200952_CR25","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ymthe.2004.05.024","volume":"10","author":"C Burger","year":"2004","unstructured":"Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S et al. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol Ther 2004; 10: 302\u2013317.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1006\/exnr.1999.7176","volume":"160","author":"AF Skorupa","year":"1999","unstructured":"Skorupa AF, Fisher KJ, Wilson JM, Parente MK, Wolfe JH . Sustained production of beta-glucuronidase from localized sites after AAV vector gene transfer results in widespread distribution of enzyme and reversal of lysosomal storage lesions in a large volume of brain in mucopolysaccharidosis VII mice. Exp Neurol 1999; 160: 17\u201327.","journal-title":"Exp Neurol"},{"key":"BFgt200952_CR27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ymthe.2006.02.012","volume":"14","author":"BA Karolewski","year":"2006","unstructured":"Karolewski BA, Wolfe JH . Genetic correction of the fetal brain increases the lifespan of mice with the severe multisystemic disease mucopolysaccharidosis type VII. Mol Ther 2006; 14: 14\u201324.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR28","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.ymthe.2005.06.438","volume":"12","author":"T Luca","year":"2005","unstructured":"Luca T, Givogri MI, Perani L, Galbiati F, Follenzi A, Naldini L et al. Axons mediate the distribution of arylsulfatase A within the mouse hippocampus upon gene delivery. Mol Ther 2005; 12: 669\u2013679.","journal-title":"Mol Ther"},{"key":"BFgt200952_CR29","doi-asserted-by":"publisher","first-page":"3302","DOI":"10.1523\/JNEUROSCI.23-08-03302.2003","volume":"23","author":"AK Hennig","year":"2003","unstructured":"Hennig AK, Levy B, Ogilvie JM, Vogler CA, Galvin N, Bassnett S et al. Intravitreal gene therapy reduces lysosomal storage in specific areas of the CNS in mucopolysaccharidosis VII mice. J Neurosci 2003; 23: 3302\u20133307.","journal-title":"J Neurosci"},{"key":"BFgt200952_CR30","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1099\/0022-1317-81-3-649","volume":"81","author":"C Smith","year":"2000","unstructured":"Smith C, Lachmann RH, Efstathiou S . Expression from the herpes simplex virus type 1 latency-associated promoter in the murine central nervous system. J Gen Virol 2000; 81: 649\u2013662.","journal-title":"J Gen Virol"},{"key":"BFgt200952_CR31","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1128\/jvi.69.12.7899-7908.1995","volume":"69","author":"X Chen","year":"1995","unstructured":"Chen X, Schmidt MC, Goins WF, Glorioso JC . Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections. J Virol 1995; 69: 7899\u20137908.","journal-title":"J Virol"},{"key":"BFgt200952_CR32","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1128\/jvi.71.9.6714-6719.1997","volume":"71","author":"JR Lokensgard","year":"1997","unstructured":"Lokensgard JR, Berthomme H, Feldman LT . The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency. J Virol 1997; 71: 6714\u20136719.","journal-title":"J Virol"},{"key":"BFgt200952_CR33","doi-asserted-by":"publisher","first-page":"4386","DOI":"10.1128\/JVI.75.9.4386-4393.2001","volume":"75","author":"H Berthomme","year":"2001","unstructured":"Berthomme H, Thomas J, Texier P, Epstein A, Feldman LT . Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same region. J Virol 2001; 75: 4386\u20134393.","journal-title":"J Virol"},{"key":"BFgt200952_CR34","doi-asserted-by":"publisher","first-page":"11342","DOI":"10.1523\/JNEUROSCI.3329-06.2006","volume":"26","author":"YH Raol","year":"2006","unstructured":"Raol YH, Lund IV, Bandyopadhyay S, Zhang G, Roberts DS, Wolfe JH et al. Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci 2006; 26: 11342\u201311346.","journal-title":"J Neurosci"},{"key":"BFgt200952_CR35","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/ana.10373","volume":"52","author":"GG Heuer","year":"2002","unstructured":"Heuer GG, Passini MA, Jiang K, Parente MK, Lee VM, Trojanowski JQ et al. Selective neurodegeneration in the murine mucopolysaccharidosis VII is progressive and reversible. Ann Neurol 2002; 52: 762\u2013770.","journal-title":"Ann Neurol"},{"key":"BFgt200952_CR36","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1006\/mthe.2000.0202","volume":"2","author":"JH Wolfe","year":"2000","unstructured":"Wolfe JH, Sands MS, Harel N, Weil MA, Parente MK, Polesky AC et al. Gene transfer of low levels of beta-glucuronidase corrects hepatic lysosomal storage in a large animal model of mucopolysaccharidosis VII. Mol Ther 2000; 2: 552\u2013561.","journal-title":"Mol Ther"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gt200952.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gt200952","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gt200952.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T09:54:14Z","timestamp":1648547654000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gt200952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,21]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["BFgt200952"],"URL":"https:\/\/doi.org\/10.1038\/gt.2009.52","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,21]]},"assertion":[{"value":"23 June 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2009","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2009","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2009","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}