{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:15:11Z","timestamp":1767150911413,"version":"build-2238731810"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T00:00:00Z","timestamp":1289433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T00:00:00Z","timestamp":1289433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1038\/gt.2010.139","type":"journal-article","created":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T07:34:51Z","timestamp":1289460891000},"page":"344-353","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss"],"prefix":"10.1038","volume":"18","author":[{"given":"H","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Herbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Zinna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C R","family":"Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K L","family":"Kirkwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,11]]},"reference":[{"key":"BFgt2010139_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1600-0757.1993.tb00220.x","volume":"2","author":"LJ Brown","year":"1993","unstructured":"Brown LJ, Loe H . Prevalence, extent, severity and progression of periodontal disease. Periodontol 2000 1993; 2: 57\u201371.","journal-title":"Periodontol 2000"},{"key":"BFgt2010139_CR2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1600-051X.1991.tb02300.x","volume":"18","author":"T Pilot","year":"1991","unstructured":"Pilot T, Miyazaki H . Periodontal conditions in Europe. J Clin Periodontol 1991; 18: 353\u2013357.","journal-title":"J Clin Periodontol"},{"key":"BFgt2010139_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF02263497","volume":"45","author":"TJ Hall","year":"1996","unstructured":"Hall TJ, Chambers TJ . Molecular aspects of osteoclast function. Inflamm Res 1996; 45: 1\u20139.","journal-title":"Inflamm Res"},{"key":"BFgt2010139_CR4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1615\/CritRevEukaryotGeneExpr.v14.i4.20","volume":"14","author":"SV Reddy","year":"2004","unstructured":"Reddy SV . Regulatory mechanisms operative in osteoclasts. Crit Rev Eukaryot Gene Expr 2004; 14: 255\u2013270.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"BFgt2010139_CR5","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/iai.64.7.2371-2380.1996","volume":"64","author":"SP Nair","year":"1996","unstructured":"Nair SP, Meghji S, Wilson M, Reddi K, White P, Henderson B . Bacterially induced bone destruction: mechanisms and misconceptions. Infect Immun 1996; 64: 2371\u20132380.","journal-title":"Infect Immun"},{"key":"BFgt2010139_CR6","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1902\/jop.2005.76.11-S.2033","volume":"76","author":"MA Taubman","year":"2005","unstructured":"Taubman MA, Valverde P, Han X, Kawai T . Immune response: the key to bone resorption in periodontal disease. J Periodontol 2005; 76: 2033\u20132041.","journal-title":"J Periodontol"},{"key":"BFgt2010139_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1600-0765.1991.tb01647.x","volume":"26","author":"GR Mundy","year":"1991","unstructured":"Mundy GR . Inflammatory mediators and the destruction of bone. J Periodontal Res 1991; 26: 213\u2013217.","journal-title":"J Periodontal Res"},{"key":"BFgt2010139_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF02555128","volume":"41","author":"S Hanazawa","year":"1987","unstructured":"Hanazawa S, Amano S, Nakada K, Ohmori Y, Miyoshi T, Hirose K et al. Biological characterization of interleukin-1-like cytokine produced by cultured bone cells from newborn mouse calvaria. Calcif Tissue Int 1987; 41: 31\u201337.","journal-title":"Calcif Tissue Int"},{"key":"BFgt2010139_CR9","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1359\/jbmr.2002.17.7.1211","volume":"17","author":"W Zou","year":"2002","unstructured":"Zou W, Bar-Shavit Z . Dual modulation of osteoclast differentiation by lipopolysaccharide. J Bone Miner Res 2002; 17: 1211\u20131218.","journal-title":"J Bone Miner Res"},{"key":"BFgt2010139_CR10","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.4049\/jimmunol.145.10.3297","volume":"145","author":"Y Ishimi","year":"1990","unstructured":"Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y et al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 1990; 145: 3297\u20133303.","journal-title":"J Immunol"},{"key":"BFgt2010139_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0378-1119(03)00816-3","volume":"320","author":"SH Yang","year":"2003","unstructured":"Yang SH, Sharrocks AD, Whitmarsh AJ . Transcriptional regulation by the MAP kinase signaling cascades. Gene 2003; 320: 3\u201321.","journal-title":"Gene"},{"key":"BFgt2010139_CR12","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.bbamcr.2006.11.011","volume":"1773","author":"AJ Whitmarsh","year":"2007","unstructured":"Whitmarsh AJ . Regulation of gene transcription by mitogen-activated protein kinase signaling pathways. Biochim Biophys Acta 2007; 1773: 1285\u20131298.","journal-title":"Biochim Biophys Acta"},{"key":"BFgt2010139_CR13","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/S0955-0674(99)00075-7","volume":"12","author":"SM Keyse","year":"2000","unstructured":"Keyse SM . Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol 2000; 12: 186\u2013192.","journal-title":"Curr Opin Cell Biol"},{"key":"BFgt2010139_CR14","first-page":"E391","volume":"264","author":"P Orcel","year":"1993","unstructured":"Orcel P, Feuga M, Bielakoff J, De Vernejoul MC . Local bone injections of LPS and M-CSF increase bone resorption by different pathways in vivo in rats. Am J Physiol 1993; 264: E391\u2013E397.","journal-title":"Am J Physiol"},{"key":"BFgt2010139_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1034\/j.1600-0765.2001.00637.x","volume":"36","author":"E Nishida","year":"2001","unstructured":"Nishida E, Hara Y, Kaneko T, Ikeda Y, Ukai T, Kato I . Bone resorption and local interleukin-1alpha and interleukin-1beta synthesis induced by Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis lipopolysaccharide. J Periodontal Res 2001; 36: 1\u20138.","journal-title":"J Periodontal Res"},{"key":"BFgt2010139_CR16","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1128\/IAI.70.6.3143-3148.2002","volume":"70","author":"Y Jiang","year":"2002","unstructured":"Jiang Y, Mehta CK, Hsu TY, Alsulaimani FF . Bacteria induce osteoclastogenesis via an osteoblast-independent pathway. Infect Immun 2002; 70: 3143\u20133148.","journal-title":"Infect Immun"},{"key":"BFgt2010139_CR17","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1097\/MLG.0b013e318033783a","volume":"117","author":"L Zhuang","year":"2007","unstructured":"Zhuang L, Jung JY, Wang EW, Houlihan P, Ramos L, Pashia M et al. Pseudomonas aeruginosa lipopolysaccharide induces osteoclastogenesis through a toll-like receptor 4 mediated pathway in vitro and in vivo. Laryngoscope 2007; 117: 841\u2013847.","journal-title":"Laryngoscope"},{"key":"BFgt2010139_CR18","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.bone.2009.01.375","volume":"44","author":"Y Ozaki","year":"2009","unstructured":"Ozaki Y, Ukai T, Yamaguchi M, Yokoyama M, Haro ER, Kaneko T et al. Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorption. Bone 2009; 44: 1169\u20131176.","journal-title":"Bone"},{"key":"BFgt2010139_CR19","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1038\/sj.onc.1210412","volume":"26","author":"DM Owens","year":"2007","unstructured":"Owens DM, Keyse SM . Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 2007; 26: 3203\u20133213.","journal-title":"Oncogene"},{"key":"BFgt2010139_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1084\/jem.20051794","volume":"203","author":"Q Zhao","year":"2006","unstructured":"Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME et al. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med 2006; 203: 131\u2013140.","journal-title":"J Exp Med"},{"key":"BFgt2010139_CR21","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1073\/pnas.0510965103","volume":"103","author":"H Chi","year":"2006","unstructured":"Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM et al. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA 2006; 103: 2274\u20132279.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFgt2010139_CR22","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.4049\/jimmunol.176.3.1899","volume":"176","author":"KV Salojin","year":"2006","unstructured":"Salojin KV, Owusu IB, Millerchip KA, Potter M, Platt KA, Oravecz T . Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol 2006; 176: 1899\u20131907.","journal-title":"J Immunol"},{"key":"BFgt2010139_CR23","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1177\/0022034509349306","volume":"88","author":"R Sartori","year":"2009","unstructured":"Sartori R, Li F, Kirkwood KL . MAP kinase phosphatase-1 protects against inflammatory bone loss. J Dent Res 2009; 88: 1125\u20131130.","journal-title":"J Dent Res"},{"key":"BFgt2010139_CR24","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1902\/jop.2007.070101","volume":"78","author":"JE Rogers","year":"2007","unstructured":"Rogers JE, Li F, Coatney DD, Otremba J, Kriegl JM, Protter TA et al. A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model. J Periodontol 2007; 78: 1992\u20131998.","journal-title":"J Periodontol"},{"key":"BFgt2010139_CR25","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1016\/j.cellsig.2007.03.013","volume":"19","author":"X Wang","year":"2007","unstructured":"Wang X, Liu Y . Regulation of innate immune response by MAP kinase phosphatase-1. Cell Signal 2007; 19: 1372\u20131382.","journal-title":"Cell Signal"},{"key":"BFgt2010139_CR26","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1038\/mt.2008.163","volume":"16","author":"CS Patil","year":"2008","unstructured":"Patil CS, Liu M, Zhao W, Coatney DD, Li F, VanTubergen EA et al. Targeting mRNA stability arrests inflammatory bone loss. Mol Ther 2008; 16: 1657\u20131664.","journal-title":"Mol Ther"},{"key":"BFgt2010139_CR27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1124\/jpet.106.112466","volume":"320","author":"KL Kirkwood","year":"2007","unstructured":"Kirkwood KL, Li F, Rogers JE, Otremba J, Coatney DD, Kreider JM et al. A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss. J Pharmacol Exp Ther 2007; 320: 56\u201363.","journal-title":"J Pharmacol Exp Ther"},{"issue":"Suppl 1","key":"BFgt2010139_CR28","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1007\/BF03354642","volume":"56","author":"PJ Marie","year":"1995","unstructured":"Marie PJ . Human endosteal osteoblastic cells: relationship with bone formation. Calcif Tissue Int 1995; 56 (Suppl 1): S13\u2013S16.","journal-title":"Calcif Tissue Int"},{"key":"BFgt2010139_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2302\/kjm.52.1","volume":"52","author":"T Miyamoto","year":"2003","unstructured":"Miyamoto T, Suda T . Differentiation and function of osteoclasts. Keio J Med 2003; 52: 1\u20137.","journal-title":"Keio J Med"},{"key":"BFgt2010139_CR30","first-page":"204","volume":"8","author":"MP Yavropoulou","year":"2008","unstructured":"Yavropoulou MP, Yovos JG . Osteoclastogenesis\u2014current knowledge and future perspectives. J Musculoskelet Neuronal Interact 2008; 8: 204\u2013216.","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"BFgt2010139_CR31","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2353\/ajpath.2007.060834","volume":"170","author":"SL Teitelbaum","year":"2007","unstructured":"Teitelbaum SL . Osteoclasts: what do they do and how do they do it? Am J Pathol 2007; 170: 427\u2013435.","journal-title":"Am J Pathol"},{"key":"BFgt2010139_CR32","doi-asserted-by":"publisher","first-page":"6408","DOI":"10.4049\/jimmunol.169.11.6408","volume":"169","author":"P Chen","year":"2002","unstructured":"Chen P, Li J, Barnes J, Kokkonen GC, Lee JC, Liu Y . Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J Immunol 2002; 169: 6408\u20136416.","journal-title":"J Immunol"},{"key":"BFgt2010139_CR33","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1002\/jcb.20649","volume":"97","author":"MS Kim","year":"2006","unstructured":"Kim MS, Magno CL, Day CJ, Morrison NA . Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES. J Cell Biochem 2006; 97: 512\u2013518.","journal-title":"J Cell Biochem"},{"key":"BFgt2010139_CR34","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.2353\/ajpath.2009.090035","volume":"175","author":"J Carlson","year":"2009","unstructured":"Carlson J, Cui W, Zhang Q, Xu X, Mercan F, Bennett AM et al. Role of MKP-1 in osteoclasts and bone homeostasis. Am J Pathol 2009; 175: 1564\u20131573.","journal-title":"Am J Pathol"},{"key":"BFgt2010139_CR35","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1210\/endo.143.8.8954","volume":"143","author":"X Li","year":"2002","unstructured":"Li X, Udagawa N, Itoh K, Suda K, Murase Y, Nishihara T et al. p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function. Endocrinology 2002; 143: 3105\u20133113.","journal-title":"Endocrinology"},{"key":"BFgt2010139_CR36","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/art.21626","volume":"54","author":"J Zwerina","year":"2006","unstructured":"Zwerina J, Hayer S, Redlich K, Bobacz K, Kollias G, Smolen JS et al. Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction. Arthritis Rheum 2006; 54: 463\u2013472.","journal-title":"Arthritis Rheum"},{"key":"BFgt2010139_CR37","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1128\/iai.60.5.1806-1812.1992","volume":"60","author":"ME Wilson","year":"1992","unstructured":"Wilson ME, Hamilton RG . Immunoglobulin G subclass response of localized juvenile periodontitis patients to Actinobacillus actinomycetemcomitans Y4 lipopolysaccharide. Infect Immun 1992; 60: 1806\u20131812.","journal-title":"Infect Immun"}],"updated-by":[{"DOI":"10.1038\/s41434-025-00579-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000}}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/gt2010139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gt2010139","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/gt2010139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T14:23:35Z","timestamp":1763994215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/gt2010139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,11]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["BFgt2010139"],"URL":"https:\/\/doi.org\/10.1038\/gt.2010.139","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,11]]},"assertion":[{"value":"21 May 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41434-025-00579-w","URL":"https:\/\/doi.org\/10.1038\/s41434-025-00579-w","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}