{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:09:57Z","timestamp":1761581397604,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hum Genome Var"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We herein report an association between <jats:italic>TMEM132D<\/jats:italic> and panic disorder (PD) in a Japanese population, evaluating the effects of <jats:italic>HLA-DRB1*13:02<\/jats:italic>, which we previously reported as a susceptibility genetic factor for PD. SNPs in <jats:italic>TMEM132D<\/jats:italic> showed significant associations with PD in subjects without <jats:italic>HLA-DRB1*13:02<\/jats:italic> (rs4759997; <jats:italic>P<\/jats:italic>=5.02\u00d710<jats:sup>\u22126<\/jats:sup>, odds ratio=1.50) but not in those with the <jats:italic>HLA<\/jats:italic> allele. <jats:italic>TMEM132D<\/jats:italic> might have a role in the development of PD in subjects without <jats:italic>HLA-DRB1*13:02<\/jats:italic>.<\/jats:p>","DOI":"10.1038\/hgv.2016.1","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T08:55:11Z","timestamp":1456390511000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population"],"prefix":"10.1038","volume":"3","author":[{"given":"Mihoko","family":"Shimada-Sugimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Otowa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-4731","authenticated-orcid":false,"given":"Seik-Soon","family":"Khor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Omae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licht","family":"Toyo-oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagisa","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Umekage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2508-9649","authenticated-orcid":false,"given":"Akinori","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryozo","family":"Kuwano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanobu","family":"Kaiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoto","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Tanii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsushi","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"BFhgv20161_CR1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1176\/ajp.151.3.413","volume":"151","author":"WW Eaton","year":"1994","unstructured":"Eaton WW, Kessler RC, Wittchen HU, Magee WJ . Panic and panic disorder in the United States. Am J Psychiatry 1994; 151: 413\u2013420.","journal-title":"Am J Psychiatry"},{"key":"BFhgv20161_CR2","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","volume":"158","author":"JM Hettema","year":"2001","unstructured":"Hettema JM, Neale MC, Kendler KS . A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 2001; 158: 1568\u20131578.","journal-title":"Am J Psychiatry"},{"key":"BFhgv20161_CR3","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3346\/jkms.2011.26.6.701","volume":"26","author":"HR Na","year":"2011","unstructured":"Na HR, Kang EH, Lee JH, Yu BH . The genetic basis of panic disorder. J Korean Med Sci 2011; 26: 701\u2013710.","journal-title":"J Korean Med Sci"},{"key":"BFhgv20161_CR4","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/mp.2010.41","volume":"16","author":"A Erhardt","year":"2011","unstructured":"Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S et al. TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol Psychiatry 2011; 16: 647\u2013663.","journal-title":"Mol Psychiatry"},{"key":"BFhgv20161_CR5","doi-asserted-by":"publisher","first-page":"e156","DOI":"10.1038\/tp.2012.85","volume":"2","author":"A Erhardt","year":"2012","unstructured":"Erhardt A, Akula N, Schumacher J, Czamara D, Karbalai N, M\u00fcller-Myhsok B et al. Replication and meta-analysis of TMEM132D gene variants in panic disorder. Transl Psychiatry 2012; 2: e156.","journal-title":"Transl Psychiatry"},{"key":"BFhgv20161_CR6","doi-asserted-by":"crossref","unstructured":"Howe AS, Buttensch\u00f8n HN, Bani-Fatemi A, Maron E, Otowa T, Erhardt A et al. Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways. Mol Psychiatry (e-pub ahead of print 22 September 2015; doi:10.1038\/mp.2015.138).","DOI":"10.1038\/mp.2015.138"},{"key":"BFhgv20161_CR7","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/jhg.2008.17","volume":"54","author":"T Otowa","year":"2009","unstructured":"Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K et al. Genome-wide association study of panic disorder in the Japanese population. J Hum Genet 2009; 54: 122\u2013126.","journal-title":"J Hum Genet"},{"key":"BFhgv20161_CR8","doi-asserted-by":"publisher","first-page":"e186","DOI":"10.1038\/tp.2012.89","volume":"2","author":"T Otowa","year":"2012","unstructured":"Otowa T, Kawamura Y, Nishida N, Sugaya N, Koike A, Yoshida E et al. Meta-analysis of genome-wide association studies for panic disorder in the Japanese population. Transl Psychiatry 2012; 2: e186.","journal-title":"Transl Psychiatry"},{"key":"BFhgv20161_CR9","first-page":"93","volume":"16","author":"J Holoshitz","year":"2013","unstructured":"Holoshitz J . The quest for better understanding of HLA-disease association: scenes from a road less travelled by. Discov Med 2013; 16: 93\u2013101.","journal-title":"Discov Med"},{"key":"BFhgv20161_CR10","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.biopsych.2013.09.018","volume":"75","author":"A Corvin","year":"2014","unstructured":"Corvin A, Morris DW . Genome-wide association studies: findings at the major histocompatibility complex locus in psychosis. Biol Psychiatry 2014; 75: 276\u2013283.","journal-title":"Biol Psychiatry"},{"key":"BFhgv20161_CR11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bbi.2015.01.002","volume":"46","author":"M Shimada-Sugimoto","year":"2015","unstructured":"Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor SS, Kashiwase K, Sugaya N et al. Immune-related pathways including HLA-DRB1(\u2217)13:02 are associated with panic disorder. Brain Behav Immun 2015; 46: 96\u2013103.","journal-title":"Brain Behav Immun"},{"key":"BFhgv20161_CR12","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.sleep.2008.12.007","volume":"10","author":"T Sasai","year":"2009","unstructured":"Sasai T, Inoue Y, Komada Y, Sugiura T, Matsushima E . Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1(*)1501\/DQB1(*)0602 finding. Sleep Med 2009; 10: 961\u2013966.","journal-title":"Sleep Med"},{"key":"BFhgv20161_CR13","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.sleep.2015.01.022","volume":"16","author":"T Sasai-Sakuma","year":"2015","unstructured":"Sasai-Sakuma T, Inoue Y . Differences in electroencephalographic findings among categories of narcolepsy-spectrum disorders. Sleep Med 2015; 16: 999\u20131005.","journal-title":"Sleep Med"},{"key":"BFhgv20161_CR14","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/ng.2520","volume":"45","author":"Y Kirino","year":"2013","unstructured":"Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E et al. Genome-wide association analysis identifies new susceptibility loci for Beh\u00e7et\u2019s disease and epistasis between HLA-B*51 and ERAP1. Nat Genet 2013; 45: 202\u2013207.","journal-title":"Nat Genet"},{"key":"BFhgv20161_CR15","doi-asserted-by":"publisher","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","volume":"5","author":"BN Howie","year":"2009","unstructured":"Howie BN, Donnelly P, Marchini J . A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 2009; 5: e1000529.","journal-title":"PLoS Genet"},{"key":"BFhgv20161_CR16","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559\u2013575.","journal-title":"Am J Hum Genet"},{"key":"BFhgv20161_CR17","doi-asserted-by":"publisher","first-page":"e357","DOI":"10.1038\/tp.2014.1","volume":"4","author":"J Haaker","year":"2014","unstructured":"Haaker J, Lonsdorf TB, Raczka KA, Mechias ML, Gartmann N, Kalisch R . Higher anxiety and larger amygdala volumes in carriers of a TMEM132D risk variant for panic disorder. Transl Psychiatry 2014; 4: e357.","journal-title":"Transl Psychiatry"},{"key":"BFhgv20161_CR18","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/nature04226","volume":"437","author":"The International HapMap Consortium","year":"2005","unstructured":"The International HapMap Consortium. A haplotype map of the human genome. Nature 2005; 437: 1299\u20131320.","journal-title":"Nature"},{"key":"BFhgv20161_CR19","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/nature02168","volume":"426","author":"The International HapMap Consortium","year":"2003","unstructured":"The International HapMap Consortium. The International HapMap Project. Nature 2003; 426: 789\u2013796.","journal-title":"Nature"},{"key":"BFhgv20161_CR20","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.hgv.771","author":"Takeshi Otowa","year":"2015","unstructured":"Otowa, Takeshi HGV Database (2015) http:\/\/dx.doi.org\/10.6084\/m9.figshare.hgv.771"}],"container-title":["Human Genome Variation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/hgv20161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/hgv20161","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/hgv20161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T09:27:19Z","timestamp":1672824439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hgv20161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,8]]}},"alternative-id":["BFhgv20161"],"URL":"https:\/\/doi.org\/10.1038\/hgv.2016.1","relation":{"references":[{"id-type":"doi","id":"10.6084\/m9.figshare.hgv.771","asserted-by":"subject"}]},"ISSN":["2054-345X"],"issn-type":[{"type":"electronic","value":"2054-345X"}],"subject":[],"published":{"date-parts":[[2016,2,25]]},"assertion":[{"value":"19 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16001"}}