{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:27:47Z","timestamp":1773408467645,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T00:00:00Z","timestamp":1290643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1038\/hr.2010.220","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T07:01:49Z","timestamp":1290668509000},"page":"274-279","source":"Crossref","is-referenced-by-count":25,"title":["Body mass index and stroke incidence in a Japanese community: the Hisayama study"],"prefix":"10.1038","volume":"34","author":[{"given":"Koji","family":"Yonemoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasufumi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayo","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumie","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kiyohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,25]]},"reference":[{"key":"BFhr2010220_CR1","unstructured":"Statistics and Information Department, Minister's Secretariat, Ministry of Health, Labour and Welfare of Japan. Vital Statistics of Japan 2001, Vol. 3. Health and Welfare Statistics Association: Tokyo, Japan, 2003."},{"key":"BFhr2010220_CR2","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1111\/j.1532-5415.1987.tb04336.x","volume":"35","author":"K Ueda","year":"1987","unstructured":"Ueda K, Fujii I, Kawano H, Hasuo Y, Yanai T, Kiyohara Y, Wada J, Kato I, Omae T, Fujishima M . Severe disability related to cerebral stroke: incidence and risk factors observed in a Japanese community, Hisayama. J Am Geriatr Soc 1987; 35: 616\u2013622.","journal-title":"J Am Geriatr Soc"},{"issue":"suppl 2","key":"BFhr2010220_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000213625","volume":"40","author":"Y Kiyohara","year":"1994","unstructured":"Kiyohara Y, Yoshitake T, Kato I, Ohmura T, Kawano H, Ueda K, Fujishima M . Changing patterns in the prevalence of dementia in a Japanese community: the Hisayama Study. Gerontology 1994; 40 (suppl 2): 29\u201335.","journal-title":"Gerontology"},{"key":"BFhr2010220_CR4","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1212\/WNL.45.6.1161","volume":"45","author":"T Yoshitake","year":"1995","unstructured":"Yoshitake T, Kiyohara Y, Kato I, Ohmura T, Iwamoto H, Nakayama K, Ohmori S, Nomiyama K, Kawano H, Ueda K, Sueishi K, Tsuneyoshi M, Fujishima M . Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study. Neurology 1995; 45: 1161\u20131168.","journal-title":"Neurology"},{"key":"BFhr2010220_CR5","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1161\/01.STR.28.3.491","volume":"28","author":"CLM Sudlow","year":"1997","unstructured":"Sudlow CLM, Warlow CP . Comparable studies of the incidence of stroke and its pathological types: results from an international collaboration. Stroke 1997; 28: 491\u2013499.","journal-title":"Stroke"},{"key":"BFhr2010220_CR6","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1253\/circj.66.987","volume":"66","author":"The Examination Committee of Criteria for \u2018Obesity Disease\u2019 in Japan, Japan Society for the Study of Obesity","year":"2002","unstructured":"The Examination Committee of Criteria for \u2018Obesity Disease\u2019 in Japan, Japan Society for the Study of Obesity. New criteria for \u2018obesity disease\u2019 in Japan. Circ J 2002; 66: 987\u2013992.","journal-title":"Circ J"},{"key":"BFhr2010220_CR7","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/sj.ijo.0800651","volume":"22","author":"N Yoshiike","year":"1998","unstructured":"Yoshiike N, Matsumura Y, Zaman MM, Yamaguchi M . Descriptive epidemiology of body mass index in Japanese adults in a representative sample from the National Nutrition Survey 1990\u20131994. Int J Obes 1998; 22: 684\u2013687.","journal-title":"Int J Obes"},{"key":"BFhr2010220_CR8","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1093\/ije\/dyh163","volume":"33","author":"Asia Pacific Cohort Studies Collaboration","year":"2004","unstructured":"Asia Pacific Cohort Studies Collaboration. Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310\u2009000 participants. Int J Epidemiol 2004; 33: 751\u2013758.","journal-title":"Int J Epidemiol"},{"key":"BFhr2010220_CR9","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1161\/01.CIR.0000161822.83163.B6","volume":"111","author":"T Kurth","year":"2005","unstructured":"Kurth T, Gaziano JM, Rexrode KM, Kase CS, Cook NR, Manson JE, Buring JE . Prospective study of body mass index and risk of stroke in apparently healthy women. Circulation 2005; 111: 1992\u20131998.","journal-title":"Circulation"},{"key":"BFhr2010220_CR10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1161\/CIRCULATIONAHA.108.772962","volume":"118","author":"PWF Wilson","year":"2008","unstructured":"Wilson PWF, Bozeman SR, Burton TM, Hoaglin DC, Ben-Joseph R, Pashos CL . Prediction of first events of coronary heart disease and stroke with consideration of adiposity. Circulation 2008; 118: 124\u2013130.","journal-title":"Circulation"},{"key":"BFhr2010220_CR11","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1161\/STROKEAHA.107.495374","volume":"39","author":"M Zhou","year":"2008","unstructured":"Zhou M, Offer A, Yang G, Smith M, Hui G, Whitlock G, Collins R, Huang Z, Peto R, Chen Z . Body mass index, blood pressure, and mortality from stroke: a nationally representative prospective study of 212\u2009000 Chinese men. Stroke 2008; 39: 753\u2013759.","journal-title":"Stroke"},{"key":"BFhr2010220_CR12","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1161\/01.STR.0000119386.22691.1C","volume":"35","author":"YM Song","year":"2004","unstructured":"Song YM, Sung J, Smith GD, Ebrahim S . Body mass index and ischemic and hemorrhagic stroke: a prospective study in Korean men. Stroke 2004; 35: 831\u2013836.","journal-title":"Stroke"},{"key":"BFhr2010220_CR13","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1001\/jama.1997.03540430051032","volume":"277","author":"KM Rexrode","year":"1997","unstructured":"Rexrode KM, Hennekens CH, Wellett WC, Colditz GA, Stampfer MJ, Rich-Edwards JW, Speizer FE, Manson JE . A prospective study of body mass index, weight change, and risk of stroke in women. JAMA 1997; 277: 1539\u20131545.","journal-title":"JAMA"},{"key":"BFhr2010220_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/ana.21950","volume":"67","author":"LA Bazzano","year":"2010","unstructured":"Bazzano LA, Gu D, Whelton MR, Wu X, Chen CS, Duan X, Chen J, Chen J, He J . Body mass index and risk of stroke among Chinese men and women. Ann Neurol 2010; 67: 11\u201320.","journal-title":"Ann Neurol"},{"key":"BFhr2010220_CR15","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1161\/01.STR.30.10.1999","volume":"30","author":"CL Hart","year":"1999","unstructured":"Hart CL, Hole DJ, Smith GD . Risk factors and 20-year stroke mortality in men and women in the Renfrew\/Paisley Study in Scotland. Stroke 1999; 30: 1999\u20132007.","journal-title":"Stroke"},{"key":"BFhr2010220_CR16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1161\/01.STR.21.2.223","volume":"21","author":"P Harmsen","year":"1990","unstructured":"Harmsen P, Rosengren A, Tsipoglanni A, Wihelmsen L . Risk factors for stroke in middle-aged men in G\u00f6thborg, Sweden. Stroke 1990; 21: 223\u2013229.","journal-title":"Stroke"},{"key":"BFhr2010220_CR17","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1136\/bmj.314.7090.1311","volume":"314","author":"AG Shaper","year":"1997","unstructured":"Shaper AG, Wannamethee SG, Walker M . Body weight: implications for the prevention of coronary heart disease, stroke, and diabetes mellitus in a cohort study of middle aged men. BMJ 1997; 314: 1311\u20131317.","journal-title":"BMJ"},{"key":"BFhr2010220_CR18","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1161\/01.STR.24.10.1484","volume":"24","author":"LL H\u00e5heim","year":"1993","unstructured":"H\u00e5heim LL, Holme I, Hjermann I, Leren P . Risk factors of stroke incidence and mortality: a 12-year follow-up of the Oslo study. Stroke 1993; 24: 1484\u20131489.","journal-title":"Stroke"},{"key":"BFhr2010220_CR19","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1161\/01.STR.0000147715.58886.ad","volume":"35","author":"K Jood","year":"2004","unstructured":"Jood K, Jern C, Wilhelmsen L, Rosengren A . Body mass index in mid-life is associated with a first stroke in men: a prospective study over 28 years. Stroke 2004; 35: 2764\u20132769.","journal-title":"Stroke"},{"key":"BFhr2010220_CR20","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1136\/jech.49.3.265","volume":"49","author":"R Selmer","year":"1995","unstructured":"Selmer R, Tverdal A . Body mass index and cardiovascular mortality at different levels of blood pressure: a prospective study of Norwegian men and women. J Epidemiol Commun H 1995; 49: 265\u2013270.","journal-title":"J Epidemiol Commun H"},{"key":"BFhr2010220_CR21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1159\/000094860","volume":"22","author":"I Oki","year":"2006","unstructured":"Oki I, Nakamura Y, Okamura T, Okayama A, Hayakawa T, Kita Y, Ueshima H, NIPPON DATA 80 Research Group. Body mass index and risk of stroke mortality among a random sample of Japanese adults: 19-year follow-up of NIPPON DATA 80. Cerebrovasc Dis 2006; 22: 409\u2013415.","journal-title":"Cerebrovasc Dis"},{"key":"BFhr2010220_CR22","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1161\/01.STR.0000169925.57251.4e","volume":"36","author":"R Cui","year":"2005","unstructured":"Cui R, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Kondo T, Watanabe Y, Koizumi A, Wada Y, Inaba Y, Tamakoshi A, JACC Study Group. Body mass index and mortality from cardiovascular disease among Japanese men and women: the JACC Study. Stroke 2005; 36: 1377\u20131382.","journal-title":"Stroke"},{"key":"BFhr2010220_CR23","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1161\/01.STR.28.7.1507","volume":"28","author":"RL Sacco","year":"1997","unstructured":"Sacco RL, Benjamini EJ, Broderick JP, Dyken M, Easton JD, Feinberg WM, Goldstein LB, Gorelick PB, Howard G, Kittner SJ, Manolio TA, Whisnant JP, Wolf PA . Risk factors. Stroke 1997; 28: 1507\u20131517.","journal-title":"Stroke"},{"key":"BFhr2010220_CR24","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1161\/01.STR.31.11.2616","volume":"31","author":"Y Tanizaki","year":"2000","unstructured":"Tanizaki Y, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Shinohara N, Arima H, Tanaka K, Ibayashi S, Fujishima M . Incidence and risk factors for subtypes of cerebral infarction in a general population: the Hisayama Study. Stroke 2000; 31: 2616\u20132622.","journal-title":"Stroke"},{"key":"BFhr2010220_CR25","unstructured":"World Health Organization. Cerebrovascular diseases: Prevention, Treatment, and Rehabilitation. Technical Report Series. World Health Organization: Geneva, Switzerland, 1971, No. 469."},{"key":"BFhr2010220_CR26","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1161\/01.STR.0000091845.14833.43","volume":"34","author":"Y Kiyohara","year":"2003","unstructured":"Kiyohara Y, Kubo M, Kato I, Tanizaki Y, Tanaka K, Okubo K, Nakamura H, Iida M . Ten-year prognosis of stroke and risk factors for death in a Japanese Community: the Hisayama Study. Stroke 2003; 34: 2343\u20132348.","journal-title":"Stroke"},{"key":"BFhr2010220_CR27","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/sj.ijo.0800435","volume":"21","author":"G De Pergola","year":"1997","unstructured":"De Pergola G, De Mitrio V, Giorgino F, Sciaraffia M, Minenna A, Di Bari L, Pannacciulli N, Giorgino R . Increase in both pro-thrombotic and anti-thrombotic factors in obese premenopausal women: relationship with body fat distribution. Int J Obes 1997; 21: 527\u2013535.","journal-title":"Int J Obes"},{"key":"BFhr2010220_CR28","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1161\/01.ATV.19.5.1361","volume":"19","author":"PE Morange","year":"1999","unstructured":"Morange PE, Alessi MC, Verdier M, Casanova D, Magalon G, Juhan-Vague I . PAI-1 produced ex vivo by human adipose tissue is relevant to PAI-1 blood level. Arterioscl Throm Vas Biol 1999; 19: 1361\u20131365.","journal-title":"Arterioscl Throm Vas Biol"},{"issue":"Suppl 1","key":"BFhr2010220_CR29","first-page":"78","volume":"32","author":"I Juhan-Vague","year":"2000","unstructured":"Juhan-Vague I, Alessi MC, Morange PE . Hypofibrinolysis and increased PAI-1 are linked to atherothrombosis via insulin resistance and obesity. Ann Med 2000; 32 (Suppl 1): 78\u201384.","journal-title":"Ann Med"},{"key":"BFhr2010220_CR30","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1001\/jama.282.22.2131","volume":"282","author":"M Visser","year":"1999","unstructured":"Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB . Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999; 282: 2131\u20132135.","journal-title":"JAMA"},{"key":"BFhr2010220_CR31","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1056\/NEJM199704033361409","volume":"336","author":"A Maseri","year":"1997","unstructured":"Maseri A . Inflammation, atherosclerosis, and ischemic events: exploring the hidden side of the moon. N Engl J Med 1997; 336: 1014\u20131016.","journal-title":"N Engl J Med"},{"key":"BFhr2010220_CR32","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1161\/01.STR.32.4.917","volume":"32","author":"M Di Napoli","year":"2001","unstructured":"Di Napoli M, Papa F, Bocola V . C-reactive protein in ischemic stroke: an independent prognostic factor. Stroke 2001; 32: 917\u2013924.","journal-title":"Stroke"},{"key":"BFhr2010220_CR33","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1161\/hs1101.098151","volume":"32","author":"NS Rost","year":"2001","unstructured":"Rost NS, Wolf PA, Kase CS, Kelly-Hayes M, Silbershatz H, Massero JM, D\u2019Agostino RB, Franzblau C, Wilson PWF . Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham Study. Stroke 2001; 32: 2575\u20132579.","journal-title":"Stroke"},{"key":"BFhr2010220_CR34","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1159\/000073579","volume":"32","author":"I Juhan-Vague","year":"2002","unstructured":"Juhan-Vague I, Morange PE, Alessi MC . The insulin resistance syndrome: implication for thrombosis and cardiovascular disease. Pathophysiol Haemost Thromb 2002; 32: 269\u2013273.","journal-title":"Pathophysiol Haemost Thromb"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr2010220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2010220","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2010220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:06:30Z","timestamp":1684429590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr2010220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,25]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["BFhr2010220"],"URL":"https:\/\/doi.org\/10.1038\/hr.2010.220","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,25]]}}}