{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:32:56Z","timestamp":1791113576945,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T00:00:00Z","timestamp":1270771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1038\/hr.2010.46","type":"journal-article","created":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T08:45:15Z","timestamp":1270802715000},"page":"616-621","source":"Crossref","is-referenced-by-count":25,"title":["Rationale and design of the Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial: a double-blinded randomized placebo-controlled trial to evaluate the antialbuminuric effects of an aldosterone blocker in hypertensive patients with albuminuria"],"prefix":"10.1038","volume":"33","author":[{"name":"on behalf of the EVALUATE Study Investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Ando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ohtsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuhiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,9]]},"reference":[{"key":"BFhr201046_CR1","first-page":"3","volume":"32","author":"T Ogihara","year":"2009","unstructured":"Ogihara T, Kikuchi K, Matsuoka H, Fujita T, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ito S, Iwao H, Kario K, Kawano Y, Kim-Mitsuyama S, Kimura G, Matsubara H, Matsuura H, Naruse M, Saito I, Shimada K, Shimamoto K, Suzuki H, Takishita S, Tanahashi N, Tsuchihashi T, Uchiyama M, Ueda S, Ueshima H, Umemura S, Ishimitsu T, Rakugi H, The Japanese Society of Hypertension Committee. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009). Hypertens Res 2009; 32: 3\u2013107.","journal-title":"Hypertens Res"},{"key":"BFhr201046_CR2","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1097\/HJH.0b013e3281fc975a","volume":"25","author":"G Mancia","year":"2007","unstructured":"Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Boudier HA, Zanchetti A, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Erdine S, Kiowski W, Agabiti-Rosei E, Ambrosioni E, Lindholm LH, Viigimaa M, Adamopoulos S, Agabiti-Rosei E, Ambrosioni E, Bertomeu V, Clement D, Erdine S, Farsang C, Gaita D, Lip G, Mallion JM, Manolis AJ, Nilsson PM, O\u2019Brien E, Ponikowski P, Redon J, Ruschitzka F, Tamargo J, van Zwieten P, Waeber B, Williams B, Management of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. 2007 Guidelines for the Management of Arterial Hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 1105\u20131187.","journal-title":"J Hypertens"},{"key":"BFhr201046_CR3","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","volume":"42","author":"AV Chobanian","year":"2003","unstructured":"Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL, Jones DW, Materson BJ, Oparil S, Wright Jr JT, Roccella EJ, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206\u20131252.","journal-title":"Hypertension"},{"key":"BFhr201046_CR4","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S0140-6736(05)71082-5","volume":"365","author":"P Ruggenenti","year":"2005","unstructured":"Ruggenenti P, Perna A, Loriga G, Ganeva M, Ene-Iordache B, Turturro M, Lesti M, Perticucci E, Chakarski IN, Leonardis D, Garini G, Sessa A, Basile C, Alpa M, Scanziani R, Sorba G, Zoccali C, Remuzzi D, REIN-2 Study Group. Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial. Lancet 2005; 365: 939\u2013946.","journal-title":"Lancet"},{"key":"BFhr201046_CR5","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/ki.2008.102","volume":"73","author":"GL Bakris","year":"2008","unstructured":"Bakris GL, Toto RD, McCullough PA, Rocha R, Purkayastha D, Davis P, GUARD (Gauging Albuminuria Reduction With Lotrel in Diabetic Patients With Hypertension) Study Investigators. Effects of different ACE inhibitor combinations on albuminuria: results of the GUARD study. Kidney Int 2008; 73: 1303\u20131309.","journal-title":"Kidney Int"},{"key":"BFhr201046_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1161\/01.HYP.0000255636.11931.a2","volume":"49","author":"S Shibata","year":"2007","unstructured":"Shibata S, Nagase M, Yoshida S, Kawachi H, Fujita T . Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 2007; 49: 355\u2013364.","journal-title":"Hypertension"},{"key":"BFhr201046_CR7","doi-asserted-by":"publisher","first-page":"3438","DOI":"10.1681\/ASN.2006080944","volume":"17","author":"M Nagase","year":"2006","unstructured":"Nagase M, Yoshida S, Shibata S, Nagase T, Gotoda T, Ando K, Fujita T . Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol 2006; 17: 3438\u20133446.","journal-title":"J Am Soc Nephrol"},{"key":"BFhr201046_CR8","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1161\/01.HYP.0000222003.28517.99","volume":"47","author":"M Nagase","year":"2006","unstructured":"Nagase M, Shibata S, Yoshida S, Nagase T, Gotoda T, Fujita T . Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 2006; 47: 1084\u20131093.","journal-title":"Hypertension"},{"key":"BFhr201046_CR9","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1161\/01.HYP.0000063885.48344.EA","volume":"41","author":"M Farjah","year":"2003","unstructured":"Farjah M, Roxas BP, Geenen DL, Danziger RS . Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat. Hypertension 2003; 41: 874\u2013878.","journal-title":"Hypertension"},{"key":"BFhr201046_CR10","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/HYPERTENSIONAHA.107.091058","volume":"50","author":"M Nagase","year":"2007","unstructured":"Nagase M, Matsui H, Shibata S, Gotoda T, Fujita T . Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress. Hypertension 2007; 50: 877\u2013883.","journal-title":"Hypertension"},{"key":"BFhr201046_CR11","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/nm.1879","volume":"14","author":"S Shibata","year":"2008","unstructured":"Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T . Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med 2008; 14: 1370\u20131376.","journal-title":"Nat Med"},{"key":"BFhr201046_CR12","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.amjcard.2004.01.007","volume":"93","author":"GH Williams","year":"2004","unstructured":"Williams GH, Burgess E, Kolloch RE, Ruilope LM, Niegowska J, Kipnes MS, Roniker B, Patrick JL, Krause SL . Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension. Am J Cardiol 2004; 93: 990\u2013996.","journal-title":"Am J Cardiol"},{"key":"BFhr201046_CR13","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1093\/ndt\/gfl780","volume":"22","author":"ML Onozato","year":"2007","unstructured":"Onozato ML, Tojo A, Kobayashi N, Goto A, Matsuoka H, Fujita T . Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney. Nephrol Dial Transplant 2007; 22: 1314\u20131322.","journal-title":"Nephrol Dial Transplant"},{"key":"BFhr201046_CR14","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1161\/01.HYP.33.1.232","volume":"33","author":"R Rocha","year":"1999","unstructured":"Rocha R, Chander PN, Zuckerman A, Stier Jr CT . Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats. Hypertension 1999; 33: 232\u2013237.","journal-title":"Hypertension"},{"key":"BFhr201046_CR15","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1161\/01.HYP.0000044937.95080.E9","volume":"41","author":"A Sato","year":"2003","unstructured":"Sato A, Hayashi K, Naruse M, Saruta T . Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension 2003; 41: 64\u201368.","journal-title":"Hypertension"},{"key":"BFhr201046_CR16","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1056\/NEJM199909023411001","volume":"341","author":"B Pitt","year":"1999","unstructured":"Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Prez A, Palensky J, Wittes J, Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999; 341: 709\u2013717.","journal-title":"N Engl J Med"},{"key":"BFhr201046_CR17","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1056\/NEJMoa030207","volume":"348","author":"B Pitt","year":"2003","unstructured":"Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J, Gatlin M, Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348: 1309\u20131321.","journal-title":"N Engl J Med"},{"key":"BFhr201046_CR18","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1161\/01.HYP.0000067463.13172.EA","volume":"41","author":"WB White","year":"2003","unstructured":"White WB, Duprez D, St Hillaire R, Krause S, Roniker B, Kuse-Hamilton J, Weber MA . Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension. Hypertension 2003; 41: 1021\u20131026.","journal-title":"Hypertension"},{"key":"BFhr201046_CR19","doi-asserted-by":"publisher","first-page":"940","DOI":"10.2215\/CJN.00240106","volume":"1","author":"M Epstein","year":"2006","unstructured":"Epstein M, Williams GH, Weinberger M, Lewin A, Krause S, Mukherjee R, Patni R, Beckerman B . Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes. Clin J Am Soc Nephrol 2006; 1: 940\u2013951.","journal-title":"Clin J Am Soc Nephrol"},{"key":"BFhr201046_CR20","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1053\/ajkd.2001.25209","volume":"38","author":"A Hartner","year":"2001","unstructured":"Hartner A, Porst M, Gauer S, Proels F, Veelken R, Hilqers KF . Glomerular osteopontin expression and macrophage infiltration in glomerulosclerosis of DOCA-salt rats. Am J Kidney Dis 2001; 38: 153\u2013164.","journal-title":"Am J Kidney Dis"},{"key":"BFhr201046_CR21","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1046\/j.1523-1755.2003.00929.x","volume":"63","author":"ER Blasi","year":"2003","unstructured":"Blasi ER, Rocha R, Rudolph AE, Blomme EA, Polly ML, McMahon EG . Aldosterone\/salt induces renal inflammation and fibrosis in hypertensive rats. Kidney Int 2003; 63: 1791\u20131800.","journal-title":"Kidney Int"},{"key":"BFhr201046_CR22","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1161\/HYPERTENSIONAHA.107.100701","volume":"51","author":"E Pimenta","year":"2008","unstructured":"Pimenta E, Gaddam KK, Pratt-Ubunama MN, Nishizaka MK, Aban I, Oparil S, Calhoun DA . Relation of dietary salt and aldosterone to urinary protein excretion in subjects with resistant hypertension. Hypertension 2008; 51: 339\u2013344.","journal-title":"Hypertension"},{"key":"BFhr201046_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1291\/hypres.27.303","volume":"27","author":"A Sato","year":"2004","unstructured":"Sato A, Saruta T . Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status. Hypertens Res 2004; 27: 303\u2013310.","journal-title":"Hypertens Res"},{"key":"BFhr201046_CR24","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1161\/01.HYP.0000230482.82239.a0","volume":"48","author":"E Pimenta","year":"2006","unstructured":"Pimenta E, Calhoun DA . Aldosterone, dietary salt, and renal disease. Hypertension 2006; 48: 209\u2013210.","journal-title":"Hypertension"},{"key":"BFhr201046_CR25","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1093\/ije\/dyp139","volume":"38","author":"IJ Brown","year":"2009","unstructured":"Brown IJ, Izoulaki I, Candeias V, Elliott P . Salt intakes around the world: implications for public health. Int J Epidemiol 2009; 38: 791\u2013813.","journal-title":"Int J Epidemiol"},{"key":"BFhr201046_CR26","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1681\/ASN.2007010097","volume":"18","author":"T Yamamoto","year":"2007","unstructured":"Yamamoto T, Noiri E, Ono Y, Doi K, Negishi K, Kamijo A, Kimura K, Fujita T, Kinukawa T, Taniguchi H, Nakamura K, Goto M, Shinozaki N, Ohshima S, Sugaya T . Renal L-type fatty acid-binding protein in acute ischemic injury. J Am Soc Nephrol 2007; 18: 2894\u20132902.","journal-title":"J Am Soc Nephrol"},{"key":"BFhr201046_CR27","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.lab.2004.12.003","volume":"145","author":"A Kamijo","year":"2005","unstructured":"Kamijo A, Sugaya T, Hikawa A, Yamanouchi M, Hirata Y, Ishimitsu T, Numabe A, Takagi M, Hayakawa H, Tabei F, Sugimoto T, Mise N, Kimura K . Clinical evaluation of urinary excretion of liver-type fatty acid\u2013binding protein as a marker for the monitoring of chronic kidney disease: A multicenter trial. J Lab Clin Med 2005; 145: 125\u2013133.","journal-title":"J Lab Clin Med"},{"key":"BFhr201046_CR28","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","volume":"53","author":"S Matsuo","year":"2009","unstructured":"Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A, Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009; 53: 982\u2013992.","journal-title":"Am J Kidney Dis"},{"key":"BFhr201046_CR29","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1291\/hypres.30.887","volume":"30","author":"Y Kawano","year":"2007","unstructured":"Kawano Y, Tsuchihashi T, Matsuura H, Ando K, Fujita T, Ueshima H, Working Group for Dietary Salt Reduction of the Japanese Society of Hypertension. Report of the Working Group for Dietary Salt Reduction of the Japanese Society of Hypertension: (2) Assessment of salt intake in the management of hypertension. Hypertens Res 2007; 30: 887\u2013893.","journal-title":"Hypertens Res"},{"key":"BFhr201046_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1440-1681.1993.tb01496.x","volume":"20","author":"T Kawasaki","year":"1993","unstructured":"Kawasaki T, Itoh K, Uezono K, Sasaki H . A simple method for estimating 24\u2009h urinary sodium and potassium excretion from second morning voiding urine specimen in adults. Clin Exp Pharmacol Physiol 1993; 20: 7\u201314.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BFhr201046_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1523-1755.2004.00701.x","volume":"66","author":"NK Hollenberg","year":"2004","unstructured":"Hollenberg NK . Aldosterone in the development and progression of renal injury. Kidney Int 2004; 66: 1\u20139.","journal-title":"Kidney Int"},{"key":"BFhr201046_CR32","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1111\/j.1523-1755.2004.00620.x","volume":"65","author":"GL Bakris","year":"2004","unstructured":"Bakris GL, Weir M, Secic M, Campbell B, Weis-McNulty A . Differential effects of calcium antagonist subclasses on markers of nephropathy progression. Kidney Int 2004; 65: 1991\u20132002.","journal-title":"Kidney Int"},{"key":"BFhr201046_CR33","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1161\/01.HYP.16.3.235","volume":"16","author":"T Fujita","year":"1990","unstructured":"Fujita T, Ando K, Ogata E . Systemic and regional hemodynamics in patients with salt-sensitive hypertension. Hypertension 1990; 16: 235\u2013244.","journal-title":"Hypertension"},{"key":"BFhr201046_CR34","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1161\/01.HYP.0000232617.48372.cb","volume":"48","author":"H Matsui","year":"2006","unstructured":"Matsui H, Shimosawa T, Uetake Y, Wang H, Ogura S, Kaneko T, Liu J, Ando K, Fujita T . Protective effect of potassium against the hypertensive cardiac dysfunction. Hypertension 2006; 48: 225\u2013231.","journal-title":"Hypertension"},{"key":"BFhr201046_CR35","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1161\/HYPERTENSIONAHA.107.098251","volume":"51","author":"M Kido","year":"2008","unstructured":"Kido M, Ando K, Onozato ML, Tojo A, Yoshikawa M, Ogita T, Fujita T . Protective effect of dietary potassium against the vascular injury in salt-sensitive hypertension. Hypertension 2008; 51: 225\u2013231.","journal-title":"Hypertension"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr201046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr201046","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr201046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:07:09Z","timestamp":1684429629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr201046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,9]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["BFhr201046"],"URL":"https:\/\/doi.org\/10.1038\/hr.2010.46","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,9]]}}}